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lamivudine + raltegravir (MK 0518B / Dutrebis / MK0518B)

✓ Approved

Merck & Co. · · Small Molecule

What is lamivudine + raltegravir?

lamivudine + raltegravir is a small molecule developed by Merck & Co.. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesMK 0518B, Dutrebis, MK0518B
CompanyMerck & Co.
Drug ClassSmall Molecule
RouteOral (PO)
StatusApproved

Mechanism of Action

Molecular Targets

lamivudine + raltegravir acts on 1 molecular target:

gag-pol, HIV-1 (gag-pol)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

lamivudine + raltegravir is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Infections and infestationsAcquired immunodeficiency syndrome✓ Approved

Related Research Articles

PubMedScientific reports2026-05-24

Numerical simulation of CO generation and migration patterns in goaf based on coupled multi-physics fields.

Ren Mengxuan M, Liu Yongli Y, Duan Bingkun B, Li Xinxu X et al.

To explore early prediction methods for goaf spontaneous combustion, a numerical simulation was conducted to investigate the generation and migration laws of indicator gases in the goaf. A multi-physics coupling model integrating flow field, temperature field and concentration field was adopted to systematically analyze the spatio-temporal evolution of the temperature field and indicator gases. Programmed heating experiments revealed that CO exhibits a good correlation with temperature at low stages. Accordingly, CO was determined as the indicator gas in the numerical simulation, and the oxygen consumption rate, CO generation rate and heat release intensity were obtained. The multi-physics coupling results demonstrate that thermal buoyancy is the dominant driving force controlling the vertical migration and spatial distribution of CO in the goaf. Under the combined effect of air leakage and thermal buoyancy, CO accumulates in the upper, deep and return side regions of the goaf, which should be prioritized for monitoring. The findings provide important theoretical and engineering support for the prevention and control of goaf spontaneous combustion.

PubMedAngewandte Chemie (International ed. in English)2026-05-24

Correspondence on "Fortification of FeS Clusters Reshapes Anaerobic CO Dehydrogenase Into an Air-Viable Enzyme Through Multilayered Sealing of O2 Tunnels".

Opdam Laura V LV, Gebhardt Peter P, Léger Christophe C, Dobbek Holger H et al.

In their recent communication in Angewandte Chemie (10.1002/anie.202508565), Suk Min Kim and coworkers have described the effect of modifying the gas channels of the CO dehydrogenase II from Carboxydothermus hydrogenoformans, an enzyme that oxidizes reversibly CO into CO2. Their goal was to use mutagenesis to slow down the arrival of O2 at the active site. They reported a large increase in the resistance against oxygen, one of the major barriers to the application of this extremely fast and efficient enzyme in biotechnological devices, with an increase in the IC50 of more than two orders of magnitudes for some variants, with only a minor impact on the affinity of the enzyme for CO. We have produced the same variants, and characterized them in depth using Protein Film Electrochemistry. We used an approach that has proven very useful to learn and understand about the reactivity of CO dehydrogenases (and other redox enzymes like hydrogenases) with O2. We found that, contrary to the claims by Kim and coworkers, the A559W and the A559W/V610H mutants are not more resistant than the wild type against oxygen.

PubMedInternational journal of food microbiology2026-05-24

Comprehensive investigations reveal high occurrence of tet(X) in blaNDM-positive Acinetobacter spp. from Chinese cattle production systems.

Wang Weiwei W, Wang Qing Q, Qiu Yanhua Y, Dai Guonian G et al.

Livestock are recognized as critical reservoirs for carbapenem-resistant bacteria (CRB), yet systematic investigations into cattle production systems remain limited. Here, we sampled cattle, humans, flies, sludge, and beef from 14 cattle farms and 3 associated slaughterhouses. Results revealed a low prevalence (3.44%) of blaNDM-positive strains (n = 27) at the farm level across seven provinces in China in 2023, with 66.67% (18/27) of strains collected from two adjacent provinces, Henan and Shandong, in central and eastern China. All blaNDM-positive strains were isolated from cattle farms, in which 88.89% (24/27) were identified as Acinetobacter, including A. indicus, A. pseudolwoffii, and A. gandensis. Notably, 62.5% (15/24) of the Acinetobacter co-carried blaNDM-tet(X), among which 93.33% (14/15) co-harbored these genes on plasmids. Conjugation assay revealed that the blaNDM-tet(X) carried by A. indicus could be co-transferred to recipients (E. coli or Salmonella) across bacterial genera via the plasmid typed to rep_481. Phylogenetic analyses revealed that high genetic similarity (PFGE band similarity ≥85% and SNPs ≤10) is present among the strains isolated from the same farm, suggesting farm-level spread of blaNDM-positive strains. Genome analyses identified an atypical genetic context for the blaNDM-tet(X): ISAba125-blaNDM-bleMBL-trpF-TAT-IS1008-tet(X)-res-ISVsa3-XerD-IS1008. Compared with other livestock production systems, blaNDM in cattle has a lower prevalence and is typically carried by Acinetobacter rather than Enterobacteriaceae. Co-existence and co-transfer of blaNDM-tet(X) could accelerate the spread of carbapenem and tigecycline resistance among food-producing animals, posing a potential public health risk. Thus, further investigation and ongoing monitoring are required.

PubMedEnvironmental science & technology2026-05-24

Identification and Spatial Analysis of Co-Occurring Pollution Sources of HCHs, PCBs, and PFASs in the EU and Potential Risks of Soil Pollution.

Hina Naila N, Glüge Juliane J, Scheringer Martin M

Soil contamination represents a major environmental concern for maintaining soil health. Among various contaminants, persistent organic pollutants (POPs) are particularly problematic due to their persistence, bioaccumulation potential, and toxicity. Anthropogenic activities significantly contribute to soil contamination with various chemicals. This study provides an overview of activities contributing to the contamination of soil by hexachlorocyclohexane isomers (HCHs), polychlorinated biphenyls (PCBs), and per- and polyfluoroalkyl substances (PFASs). EU-wide databases were used to map spatial patterns, co-occurrence of multiple pollution-causing activities at a high resolution of 1 km2, and potential cocontaminated areas. There are approximately 385 locations where sources of PCBs, HCHs, and PFASs co-occur within 1 km2, with 10% of these locations identified as potentially cocontaminated with more than one pollutant. The identified activities can serve as a starting point for EU Member States that are still in the process of creating, or planning to create, an inventory of historical and current pollution-related activities associated with soil contamination. Furthermore, the results serve as proof of concept to demonstrate the spatial co-occurrence of pollution-causing activities posing risks of cocontamination. The evidence provided by these data sets supports soil monitoring, targeted decision making, and environmental management practices.

PubMedJournal of hazardous materials2026-05-24

Corrigendum to "Co-occurrence of microplastics and endocrine-disrupting chemicals in subantarctic seabirds" [J. Hazd. Mater. 509 (2026) 142018].

Fragão Joana J, Manno Clara C, Phillips Richard A RA, Cunha Sara C SC et al.

PubMedInfectious diseases and therapy2026-05-24

HBV Serological Profiles and Vaccination Status in People with HIV in the Transition to a Tenofovir-Sparing Era: Insights from a Large HIV Cohort.

Foncillas Alberto A, De La Mora Lorena L, Berrocal Leire L, de Lazzari Elisa E et al.

The increasing adoption of tenofovir (TXF)-sparing antiretroviral therapy (ART) raises concerns regarding hepatitis B virus (HBV) susceptibility and reactivation risk among people with HIV (PWH). We characterized HBV serological profiles and vaccination status according to ART composition in a real-world cohort. A cross-sectional study of all PWH in active follow-up at Hospital Clínic, Barcelona, as of 30 June 2025. ART regimens were categorized as TXF-containing or TXF-sparing, with or without lamivudine (3TC). HBV serological patterns were classified as chronic infection, serologically resolved infection, isolated HBV core antibody (anti-HBc), no exposure/immunity, and vaccine-induced immunity. Demographic and clinical characteristics were compared using nonparametric and chi-squared/Fisher's tests. Among the 6437 participants included (82% cisgender men; median age 48 years [IQR 39-58]), 3519 (55%) received TXF-containing and 2918 (45%) TXF-sparing regimens, of whom 1702/2918 (58%) were with 3TC. HBV serological distribution was: 2% chronic infection, 26% serologically resolved infection, 5% isolated anti-HBc, 52% vaccine-induced immunity, and 15% without exposure/immunity (50% documented prior vaccination attempts, 32% nonresponders, and 31% with prior anti-HBs detection). Overall, 1280 (20%) lacked protective HBV immunity (isolated anti-HBc or negative serology for all markers), including 530 (41%) on TXF-free regimens. TXF recipients were younger (47 versus 50 years, p < 0.001), more often migrants (58% versus 49%, p < 0.001), had lower suppression rates (91% versus 97%, p < 0.001), a higher proportion of previous virological failure(s) (26% versus 21%, p < 0.001), and a lower number of prior ART regimens (median 3 versus 4, p < 0.001). One in five PWH lacked effective HBV immunity, including 41% of whom were receiving TXF-sparing strategies. In the context of increasing use of TXF-sparing strategies, improvements in systematic HBV screening, vaccination, and risk-based monitoring are essential to prevent HBV-related morbidity.

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