Drug Database
DI

diosmin + hesperidine (Daflon / Capiven / Detralex)

✓ Approved

Servier · therapeutic agent

What is diosmin + hesperidine?

diosmin + hesperidine is a therapeutic agent developed by Servier. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesDaflon, Capiven, Detralex
CompanyServier
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, Servier

Therapeutic Indications

diosmin + hesperidine is developed for 2 unique indications across 2 therapeutic areas.

Therapeutic AreaConditionPhase
Gastrointestinal disordersAbdominal pain✓ Approved
Vascular disordersPeripheral venous disease✓ Approved

Related Research Articles

PubMedFood & function2026-05-27

Integrated RNA-seq and network pharmacology analyses suggest PI3K-Akt and NF-κB pathway modulation in the protective effects of diosmin against experimental colitis.

Wang Shuo S, Tan Cheng C, He Haodong H, Li Xiangyun X et al.

Ulcerative colitis (UC), a chronic inflammatory bowel disease, remains difficult to treat due to incomplete understanding of its mechanisms and limited therapeutic options. Diosmin, a natural citrus-derived flavonoid, has shown promising anti-inflammatory effects, but its molecular mechanisms in UC are unclear. In this study, we investigated the protective role of diosmin using dextran sulfate sodium (DSS)-induced colitis in mice and LPS-stimulated HT-29 cells, integrating transcriptomic and network pharmacology analyses. Diosmin treatment significantly alleviated colitis symptoms, reduced inflammation, preserved colon length, and enhanced intestinal barrier integrity, with efficacy comparable to 5-aminosalicylic acid. RNA-seq and network pharmacology identified PI3K-Akt and NF-κB as key pathways associated with diosmin-mediated protection, while molecular docking was used as a supportive computational analysis to explore potential interactions with selected hub-associated proteins. Experimental validation confirmed that diosmin inhibited activation of PI3K-Akt-mTOR and NF-κB signaling, decreased pro-inflammatory cytokines (TNF-α, IL-1β and IL-6), increased IL-10, promoted intestinal barrier repair via upregulation of ZO-1, occludin, and E-cadherin, and suppressed apoptosis of colonic epithelial cells. Together, these findings suggest that diosmin exerts multi-target protective effects against experimental colitis by modulating inflammation, supporting barrier integrity, and regulating key signaling pathways, providing mechanistic insight into the actions of this citrus-derived bioactive compound in colitis.

PMID 42191164
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PubMedInternational journal of molecular sciences2026-05-27

Natural Molecules for Brain Health and Resilience.

Venetsanaki Vasiliki V, Pardali Eleni C EC, Cholevas Christos C, Grammatikopoulou Maria G MG et al.

The global rise in cognitive decline and neurodegenerative disorders has intensified the search for safe and accessible strategies to support brain health. In recent years, nutraceuticals have gained considerable attention as potential modulators of neurological function due to their antioxidant, anti-inflammatory, and neuroprotective properties. Increasing evidence suggests that oxidative stress, neuroinflammation, mitochondrial dysfunction, and impaired neurovascular integrity play central roles in the pathogenesis of several neurodegenerative diseases, namely Alzheimer's, Parkinson's disease and autism spectrum disorder, among others. This narrative review provides an integrated overview of selected nutraceuticals with potential relevance to brain-related disorders, including biotin, folinic acid, flavonoids (apigenin, diosmin, luteolin, naringin, pycnogenol, and quercetin), huperzine A, Lion's mane, olive oil polyphenols, oleuropein and palmitoylethanolamide. Rather than presenting a purely descriptive summary, we considered both mechanistic and clinical evidence, highlighting differences in the strength, consistency, and quality of available data across compounds. Among the reviewed compounds, huperzine A, specific flavonoids-particularly luteolin-and olive oil polyphenols demonstrated relatively stronger and more consistent support across experimental models and emerging clinical studies, mainly through modulation of cholinergic signaling, neuroinflammatory pathways, and oxidative stress responses. In contrast, evidence for other agents remains limited, heterogeneous, or primarily at the preclinical level. Overall, this review aims to provide a clearer and more structured synthesis of the current literature on neuronutrition, identifying compounds with the most promising profiles while outlining key limitations and research gaps that need to be addressed to better define their role in brain health.

PMID 42196321
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PubMedPreparative biochemistry & biotechnology2026-05-24

Optimization of ultrasound-assisted pectinase extraction of flavonoids from peppermint leaves and evaluation of their antioxidant activity.

Liu Bei B, Hu Jinzhong J, Feng Panpan P, Xu Juan J et al.

Peppermint (Mentha piperita L.) is valued for its bioactive flavonoids. However, the combined application of ultrasound and pectinase for flavonoid extraction from peppermint has not been thoroughly investigated. This study developed an ultrasound-assisted pectinase extraction (UAPE) process for efficient and green extraction of flavonoids from peppermint leaves. Utilizing the response surface methodology (RSM), we found that the best extraction circumstances included adding 1.5% pectinase, applying ultrasound for 41 min at 51 °C, and maintaining a liquid-to-solid ratio of 32 mL/g, which led to a 12.87 ± 0.04 g/100 g DW yield of total flavonoids. Ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) analysis of the flavonoids resulted in the determination of 38 compounds. Quantitative analysis of four target compounds revealed that hesperidin was the most abundant at 892 ± 10 μg/g DW, and then diosmin (452 ± 10 μg/g DW), linarin (374 ± 5 μg/g DW), and a significantly lower concentration of acacetin (0.8 ± 0.08 μg/g DW). Furthermore, the flavonoid extract exhibited antioxidant activity, demonstrating half maximal inhibitory concentration (IC50) values of 0.0241 and 0.0243 mg/mL for 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radicals, respectively. This study lays the groundwork for the potential exploitation and application of peppermint resources.

PMID 42176351
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PubMedPhytotherapy research : PTR2026-05-19

Plants and Plant-Derived Compounds Mediate Protection Across Diverse Pathological Conditions by Targeting the PANoptosis Pathways.

Yarmohammadi Fatemeh F, Miraghaee Seyed Shahram SS, Karimi Gholamreza G

PANoptosis is a complex inflammatory programmed cell death pathway that integrates the key mechanistic features of pyroptosis, apoptosis, and necroptosis. It represents a crucial innate immune mechanism for eliminating infected or damaged cells; however, its dysregulation is implicated in the pathogenesis of a wide spectrum of diseases, including sepsis, myocardial infarction, acute organ injuries, and cancer. Consequently, targeting PANoptosis has garnered significant interest as a novel therapeutic strategy. This review explored the potent modulatory effects of herbal medicines and their bioactive compounds on PANoptotic pathways. Preclinical evidence indicated that numerous plant-derived compounds (including, costunolide, artemetin, lycopene, amentoflavone, sulforaphane, licochalcone B, hesperidin, apigenin, and diosmin) and traditional formulations (such as Danggui Buxue, Xian Ling Gu Bao decoction, Xiao Chai Hu decoction, Dachaihu decoction, and Dachengqi decoction dispensing granule) can effectively suppress the core molecular drivers of PANoptosis, such as caspase-1, caspase-3, caspase-8, RIPK1, RIPK3, MLKL, and GSDMD, alongside key inflammasome components like NLRP3. Their mechanisms of action are multi-faceted, encompassing the downregulation of upstream sensors (e.g., ZBP1), the attenuation of pro-inflammatory cytokines (IL-1β, IL-6, TNF-α, IL-18), and the enhancement of cellular antioxidant defenses via the Nrf2 pathway and enzymes like SOD and CAT. By inhibiting PANoptosis, these natural products demonstrate substantial protective potential across diverse models of cardiovascular, pulmonary, renal, hepatic, and neurological diseases.

PMID 42152625
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PubMedChemistryOpen2026-05-15

Flavonoid Inhibition of Bacillus licheniformis LP-8 Lipase: In Vitro and In Silico Insights Into Anti-Obesity Potential.

Bayrak Songul S, Omeroglu Mehmet Akif MA, Senol Halil H

Lipase inhibition is a key strategy for controlling dietary fat absorption and managing obesity. In this study, lipase produced from Bacillus licheniformis LP-8 (GenBank accession number: PX970421), using waste frying oil, was used to evaluate the inhibitory potential of selected flavonoid compounds. In vitro inhibition assays revealed IC50 values ranging from 1.28 to 3.51 μM, with syringetin exhibiting the strongest inhibitory activity (IC50 = 1.28 ± 0.009 μM), surpassing the reference inhibitor, orlistat (IC50 = 2.13 ± 0.010 μM). Structure-activity relationship analysis indicated that electron-donating substituents, particularly methoxy and hydroxyl groups on the B-ring, play a crucial role in enhancing lipase inhibition. To further elucidate the interaction mechanisms, molecular docking and molecular dynamics (MD) simulations were performed. Induced Fit Docking results demonstrated favorable binding affinities for syringetin, diosmin, and isorhamnetin-3-O-rutinoside, with syringetin showing the most stable binding profile. Subsequent 250 ns MD simulations confirmed the structural stability of the lipase-syringetin complex through persistent hydrogen bonding and π-π interactions, indicating a well-oriented and stable binding mode. Overall, the combined experimental and computational findings highlight the potential of flavonoids, particularly syringetin, as promising natural lipase inhibitors for obesity-related applications.

PMID 42136083
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PubMedFoods (Basel, Switzerland)2026-05-04

Honey Lemon Alleviates Alcoholic Liver Disease via Multi-Target Synergistic Mechanisms: An Integrated Study of Network Pharmacology, Molecular Docking, and Animal Experiments.

Zhou Yaxi Y, Xu Dong D, Bu Meichao M, Li Ke K et al.

Honey lemon (H&L) is a traditional beverage known for its potential liver-protective effects, but its mechanisms against alcoholic liver disease (ALD) remain poorly understood. This study aimed to investigate the hepatoprotective properties of H&L and explore its multi-target mechanisms in alleviating ALD. Using network pharmacology and molecular docking, we identified 26 bioactive compounds in H&L and 335 potential targets associated with ALD. Pathway enrichment analysis revealed that H&L might exert its influence by regulating inflammation, oxidative stress and ethanol metabolism. Molecular docking further demonstrated strong binding interactions between key flavonoids (hesperidin, diosmin, and eriocitrin) and crucial targets, such as AKT1, SRC, STAT3, as well as ethanol-metabolizing enzymes like ADH, ALDH, and CYP2E1. In vivo experiments suggested that H&L alleviated liver injury and significantly improved selected indicators related to ethanol metabolism, oxidative stress, and inflammatory response. For several variables, including ALT/AST, ALDH, IL-6, and hepatic ethanol content, improvement trends were observed, although not all differences reached statistical significance. Overall, the results suggest that the protective effect of H&L against ALD may be associated with a multi-component, multi-target, and multi-pathway mode of action, supporting its potential for further investigation as a functional food candidate.

PMID 42073271
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