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Factor VIIIa (LongAte)

✓ Approved

PolyTherics Limited · F8 · Recombinant Proteins

What is Factor VIIIa?

Factor VIIIa is a recombinant proteins developed by PolyTherics Limited. It is approved for therapeutic indications via injectable (others) or intravenous (iv) or subcutaneous injection.

Drug Profile

Brand NamesLongAte
CompanyPolyTherics Limited
Drug ClassRecombinant Proteins, Cell-based Therapies
Molecular TargetF8
RouteInjectable (Others), Intravenous (IV), Subcutaneous Injection
StatusApproved
Sources: ClinicalTrials.gov, PolyTherics Limited

Mechanism of Action

Molecular Targets

Factor VIIIa acts on 1 molecular target:

F8coagulation factor VIII (AHF, FVIII)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

Factor VIIIa is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Congenital, familial and genetic disordersFactor VIII deficiency✓ Approved

Related Research Articles

PubMedFrontiers in pharmacology2026-07-25

Fibroblast growth factor 2 (FGF2) modulates the excitability of brain noradrenergic and serotonergic neurons: possible involvement of FGFR1 and FGFR4 receptors.

Paliokha Ruslan R, Racicky Matej M, Grinchii Daniil D, Khoury Talah T et al.

Fibroblast growth factor 2 (FGF2), in addition to its primary function in the connective tissue, plays also a role in the central nervous system (CNS). Thus, anxiolytic, antidepressant, and pro-addictive properties of this molecule have been reported. Our previous study showed that pro-alcohol consumption effect of FGF2 is mediated, at least in part, via its interaction with the central dopaminergic system. The present study aimed to test the hypothesis that pro-addictive and/or antidepressant-like effects of FGF2 can also be linked with FGF2-noradrenaline and FGF2-serotonin (5-HT) interactions. Adult male Wistar rats, weighing 250-350 g, were treated with the recombinant FGF2, selective inhibitors of FGFR1 (PD173074), FGFR2 (lirafugratinib), FGFR4 (BLU9931), or corresponding vehicle. The excitability of the noradrenergic neurons of the locus coeruleus (LC) and serotonergic (5-HT) neurons of the dorsal raphe nucleus (DRN) was assessed using the single-unit in vivo electrophysiology under chloral hydrate anesthesia. We found that FGF2 stimulated the burst firing of noradrenergic neurons and inhibited the burst firing of 5-HT neurons. PD173074 decreased the density of the spontaneously active noradrenergic neurons in the locus coeruleus, whereas BLU9931 had a stimulatory effect on the burst activity of 5-HT neurons. The psychoactive effects of the FGF2 might be mediated, at least in part, via its interaction with the central monoaminergic circuits. The FGF2-catecholaminergic interactions are putatively mediated via FGFR1, and FGF2-5-HT-crosstalk-via FGFR4. These two receptors can be thus potential targets for the future CNS drugs.

PMID 42499486
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PubMedMarine environmental research2026-07-25

Week-long mesocosm spill tank experiments reveal distinct behaviour, fate, and ecological risks of bio-derived oils.

Xin Qin Q, Farooqi Hena H

The increasing marine transport of Hazardous and Noxious Substances (HNS), including bio-derived oils, raises concerns regarding their behaviour, fate, and ecological impacts following accidental releases. Bio-derived oils vary widely in composition depending on feedstocks and production processes, leading to uncertainty in associated spill behaviour and potential environmental risk. Improved weathering studies are therefore needed to support marine spill preparedness and response. Week-long mesocosm tank experiments were conducted to examine the fate and biological effects of three representative bio-derived oils (canola oil, biodiesel, and wood oil) in simulated nearshore marine waters. In each test, 1.0 L of oil was released into 1200 L of artificial seawater (15 °C) containing 1.2 kg of pre-mixed sediment and subjected to continuous high-energy wave mixing for seven days. Volatile organic carbon concentrations in the headspace above the spill were negligible for all oils. Water and sediment samples were collected at intervals for chemical analysis and ecotoxicity testing. Wood oil resulted in the highest dissolved and total organic carbon concentrations (up to 280 mg/L), caused sustained seawater acidification (pH decreased from 8.3 to 7.8-8.0), completely disappeared from the water surface, and accumulated extensively in sediments. Biodiesel and canola oil generated lower dissolved concentrations (less than 21 mg/L), with dispersed oil droplets persisting in the water column. The seawater pH remained stable at 8.3 throughout the week-long tests for both biodiesel and canola oil. Approximately 50% of the canola oil remained recoverable from the water surface after one week of wave action, whereas no recoverable biodiesel or wood oil residues were observed on the water surface. Ecotoxicological assays demonstrated sustained toxic effects in waters contaminated with biodiesel and wood oil. These results highlight the diverse weathering behaviours and ecological risks of bio-derived oils, emphasizing the need for oil-specific approaches to marine HNS spill risk assessment and response.

PMID 42497506
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PubMedInternational journal of phytoremediation2026-07-25

Phytoremediation ability of Hydrocotyle umbellata L. under different arsenic treatment levels by applying supervised statistical and machine analysis.

Saeed Sidra Hussan SH, Shah Ghulam Mujtaba GM, Gazder Uneb U, Mahmood Qaisar Q et al.

Arsenic pollution of water and soil is a global environmental and public health issue that requires sustainable remediation. Metal-tolerant plant species are used in phytoremediation to significantly remove metals from contaminated locations. This study tested Hydrocotyle umbellata L. against five Arsenic concentrations (500,750,1000,1250,1500 µg L-1 from T1 to T5 respectively,) in Hoagland solution for 10 days to assess its phytoextraction potential. This was done using triplicate randomized block design. Pearson Correlation analysis, ANOVA, Multivariate Regression, and CART models are used for statistical analyses. These statistical characteristics were used to examine H. umbellata's Arsenic uptake and its effects on factors like fresh and dry weight, translocation factor (TF), bio-concentration factor (BCF), chlorophyll content (Chl.), and electrolyte leakage. All treatments had BCF greater than 1 and a maximum BCF value was shown by T5 as 32.65. The strong metal uptake, greatest BCF reduced dry weight indicates physiological stress in H. umbellata, which can collect and translocate Arsenic from roots to stolon. Highest BCF and TF values accompanying As translocation to shoots indicate H. umbellata's phytoextraction capacity and adaptation to Arsenic stress.

PMID 42500851
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PubMednpj aging2026-07-25

FOSL2-driven SASP in endometrial stroma promotes the inflammation of endometriosis.

Shi Weiwei W, Tang Xinyi X, Yang Fei F, Yin Han H et al.

Endometriosis (EMs) is characterized by chronic pelvic inflammation, but the etiology of this inflammation remains poorly understood. The senescence-associated secretory phenotype (SASP), whereby senescent cells secrete pro-inflammatory cytokines, is a potential mechanism. This study investigates the pro-inflammatory SASP in EMs and its underlying influences. Through molecular assays and single-cell RNA-seq analysis, we found a subgroup of endometrial stromal cells (ESCs) marked by SASP in both eutopic endometrium and endometriotic lesions of EMs patients. The transcription factor FOSL2 was aberrantly overexpressed in this ESC subgroup; its overexpression induced cellular senescence and the secretion of SASP factors, while FOSL2 knockdown reversed these effects. Conditioned medium from ESCs with high FOSL2 expression promoted M2 macrophage polarization and recruitment. Mechanistically, FOSL2 overexpression in ESCs was regulated by the PGE2/cAMP/PKA signaling pathway, and FOSL2 modulated SASP through the activation of NF-κB signaling. In conclusion, the SASP in ESCs, regulated by FOSL2, contributes to chronic pelvic inflammation and immune system disruption in EMs patients. Targeting FOSL2 to reverse the SASP may offer a promising therapeutic strategy for EMs.

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PubMedMultiple sclerosis journal - experimental, translational and clinical2026-07-25

Insights from a Danish nationwide implementation of patient-reported outcomes in multiple sclerosis.

Holm Rolf Pringler RP, Pontieri Luigi L, Mahler Mie Reith MR, Joensen Hanna H et al.

Multiple sclerosis (MS) monitoring often relies on traditional methods like the expanded disability status scale (EDSS) and magnetic resonance imaging, which may not fully reflect patients' health. Patient-reported outcomes (PROs) provide valuable insights into patients' experiences of their disease. This study evaluated the Danish implementation of PROs for people with MS (PwMS) 3 years post-launch, comparing clinical and demographic characteristics between PRO users and non-users, and assessing PRO adherence. As of 1 January 2025, 2121 PwMS had signed up for PRO, compared to 14,125 who did not. PRO users were younger (mean age 50.6 vs. 53.2 years), more frequently female (73.6% vs. 68.0%), had a shorter disease duration (15.1 vs. 16.4 years), and were more likely to be on high-efficacy disease-modifying therapies (75.6% vs. 62.2%). Additionally, fewer PRO users had low EDSS scores (<3, 53.7% vs. 56.1%) and high scores (>6, 16.5% vs. 18.9%). Most enrolled patients lived in Region Hovedstaden (75.1%). The study highlights differences in profile between PRO users and non-users, demonstrating the PRO platform's adaptability across different ages and disability levels in PwMS. However, these findings also highlight potential implementation challenges and emphasize the need for sustained commitment to support long-term use of PRO.

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PubMedWorld journal of otorhinolaryngology - head and neck surgery2026-07-25

Thai Translation and Validation of Chronic Rhinosinusitis-Patient Reported Outcome (CRS-PRO).

Chitsuthipakorn Wirach W, Pooldum Vorachai V, Phetpong Juthaporn J, Lawpoolsri Saranath S et al.

The Chronic Rhinosinusitis Patient-Reported Outcome (CRS-PRO) questionnaire was recently developed for use in chronic rhinosinusitis (CRS) patients. This instrument was developed using current diagnostic criteria. This study aimed to translate and validate CRS-PRO for Thai CRS patients. The three-phase translation process and validation were conducted at Rajavithi Hospital, a tertiary hospital in Bangkok, Thailand. Adults (> 18 years) with primary CRS, diagnosed using EPOS2020 criteria, were recruited alongside non-CRS controls. Discriminant validity was assessed by comparing scores between CRS patients and non-CRS controls. Concurrent validity was evaluated by correlating CRS-PRO with the Thai version of the Sinonasal Outcome Test-22 (SNOT-22). Reliability was assessed using internal consistency (Cronbach's alpha) and test-retest reliability using intraclass correlation coefficient (ICC). A total of 85 CRS patients and 40 non-CRS controls were enrolled. The Thai CRS-PRO was completed in (101.80 ± 26.36) seconds. CRS patients had significantly higher scores than controls (16 [10-24] vs. 2 [0-5], p < 0.001) (median [IQR]). CRS-PRO demonstrated strong concurrent validity with SNOT-22 (ρ = 0.82, p < 0.001), high internal consistency (Cronbach's alpha = 0.89), and high test-retest reliability (ICC = 0.81, 95% confidence interval 0.72-0.88). The Thai-translated CRS-PRO has been developed and validated. It demonstrated significant discriminant validity between patients and non-patients, a very strong correlation with the Thai version of SNOT-22, and good reliability. Its brevity and time efficiency support its applicability in both clinical practice and research, enhancing its potential for widespread adoption.

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