Drug Database
PH

phenylpropanolamine (Dristan SR / Histabid / Dexatrim)

✓ Approved

Lumara Health · Small Molecule · Small Molecule

What is phenylpropanolamine?

phenylpropanolamine is a small molecule developed by Lumara Health. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesDristan SR, Histabid, Dexatrim
CompanyLumara Health
Drug ClassSmall Molecule
RouteOral (PO)
StatusApproved

Therapeutic Indications

phenylpropanolamine is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Respiratory, thoracic and mediastinal disordersCough✓ Approved

Related Research Articles

PubMedJournal of biomechanics2026-09-19

Modeling tendon viscoelastic properties using a system identification approach.

Valencia Miles M, Chow Hanna H, Manross Katelyn K, Casler Richard J RJ et al.

Viscoelasticity is characteristic of tendon mechanical behavior and is thought to reflect underlying structure, which can change with exercise, aging and pathology. We used ramp stretch experiments to measure the stress-relaxation response of rat tail tendon fascicles. System identification methods were applied to fit viscoelastic models to these measurements, enabling exploration of several possible viscoelastic model structures and quantification of the models' viscoelastic parameters. While tendons have been modeled as springs or quasi-linear viscoelastic materials, we found that tendons are well fit by a viscoelastic model consisting of a single Kelvin-Voigt (KV) element in series with a spring. From the viscoelastic model structure, we can predict tendon behavior beyond experimental measurements, providing insight into muscle-tendon interactions. The model comprising a series KV element and spring exhibits a force-frequency relationship that may protect muscles from high frequency damage and implies that most of the energy storage and power amplification of tendons is provided by the extracellular matrix rather than collagen fibers. The elastic modulus of the KV element was similar to that of single collagen fibers and increased with genipin treatment but not age. The elastic modulus of the series spring increased with age but not genipin treatment. The time constant of stress-relaxation increased over time, suggesting that rat tail tendon fascicles are more like amorphous polymers than quasi-linear viscoelastic materials. This approach revealed previously unknown properties of tendons which demonstrate that they are exquisitely designed to protect muscles and recover elastic energy across timescales.

PubMedFood science and technology international = Ciencia y tecnologia de los alimentos internacional2026-09-19

Inactivation of Escherichia coli and Bacillus cereus in Myungran jeotgal (Korean traditional salted pollack roe) using floating electrode-dielectric barrier discharge plasma.

Hong Hyuk Soo HS, Jeon Eun Bi EB, Cho Sung Rae SR, Park Shin Young SY

Nonthermal plasma technology has garnered significant attention for its food preservation capabilities. However, the applicability of floating electrode-dielectric barrier discharge (FE-DBD) plasma in this regard has not been explored. Therefore, the effects of FE-DBD plasma (1.1 kV, 43 kHz, N2 1.5 m/s, and 1-90 min) on Escherichia coli and Bacillus cereus and on the quality characteristics (pH, Hunter colors) of Myungran jeotgal (a traditional Korean salted fermented pollack roe) were investigated. When FE-DBD plasma was applied for 1, 5, 10, 20, 30, 60, and 90 min, E. coli and B. cereus contents decreased by 0.03-1.35 log and 0.04-1.02 log colony-forming unit (CFU)/g, respectively. After a treatment of 90 min, both bacterial species showed a reduction of >1 log CFU/g. When the first-order kinetic model was applied, E. coli showed a D-value of 65.37 (R2 = 0.99) and B. cereus showed a D-value of 88.50 (R2 = 0.98). After FE-DBD plasma treatment, the pH significantly decreased from 5.87 to 5.75, lightness (L*) decreased, and redness (a*) significantly increased (p < .05). However, the yellowness (b*) was not significantly different (p > .05). These changes can be attributed not to the direct effects of the FE-DBD plasma but rather to an increase in the surface moisture caused by the internal moisture diffusion during treatment under ambient conditions and to the associated quality changes occurring during the treatment process. Further studies incorporating temperature control during treatment would suggest that FE-DBD plasma could be utilized as an effective nonthermal sterilization technology for M. jeotgal.

PubMedMaterials horizons2026-09-18

A ferroelectric-resistive dual-mode capacitor for unified KV-cache and weight storage toward Transformer acceleration.

Lee Youngseo Y, Choi Minki M, Kim Nawoon N, Lee Seonjeong S et al.

This study proposes processing-in-memory (PIM) architecture based on a dual-mode capacitor to address the memory bottleneck and power consumption issues arising from the rapid expansion of large language models (LLMs). In large-scale AI systems, the key-value cache (KV-cache) is essential for handling massive parameters; however, as the cache size increases proportionally with context length, DRAM usage and power consumption surge, leading to memory bottlenecks. To mitigate this, we introduce a PIM architecture that performs computations directly within memory, thereby reducing data transfer overhead. While the conventional analog PIM architecture enables fast and energy-efficient computation, it is unsuitable for dynamic attention operations in Transformer models and suffers from increased power consumption and reduced endurance due to frequent write operations in KV-cache processing. To overcome these limitations, the proposed dual-mode capacitor supports both ferroelectric tunnel junction (FTJ) and resistive random-access memory (RRAM) modes, enabling selective functionality depending on computational demands, providing low-power and high-speed operation in FTJ mode and high-reliability, multilevel data storage in RRAM mode. Experimental results confirmed that the HfZrOx (HZO) device can be irreversibly converted from the FTJ mode to the RRAM mode through a forming process. Accordingly, individual cells within the same array architecture can be preconfigured in either the FTJ or RRAM mode according to their designated functions, thereby enabling the integrated implementation of KV-cache storage, weight storage, and multiply-and-accumulate (MAC) operation.

PubMedJournal of applied clinical medical physics2026-09-18

Commissioning and end-to-end validation of a combined surface-guided and triggered kV imaging workflow for breath-hold SBRT on a Varian TrueBeam.

Osunkwor Offormata E OE, Ndlovu Alois A, Teboh Roland F RF

Respiratory motion introduces significant geometric uncertainty in Stereotactic Body Radiotherapy (SBRT) for thoracic and abdominal tumors. Deep Inspiration Breath-Hold (DIBH) mitigates this, but the surface signal alone may not reflect internal target position, supporting the need for real-time internal-anatomy verification during delivery. To commission a Surface-Guided Radiation Therapy (SGRT) system and validate an integrated SGRT + Image-Guided Radiation Therapy (IGRT) + triggered kV imaging (SITI) workflow for DIBH SBRT. The LAP LUNA 3D SGRT system was commissioned per AAPM TG-302 using phantom-based assessment of static and dynamic localization accuracy, reproducibility, and latency. An end-to-end test using a dynamic phantom validated the SITI workflow. Point dose was measured with an ion chamber under four scenarios: SGRT-only delivery, full SITI delivery, and SITI with induced 1 and 2 mm uncorrected 3D shifts. Static localization accuracy was better than 0.5 mm / 0.3°, with reproducibility within 0.2 mm / 0.1°. Dynamic testing confirmed sub-millimeter spatial accuracy and a 31.6 ms latency, well below the AAPM TG-302 100 ms tolerance. The 1 and 2 mm uncorrected shifts produced point-dose reductions of 0.9% and 2.2% relative to the SITI reference, consistent with the ∼1%/mm local dose gradient. Both shifts were clearly visualized on triggered kV images, confirming detection of sub-tolerance residual displacements undetected by surface guidance alone. The LAP LUNA 3D system meets the technical requirements for SBRT. The SITI workflow is technically feasible and provides real-time visualization of internal target position during delivery, offering a robust motion-management strategy for DIBH SBRT of mobile thoracic and abdominal targets.

PubMedRSC advances2026-09-18

Enhanced CO2 conversion via synergistic effect of dielectric barrier discharge plasma and halogen-modified g-C3N4.

Rao Mudadla Umamaheswara MU, Cho Phyu Phyu PP, Vidyasagar Devthade D, Joseph Sneha S et al.

Carbon dioxide (CO2) conversion is a key challenge in addressing global warming and the associated climate change. Non-thermal plasma activation of CO2 is a viable alternative to traditional thermal catalytic routes for converting CO2 into CO and O2. In this study, a dielectric barrier discharge (DBD) plasma reactor operated under ambient conditions was developed and demonstrated for CO2 conversion to CO. The integration of halogen-modified g-C3N4 markedly enhanced CO2 conversion relative to the unpacked condition. The addition of a photocatalyst to the plasma reactor improved plasma discharge parameters, and the synergy present between the catalyst and plasma reactor promoted the conversion. The maximum conversion of CO2 attained was approximately 11% with Br/g-C3N4 at an applied voltage of 22 kV. Additionally, halogen doping enhanced CO selectivity and energy efficiency. Furthermore, the integration of the photocatalyst with DBD avoids coke formation, which is one of the limiting steps in high temperature CO2 activation.

PubMedSocial psychiatry and psychiatric epidemiology2026-09-18

Development of a peer support program for persons with mental health conditions in India: a formative qualitative study with expert validation of program components.

Kundurthi Venkatesh V, K Reddy Shanivaram S, Jagannathan Aarti A, Berigai Parthasarathy Nirmala N et al.

Improving support for persons with long-term mental health challenges is a key concern in global mental health care. In recent years, peer support (PS) has been recognised as a person-centred and recovery-oriented approach for persons with mental health conditions. While most PS research originates from high-income countries, there's a notable gap in the literature and structured programs within low- and middle-income countries, including India. This study aimed to develop and validate a culturally adapted PS program for persons with mental health conditions tailored to the Indian context. An exploratory qualitative design was used, following the three-phase approach: (I) a systematic literature review, (II) qualitative in-depth interviews with diverse mental health stakeholders (N = 31), and (III) development and expert validation. Interviews were conducted by KV in both face-to-face and online settings, using English, between June and December 2023. Each session lasted between 75 and 120 min and was audio-recorded with the participant's consent. A purposive sampling strategy was employed, and data collection continued until data saturation was achieved. The finalised program, validated by experts using Lawshe's CVR (≥ 0.71), is structured around seven key themes: Core Principles of Peer Support, Structure and Process of Peer Support Groups, Content and Focus of Peer Support Interactions, Roles and Responsibilities, Guidelines for Safe and Effective Peer Support, Challenges in Peer Support Groups, and Ethical Considerations. This developed peer support program (PSG) has been systematically designed to help form and facilitate peer support groups for persons with mental health conditions, and it now requires feasibility and effectiveness testing through larger experimental trials.

+9996 more articles available with a free account

Sign up free to view all articles →

Ask about phenylpropanolamine