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propafenone hydrochloride (propafenone, SR / propafenone SR / Rythmol SR)

✓ Approved

GSK · SCN5A · Small Molecule

What is propafenone hydrochloride?

propafenone hydrochloride is a small molecule developed by GSK. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand Namespropafenone, SR, propafenone SR, Rythmol SR
CompanyGSK
Drug ClassSmall Molecule
Molecular TargetSCN5A
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, GSK

Mechanism of Action

Molecular Targets

propafenone hydrochloride acts on 1 molecular target:

SCN5Asodium voltage-gated channel alpha subunit 5 (CMD1E, SSS1)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

propafenone hydrochloride is developed for 2 unique indications across 1 therapeutic area.

Therapeutic AreaConditionPhase
Cardiac disordersAtrial fibrillation✓ Approved
Cardiac disordersVentricular fibrillation✓ Approved

Related Research Articles

PubMedCardiovascular research2026-09-19

Artificial intelligence-derived splenic response in cardiac positron emission tomography is associated with major adverse cardiovascular events: a multi-site study.

Ramirez Giselle G, Dharmavaram Naga L NL, Shanbhag Aakash A, Miller Robert J H RJH et al.

Inadequate pharmacologic stress may limit the diagnostic and prognostic accuracy of myocardial perfusion imaging (MPI). The splenic ratio (SR), a measure of stress adequacy, has emerged as a potential imaging biomarker. We developed an artificial intelligence (AI) method to derive SR and evaluated the prognostic value in a large multicentre 82Rb-PET cohort undergoing regadenoson stress testing. We retrospectively analysed 16 650 patients from six sites in the REFINE PET registry with clinically indicated MPI and linked clinical outcomes. SR was calculated using fully automated algorithms as the ratio of splenic uptake at stress vs. rest. Patients were stratified by SR into decile groups. The primary outcome was major adverse cardiovascular events (MACE). Survival analysis was conducted using Kaplan-Meier and Cox proportional hazards models adjusted for clinical and imaging covariates, including myocardial flow reserve (MFR ≥2 vs. <2) and presence of ischaemia. The cohort had a median age of 69 years, with 59% male patients. Common risk factors included hypertension (81%), dyslipidaemia (77%), diabetes (35%), and prior coronary artery disease (31%). Median follow-up was 3.4 years. Patients with high SR in the testing cohort (n = 950) had an increased risk of MACE [hazard ratio (HR) 1.19, 95% confidence interval (CI) 1.06-1.34, P = 0.005]. Among testing patients with preserved MFR (≥2; n = 8067), high SR remained independently associated with MACE (HR 1.43, 95% CI 1.20-1.70, P < 0.001). Even among patients with preserved MFR and no ischaemia in the testing cohort(MFR≥2, SDS<2; n = 6508), high SR remained independently associated with MACE (HR 1.54 95% CI 1.26-1.88, P < 0.001). Elevated AI-derived SR was independently associated with adverse cardiovascular outcomes, including among patients with preserved MFR. These findings support SR as a novel, automated imaging biomarker for risk stratification in 82Rb PET MPI.

PMID 42762227
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PubMedJournal of environmental management2026-09-19

Low-release biochar for improving coastal reclaimed Saline-Alkali soil: Short-Term physicochemical responses and exploratory microbial transcriptional associations under controlled pot conditions.

Li Wen Tao WT, Liu Lin L, Wang Kang K, Zhang Saiwei S et al.

Coastal land reclamation is an important approach to expanding useable land, yet reclaimed soils are often constrained by low fertility, weak structural stability, and saline-alkaline stress. Considering traditional amendments may introduce environmental risks in sensitive coastal settings, this study evaluated the short-term responses of coastal reclaimed saline-alkali soil (Hengsha Island, Shanghai) under controlled pot conditions to a novel low-release biochar (BC-SR). Ten days after application, conventional biochar (BC-O) increased soil salinity to 2.5 times the initial level and raised pH by 0.22, whereas BC-SR exerted negligible disturbance on salinity and pH. Soil organic carbon (SOC) exhibited a net 13% reduction under BC-O during incubation, whereas BC-SR induced a 24% net rise in SOC alongside improved macroaggregate formation and microbial biomass. This effect of BC-SR further elevated the net SOC increment to 105% in the plant-containing treatments, whereas SOC decreased by 41% in the plant-only control. Exploratory metatranscriptomic analysis indicated that the treatment combining plant and BC-SR was associated with higher transcript abundances of genes related to the Calvin-Benson-Bassham cycle and other carbon fixation pathways. Overall, these findings provide short-term evidence that low-release biochar could reduce release-related risk signals while increasing soil organic carbon and improving fertility properties in reclaimed coastal saline-alkali soils under controlled pot conditions.

PMID 42762556
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PubMedCardiovascular research2026-09-19

Lysosomal signaling pathways influence heart rhythm, and regulate atrial function.

Akerman Emily E, Capel Rebecca A RA, Rog-Zielinska Eva A EA, Winbo Annika A et al.

In the heart, endogenous nicotinic acid adenine dinucleotide phosphate (NAADP) triggers lysosomal calcium (Ca2+) release to augment sarcoplasmic reticulum (SR) Ca2+ sequestration, producing larger Ca2+ transients. However, the role of lysosomal Ca2+ signals in pacemaker activity, a distinct Ca2+-operated function of the sinoatrial node (SAN), or in the atrial myocardium has not been investigated. Pharmacological or genetic ablation of the NAADP pathway inhibits the spontaneous beating rate response to β-adrenergic stimulation in intact SAN. We found intracellular signaling microdomains between lysosomes and neighboring SR or mitochondria in mouse, and goat tissue. The spatial relationship between lysosomes and other Ca2+-handling organelles are altered in goat atrial fibrillation. Furthermore, we demonstrate atrial myocytes produce 3'-5'-cyclic adenosine monophosphate (cAMP) in response to lysosomal signaling, adding a novel trigger for cyclic nucleotide signaling. Our findings support the hypothesis that lysosomal Ca2+ signaling contributes to regulation of cardiomyocyte cAMP levels and pacemaker activity.

PMID 42760609
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PubMedFrontiers in plant science2026-09-19

Drip fertigation technique with planting models strategies trigger grain filling, endogenous hormonal changes and maize productivity under semi-arid regions.

Wang Jiaqi J, Diao Jian J, Xu Zhe Z, Ma Ning N et al.

Mulch drip fertigation strategies have been widely adopted to improve maize productivity in semi-arid regions. However, the impact of the mulch-based drip fertigation on endogenous hormone dynamics in crops and grain yield has not been fully elucidated, and the biochemical mechanisms underlying yield improvement under different drip fertigation strategies remain unclear. Grain filling has a significant impact on maize production. The aim of this study was to explore the effect of plastic film mulching materials on maize grain filling under a drip fertigation strategy, and the relationship between this effect and changes in endogenous hormones. This study compared biodegradable film mulching (BM) with soil crust ridges (SR) under high (H), medium (M), and low (L) drip irrigation conditions, and measured that the grain filling characteristics and changes in grain endogenous hormones in various parts of maize ears during the growth stage. The results showed that the grain filling rate, dry matter plant-1, hormone changes, yield components, water use efficiency (WUE), and ET of maize under the BMH treatment were significantly higher than those under the SR treatment. BMH treatment significantly increased soil water storage significantly increased plant hormone contents such as abscisic acid (ABA), indole-3-Acetic acid (IAA), and zeatin + Zeatin Riboside (Z+ZR), and decreased the evolution rate of gibberellins (Gas) and ethylene, thereby increasing maize yield. These results indicate that BMH treatment improved the filling process, soil respiration rate, WUE, yield, and yield composition of maize. High drip fertigation with BM or SR treatment significantly affected endogenous hormone changes, thereby regulating the activity grain-filling period (AGP), maximum grain-filling rate (Gmax), maximum grain weight (Wmax), mean grain-filling rates (Gmean) and occurrence time of maximal filling rate (Tmax) of maize. In addition, high drip fertigation and the BM strategy significantly increased soil water storage and soil respiration rate during the grain filling period. Based on these results, we conclude that BMH significantly improved soil water storage, thereby regulating the maize grain filling rate, which was significantly correlated with the balance of endogenous hormones in the grains.

PMID 42760979
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PubMedJournal of molecular graphics & modelling2026-09-19

First-principles study of ferromagnetism and thermoelectric aspects of Sr(Pr/Nd)2S4 spinel chalcogenides as promising aspirants for spintronic and energy applications.

Alofi Ayman S AS, El-Badry Basma A BA, Ayaz Aiman A, Mustafa Ghulam M GM et al.

This article investigates the rare-earth-doped spinel chalcogenides Sr(Pr/Nd)2S4 for spintronics and thermoelectric applications. Spin-dependent structure optimization reveals their stability in the ferromagnetic state. Tolerance factors, formation energies, ab initio molecular dynamics simulations, and phonon band structures are calculated to evaluate their structural and thermodynamic stability. The spin-polarization density calculations and band structure analysis show 100% spin polarization and a ferromagnetic semiconducting nature. The spin-↑ channel has band gaps of ∼1.75 and 0.70 eV, and the spin-↓ channel is insulating. The exchange energies (Δx(f), Δx(pf)) and exchange constants (Noα, Noβ) are measured based on the strong coupling between the 4f-state of Pr/Nd and 3p-orbitals of S, leading to the creation of localized magnetic moments and the emergence of intriguing magnetic phenomena. Additionally, analyzing the electrical conductivity, power factor, thermal conductivity, and Seebeck coefficient by means of the BoltzTrap code helps to assess their suitability for transport applications. Thermoelectric performance has been measured by the figure of merit values of 0.84 and 0.58 for SrPr2S4 and SrNd2S4, respectively. The substantial values of transport parameters make these materials an evolving class for Spin electronics and thermal energy harvesting systems.

PMID 42762768
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PubMedTree physiology2026-09-19

Mycorrhizal tree dominance effects on community-level nutrient status and resorption efficiency depend on tree diversity in a subtropical young forest.

Zhang Wei W, Xu Yi-Jie YJ, Pan Bao-Xu BX, Hu Jun-Kai JK et al.

Tree mycorrhizal type and tree species diversity are pivotal drivers of nutrient contents and resorption of individual plants. However, it is unclear how community-level nutrient status and resorption will change along mycorrhizal tree dominance, in particular how the trends vary with tree diversity. We investigated the impacts of arbuscular mycorrhizal tree dominance (AMD) nested with tree species richness (SR) on the community-level leaf and litter carbon (C), nitrogen (N) and phosphorus (P) contents, stoichiometric ratios, and N resorption efficiency (NRE) and P resorption efficiency (PRE), and soil available nutrient status. Our results showed that leaf and litter C and N contents and C:P and N:P ratios generally declined, but leaf P content, and nutrient resorption efficiencies (i.e., NRE, PRE and NRE:PRE ratio) increased with increasing AMD. Moreover, soil inorganic N (i.e., NH4+-N and NO3--N) and available P contents declined with increasing AMD. Our findings demonstrated that the effects of AMD on plant and soil nutrient status varied with tree SR, showing amplified effects of AMD on plant nutrient status and weaken effects on soil available nutrient and plant nutrient resorption in high-diverse community. In addition, we conclude that the 'nutrient concentration control' is the key driving mechanism of leaf NRE, but 'stoichiometry control' is a main regulator of PRE in subtropical forests. Our results provide a guidance of using mycorrhizae-associated tree species to achieve more available nutrient resources and thereby improving productivity in mixture plantations.

PMID 42762096
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