Drug Database
DI

diosmin + hesperidine (Daflon / Capiven / Detralex)

✓ Approved

Servier · therapeutic agent

What is diosmin + hesperidine?

diosmin + hesperidine is a therapeutic agent developed by Servier. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesDaflon, Capiven, Detralex
CompanyServier
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, Servier

Therapeutic Indications

diosmin + hesperidine is developed for 2 unique indications across 2 therapeutic areas.

Therapeutic AreaConditionPhase
Gastrointestinal disordersAbdominal pain✓ Approved
Vascular disordersPeripheral venous disease✓ Approved

Related Research Articles

PubMedReproductive toxicology (Elmsford, N.Y.)2026-10-28

Gonadoprotective effects of diosmin against radiation-induced testicular dysfunction: Mechanistic spotlight on JAK/STAT pathway and autophagic machinery.

Moustafa Nada Mehrez NM, Michel Haidy E HE, Said Riham S RS, Mantawy Eman M EM

Radiotherapy is an effective therapeutic modality for many malignant tumors; however, it poses a significant threat to male reproductive health. This study aimed to investigate the radioprotective potential of diosmin, a flavonoid with well-established antioxidant and anti-inflammatory properties, against radiation-induced testicular injury and elucidate the underlying mechanisms. Adult male Sprague-Dawley rats were randomly allocated into four experimental groups: control, diosmin-treated, irradiated, and irradiated plus diosmin-treated. Testicular injury was induced by subjecting rats to a single 10 Gy dose of γ-radiation, while diosmin was administered orally at 50 mg/kg for 14 consecutive days. Diosmin administration markedly counteracted radiation-induced decline in serum testosterone levels, sperm count, motility, and viability, as well as reduction in testicular weights. Histopathological analysis revealed preservation of testicular architecture with diosmin treatment, as evidenced by increased seminiferous tubule diameter and epithelial thickness. Moreover, diosmin improved the antioxidant capacity of irradiated testis by elevating reduced glutathione levels and enhancing catalase activity. In addition, diosmin attenuated radiation-induced testicular inflammation by inhibiting NF-κB nuclear translocation and reducing the levels of the pro-inflammatory cytokine IL-6. Subsequently, diosmin suppressed irradiation-induced activation of the JAK/STAT signaling pathway by inhibiting the phosphorylation of JAK1 and STAT3. Furthermore, diosmin modulated the expression of autophagy-related markers through downregulating Beclin-1 expression while increasing p62/SQSTM1 accumulation. In conclusion, diosmin effectively mitigates irradiation-induced testicular damage by suppressing oxidative stress and inflammation, inhibiting the activation of the p-JAK1/p-STAT3 signaling pathway, and regulating testicular autophagy. These findings highlight diosmin as a potential therapeutic agent for safeguarding testicular function during radiotherapy.

PMID 42951116
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PubMedInternational journal of molecular sciences2026-10-27

Diosmin Attenuates PTSD-like Behaviors and Hippocampal Astrocyte Alterations with Reduced STAT1 and CXCL9 Expression in an SPS&S Mouse Model.

Zhang Xinchao X, Ren Mengjie M, Xu Anke A, Liu Jintian J et al.

Diosmin is a citrus-derived flavone glycoside with anti-inflammatory activity in preclinical models. This study aimed to investigate the effects of diosmin on PTSD-like behaviors, astrocyte morphology, and the expression of STAT1 and CXCL9 in a single prolonged stress and shock (SPS&S) mouse model, and to assess whether Stat1 knockdown could mimic diosmin's effects in primary astrocytes. Male C57BL/6J mice were assigned to the control, SPS&S, and SPS&S + diosmin groups and underwent 14 days of treatment. Behavioral assessments included open-field and elevated plus-maze tests, alongside cue- and context-associated fear tests, complemented by GFAP-based morphometry, immunofluorescence, Western blotting, serum cytokine assays, hippocampal RNA sequencing, and quantitative reverse-transcription PCR (qRT-PCR). The results indicated that diosmin significantly enhanced exploratory behavior and reduced fear responses compared to SPS&S alone, alongside notable alterations in hippocampal astrocyte morphology and a shift in cytokine profiles, with decreased pro-inflammatory cytokines and increased anti-inflammatory markers. RNA sequencing revealed 297 differentially expressed genes, particularly highlighting the roles of Stat1 and Cxcl9, both of which were significantly downregulated upon diosmin treatment. Furthermore, diosmin modulated astrocyte responses to inflammatory stimuli in primary cultures. These findings suggest that diosmin exerts protective effects against PTSD-like symptoms by regulating astrocytic function and immune-related pathways, with STAT1 signaling serving as a key but non-exclusive downstream mechanism underlying its therapeutic actions. Future studies should further elucidate the full spectrum of associated pathways to advance the development of targeted interventions for PTSD.

PMID 42942109
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PubMedPharmaceuticals (Basel, Switzerland)2026-10-27

Natural Modulators of the PPARγ-Adiponectin Axis in Insulin Resistance: Structural Pharmacology, Receptor-State Selectivity, and Translational Readiness.

Floriana Vasilica Pirscoveanu Denisa PD, Trasca Diana-Maria DM, Kamal Adina Maria AM, Varut Renata Maria RM et al.

Insulin resistance reflects maladaptive communication among adipose tissue, the liver, skeletal muscle, immune cells, and the vasculature. Peroxisome proliferator-activated receptor gamma (PPARγ) is a validated insulin-sensitizing target, but classical full agonism couples metabolic efficacy to weight gain, fluid retention, and skeletal liability. This critical narrative review evaluates plant-derived and dietary molecules through a receptor-state framework that distinguishes direct binding from reporter activation and separates full agonism, partial agonism, selective modulation, antagonism with retained metabolic function, and post-translational control of PPARγ. Adiponectin is considered a functional inter-organ circuit linking adipocyte PPARγ activity to AdipoR1/AdipoR2 signaling, AMPK, PPARα, ceramide metabolism, glucose disposal, and fatty-acid oxidation. Amorfrutins provide the most coherent target-led natural-product evidence, whereas chelerythrine offers a structurally defined selective-modulation benchmark; honokiol, diosmin, betulinic acid, valerenic acid, punicic acid, alkamides, and defined extracts show heterogeneous mechanistic and translational maturity. Human evidence linking natural PPARγ ligands to verified target engagement and improved insulin sensitivity remains limited. We therefore propose a seven-stage translational roadmap connecting chemical identity, orthogonal binding, receptor-state pharmacology, cellular function, tissue exposure, mechanism-matched safety, and randomized human proof.

PMID 42943204
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PubMedJournal of ethnopharmacology2026-10-16

Ziziphora clinopodioides Flavonoids exerts neuroprotective effects through PI3K/Akt pathway to improve ischemic stroke.

Zhuo Xingjie X, Li Siyi S, Zhang Wencong W, Deng Mingcong M et al.

Ziziphora clinopodioides Lam. is a traditional Uyghur medicinal herb used for centuries in Xinjiang, China, to treat cardiovascular and cerebrovascular disorders. According to local ethnopharmacological records, it is traditionally employed to promote blood circulation, remove blood stasis, calm the heart, and relieve chest tightness and palpitations. Modern studies have shown that its total flavonoids (ZCF) possess anti-inflammatory and antioxidant activities. Ischemic stroke (IS) is a leading cause of death and disability, involving neuroinflammation, oxidative stress, and blood-brain barrier (BBB) disruption. However, the neuroprotective mechanism of ZCF against IS and its active constituents remain unclear. This study aimed to elucidate the neuroprotective mechanism of ZCF against IS and to identify its potential active flavonoids. Network pharmacology and transcriptomics were used to predict core pathways, followed by in vitro and in vivo experiments. Neurological deficits, infarct volume, BBB integrity, and PI3K/Akt-related inflammatory/oxidative markers were assessed. The PI3K inhibitor LY294002 was used, and active flavonoids were screened by molecular docking, molecular dynamics simulations, and ELISA. Integrated transcriptomics and network pharmacology identified that ZCF modulates the PI3K/Akt pathway. In MCAO/R-treated rats, ZCF reduced cerebral infarction, and preserved neuronal morphology. ZCF protected BBB integrity by restoring ZO-1, Occludin, Claudin-5, reducing MMP-9 and MMP-2 levels, rebalancing the Ang-1/Ang-2 ratio, decreasing NaF permeability, and increasing TEER. ZCF activated PI3K/Akt signaling in both bEnd.3 cells and MCAO/R-treated rat brain tissues, and the PI3K inhibitor LY294002 reversed ZCF-mediated regulation of tight junction proteins, matrix metalloproteinases, and Ang-1/Ang-2, suggesting that ZCF preserves BBB integrity at least partly through a PI3K/Akt-dependent mechanism. ZCF inhibited the TLR4/NF-κB/NLRP3 axis, reduced IL-1β, IL-6, TNF-α and MDA, and up-regulated Nrf2 and SOD, and these effects were reversed by LY294002. Molecular docking and MD simulations suggested that Diosmin, Glycitin, and Tilianin may form stable binding with PI3K. Diosmin, Glycitin and Tilianin could significantly restore the activity of PI3K in PC12 cells treated with OGD/R, reduce the levels of IL-1β, IL-6, TNF-α and MDA, and enhance the activity of SOD. Under preconditioning conditions, ZCF maintains BBB and inhibits neuroinflammation and oxidative stress through integrity and PI3K/Akt dependence, thereby exerting anti-IS protection. Diosmin, Glycitin, and Tilianin are potential active flavonoids that may contribute to PI3K/Akt activation.

PMID 42887834
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PubMedMedical oncology (Northwood, London, England)2026-10-08

Nano-Diosmin mitigates EAC-induced renal injury through Nrf2-mediated antioxidant activation and NF-κB-dependent apoptotic suppression.

Alshammari Ahmad Najem AN, Alfawaz Mohammed Saleh MS, Oraby Fatma F, Mohamed Ahmed M AM et al.

The present study provides the first evidence of the anticancer-associated renoprotective efficacy of diosmin (DI) delivered via chitosan nanoparticles (DI-CHNPs) in mice bearing Ehrlich ascites carcinoma (EAC). Sixty female Swiss albino mice were divided into six groups: controls, DI, DI-CHNPs, EAC, EAC+DI, and EAC+DI-CHNPs. Treatments involved DI or DI-CHNPs (100 mg/kg/day) for 20 days with or without tumor induction. DI-CHNPs significantly reduced tumor burden, as evidenced by lower body weight gain, abdominal circumference, tumor volume, and viable tumor cell count, and these effects were superior to free DI. DI-CHNPs also prolonged survival and improved renal function markers (urea, creatinine, electrolytes), indicating that attenuation of tumor progression was accompanied by reduced secondary renal injury. Antioxidant defenses in kidney tissues were strengthened through increased superoxide dismutase, catalase, glutathione peroxidase activities, and reduced glutathione levels, alongside reduced malondialdehyde. DI-CHNPs activated the Nrf2/HO-1/NQO1 pathway while down-regulated the inflammatory pathways controlling genes (Tgfb 1, Nfkb 1, Il6) and pro-apoptotic markers (Bax, Caspase-3), with increased Bcl-2 expression. Histopathological and ultrastructural analyses confirmed superior renal protection compared with DI. Molecular docking provided in silico supportive evidence for DI interaction with Nrf2, NF-κB, caspase-3, and TGF-β-related molecular targets involved in oxidative stress, inflammation, and apoptosis. Overall, the findings suggest that nanoparticle formulation enhanced the therapeutic performance of DI, likely through improved stability and sustained-release properties, resulting in superior antitumor efficacy and attenuation of tumor-associated renal injury.

PMID 42848291
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PubMedNatural product research2026-10-07

Phytochemical profiling and biological evaluation of Duranta serratifolia (Griseb.) Kuntze cultivated in Egypt: HPLC and lC-mS characterization, antimicrobial and anticancer activities, and in silico validation.

Mahmoud Asmaa A AA, Eid Mona M MM, Mahrous Fatma S FS, Afifi Tarek H TH et al.

The present study provides a phytochemical and biological evaluation of Duranta serratifolia (Griseb.) Kuntze cultivated in Egypt. Preliminary screening revealed the predominance of flavonoids and phenolic compounds, which was supported by high total phenolic (101.6 mg ± 2.1 GAE/g) and flavonoid (166.3 ± 1.1 mg QuE/g) contents. HPLC and LC-MS analyses identified diverse phenolic acids and flavonoid glycosides, with cinnamic acid, naringenin, kaempferol, quercetin derivatives, and diosmin as major constituents. The extract exhibited potent antimicrobial activity, particularly against Bacillus subtilis and Candida albicans, with low MIC values, alongside antioxidant capacity (DPPH IC50 = 12.77 ± 0.4 µg/mL). Cytotoxic effects were observed against MCF-7 and PC-3 cancer cell lines. TEM analysis confirmed microbial ultrastructural damage. Molecular docking demonstrated strong binding affinities of major flavonoids towards β-lactamase and DHFR, supporting the in vitro findings. These results highlight D. serratifolia (Griseb.) Kuntze as a source of bioactive natural products with therapeutic potential.

PMID 42839256
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