Drug Database
KE

ketoprofen spray

✓ Approved

Giuliani · PTGS1 · Small Molecule

What is ketoprofen spray?

ketoprofen spray is a small molecule developed by Giuliani. It is approved for therapeutic indications via transdermal.

Drug Profile

CompanyGiuliani
Drug ClassSmall Molecule
Molecular TargetPTGS1, PTGS2
RouteTransdermal
StatusApproved
Sources: ClinicalTrials.gov, Giuliani

Mechanism of Action

Molecular Targets

ketoprofen spray acts on 2 molecular targets:

PTGS1prostaglandin-endoperoxide synthase 1 (COX3, PCOX1)
PTGS2prostaglandin-endoperoxide synthase 2 (GRIPGHS, hCox-2)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

ketoprofen spray is developed for 2 unique indications across 2 therapeutic areas.

Therapeutic AreaConditionPhase
Hepatobiliary disordersHepatitis✓ Approved
Musculoskeletal and connective tissue disordersMusculoskeletal pain✓ Approved

Related Research Articles

PubMedLangenbeck's archives of surgery2026-11-11

Prospective comparative evaluation of povidone-iodine sitz bath and silver-based antimicrobial spray in postoperative perianal wound care: impact on healing outcomes, patient satisfaction, and treatment compliance.

Samal Subhashree Subhadarshini SS, S Kandeshwaran K, Gopinathan Athira A

Perianal surgical wounds are likely to take longer to heal and get infected due to constant contamination, moisture and pain during defecation. Povidone-iodine has long been applied in the postoperative treatment, and silver-based agents have become an alternative with an excellent antimicrobial effect and patient-friendly characteristics. This study was intended to compare the outcomes on postoperative perianal wound-healing between the application of povidone-iodine sitz bath and silver-based antimicrobial spray, with additional evaluation of patient satisfaction and treatment compliance with the assigned wound care regimen. It is a hospital-based observational study conducted over a period of 4 months in a tertiary care centre. A total of one hundred patients subjected to surgery for haemorrhoids, fissure in ano, or fistula in ano were recruited and split into two equal groups. Group A received a povidone-iodine sitz bath, and Group B received a silver-based antimicrobial spray. The main outcome was time to heal wounds. The secondary outcomes were postoperative pain (VAS), patient satisfaction score (PSS), treatment compliance index (TCI), and wound-related complications. Statistical significance was set at p < 0.05. Baseline characteristics were comparable among groups. Mean wound-healing time was significantly shorter in the povidone-iodine cohort (14.2 ± 3.1 days) compared to the silver group (16.8 ± 3.6 days; p = 0.001). Surgical site infection was lower with povidone-iodine (6% vs. 18%; p = 0.048). Silver-based spray was associated with significantly lower postoperative pain scores, higher patient satisfaction scores (composite PSS: 7.9 ± 0.9 vs. 6.5 ± 1.1; p < 0.001), and superior treatment compliance at both Week 2 (92.1% vs. 74.2%; p < 0.001) and Week 4 (88.4% vs. 66.8%; p < 0.001). Wound-related complications were more frequent in the silver cohort. Povidone-iodine sitz bath provides superior healing and infection control, whereas silver-based antimicrobial spray significantly improves postoperative comfort, patient satisfaction, and treatment compliance highlighting the importance of patient-centred factors in wound care selection following perianal surgery.

PMID 43009686
Read full article →
PubMedRSC advances2026-11-11

Ionic-liquid-derived fluorine-containing carbon surface engineering of LiFePO4 for enhanced electrochemical performance.

Fallah Hiba El HE, Amarray Amina A, Sadid Achraf A, Bouaakil Ikram I et al.

Lithium iron phosphate (LFP) is a safe and stable cathode material for lithium-ion batteries; however, its relatively low energy density and limited electronic conductivity restrict its use in high-performance applications. Here, a scalable spray drying-assisted lithiation was developed to engineer fluorine-containing carbonaceous surface layers on LFP. Iron phosphate was first synthesized via co-precipitation and subsequently lithiated through a spray drying process in the presence of the ionic liquid [BMIM][PF6], which acts as a multifunctional precursor for in situ carbon coating and fluorine-containing surface species. X-ray diffraction confirmed the formation of phase-pure olivine LFP, while electron microscopy revealed a conformal surface layer of approximately 5 ± 0.8 nm for the optimized material. Raman spectroscopy showed D/G intensity ratios of approximately 1.02 and 0.99 for LFP-20 and LFP-30, respectively, indicating a carbonaceous surface layer with a modestly higher degree of graphitic ordering at the higher [BMIM][PF6] content. X-ray photoelectron spectroscopy and Near Edge X-ray Absorption Fine Structure (NEXAFS) analyses confirmed carbon-containing and fluorine-containing surface species, consistent with the formation of an ionic-liquid-derived interfacial layer. Thermogravimetric analysis estimated carbon contents of approximately 5 and 6 wt% for LFP-20 and LFP-30, respectively. The optimized LFP-30 exhibited a tap density of 1.30 g cm-3 compared with 0.75 g cm-3 for the glucose-derived reference LFP-G. Electrochemically, LFP-30 delivered approximately 160 mAh g-1 at 0.1C, together with improved rate capability and stable cycling performance. These results demonstrate that integrating ionic-liquid-derived surface modification with spray drying-assisted lithiation provides a scalable approach for simultaneously tailoring surface chemistry, electronic transport, and particle packing in LFP cathodes.

PMID 43011891
Read full article →
PubMedACS applied bio materials2026-11-11

Sustainable Microelectrode Fabrication for Electrochemical Impedance-Based In Situ Monitoring In Vitro Models.

Cardoni Francesco F, Casalini Stefano S, Ferraro Davide D, Mazo Vega Manuel María MM et al.

The development of sustainable microelectronic fabrication strategies is increasingly important due to the environmental and economic limitations of conventional photolithography and vacuum-based metal deposition processes. These approaches typically require hazardous chemicals and high energy consumption. In this work, we address these challenges by introducing an environmental friendly fabrication route for patterning gold microelectrodes, based on inkjet-printed dextran sacrificial masks and spray-coated gold nanoparticles (AuNPs) synthesized via pulsed laser ablation. Inkjet printing enables maskless and material-efficient patterning, while spray coating provides a low-temperature and scalable route for the deposition of conductive nanoparticle networks. The resulting microelectrodes exhibit excellent electrical conductivity (sheet resistance of 37.01 ± 12.09 Ω/square and conductivity of 0.0037 ± 0.0008 MS/cm) and well-defined interdigitated geometries suitable for bioelectronic applications. To evaluate their performance, human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are cultured directly on the electrodes. Electrochemical impedance spectroscopy (EIS) is employed as a label-free and real-time technique to monitor cell-electrode interactions and temporal variations in cell coverage and viability. EIS measurements, supported by equivalent circuit modeling, reveal distinct phases corresponding to initial cell adhesion, progressive remodeling of the cellular layer, and long-term reduction in viability, further validated by optical measurements. Overall, this work demonstrates a sustainable and cost-effective fabrication strategy for gold microelectrodes, enabling quantitative, noninvasive monitoring of cellular dynamics through impedance-derived parameters and image-based validation of cell coverage evolution.

PMID 43012415
Read full article →
PubMedAnalytical chemistry2026-11-11

96-Sample Parallel BioSPME-DART-MS Platform for Rapid Screening of Fentanyl and its Analogues in Biofluids.

Zhou Wei W, Driezen Marc M, Pawliszyn Janusz J

Solid-phase microextraction (SPME) with biocompatible coating material is highly compatible with ambient mass spectrometry (AMS), such as direct analysis in real time (DART), for improving sensitivity and reducing matrix effects. However, the practical throughput of SPME-DART-MS remains limited by the mismatch between parallel sample preparation and device-to-source transfer. Here, we introduce a 96-sample parallel BioSPME-DART-MS platform that integrates automated SPME extraction, 96-channel liquid transfer, and a matched 96-position DART mesh interface. This design enables 96 biological samples to be processed in a plate-based format, greatly improves workflow transferability. Thin HLB/PAN-coated SPME blades were used to provide bio-compatible extraction and cleanup from whole blood, plasma, and urine. After desorption in 200 μL of solvent, only 5 μL of the extract was transferred to the DART mesh for rapid MS/MS screening, while the remaining solution was retained for sequential LC-MS/MS confirmation without additional sample preparation. The system enabling an average analysis time of approximately 40 s per sample. Using six fentanyl and its analogues as model analytes, the BioSPME-DART-MS method achieved good sensitivity across the three biofluids, with limits of detection of 0.10-0.50 ng mL-1 in whole blood, 0.03-0.20 ng mL-1 in plasma, and 0.01-0.20 ng mL-1 in urine. In addition, a comparative study of absolute matrix effects revealed that chromatography-free DART-MS and blade spray-MS remained susceptible to ion suppression, whereas LC-ESI-MS showed negligible matrix effects. This platform establishes a high-throughput, two-tier SPME-MS workflow that combines rapid ambient MS screening with chromatography-based confirmation.

PMID 43010421
Read full article →
PubMedBMC oral health2026-11-11

Gas-driven needle-free dental injection enables tunable and predictable soft-tissue penetration: high-speed kinematic and micro-computed tomography validation.

Yoon Jeonghyun J, Kim Hyuntae H, AlQarni Mohammad M, Alkeshan Mohammad M et al.

Needle-free jet injectors are a promising alternative to conventional dental needles, particularly for patients with injection-related fear. However, the actuation mechanism can substantially affect jet formation, delivery consistency, and tissue penetration. This study compared portable gas-driven jet injectors with a conventional spring-driven device and evaluated whether jet velocity could be used to modulate penetration behavior in soft tissue. Four gas-driven injectors with different inlet-side restriction settings were compared with a spring-driven comparator. High-speed imaging was used to quantify piston motion, flow rate, and jet velocity. Soft-tissue penetration was assessed in ex vivo chicken breast using a radiopaque silver nitrate tracer and micro-computed tomography (micro-CT). Penetration volume, maximum depth, maximum cross-sectional area, depth of maximum area, and average cross-sectional area were analyzed. The gas-driven injectors showed smooth piston advancement, quasi-steady jet profiles, and complete discharge, whereas the spring-driven comparator showed an impulsive early peak, recoil, fan-spray tendency, and incomplete discharge. Mean jet velocity exceeded 13 m/s in all gas-driven groups but was 2.40 m/s in the spring-driven group despite a much higher peak velocity. Micro-CT showed no significant between-group difference in detectable tracer volume. Increasing jet velocity in the gas-driven groups was associated with deeper and narrower penetration tracts, whereas lower jet velocities produced shallower and broader dispersion. Gas-driven needle-free injection provided more stable kinematics and more controllable penetration geometry than the spring-driven comparator under the present ex vivo conditions. Velocity-based regulation may enable procedure- and site-specific optimization of needle-free dental local anesthesia, although clinical validation in intraoral tissues is still required.

PMID 43009950
Read full article →
PubMedEuropean journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V2026-11-10

Antibacterial, antibiofilm, mucus penetration properties and pulmonary biocompatibility of inhalable spray-dried levofloxacin-ambroxol composite microparticles.

Suraweera Ruwani K RK, Panthi Vijay Kumar VK, Hickson Sarah M SM, Yarlagadda Tejasri T et al.

This study evaluated the antibacterial and biofilm-disruption activities of spray-dried levofloxacin (LVX) and ambroxol (AMB) composite dry powder inhaler (DPI) formulations against laboratory and clinical strains of P. aeruginosa and a clinical S. aureus strain. Cytotoxicity and pro-inflammatory activity of the formulations were investigated in THP-1 derived macrophages, healthy and COPD bronchial epithelial cells (HBE), and mucus penetration using an artificial mucus model. Spray dried LVX retained antibacterial activity against PA14 (MIC50 0.075-0.099 µg/mL versus 0.076 µg/mL for free LVX), whereas free AMB showed no antibacterial activity. Formulations containing higher AMB proportions, exhibited greater antibacterial activity than free LVX against AUST-02 and 2.1. The developed formulations also enhanced biofilm disruption against PA14 and AUST-02. AMB improved penetration of spray-dried LVX, particularly with F4 (LVX:AMB 1:1 with 5 % leucine) showing statistically significant (p < 0.05) penetration enhancement compared to free LVX (60.8 % and 82.8 % in 2 h) at 16 µg/mL. All formulations maintained high cell viability (>83 %) in THP-1 macrophages, while no significant cytotoxicity or increase in IL-8 production was observed. Overall, the prepared composite antibiotic microparticles demonstrated superior antibacterial activity against the tested clinical strains, enhanced biofilm disruption and LVX mucus penetration, while preserving pulmonary biocompatibility in the tested cell models.

PMID 43008901
Read full article →

+9996 more articles available with a free account

Sign up free to view all articles →

Ask about ketoprofen spray