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Fluosol-DA (Fluosol)

✓ Approved

Mitsubishi Tanabe Pharma Corporation · Small Molecule · Small Molecule

What is Fluosol-DA?

Fluosol-DA is a small molecule developed by Mitsubishi Tanabe Pharma Corporation. It is approved for therapeutic indications via unknown.

Drug Profile

Brand NamesFluosol
CompanyMitsubishi Tanabe Pharma Corporation
Drug ClassSmall Molecule
RouteUnknown
StatusApproved
Sources: ClinicalTrials.gov, Mitsubishi Tanabe Pharma Corporation

Therapeutic Indications

Fluosol-DA is developed for 2 unique indications across 2 therapeutic areas.

Therapeutic AreaConditionPhase
Blood and lymphatic system disordersAnaemia✓ Approved
Neoplasms benign, malignant and unspecified (incl cysts and polyps)Neoplasm malignant✓ Approved

Related Research Articles

PubMedJournal of neonatal-perinatal medicine2026-11-11

Effects of umbilical cord milking versus delayed cord clamping on cerebral oxygenation and ductus arteriosus closure in preterm infants: RCT.

Awad Hisham A HA, Imam Safaa S SS, Ismail Rania I RI, Elsayed Tarek H TH et al.

BackgroundDelayed cord clamping (DCC) and umbilical cord milking (UCM) are placental transfusion techniques that improve oxygen delivery and cardiac output. UCM enhances cerebral oxygenation without delaying resuscitation. Functional closure of the ductus arteriosus (DA) usually occurs within 48 hours after birth in full-term infants, with a high incidence of persistent DA in premature infants.ObjectiveTo investigate the effects of UCM and DCC on functional ductus arteriosus closure and cerebral tissue oxygenation.MethodsThis randomized controlled clinical trial included 100 preterm infants who were allocated to either the UCM group (n = 50) or the DCC group (n = 50). crSO2 and cfTOE were measured after resuscitation and at 12, 24, and 48 hours of life. Echocardiography was performed at 6, 12, 18, 24, and 48 hours of life to assess functional DA closure.ResultsRepeated-measures analysis showed no statistically significant between-group differences in changes in crSO2 (P = 0.194), cfTOE (P = 0.140), or functional DA closure (P = 0.372).ConclusionUCM and 60-second DCC showed no statistically significant differences in cerebral tissue oxygenation improvement or functional ductus arteriosus closure during the first 48 hours of life.

PMID 43010185
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PubMedAnalytical chemistry2026-11-11

A Synergistic Experimental and Computational Approach to the Design of MIPs Targeting Metronidazole.

Lo Presti Alessandro A, Bellomo Mariastefania M, Panzera Fortunata F, Abate Chiara C et al.

Metronidazole (MTZ) is a widely used nitroimidazole antibiotic, and its persistence has raised growing concerns as an emerging environmental contaminant. This study focuses on the design of an electrochemical sensor based on Molecularly Imprinted Polymers (MIPs) for its detection, by a synergistic computational-experimental strategy. A hierarchical computational framework combining conformational sampling, density functional theory and finite-temperature condensed-phase ab initio molecular dynamics was employed to evaluate aniline (ANL) and dopamine (DA) as candidate monomers. Static calculations provided a preliminary screening based on monomer-template complex stability, while molecular dynamics simulations assessed the dynamic balance between potential template affinity and reversibility. Although DA exhibited more persistent hydrogen-bonding and aromatic interactions, ANL showed a more favourable interaction profile, promoting efficient MTZ removal and accessible recognition cavities. These findings support the selection of ANL as the optimal functional monomer. The ANL-based MIP was therefore electropolymerized on screen-printed carbon electrodes (SPCEs) via cyclic voltammetry (CV) and characterized via differential pulse voltammetry (DPV) using K3Fe(CN)6, yielding an imprinting factor (IF) of 2.6, a linear response in the range of 27-129 nmol L-1, a sensitivity of 26.01 A L mol-1, and limits of detection and quantification of 6.7 and 22.3 nmol L-1, respectively. The sensor also showed good repeatability, reproducibility, and negligible interference from other antibiotics. Its superior analytical performance relative to the corresponding DA-based MIP experimentally confirms the computational prediction. These findings demonstrate that combining atomistic pre-screening with targeted experimental validation can reduce empirical trial-and-error and accelerate the rational development of selective MIP-based sensors.

PMID 43010495
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PubMedAnalytical chemistry2026-11-11

Ultrasensitive Quantification of Poloxamer 188 in Adeno-Associated Virus Products by All-Ion Fragmentation MS/MS.

Zhang Sisi S, Wang Jing J, Xiao Hui H, Li Ning N

Poloxamer 188 (P188; Pluronic F68) is a nonionic surfactant frequently used in biotherapeutics, particularly in adeno-associated virus (AAV) formulations, in which it is present at trace concentrations (0.001%-0.005%). However, its accurate quantification is difficult, because of its low abundance, frequently limited sample volumes, and the ionization variability of its PEO-PPO-PEO triblock. Here, we developed an all-ion fragmentation (AIF) workflow with 44 Da and 58 Da neutral-loss-triggered data dependent (dd)-MS2 that fragments all precursors and performs quantification via the polyethylene glycol (PEG) diagnostic ion (m/z 133.1), thereby decreasing spectral complexity and adduct variability. In contrast to the most sensitive reported method, LC-MRM, using a 20 μL injection volume, which achieved a dynamic range of 250-10,000 ng/mL (0.000025%-0.001%), our method achieved a 0.00002% LLOQ with 1 μL injections, thus providing an ∼20-fold sensitivity gain that enables replicate analysis and a dynamic range 2 orders of magnitude wider (0.00002%-0.1%). Our assay is vendor-, formulation-, and LC-buffer-agnostic, and achieves ±10% accuracy and ∼10% CVs across AAV-relevant levels. Significant P188 losses attributable to container adsorption were observed; incorporation of 50% acetonitrile restored recovery and is recommended for sample preparation.

PMID 43010524
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PubMedJournal of mass spectrometry and advances in the clinical lab2026-11-11

GC-IMS Combined with Chemometrics Analysis of Volatile Organic Compounds Facilitates CREC Identification.

Zheng Yunwei Y, Li Fuxing F, Zhao Chuwen C, Wang Hong H et al.

Escherichia coli (E. coli) is a clinically significant pathogen. Early identification of carbapenem-resistant E. coli (CREC) is critical for reducing mortality. Gas chromatography-ion mobility spectrometry (GC-IMS) combined with chemometric analysis was used to detect volatile organic compounds (VOCs) from 40 clinical E. coli isolates. A two-phase experimental design was implemented: an exploratory phase with six replicates and a validation phase with 40 isolates. Bacteria were cultured in BacT/ALERT® SA broth, and VOCs were analyzed at specific time points. Imipenem (IPM) was added to induce metabolic stress, whereas pyridine-2,6-dicarboxylic acid (DPA) was used to enhance New Delhi metallo-β-lactamase (NDM)-type CREC discrimination. Principal component analysis (PCA) and partial least squares discriminant analysis (PLS-DA) were applied to identify key VOCs. GC-IMS analysis revealed 55 VOCs as detectable signals, of which 30 were tentatively identified. In the absence of IPM, only three VOCs showed significant differences between carbapenem-sensitive E. coli (CSEC) and CREC. However, upon the addition of IPM, the number of differentially expressed VOCs increased to 17. PCA and PLS-DA identified 13 key VOCs (including four ketones, two esters, one aldehyde, one pyrazine, and five unknown compounds) that effectively distinguished CSEC from CREC. The addition of DPA further enabled the detection of nine additional VOCs, which may serve as potential markers for identifying NDM-type CREC. GC-IMS combined with chemometrics analysis can quickly distinguish CREC from CSEC through analysis of VOC spectra. The addition of IPM and DPA increases metabolic differences, providing a promising method for the rapid detection of CREC.

PMID 43011622
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PubMedAnalytical chemistry2026-11-11

Electrochemically Driven Luminescence without Liquid Electrolyte: A Sensing Platform via Eutectic Gallium-Indium Solid-State Junctions.

Huang Shi S, Song Zhiping Z, Yang Weiqiang W, Ni Jiancong J et al.

Electrochemiluminescence (ECL) is a powerful sensing technique but typically relies on liquid electrolytes and multi-electrode configurations, limiting device miniaturization and integration. Here, we report a solid-state electrochemically driven luminescent sensing platform based on two-electrode junctions comprising an indium tin oxide bottom electrode, a Ru(bpy)32+-TPrA@Nafion active layer (TPrA: tripropylamine), and a soft eutectic gallium-indium (EGaIn) top electrode. Nafion serves as a porous host matrix that immobilizes the luminophore and co-reactant while facilitating analyte uptake, whereas EGaIn provides a simple conformal electrical contact for solid-state operation. Despite the absence of a liquid electrolyte during electrical excitation, the junctions retain key characteristics of classical Ru(bpy)32+ electrochemistry. The luminescence is enhanced by the co-reactant TPrA and quenched by dopamine (DA), enabling quantitative sensing based on modulation of the emission intensity. The platform exhibits a linear response to dopamine over a concentration range of 1.0 × 10-10-1.0 × 10-4 M with a detection limit of 5.1 × 10-11 M, together with excellent reproducibility, selectivity, operational stability, and satisfactory recovery in human serum samples. These results demonstrate that ECL-inspired sensing chemistry can be implemented in a solid-state device architecture, providing a promising strategy for integrated luminescent sensing platforms and miniaturized analytical devices.

PMID 43010430
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PubMedSmall methods2026-11-11

Modulated Laser-Assisted Nanopore Fabrication With Ammonium Sulfate for Single-Molecule Sensing.

Matsuda Kyosuke K, Hirano Taichi T, Takahashi Shu S, Hagiwara Hidetaka H et al.

Nanopore sensing provides a label-free platform for single-molecule analysis. To achieve reliable solid-state nanopore sensing, however, it is essential to optimize appropriate nanopore fabrication methods, as variations in pore diameter, geometry, surface state, and fabrication residues can affect molecular discrimination capability. Here, we report a temporally modulated CW laser-assisted dielectric breakdown method for facilitating in-situ fabrication of nanopores in silicon nitride membranes, coupled with ammonium sulfate electrolytes to improve sensing performance. Systematic characterization revealed that temporally modulated CW laser minimizes contamination/debris formation during pore fabrication and yields improved nanopore sensing. Streaming-potential measurements and interfacial ion-transport simulations suggest that ammonium-containing electrolytes modify the SiN nanopore interface by promoting NH4 + adsorption on the inner pore surface as well as SO4 2- ions, thereby enhancing DNA-pore interactions. This effect slowed a subset of DNA translocation events, enabling longer dwell-time observations and differentiation between poly(dA) and poly(dC) blockade populations. Furthermore, aptamer-assisted detection enabled detection of Scp1-bound aptamer complexes under conditions where the protein alone tended to clog the pore. The Scp1-aptamer complex showed prolonged dwell times compared with those of free aptamers, even under 0.14 M KCl. Together, these results demonstrate that integrating our approach provides an improved approach for high-performance single-molecule nanopore detection.

PMID 43010576
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