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Fluosol-DA (Fluosol)

✓ Approved

Mitsubishi Tanabe Pharma Corporation · Small Molecule · Small Molecule

What is Fluosol-DA?

Fluosol-DA is a small molecule developed by Mitsubishi Tanabe Pharma Corporation. It is approved for therapeutic indications via unknown.

Drug Profile

Brand NamesFluosol
CompanyMitsubishi Tanabe Pharma Corporation
Drug ClassSmall Molecule
RouteUnknown
StatusApproved
Sources: ClinicalTrials.gov, Mitsubishi Tanabe Pharma Corporation

Therapeutic Indications

Fluosol-DA is developed for 2 unique indications across 2 therapeutic areas.

Therapeutic AreaConditionPhase
Blood and lymphatic system disordersAnaemia✓ Approved
Neoplasms benign, malignant and unspecified (incl cysts and polyps)Neoplasm malignant✓ Approved

Related Research Articles

PubMedAnalytica chimica acta2026-09-19

Polarity-switchable photoelectrochemical sensor enabled by in situ polydopamine-regulated Z-scheme charge transfer for dopamine detection.

Zhao Runze R, Zhang Lu L, Wang Aoze A, Xu Xiaoyan X et al.

Photoelectrochemical (PEC) sensing has emerged as a powerful analytical technique because of its high sensitivity and low background noise. However, most reported PEC sensors rely exclusively on photocurrent intensity as the analytical output, making them susceptible to environmental fluctuations and nonspecific interference, which compromises detection reliability and selectivity. Developing a polarity-resolved PEC sensing strategy that employs photocurrent polarity rather than signal magnitude as the readout therefore represents an attractive yet largely unexplored approach. Herein, a photocurrent polarity-switchable PEC sensor was developed for dopamine (DA) detection by integrating BiOI/BiOCl, Cu2O@CuO, and ZnIn2S4 into a cascaded heterostructure with well-matched energy levels. Under dual-wavelength excitation, the synergistic effect of energy-band alignment and Z-scheme-like charge transfer facilitated efficient separation and directional migration of photogenerated charge carriers, producing stable bidirectional photocurrent outputs. During sensing, DA simultaneously served as the target analyte and underwent in situ oxidative polymerization to form a polydopamine (PDA) film on the electrode surface. The PDA layer regulated interfacial charge-transfer kinetics through oxygen adsorption and redistribution of charge-carrier migration pathways, thereby inducing photocurrent polarity reversal and amplifying the photoelectrochemical response. More importantly, DA generated a photocurrent polarity opposite to that produced by common interfering species, enabling polarity-resolved discrimination with markedly improved analytical selectivity. The proposed sensor exhibited a wide linear range from 100nM to 5 mM with a detection limit of 33.3 nM under alternating blue and red light irradiation. This work establishes an analyte-induced photocurrent polarity-switching strategy by coupling heterojunction engineering with interfacial charge regulation. The introduced polarity-resolved sensing mode provides an additional analytical dimension beyond conventional intensity-dependent PEC sensing, improving signal discrimination and anti-interference capability and offering a promising route for dopamine-specific PEC sensing.

PMID 42763147
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PubMedInternational urology and nephrology2026-09-19

Therapeutic efficacy and predictive factors for treatment outcomes of transurethral incision of the bladder neck in women with voiding dysfunction due to an underactive bladder.

Jhang Jia-Fong JF, Yu Wan-Ru WR, Jiang Yuan-Hong YH, Kuo Hann-Chorng HC

Transurethral incision of the bladder neck (TUI-BN) can effectively improve voiding efficiency in women with bladder neck obstruction. However, its role in women with low detrusor contractility remains unclear. This study retrospectively evaluated the clinical efficacy of TUI-BN and identified predictive factors for treatment failure in women with detrusor underactivity (DU). Women with videourodynamic study (VUDS)-proven bladder neck dysfunction (BND) with DU, detrusor acontractility (DA), and neurogenic lower urinary tract dysfunction (NLUTD) who underwent TUI-BN were retrospectively analyzed. Treatment outcomes were graded according to the ability to void spontaneously and postvoid residual (PVR) volume. Successful treatment was defined as self-voiding with a PVR of <33% of bladder capacity. Treatment outcomes were assessed and compared among the different BND subgroups. A total of 212 women were analyzed, including 76 with DU, 75 with DA, and 61 with NLUTD. Among the three subgroups, patients with DA had the highest success rate (84.0%), followed by those with DU (77.6%), whereas those with NLUTD had the lowest success rate (67.2%) (p = 0.068). Logistic regression analysis of clinical and VUDS parameters showed that a large PVR, NLUTD, and chronic medical disease were predictors of treatment failure after TUI-BN. Patients with successful outcomes had significantly increased maximum flow rate, voiding efficiency, and bladder contractility index and significantly decreased PVR and bladder outlet obstruction index after TUI-BN CONCLUSION: TUI-BN is an effective surgical procedure for improving voiding efficiency in women with VUDS-proven BND and low detrusor contractility. A high PVR, had central nervous system-associated NLUTD, and chronic medical diseases may predict less favorable treatment outcomes.

PMID 42760472
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PubMedMeat science2026-09-19

Geographical origin authentication of beef from Canada, Australia and Mexico using visible-near infrared spectroscopy and chemometric approaches.

León-Ecay Sara S, López-Campos Óscar Ó, López-Maestresalas Ainara A, Insausti Kizkitza K et al.

Enhancing meat import controls is essential to protect domestic production and ensure fair-trade. This study evaluated the potential of visible-near infrared spectroscopy (Vis-NIRS; 350-2500 nm) combined with chemometrics to classify beef ribeye steaks according to country of origin (CoO): Canada (CAD), Australia (AUS) and Mexico (MEX). In total, 120 ribeye steaks from CAD barley-fed (n = 30), CAD corn-fed (n = 30), MEX grain-fed (n = 30), and AUS grass-fed (n = 30) cattle were classified using partial least squares-discriminant analysis (PLS-DA) and linear/radial support vector machines (L/R-SVM). When modelling CAD barley, MEX and AUS samples, PLS-DA and L-R/SVM correctly classified 95.83-100% and 100% of samples in Train and Test, respectively, across Vis, NIR and Vis-NIR regions. For CAD-corn, MEX and AUS, classification performance ranged from 88.00 to 100% and 75.00-100% in Train and Test, respectively. When broadening applicability by combining CAD feeding systems (CAD mix; n = 15 barley+15 corn), all models correctly classified 91.67-100% (Train) and 83.33-100% (Test) of CAD mix, MEX and AUS samples, except for NIR R-SVM (66.67% for MEX in Test). Dimensionality reduction by variable importance in projection (VIP) from PLS-DA correctly classified 95.83-100% and 83.33-100% of samples in Train and Test, respectively, using models built with 5 wavelengths in the Vis region or 7 bands (6 Vis+1 NIR) in the Vis-NIR region. These wavelengths were mainly associated with meat colour pigments, moisture and fatty acids. These results demonstrate that Vis-NIRS is a reliable and rapid tool for beef CoO authentication. Vis-NIRS implementation could enhance supply chain transparency and support the digitalization of routine import control systems.

PMID 42762648
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PubMedCureus2026-09-19

Urgent da Vinci-Assisted Laparoscopic Repair of an Incarcerated Adult Bochdalek Hernia Presenting With Large-Bowel Obstruction: A Case Report and Literature Review.

Martinez Rosales Orlando O, Mohammed Ricardo R

Bochdalek hernias (BHs) are a rare form of diaphragmatic hernia in adults. They are typically diagnosed in infancy or childhood; however, in rare cases, they may be discovered in completely asymptomatic adults. Because this condition is uncommon, it can be mistaken for other conditions and misdiagnosed, exposing patients to unnecessary treatments. We present the case of a 33-year-old man with a past medical history of hypertension who presented to the ED with a four-day history of severe abdominal pain, nausea, and vomiting. CT of the abdomen and pelvis with contrast showed findings consistent with a mechanical large-bowel obstruction secondary to an incarcerated BH containing the splenic flexure of the colon and omental fat. The patient was successfully treated using a da Vinci-assisted laparoscopic approach with mesh repair. At the three-month follow-up, the patient remained asymptomatic, without clinical signs of recurrence. In adults, a BH is an uncommon form of diaphragmatic hernia. As many cases are asymptomatic, a high index of suspicion is needed because diagnosis can be challenging. Modern surgical techniques can improve patient recovery and result in shorter hospital stays, with minimal morbidity and mortality. In this case report, we demonstrate that a robot-assisted laparoscopic approach was a safe and effective means of repairing this hernia and provide an overview of the current literature.

PMID 42761888
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PubMed3 Biotech2026-09-19

Acemannan as a potential therapeutic agent for cognitive impairment via modulation of cholinergic, oxidative, and inflammatory pathways: in vivo and in silico evidence.

Alzarea Sami I SI, Alsahli Tariq G TG, Alzarea Abdulaziz Ibrahim AI, Almutairi Mashan M et al.

Cognitive impairment is a major feature of neurodegenerative disorders and is associated with cholinergic dysfunction, oxidative stress, neuroinflammation, and impaired neuroplasticity. Acemannan, a bioactive acetylated β-(1→4)-linked polymannan derived from Aloe vera (Aloe barbadensis Mill.), exhibits antioxidant and anti-inflammatory properties, suggesting potential neuroprotective effects. This study investigated the neuroprotective effect of acemannan against scopolamine-induced cognitive impairments in Wistar rats. Morris Water Maze, Y-maze, Novel Object Recognition, and rotarod tests were used to assess behavioral activity. Upon completion of the treatment, biochemical analysis such as neurotransmitters (Ach, GABA, DA, 5HT, Glu), cholinergic markers (AChE, ChAT), oxidative stress indicators (MDA, NO) antioxidant enzymes (SOD, CAT, GSH), inflammatory cytokines (IL-1β, IL-6, TNF-α), and apoptotic/neuroplasticity markers (caspase-3, BDNF, CREB, SIRT1, PGC-1α) and Histopathology were also performed. Additionally, molecular docking was conducted using GlycoTorch Vina, a carbohydrate-specific molecular docking tool, to investigate the binding interactions and affinity of acemannan with selected protein targets. The in vitro analysis showed an AChE inhibitory effect. Administration of scopolamine impaired cognitive and motor activity, as indicated by increased oxidative and inflammatory markers and disrupted neurotransmitter levels. However, acemannan treatment reversed these abnormal effects and improved behavioral performance. Additionally, it restored the levels of neurotransmitters (Ach, GABA, DA, 5HT, Glu), cholinergic enzymes (AChE, ChAT), reduced oxidative stress markers (MDA, NO), and inflammatory markers (IL-1β, IL-6, TNF-α), and increased antioxidant enzymes (SOD, CAT, GSH), decreased Caspase-3,enhanced neuroplasticity markers (BDNF, CREB, SIRT1, PGC-1α). Acemannan showed substantial neuroprotection, with mostly normal pyramidal cells. Molecular docking revealed that acemannan showed favorable binding affinity with CHRM1 (5CXV, - 6.1 to - 5.4 kcal/mol), followed by BDNF (1B8M, - 4.8 to - 4.4 kcal/mol), and TNF-α (7JRA, - 4.3 to - 3.0 kcal/mol). Overall, acemannan attenuated scopolamine-induced cognitive impairment through multiple neuroprotective mechanisms, supporting its potential as a neuroprotective candidate for cognitive dysfunction associated with neurodegenerative disorders in this model of rats. The online version contains supplementary material available at https://doi.org/10.1007/s13205-026-05068-4.

PMID 42761372
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PubMedBiomedical chromatography : BMC2026-09-19

Simultaneous Quantification of Eight Bioactive Markers Coupled With HPLC Fingerprint and Chemometric Analysis for Quality Discrimination of Saposhnikovia divaricata From Diverse Geographical Origins.

Liu Wenping W, Liu Meng M, Zhao Wenlong W, Sun Jin J et al.

Saposhnikovia divaricata (SD, Chinese name: Fangfeng) is a commonly used herbal medicine in traditional Chinese medicine (TCM), yet unclear chemical profiling and remarkable quality heterogeneity among commercial batches restrict its standardized quality supervision. This study established an integrated strategy combining high-performance liquid chromatography (HPLC) fingerprinting and multivariate chemometrics to quantify bioactive compounds and discriminate geographical origins of SD. Eight bioactive markers including four chromones and four coumarins were unambiguously assigned among 18 shared characteristic fingerprint peaks. Obvious disparities in target compound contents were observed between geographically distinct samples. Fingerprint similarity results confirmed overall chemical consistency across all batches, accompanied by intra-region quality fluctuation. Geographical habitats exerted prominent effects on the accumulation of eight target constituents in SD. Combined hierarchical cluster analysis (HCA) and partial least squares discriminant analysis (PLS-DA) models successfully separated batches from different habitats, and three differential markers (prim-O-glucosylcimifugin, cimifugin, and imperatorin) were screened to interpret regional chemical divergence. In conclusion, this study provides an experimental foundation for drug quality control and the discovery of quality markers for SD. Imperatorin can be supplemented to construct a multi-index comprehensive quality evaluation system for SD.

PMID 42760850
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