Drug Database
CA

calcium carbonate (Cimascal / Cimascal D Forte)

✓ Approved

CPEX Pharmaceuticals, Inc. · VDR

What is calcium carbonate?

calcium carbonate is a therapeutic agent developed by CPEX Pharmaceuticals, Inc.. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesCimascal, Cimascal D Forte
CompanyCPEX Pharmaceuticals, Inc.
Molecular TargetVDR
RouteOral (PO)
StatusApproved

Mechanism of Action

Molecular Targets

calcium carbonate acts on 1 molecular target:

VDRvitamin D receptor (NR1I1, PPP1R163)
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Therapeutic Indications

calcium carbonate is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Musculoskeletal and connective tissue disordersOsteoporosis✓ Approved

Related Research Articles

PubMedPreparative biochemistry & biotechnology2026-05-24

Egg shell powder: an inexpensive material for detoxification of sugarcane bagasse acid hydrolysate, cells immobilization agent and nutritional supplement for ethanol and xylitol production.

Zhan Larissa L, A F Antunes Felipe F, Yaverino-Gutierrez Mario Alberto MA, da Silva Silvio S SS et al.

Enhancing the sustainability of fermentation processes increasingly involves the reuse of bio-residues to replace synthetic reagents and reduce environmental impact, as well as the increase process yield and optimization reducing cost of process. This study investigates the integration of eggshell as a low-cost, renewable alternative in the production of second-generation (2G) ethanol and xylitol from sugarcane bagasse hydrolysates. Eggshell naturally comprises of about 97% calcium carbonate in its composition, besides being readily available due to the extensive consumption of eggs in various sectors. Applications of eggshell were evaluated across multiple process stages, including pretreatment, detoxification, cell immobilization, and nutritional supplementation. Eggshell proved effective in supporting fermentation, particularly due to its high calcium carbonate content and natural alkalinity, which contribute to pH regulation and nutrient supply. Using immobilized cells in flask-scale fermentations, ethanol and xylitol production yields (YP/S) of 0.21 and 0.20 g/g, and productivities (QP) of 0.09 and 0.31 g/L·h, respectively were achieved. Furthermore, eggshell proved to be successful to decrease concentrations of inhibitors molecules present in hemicellulosic hydrolysate derived from sugarcane bagasse in more than 90% of 5-HMF and furfural, besides of partial removal of other compounds such as syringaldehyde and ferulic acid. These results demonstrate the feasibility of using eggshell powder as a multifunctional additive, offering an environmentally friendly and cost-effective approach to improve the overall performance of 2 G ethanol and xylitol bioproduction.

PubMedScientific reports2026-05-24

Dense MASW shear-wave imaging of weak-zone networks and preferential leachate pathways beneath rumah landfill site, central saudi arabia.

Abdelrahman Kamal K, Alarifi Saad S SS

Landfills in arid regions may contribute to potential soil and groundwater concerns, as episodic rainfall, heterogeneous cover materials, and fractured carbonate bedrock may create preferential infiltration pathways. In central Saudi Arabia, landfill sites commonly overlie carbonate formations where weathering, fracturing, and dissolution can produce strong lateral variations in near-surface stiffness and hydraulic susceptibility. This study presents a dense MASW-based stiffness model to screen for shallow weak zones and fractured/weathered carbonate intervals beneath Rumah landfill site in central Saudi Arabia. We acquired 26 MASW profiles using a 24-channel split-spread array with 1 m receiver spacing and a 10 kg weight-drop source, and processed the data to image the near surface to an effective depth of approximately 30 m. The resulting 2D shear-wave velocity sections define three Vs-based geoseismic units: (1) a surficial cover/near-surface low-stiffness unit with Vs of approximately 0.35-0.76 km/s and thickness of about 2-8 m; (2) an intermediate fractured/weathered carbonate interval with Vs of approximately 0.76-1.50 km/s and typical thickness of about 5-15 m; and (3) a deeper competent carbonate/limestone domain with Vs > 1.50 km/s, locally approaching approximately 2.3 km/s. Localized low-Vs weak zones (< 0.76 km/s) are repeatedly detected, mainly within the upper 2-12 m and commonly 2-6 m thick. These anomalies are interpreted as zones of reduced shear stiffness that may reflect disturbed ground, elevated moisture, increased porosity, weathering, fracturing, or combinations of these factors. The results, therefore, provide a defensible MASW-based pathway-susceptibility screening framework and identify priority targets for confirmatory drilling, hydrochemical sampling, and fluid-sensitive geophysical methods such as ERT/IP. The findings should be interpreted as evidence of susceptibility and subsurface heterogeneity, not as direct proof of active leachate migration.

PubMedJournal of environmental management2026-05-24

Observed divergence in vegetation sensitivity to climate variability across bedrocks in Southwest China based on new long-term series data (1982-2022).

Jiao Fusheng F, Xu Xiaojuan X, Gong Haibo H, Yan Shaoqing S et al.

The vegetation sensitivity to climate variability is an important component of ecosystem response to environmental perturbation. Understanding the vegetation sensitivity and its trends is crucial for the ecosystem management. However, this aspect remains inadequately understood for the Southwest China region with highly eco-fragile karst ecosystems. By employing a latest remote-sensed vegetation index, we examined the vegetation sensitivity index (VSI) of three bedrocks and its temporal trends. The bedrocks were categorized as continuous carbonate region (CCR) (more than 65% carbonate rock) or discontinuous carbonate region (DCR) (15-65% carbonate rock). The results showed that vegetation sensitivity exhibited high spatial heterogeneity during the 1982-2022 growing season. In general, VSI was higher in the Yunnan-Guizhou Plateau and the Hengduan Mountains, indicating that these high-altitude areas are highly sensitive to climate. The DCR region has the largest mean VSI, indicating more sensitive to climate than other bedrocks. Vegetation sensitivity decreased significantly in more than 56% of the area covered by vegetation. The greatest reduction in VSI was observed in DCR areas. Temperature was the primary driver of vegetation sensitivity in CCR regions, while precipitation dominated vegetation in DCR regions. Climate controls on VSI were likewise time-varying. The effect of temperature in the CCR was increasing, while the effect of radiation in karst areas was decreasing. The turning points occurred in the period of 2005-2010, indicating that ecological engineering had a lag effects on vegetation sensitivity reduction. Our findings provide unique insights for practicing site-specific ecological restoration on different bedrock.

PubMedEnvironmental research2026-05-24

Biochar for Multi-Metal Stabilization in Smelting Soils: Long-Term Performance and Mechanisms under Freeze-Thaw and Dry-Wet Cycles.

Zhao Wenchu W, Wen Dongdong D, Xiong Jiaping J, Yu Zhi Z et al.

Despite extensive research, the long-term performance of biochar (BC) for stabilizing multiple heavy metals (HMs) under realistic environmental stresses remains unclear. This study investigated the effects of freeze-thaw and dry-wet cycles on the long-term stabilization behavior of HMs in smelting-contaminated soils amended with BCs under accelerated aging conditions. BC application increased the residual and carbonate fractions while reducing exchangeable fractions. However, freeze-thaw and dry-wet cycles induced contrasting effects on HM stability: Freeze-thaw cycling caused physical damage to BCs, resulting in a 3.4-fold increase in HM leaching and promoting the transformation of residual metals into exchangeable and carbonate fractions. In contrast, dry-wet cycling reduced HM mobility by driving metals from exchangeable to Fe/Mn oxide-bound fractions, indicating a shift toward a more stable chemical equilibrium. Multiscale characterization further revealed that the destabilization under freeze-thaw was primarily driven by structural breakdown of BC, whereas dry-wet cycles promoted the formation of phosphate and carbonate precipitates with HMs, thereby enhancing BC long-term stabilization capacity. These findings provide mechanistic insights into BC-mediated HMs stabilization under environmental stresses.

PubMedScientific reports2026-05-24

Linking soil physicochemical properties to leaf nutrient composition in olive orchards on semi-arid calcareous soils.

Cetinkaya Hakan H, Kılıç Ahmet A, Türker Serdar S, Gözel Hatice H

This study examines whether bulk soil nutrient pools reliably reflect leaf nutrient status in olive orchards under alkaline, calcareous conditions, where carbonate buffering is known to constrain nutrient availability. We evaluated soil-leaf nutrient relationships in 25 rainfed olive orchards ('Kilis Yaglik') in southeastern Türkiye over two consecutive years (2017-2018). Soils remained strongly alkaline and highly calcareous, while organic matter declined by approximately 35% between years. Leaf nutrient composition did not consistently track soil nutrient dynamics. While some soil nutrients exhibited interannual variation, corresponding leaf responses were element-specific and not uniformly aligned with soil changes. Correlation and principal component analyses revealed variable and year-dependent associations between soil and leaf nutrients, with no reproducible, strong soil-leaf relationships across years. These findings indicate that, under carbonate-buffered conditions, bulk soil nutrient pools are not reliable predictors of canopy nutrient status. Instead, leaf nutrient composition appears to reflect integrated and element-specific availability patterns rather than direct soil-plant coupling.

PubMedTissue engineering. Part A2026-05-24

Identifying Mechano-Modulators of Myometrial Contractility in a Scalable Hydrogel Culture Platform.

Claure Isabella C IC, Klapperich Catherine M CM, Wong Joyce Y JY

Maternal and fetal health during pregnancy is closely tied to contractile modulation of the uterine myometrium, as dysfunctional contractions underlie pregnancy complications such as preterm labor and postpartum hemorrhaging. Structural abnormalities increase the risk for pregnancy complications, yet the complex interplay between biochemical and biomechanical cues in the myometrial microenvironment is not well defined. Significant gaps in our understanding of myometrial physiology and the lack of physiologically relevant research tools to enable systematic investigation have resulted in a largely ineffective and nonspecific therapeutic landscape for myometrial contractile modulation during pregnancy. We address this unmet need by developing a widely accessible approach for in vitro hydrogel platform fabrication to advance the study of agonist-mediated calcium responses in myometrial cells. We directly fabricated polyacrylamide hydrogels in polypropylene multiwell plates and Petri dishes and validated their mechanical properties and use as a mechanically tunable cell culture substrate. Using "physiological" matrix conditions during pregnancy, a fluorescent calcium mobilization assay was implemented in a plate-reader-based workflow to determine the dose sensitivity of myometrial cells to the endogenous agonist oxytocin. Using hydrogels with elastic moduli spanning physiological, pathological, and supraphysiological conditions in the myometrium, we assessed stiffness-mediated effects in myometrial cell behavior, including agonist-mediated calcium responses. We observed the mechanosensitive modulation of calcium response curve amplitude in oxytocin-stimulated myometrial cells. Myometrial cell behavior on mechanically tunable substrates was compared against widely used tissue culture plastic, and the observed changes to myometrial cell morphology and calcium responses highlight the significant influence of supraphysiological substrates. To explore complex pathological microenvironments, myometrial cells were exposed to the proinflammatory trigger lipopolysaccharide (LPS) before agonist stimulation. In our studies, LPS exposure altered calcium responses during oxytocin stimulation in cells cultured on supraphysiological substrates. Altogether, we present an easily adoptable in vitro hydrogel platform with scalable fabrication and versatile application use, including new directions in myometrial mechanobiology.Impact StatementWe investigated mechanosensitive modulation of agonist-mediated calcium responses in myometrial cells during pregnancy using a high-throughput in vitro polyacrylamide hydrogel platform. Polypropylene labware enabled scalable fabrication of an in vitro hydrogel platform without being costly or labor-intensive. Our studies found that oxytocin-stimulated calcium responses in myometrial cells are sensitive to nonphysiological matrix conditions. This work highlights the importance of using physiologically relevant engineered microenvironments and represents new directions for understanding myometrial mechanobiology. Our platform can help accelerate the identification of agonists and antagonists to counteract dysfunctional myometrial contractions and can be used more broadly in other tissues that exhibit mechanosensitive pathologies.

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