Drug Database
PH

phenylpropanolamine (Dristan SR / Histabid / Dexatrim)

✓ Approved

Lumara Health · Small Molecule · Small Molecule

What is phenylpropanolamine?

phenylpropanolamine is a small molecule developed by Lumara Health. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesDristan SR, Histabid, Dexatrim
CompanyLumara Health
Drug ClassSmall Molecule
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, Lumara Health

Therapeutic Indications

phenylpropanolamine is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Respiratory, thoracic and mediastinal disordersCough✓ Approved

Related Research Articles

PubMedRSC advances2026-07-25

Enhancing broadband electromagnetic wave absorption performance of NZFO/BSTO multiferroic materials in the X and Ku bands.

Tung Do Khanh DK, Son Tung Bui B, Viet Nguyen Van NV, Truong Nguyen Xuan NX et al.

Multiferroic composites with the composition xNi0.5Zn0.5Fe2O4/(1 - x)(Ba0.8Sr0.2TiO3) (denoted as NZFO/BSTO) (where x = 0, 0.1, 0.2, 0.3, 0.4, and 1.0) were fabricated using a solid-state reaction method combined with spark plasma sintering. The obtained materials exhibited an average particle size of approximately 500 nm. X-ray diffraction analysis confirms the co-existence of the ferromagnetic Ni0.5Zn0.5Fe2O4 (NZFO) phase and the ferroelectric Ba0.8Sr0.2TiO3 (BSTO) phase. As the NZFO content increases from x = 0.1 to 0.4, the saturation magnetization (M s) rises from 13.6 to 56.9 emu g-1, while the remanent magnetization (M r) increases from 0.71 to 1.88 emu g-1. Simultaneously, the P-E hysteresis loops become more pronounced, with a significant increase in both the maximum polarization (P m) and remanent polarization (P r). The coercive electric field (E c) also increases markedly from 1.94 kV cm-1 to 3.56 kV cm-1 under an applied electric field of 12.5 kV cm-1. The composite with the ferromagnetic phase fraction x = 0.4 exhibits excellent broadband electromagnetic wave absorption performance. At thicknesses of 2.0 mm and 2.5 mm, the effective absorption bandwidth exceeds 5.4 GHz and 5.7 GHz, respectively. Notably, minimum reflection loss (RLmin) values of -48.3 dB and -43.9 dB are achieved at 15.7 GHz and 12.6 GHz, respectively. These results demonstrate the strong potential of the material for practical applications in electromagnetic wave absorption in the X-band and Ku-band frequency ranges, particularly in radar stealth and military technologies.

PMID 42500411
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PubMedDose-response : a publication of International Hormesis Society2026-07-25

Dose Reconstruction After a WD‒XRF Spectrometer Accident Using Minute-Rate TLD Measurements.

Gao Yiying Y, Wang Haoyu H, He Ling L, He Liangguo L et al.

Accurate dose estimation following radiation accidents remains challenging, particularly when personal dosimeter data are unavailable. This study presents a practical post-accident dose reconstruction approach based on minute-rate thermoluminescent dosimeter (TLD) measurements combined with exposure scenario reconstruction, demonstrated through a wavelength-dispersive X-ray fluorescence (WD‒XRF) spectrometer accident. The exposure scenario was reconstructed by placing LiF(Mg,Cu,P) TLDs at seven representative positions corresponding to head and hand locations, with the spectrometer operated under the recorded technical parameters (40 kV, 7 mA). Minute personal dose equivalent rates, H p'(10), were measured and combined with reconstructed retention times to calculate cumulative doses, from which skin absorbed doses were derived. The measured dose rates ranged from 0.13 to 358.38 mSv/min for the head and from 0.07 to 620.24 mSv/min for the hands. The resulting cumulative skin absorbed doses were 7.58 Gy for the head and 12.52 Gy for the hands, consistent with reported dose ranges associated with localized radiation injury. This approach provides a feasible supplementary strategy for retrospective dose reconstruction under emergency or resource-limited conditions when conventional dosimetric information is unavailable.

PMID 42500306
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PubMedPhysica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)2026-07-25

Optimising beam quality for chest X-ray imaging: Insights from over two decades of peer reviewed publication.

Devery Ms Clare MC, Sweetman Lorna L, Cody Dervil D

Optimisation of beam quality for chest radiography has been extensively investigated and reported on, but there are few comparisons of the reported study methods, outcomes and recommendations. This work aims to compile the available data on this subject with the objective of identifying and categorising the methods used to optimise chest x-ray (CXR) imaging, and to determine if a particular beam quality can be distinguished as optimal. A literature review was carried out on papers investigating optimisation of beam quality for CXR exposures. The identified studies (n = 29, spanning 2001-2020) were grouped into descriptive categorical variables. Statistical analysis (Fisher's exact testing) was used to investigate the relationships between the materials, methods and results drawn from literature concerning the CXR optimisation process. The primary decisions in each CXR optimisation study concern the type of source image used and the image assessment approach adopted. Across the literature, 240 potential combinations of methodological variables were found. The findings are highly variable, and no standardised optimisation approach emerges. The literature provides no definitive evidence for an optimal beam quality in chest radiography. While the most frequently recommended tube voltages were in the 90-110 kV range, this accounted for only 43% of studies. Only one-third of the analysed studies accounted for the influence of filtration. These findings pose a challenge for medical physicists engaging in optimisation activities in clinical departments and support the case for standardising both the approaches for optimisation of the technical parameters in general radiography, and the reporting of same.

PMID 42497642
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PubMedPesticide biochemistry and physiology2026-07-24

The neurotoxicity of Chlorantraniliprole to Helicoverpa armigera larvae.

Zhang Lingna L, Hou Jiayin J, Li Yuxin Y, Wei Xinghui X et al.

Chlorantraniliprole (CAP) is a mainstream diamide insecticide widely used against lepidopteran pests such as Helicoverpa armigera. Given that most insecticides act via neurotoxic mechanisms, we reasoned that CAP, despite its well-established action on ryanodine receptors (RyRs), may also disrupt nervous system function through additional targets. Insect neurotoxicity is a coordinated process involving neurons and glial cells: voltage-gated sodium (Nav) and potassium (Kv) channels are common insecticide targets, however, their involvement in CAP-induced neurotoxicity has not been established, and glial contributions are poorly understood. We elucidated CAP's multi-target mechanisms by constructing the first single-cell transcriptomic atlas of the H. armigera ventral nerve cord (VNC) using scRNA-seq, validated by whole-cell patch-clamp electrophysiology and RT-qPCR. Results showed that CAP modulated the kinetics of Nav channel in a concentration-dependent manner and suppressed Kv channel currents, confirming both as novel non-canonical targets. scRNA-seq identified VNC cell types, identifying NKCC (perineurial glia-enriched) and UGT39B1 (subperineurial glia-enriched); both were upregulated after 24 h LC30 CAP exposure. These results indicate that CAP modulates Nav and Kv channels at relatively high concentrations. As potential functional targets, these channels supplement the primary RyR-mediated action of CAP, and imply a partial mechanistic similarity to pyrethroids via regulation of Nav channels. Moreover, the VNC atlas facilitated the identification of glial-specific markers (NKCC and UGT39B1), clarifying glial involvement. Collectively, our work advances multi-target understanding of diamide insecticides, provides candidate synergists, and supports "neuron-glial dual-target" strategies for managing H. armigera resistance.

PMID 42493017
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PubMedJournal of developmental biology2026-07-24

Evolutionary Analysis of Vertebrate KCNH Voltage-Gated Potassium Channels and Spatial Expression of kcnh Genes in Zebrafish Embryos.

Wu Kuangyi K, Wang Dingxun D, Dong Ziyu Z, Zhou Alice Yahui AY et al.

Voltage-gated potassium channels (Kv) are a large family of potassium channels composed of 40 members across 12 subtypes. The KCNH genes encode three subfamilies of voltage-gated potassium channels: Kv10 (EAG, ether à go go), Kv11 (ERG, EAG-related gene), and Kv12 (ELK, EAG-like K). Kv channels play prominent roles in neuronal and cardiovascular systems. Mutations in Kv channels have been linked to many human diseases, such as epilepsy, heart arrhythmias, and cancers. Significant progress has been made in understanding protein structures, physiological functions, and pharmacological modifiers. However, the evolutionary history and gene expression of vertebrate KCNH genes during embryonic development remain largely unknown. We systematically identified and cloned 14 kcnh genes in zebrafish. Then, we examined the vertebrate KCNH channel evolution by phylogenetic and syntenic analyses. Our data reveal that the three subtypes of the KCNH gene family had already evolved in invertebrates, long before the emergence of vertebrates. The number of vertebrate KCNH genes increased, most likely due to whole-genome duplications (WGDs). In addition, we examined zebrafish kcnh gene expression during early embryogenesis by in situ hybridization. Each subgroup's genes showed similar but distinct gene expression domains with some exceptions. Most of them were expressed in neural tissues. Notably, kcnh6a showed robust expression in the developing heart, consistent with its conserved role in cardiac repolarization. Additionally, a few kcnh genes were transiently expressed in non-neural tissues, such as somites and the notochord, suggesting they may have a unique role in embryonic development. Our phylogenetic and developmental analyses of KCNH channels shed light on their evolutionary history and potential roles during embryogenesis, in line with their physiological functions and human channelopathies.

PMID 42496271
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PubMedNature communications2026-07-24

Nanofiber-like polar configurations enable ultrahigh energy storage in relaxor ferroelectrics via high-entropy design.

Liu Ning N, Xie Aiwen A, He Liqiang L, Tian Ao A et al.

Dielectric capacitors are highly promising for advanced power electronics due to their superior power density. However, their widespread application has been limited by inadequate energy storage performance. In this work, we propose a distinct strategy, centered on creating a nanofiber-like polar configuration, to achieve ultrahigh energy storage performance in relaxor ferroelectrics. This is realized through a high-entropy composition design in NaNbO3-based perovskites, where multiple cations with significant ferroelectric activity and ionic radius differences are introduced at both A- and B-sites. This approach effectively disrupts the long-range ferroelectric and antiferrodistortive orders simultaneously. The resulting nanofiber-like domain structure, which features several nanometers in length but only a few unit cells in width, exhibits a low-hysteresis and nearly linear polarization response to applied electric field (E). Consequently, an exceptional energy storage density (Wrec) of ~19.3 J cm-3, a high efficiency (η) of ~95.2%, and an impressive Wrec/E coefficient of 208 J kV mm-3 are simultaneously achieved in the NaNbO3-(Bi0.5Li0.5)(Ti0.8Zr0.1Sn0.1)O3 multilayer ceramic capacitors. These results underscore the immense potential of the nanofiber-like polar configuration strategy for developing high-performance dielectric energy storage materials.

PMID 42493494
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