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Factor IX (AlphaNine SD / AlphaNine)

✓ Approved

Mitsubishi Tanabe Pharma Corporation · F9 · Cell-based Therapies

What is Factor IX?

Factor IX is a cell-based therapies developed by Mitsubishi Tanabe Pharma Corporation. It is approved for therapeutic indications via injectable (others) or intravenous (iv).

Drug Profile

Brand NamesAlphaNine SD, AlphaNine
CompanyMitsubishi Tanabe Pharma Corporation
Drug ClassCell-based Therapies
Molecular TargetF9
RouteInjectable (Others), Intravenous (IV)
StatusApproved
Sources: ClinicalTrials.gov, Mitsubishi Tanabe Pharma Corporation

Mechanism of Action

Molecular Targets

Factor IX acts on 1 molecular target:

F9coagulation factor IX (P19, F9 p22)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

Factor IX is developed for 3 unique indications across 2 therapeutic areas.

Therapeutic AreaConditionPhase
Vascular disordersExtravasation blood✓ Approved
Congenital, familial and genetic disordersFactor IX deficiency✓ Approved
Vascular disordersHaemorrhage✓ Approved

Related Research Articles

PubMedMethods in cell biology2026-05-24

MINFLUX nanoscopy to study the NK cell immune synapse.

Ross Nora N, Leaman Daniel P DP, Matthias Jessica J, Zwick Michael B MB et al.

Antibody dependent cellular cytotoxicity (ADCC) is an effector function performed by natural killer (NK) cells to target and clear viral infections and cancer. ADCC is a critical feature of several antibody and cellular therapeutics as well as vaccination strategies. Using microscopy to understand the details of molecular events driving ADCC is essential to improving such therapeutics but has been limited by technologies that cannot practically provide the spatial resolution necessary to study protein function at the single molecule level in cells. In this chapter, we describe a model system using MINFLUX nanoscopy to study the molecular distribution of human FcγRIIIa (CD16a), the IgG receptor, in the NK cell immunological synapse during ADCC. The technique described here will enable further exploration of how CD16a drives NK cell ADCC and can also be applied to the study of other important protein receptors for which nanometer localization precision is needed.

PMID 42177047
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PubMedBMC psychology2026-05-24

Validation and psychometric properties of the Turkish version of the brief sense of community scale.

Dogan Ali Huseyin AH, Elbi Huseyin H, Ozcan Fatih F, Aydemir Omer O

This study aims to adapt the Brief Sense of Community Scale into Turkish and to evaluate its psychometric properties among an adult cohort. This study involved 313 volunteers aged 18 years or older. The scale's linguistic and cultural adaptation was performed through forward and backward translation, an expert panel review, and a pilot test. Construct validity was assessed using confirmatory factor analysis; internal consistency was evaluated with Cronbach's alpha, McDonald's omega, item-total correlations, and the changes in reliability coefficients after item removal. For criterion and convergent validity, correlations were calculated with the psychological well-being, perceived social support, and quality-of-life scales. The Cronbach's alpha coefficient for the Turkish version of the Brief Sense of Community Scale was 0.882, and the McDonald's omega coefficient was 0.885. Item-total correlations ranged from 0.461 to 0.786, and removing any item did not significantly improve internal consistency. Confirmatory factor analysis showed that the four-dimensional structure of the scale (Needs Fulfillment, Group Membership, Influence, and Emotional Connection) fit the data well (CFI = 0.985; TLI = 0.970; RMSEA = 0.069; SRMR = 0.026). Additionally, the Composite Reliability (CR) was 0.936, and the Average Variance Extracted (AVE) was 0.648. The total BSCS score showed moderate positive correlations with psychological well-being (r = 0.420; p < 0.001) and quality of life (r = 0.419; p < 0.001), and a weaker positive correlation with perceived social support (r = 0.238; p < 0.001). In a further comparison by recruitment source, the BSCS total and sub-dimension scores did not differ significantly between participants from psychiatry outpatient clinics and family medicine clinics. These findings demonstrate that the Brief Sense of Community Scale is a valid and reliable measure of sense of community among Turkish adults. The scale's concise, practical structure supports its use in community-based research and in mental health practices.

PMID 42177564
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PubMedEuropean journal of pharmacology2026-05-24

Sulfonated peptide alleviates hypertensive renal injury via antioxidant, anti-inflammatory, and renal metabolomics.

Li Yuexiu Y, Song Siyi S, Lin Qianxia Q, Jin Huoxi H

Excessive dietary salt intake is a well-established risk factor for hypertension, with numerous underscoring its significant role in the pathogenesis of cardiovascular diseases. Dietary management is widely recognized as essential for both the prevention and treatment of hypertension. This study aimed to evaluate the preventive efficacy of a sulfonated peptide, Leucyl-glycyl-asparaginyl-glycyl-cysteinylsulfonic acid-proline (Leu-Gly-Asn-Gly-Cya-Pro, SLP), against high-salt-induced hypertension and renal injury, thereby providing new insights into hypertension prevention strategies. Compared with the unsulfonated peptide, Leucyl-glycyl- asparaginyl-glycyl-cysteinyl-proline (Leu-Gly-Asn-Gly-Cys-Pro, LP), SLP was more effective in attenuating the elevation of blood pressure, inhibiting renal fibrosis, improving markers of renal injury (alpha-1-microglobulin and uric acid), and reducing levels of inflammatory factors and adhesion molecules (intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and interleukin-1β). Additionally, SLP upregulated endothelial nitric oxide synthase while downregulating inducible nitric oxide synthase in the kidney. Similarly, high levels of nuclear factor-kappa B and phosphorylated nuclear factor-kappa B induced by high-salt in the kidney were effectively prevented by SLP treatment. Furthermore, SLP exerted antihypertensive effects through the regulation of tryptophan, purine, glycerophospholipid, and cysteine metabolism, as well as the citrate cycle. Overall, sulfonation modification enhances the anti-inflammatory and metabolic regulatory activities of peptides, with the sulfonated peptides SLP significantly preventing high-salt-induced hypertension and its associated renal complications.

PMID 42176725
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PubMedJournal of molecular graphics & modelling2026-05-24

Supramolecular host-guest interactions of TRYVIO and VAFSEO with a benzotriazole nanocapsule: A density functional theory study.

Farzand Tayyaba T, Naz Mubeen M, Latif Sidra S, Yar Muhammad M et al.

The potential of a benzotriazole-based supramolecular nanocapsule (Cap-GB) as a drug delivery carrier for chronic kidney disease (CKD) therapeutics was investigated using density functional theory (DFT). The geometry optimization and interaction energies were performed at ꞷB97XD/6-31G (d, p) to determine the stability and binding capabilities of the ACT-132577@Cap-GB and AKB-6548@Cap-GB host-guest complexes. The computed interaction energies for both the complexes indicated that the TRYVIO exhibits a stronger binding (-43.20 kcal/mol) compared to the VAFSEO (-35.15 kcal/mol). NCI analysis showed that hydrogen bonding and van der Waals interactions predominantly played a pivotal role in the stability of the complexes. The non-covalent nature of these interactions was also confirmed by the QTAIM analysis, which identifies bond critical points with positive Laplacian values, which rectify the NCI analysis. Frontier molecular orbital analysis showed that the HOMO-LUMO energy gap decreased slightly with drug encapsulation, particularly in the case of AKB-6548@Cap-GB (8.12 eV), which indicates the improved conductivity of the nanocapsule. Charge transfer analyses showed the redistribution of charges between the drugs and the surface of the capsule. The higher value of dipole moments of the complexes indicated their high polarity and improved solubility in the polar solvents. Overall, the findings establish the benzotriazole supramolecular nanocapsule as an effective therapeutic carrier of CKD therapeutics.

PMID 42176414
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PubMedAdvances in therapy2026-05-24

Psychometric Validation of the Weight and Emotions Scale (WES) in Adults with Obesity or Overweight.

Kanu Chisom C, Karn Hayley H, Clucas Claudine C, Goetz Iris I et al.

Individuals with obesity or overweight experience a substantial socioemotional burden and lower quality of life. Existing patient-reported outcome (PRO) instruments do not adequately measure emotional functioning concepts important to individuals with obesity/overweight. This study describes the psychometric properties of the Weight and Emotions Scale (WES), a new PRO measure to evaluate emotional functioning in adults with obesity or overweight. 120 adults completed two web-based surveys (baseline, week 2). Survey 1 comprised the 16-item WES, Control of Eating Questionnaire, Impact of Weight on Quality of Life-Lite Clinical Trials Version, Impact of Weight on Self-Perceptions Questionnaire, and Patient Global Impression of Severity (PGIS) 'Overall Emotional Impact of Weight.' Survey 2 included the WES and PGIS 'Overall Emotional Impact of Weight.' Factor structure, reliability, and validity of the WES were assessed. Exploratory factor analysis of the WES supported a two-factor structure as items loaded strongly (≥ 0.59) on factors corresponding to positive and negative feelings. The unidimensional framework was revised to include two WES domains ('Positive Feelings' [8 items] and 'Negative Feelings' [8 items]). The WES domain and total scores demonstrated excellent internal consistency (Cronbach's alpha ≥ 0.90) and good test-retest reliability (intraclass correlation coefficient: 0.87-0.89). Convergent validity of the WES was demonstrated via large correlations with the Impact of Weight on Quality of Life-Lite Clinical Trials Version 'Psychosocial' score and items, Impact of Weight on Self-Perceptions Questionnaire total score, and PGIS 'Overall Emotional Impact of Weight.' Known-groups validity was demonstrated via higher WES domain and total scores in participants who reported feeling good about their weight (PGIS 'Overall Emotional Impact of Weight'). The final version of the WES with 16 items is a reliable and valid PRO measure for assessing emotional functioning in individuals with obesity or overweight, with potential utility in observational studies, clinical trials, and clinical practice.

PMID 42176180
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PubMedMethods in enzymology2026-05-24

SMART deep learning tools to accelerate the characterization of natural product structures from their NMR data.

Ryu Byeol B, Kim Myeong Ji MJ, Xu Wangdong W, Zhang Chen C et al.

Diverse terrestrial and marine organisms produce biologically active natural products, many of which have inspired some of humanity's most effective medicines. A critical step in developing natural product-based therapeutics is the complete elucidation of molecular structure, a process that integrates multiple spectroscopic techniques, with nuclear magnetic resonance (NMR) spectroscopy playing a central role. However, interpreting NMR data requires significant expertise and access to costly instrumentation, posing challenges to efficient structural characterization. To address this, we have developed two complementary artificial intelligence tools, SMART 2.1 and DeepSAT, which assist in identifying structurally related molecules based on a compound's 1H-13C HSQC NMR spectrum. This paper presents step by step instructions for using these tools to accelerate the structure elucidation of novel natural products.

PMID 42177060
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