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Factor VIIIa (LongAte)

✓ Approved

PolyTherics Limited · F8 · Recombinant Proteins

What is Factor VIIIa?

Factor VIIIa is a recombinant proteins developed by PolyTherics Limited. It is approved for therapeutic indications via injectable (others) or intravenous (iv) or subcutaneous injection.

Drug Profile

Brand NamesLongAte
CompanyPolyTherics Limited
Drug ClassRecombinant Proteins, Cell-based Therapies
Molecular TargetF8
RouteInjectable (Others), Intravenous (IV), Subcutaneous Injection
StatusApproved
Sources: ClinicalTrials.gov, PolyTherics Limited

Mechanism of Action

Molecular Targets

Factor VIIIa acts on 1 molecular target:

F8coagulation factor VIII (AHF, FVIII)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

Factor VIIIa is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Congenital, familial and genetic disordersFactor VIII deficiency✓ Approved

Related Research Articles

PubMedTheScientificWorldJournal2026-09-19

Evaluating Safety and Efficacy of Bio-Immune (Andrographolide) in Managing URTI Symptoms: A Randomized, Double-Blinded, Placebo-Controlled, Single-Center, Comparative Study.

Singh Shashi Chandrama SC, Choudhary Muskan M, Choudhary Khushi K, Singh Harsh Pal HP

Bio-Immune is a standardized extract containing andrographolide, a diterpenoid lactone derived from the aerial parts of Andrographis paniculata (commonly known as Kalmegh), and the carrier, 2-hydroxypropyl beta-cyclodextrin. Kalmegh has long been used to treat uncomplicated upper respiratory tract infection (URTI) in complementary and alternative medicine. A randomized, double-blind, placebo-controlled clinical trial was conducted to evaluate the efficacy of Bio-Immune (≥ 17% w/w andrographolide content). Participants were randomized to receive either 100 mg Bio-Immune twice daily or placebo for a 5-day intervention period (Clinical trial registration number: CTRI/2024/12/077632, Registered 4, December 2024). The primary outcome measure was the Wisconsin Upper Respiratory Symptom Survey-21 (WURSS-21) score; secondary outcomes included Visual Analogue Scale (VAS) and Numeric Rating Scale (NRS) scores, nasal mucus weight, C-reactive protein (CRP), Interleukin-8 (IL-8), and Immunoglobulin A (IgA) in nasal wash, along with safety. Of 67 screened participants, 56 were enrolled, and 55 completed the study. The WURSS-21, VAS, and NRS scores in the Bio-Immune group improved, with statistically significant reductions suggesting relief from symptoms associated with uncomplicated URTI and sustained functional improvement owing to Bio-Immune supplementation. Although the placebo group showed gradual improvement over time, the speed and magnitude of recovery were consistently and statistically superior in the Bio-Immune cohort, with significant changes evident by 6 h after supplementation. Furthermore, a significant reduction in nasal mucus weight was observed by Day 5, accompanied by minor downward trends in CRP and IL-8, which lacked adequate statistical support. No adverse events were reported during the intervention period. Clinical findings support the efficacy of Bio-Immune at a lower dose in providing URTI symptom relief compared with placebo in a shorter intervention period. Clinical Trial Registry of India: CTRI/2024/12/077632; ClinicalTrials.gov identifier: NCT06689995.

PMID 42760788
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PubMedFrontiers in medicine2026-09-19

Elevated ALT correlates with severe liver injury, monocyte infiltration, and Pro-inflammatory immune dysregulation in chronic hepatitis B virus infection.

Huang Jian J, Xu Ning N, Liang Xiuyan X, Cai Defeng D

Hepatitis B virus (HBV) infection remains a global health burden. Although alanine aminotransferase (ALT) is a well-established marker of liver injury, its relationship with immune infiltration, monocyte activation, and inflammatory immune skewing in chronic HBV infection remains incompletely understood. This study aimed to investigate the associations of ALT with liver injury, monocyte infiltration, and hepatic immune microenvironment dysregulation. A total of 192 HBV-infected patients and 37 healthy controls were enrolled. Serum ALT, AST, HBV seromarkers, HBV-DNA, alpha-fetoprotein (AFP), and serum fibrosis markers (COLIV, HA, PIIINP, LN) were measured. Univariate and multivariate regression analyses were used to adjust for confounders including age, sex, HBV-DNA, fibrosis markers, and HBeAg status. Transcriptomic data from the GSE84044 liver biopsy cohort (n = 105) were analyzed using the xCell algorithm to evaluate hepatic immune infiltration, macrophage polarization, and immune scores. Gene set enrichment analysis (GSEA) was performed to explore monocyte chemotaxis, activation, and WNT/β-catenin signaling pathway. Chronic hepatitis B (CHB) patients showed significantly elevated ALT and AST. Higher ALT levels were strongly associated with elevated fibrosis markers and AFP, indicating more severe liver injury. Peripheral monocytes count and intrahepatic monocyte infiltration were both significantly increased in high-ALT patients. However, after multivariate adjustment, ALT was no longer independently associated with monocyte infiltration, suggesting that the association was largely attributable to overall disease severity rather than a specific ALT-related association. GSEA showed that ALT was positively correlated with monocyte chemotaxis, activation, macrophage differentiation, and WNT/β-catenin signaling pathway. Immune landscape analysis revealed a pro-inflammatory immune profile in high-ALT patients, characterized by increased M1 macrophages, CD8+ T cells, and elevated immune scores, accompanied by decreased Tregs and Th1 cells. Elevated ALT in chronic HBV infection correlates with severe liver injury and a pro-inflammatory, dysregulated hepatic immune microenvironment characterized by enhanced monocyte infiltration and M1 macrophage polarization. Transcriptomic associations reveal a statistical link between WNT/β-catenin signaling activation and hepatic immune dysregulation in HBV-related liver injury; these correlative findings provide preliminary clues for developing immunomodulatory therapeutic strategies for CHB.

PMID 42761001
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PubMedNature communications2026-09-19

Whisker-based tactile flight for tiny drones.

Ye Chaoxiang C, de Croon Guido G, Hamaza Salua S

Tiny flying robots hold great potential for search-and-rescue, safety inspections, and environmental monitoring, but their small size and limited computational resources constrain onboard sensing capabilities. Inspired by animals such as rats and moles which rely on lightweight whiskers to navigate and perceive their surroundings through touch, we present a 3.2-gram whisker-based tactile sensing apparatus that enables tiny drones to perceive and interact with their environment through gentle physical contact, even in complete darkness. The apparatus employs barometers at the base of each whisker to estimate contact depth in flight, enabling obstacle localization while minimizing contact-induced destabilization. To compensate for sensor noise and drift during sustained contact, we develop a tactile depth estimation pipeline that achieves millimeter-scale depth estimation accuracy. Together, these innovations enable tiny drones to autonomously avoid obstacles, contour surfaces, and explore confined spaces, guided by onboard tactile sensing across both rigid and soft environments. Running entirely onboard a microcontroller with just 192 KB of memory, our system demonstrates autonomous tactile flight across various scenarios. This bio-inspired approach extends perception for mobile robots beyond vision, opening new possibilities for autonomous operations in visually degraded and GPS-denied environments.

PMID 42760291
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PubMedAssessment2026-09-19

Evidence of Strong Overlap Between Perceived Stress Scale and Neuroticism Item Structure in Two Samples.

Vrshek-Schallhorn Suzanne S, Cole Elli E, Corneau Gail G, Meneses Christopher C et al.

Life stress is central to models of psychopathology, and traditions have focused on either assessing stress exposure-what occurs in the environment-or stress responding-the person's multimodal reaction to the exposure, including stress perception. The Perceived Stress Scale (PSS) is the most widely used measure of stress perception in psychopathology and health research; although it was intended to measure appraisals of transient stressors, it is often used as a stand-in for stress exposure. However, the PSS may inadvertently measure a general neuroticism factor (i.e. a stable tendency to experience negative emotion) rather than capture environmental conditions or situational appraisals. Therefore, we investigated the structural relationships between perceived stress and neuroticism in two samples. In secondary analyses of samples randomly split into two equal halves, we conducted exploratory factor analyses of perceived stress and neuroticism, followed by confirmatory factor analyses. The results suggest a substantially common structure characterized by a shared overwhelmed factor plus smaller specific factors for low self-efficacy (entirely derived from perceived stress) and self-dislike (derived from neuroticism). The PSS was also correlated more with neuroticism than with stress exposure in a subsample. Researchers using the PSS should consider that the measure may largely capture trait neuroticism and poor self-efficacy.

PMID 42760815
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PubMedBMC psychology2026-09-19

Measuring body checking and avoidance in adolescents: validation of a behavioral questionnaire.

Beer Clara Sophie CS, Zillmer Stephan S, Drießnack Nelly N, Jaite Charlotte C et al.

Body image distortion (BID) is central to eating disorder (ED) pathology and is closely linked to body dissatisfaction. While most questionnaires assess affective, cognitive, or perceptual components of body image, the behavioral component manifesting in body checking (BC) and body avoidance (BA) has received comparatively little attention. Given that EDs typically emerge during adolescence, validated measures of behavioral BID are particularly needed for this age group. The Body Checking and Avoidance Questionnaire (BCAQ) is the only instrument assessing both BC and BA, but it has not yet been validated in adolescents. The present study aimed to evaluate the BCAQ in a clinical sample of female German adolescents with (atypical) anorexia nervosa. Factor structure, internal consistency, and convergent and known-groups validity were examined. An initial confirmatory factor analysis of the original 27-item BCAQ indicated poor model fit. An exploratory factor analysis identified four items with low or inconsistent loadings. Analyses of the resulting 23-item version yielded a preliminary three-factor structure and demonstrated good reliability (Cronbach's α = 0.78-0.94) and satisfactory convergent validity, while known-groups comparisons provided limited and exploratory evidence, with a small group difference observed only for avoidance behavior. These findings provide preliminary evidence for the use of the adapted 23-item BCAQ to assess behavioral aspects of body image distortion in adolescents with (atypical) anorexia nervosa. Further longitudinal research is needed to evaluate the measure's temporal stability.

PMID 42760571
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PubMedGut pathogens2026-09-19

Retraction Note: Prevalence and pathologic effects of colibactin and cytotoxic necrotizing factor‑1 (Cnf 1) in Escherichia coli: experimental and bioinformatics analyses.

Morgan Radwa N RN, Saleh Sarra E SE, Farrag Hala A HA, Aboulwafa Mohammad M MM

PMID 42760576
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