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calcium polycarbophil (Polyful / Colonel)

✓ Approved

Astellas Pharma · Small Molecule · Small Molecule

What is calcium polycarbophil?

calcium polycarbophil is a small molecule developed by Astellas Pharma. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesPolyful, Colonel
CompanyAstellas Pharma
Drug ClassSmall Molecule
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, Astellas Pharma

Therapeutic Indications

calcium polycarbophil is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Gastrointestinal disordersIrritable bowel syndrome✓ Approved

Related Research Articles

PubMedFoods (Basel, Switzerland)2026-06-12

Superiority of Organic Calcium Fertilizers over Inorganic Counterparts in Enhancing Fruit Firmness and Quality of Blue Honeysuckle (Lonicera caerulea L.).

Chen Yuxi Y, Li Wei W, Ji Xuefei X, She Haihui H et al.

Blue honeysuckle is an emerging small berry with high nutritional value; However, the soft texture of its fresh fruit leads to poor storability and transportability, severely limiting its economic returns. Calcium is a key element in maintaining the structural integrity of plant cell walls and membranes, and plays a decisive role in fruit firmness and postharvest quality. To elucidate the effects of different calcium fertilizers on the fruit firmness, yield, and fruit quality of blue honeysuckle, a two-year field experiment was conducted using foliar application of 2 L of calcium fertilizer (CaC, CaA, CaL, SAC and AAC) at a concentration of 1 mg/L, with the control receiving an equal volume of water. The results showed that sugar alcohol calcium had the best effect on fruit firmness, fresh weight, yield, solid-acid ratio, total anthocyanins, and ascorbic acid, significantly improving yield and quality. Amino acid calcium was most effective in increasing fruit volume and fruit number per plant. Calcium acetate and calcium lactate showed balanced improvements across indicators. Calcium chloride significantly enhanced fruit shape index, total phenols, and total flavonoids. These findings elucidate the specific effects of various treatments on key fruit traits, providing a theoretical basis for precision cultivation and quality regulation, thereby facilitating the standardization and high-quality development of the industry.

PMID 42279642
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PubMedbioRxiv : the preprint server for biology2026-06-12

Precise calcium-to-spike inference using biophysical generative models.

Broussard Gerard Joey GJ, Diana Giovanni G, Urra Quiroz Francisco J FJ, Sermet B Semihcan BS et al.

The intramolecular dynamics of fluorescent calcium indicators distort the relationship between calcium signals and action potentials ("spikes"), hampering efficient spike inference from calcium imaging. To address this problem, we characterized the calcium response kinetics of three widely used indicators, GCaMP6f, jGCaMP7f, and jGCaMP8f, using in vitro stopped-flow measurements and brain slice recordings. We identify previously unreported kinetic features, including use-dependent slowing of fluorescence decay, that introduce systematic errors in linear model-based inference methods. Using these observations, we developed a multistate model of GCaMP and used it to create biophysically-inspired Bayesian Sequential Monte Carlo and machine learning inference models trained on synthetic datasets. These methods outperform existing methods on spike timing accuracy and correlation benchmarks derived from diverse cell types. Our results show that using synthetic data derived from our biophysical model yields a decoder that outperforms even those trained on extensive experimental data. By separating indicator characterization from inference, our framework, C alcium S pike P rocessing using I ntegrated K inetic E stimation and S imulation (C-SPIKES), provides a generalizable strategy applicable to existing and future calcium indicators.

PMID 42282678
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PubMedInternational journal of molecular sciences2026-06-12

Sustainable Synthesis of Calcium Propionate from Cockle Shell Biowaste for Food Additive Production.

Seangarun Chaowared C, Boonchom Banjong B, Seesanong Somkiat S, Boonmee Wimonmat W et al.

Calcium propionate (Ca(CH3CH2COO)2) was successfully synthesized from cockle shell biowaste through a reaction with propionic acid at concentrations of 80%, 90%, and 99%, valorizing seafood processing biowaste as a renewable calcium source in support of circular economy principles. The synthesis was conducted at ambient temperature with a fixed CaCO3: propionic acid molar ratio of 1:2, enabling rapid reaction completion without external heating or complex purification steps. The prepared samples were characterized by FTIR, XRD, TGA, and SEM techniques, which confirmed the formation of calcium propionate monohydrate (Ca(CH3CH2COO)2·H2O), while XRF confirmed more than 97 wt% CaO across all samples with non-toxic impurities corresponding to compositional requirements for food additive calcium propionate (E282). The sample prepared using 80% propionic acid exhibited the highest yield (90.24%) and soluble percentage (98.23%). The proposed approach demonstrates an effective valorization of cockle shell waste into a food additive, calcium propionate, offering advantages in terms of sustainability, cost efficiency, and scalability, and highlighting its strong potential for industrial food additive production within a circular economy framework.

PMID 42278480
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PubMedNutrients2026-06-12

Comparison of Risk Profiles, Nutrient Intake, and Kidney Function of Calcium Oxalate Stone Formers with and without Enteric Hyperoxaluria. A Matched Case-Control Study.

Ernsten Charlotte C, Spuck Nikolai N, Hesse Albrecht A, Siener Roswitha R

Objectives: This study compared the risk profiles, nutrient intake, and kidney function of calcium oxalate stone formers with and without enteric hyperoxaluria. Methods: Thirty-seven patients with calcium oxalate stone disease and enteric hyperoxaluria (cases) and 37 sex- and age-matched idiopathic calcium oxalate stone formers (controls) were enrolled. Patients did not receive any nutritional counseling prior to the start of the study, and they discontinued medications affecting urinary parameters four weeks before their study participation. Anthropometric, clinical, and metabolic parameters were recorded. Dietary and 24-h urinary variables were measured under the habitual diet and under a balanced, standardized diet. The [13C2] oxalate absorption and calcium loading tests were carried out. Results: The median [13C2] oxalate absorption was significantly higher in cases (14.8%) than in controls (8.9%). Under the balanced diet, hypocitraturia, hypomagnesuria, low urine volume and pH value were significantly more common in the case group, whereas hypercalciuria occurred more frequently in the control group, affecting 45.9% of controls and 5.4% of cases. Furthermore, the control group exhibited a greater reduction in urinary calcium excretion under the balanced diet. Urinary oxalate excretion and the ion-activity product index of calcium oxalate were significantly higher under both diets, with a greater decline observed in the case group under the balanced diet. The estimated glomerular filtration rate (eGFR) was lower in cases. A multivariable linear regression analysis revealed a significant association between urine pH and eGFR. Conclusions: Calcium oxalate stone formers with and without enteric hyperoxaluria benefit from a balanced diet and sufficient fluid intake. The reduction in urinary oxalate excretion and the biochemical risk of recurrent calcium oxalate stone formation were even more pronounced in patients with enteric hyperoxaluria. Particular attention should be paid to low urine pH, as it is hypothesized to be a potential indicator of impaired kidney function.

PMID 42280431
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PubMedbioRxiv : the preprint server for biology2026-06-12

Dorsal striatal circuit mechanisms contributing to astrocyte modulation of alcohol-related behaviors.

Ardinger Cherish C, Kalelkar Anagha A, Madden Maxwell M, Gunda Ananya A et al.

The dorsolateral striatum (DLS) is a key site for coordinating the alcohol-induced stimulant response, a behavioral marker predictive of future alcohol use disorder. Although ethanol (EtOH) affects all brain cells, little is known about the contribution of non-neuronal DLS cell types to EtOH-induced stimulation. We used ex vivo two photon calcium imaging, in vivo fiber photometry of astrocyte and neuronal GCaMP, and astrocyte-specific manipulations in mice to determine DLS astrocyte contributions to EtOH-induced stimulation and voluntary EtOH drinking behavior. Using fiber photometry of GRAB-ACh sensors and cell-type specific chemogenetics, we also assessed the role of cholinergic signaling in observed astrocyte EtOH effects. As expected, intraperitoneal EtOH injections (0.5-2g/kg) evoked a stimulant response, evidenced by increased locomotion compared to saline. In parallel, EtOH dose-dependently decreased astrocyte calcium activity but had minimal effects on direct and indirect pathway neuronal activity. Mimicking this reduction with astrocyte-specific expression of CalEX, a calcium extruding pump, facilitated EtOH stimulation compared to mice expressing a control fluorophore. Hence, EtOH-induced suppression of DLS astrocyte activity contributes to stimulation. Astrocyte calcium signaling is a well-known target of neuromodulation. Fiber photometry recordings of extracellular acetylcholine (ACh) levels via GRAB-ACh imaging showed inhibition of ACh release by acute EtOH. We virally expressed the excitatory chemogenetic actuator hM3Dq in striatal cholinergic interneurons to assess whether artificially increasing ACh release blocks EtOH-induced inhibition of astrocytic calcium activity. Despite facilitating ACh release, this manipulation did not impact astrocyte calcium activity under control (saline) or EtOH conditions. Together, this work identifies DLS astrocytes as key contributors to EtOH-induced stimulation and highlights the importance of considering astrocyte-neuron interactions in evaluating alcohol effects.

PMID 42282508
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PubMedThe journal of trauma and acute care surgery2026-06-12

Ionized calcium after trauma should be interpreted as a pH-dependent resuscitation trajectory.

Yang Yuting Y

PMID 42283426
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