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meningococcal A vaccine

✓ Approved

Zhejiang Tianyuan · Vaccine · Vaccine

What is meningococcal A vaccine?

meningococcal A vaccine is a vaccine developed by Zhejiang Tianyuan. It is approved for therapeutic indications via injectable (others).

Drug Profile

CompanyZhejiang Tianyuan
Drug ClassVaccine
RouteInjectable (Others)
StatusApproved
Sources: ClinicalTrials.gov, Zhejiang Tianyuan

Therapeutic Indications

meningococcal A vaccine is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Infections and infestationsMeningococcal bacteraemia✓ Approved

Related Research Articles

PubMedAAPS PharmSciTech2026-09-19

Comprehensive Stability Assessment of Squalene in a Nanoemulsion Adjuvant and the SpiN-Tec Vaccine: HPLC Quantification, Stress Testing, and Stability Studies.

Gomes Isabela Pereira IP, Rivelli Graziella Gomes GG, Bagno Flávia Fonseca FF, Hojo-Souza Natália Satchiko NS et al.

Squalene-based nanoemulsions are widely used as adjuvants in vaccine formulations, but their stability can be affected by environmental factors such as pH, oxidative stress, temperature, and light. We have produced a squalene nanoemulsion (CTVad1) to support the clinical development of new vaccines. This study aimed to develop and validate an HPLC method for squalene quantification in SpiN-Tec, a recombinant protein vaccine against COVID-19. We also aimed to evaluate the stability of the CTVad1 adjuvant and SpiN-Tec under controlled storage conditions. A reversed-phase HPLC method was developed and validated, and comprehensive forced degradation studies were performed on the raw material and SpiN-Tec under acidic, basic, oxidative, thermal, and photolytic conditions to demonstrate the stability-indicating capability of the method. Physicochemical, morphological, and biological characteristics were assessed, and stability studies of both the vaccine and the CTVad1 adjuvant were performed under accelerated and long-term conditions. The HPLC method was selective, precise, accurate, linear, and robust. Squalene raw material degraded under all tested conditions, whereas formulation in nano-sized globules improved its stability, with degradation observed only under hydrogen peroxide and light exposure. CTVad1 remained stable over time, exhibiting only minor, non-critical changes within the specification limits in both accelerated and long-term stability studies, regardless of the glass packaging used (clear or amber). In addition, the SpiN-Tec vaccine maintained its physicochemical and biological integrity under all tested conditions, with all evaluated parameters remaining within the established specification ranges. Our findings demonstrate that proper formulation, packaging, and storage conditions can preserve squalene stability in nanoemulsion-based vaccines, ensuring the quality, safety, and efficacy of the SpiN-Tec vaccine and its adjuvant throughout shelf life.

PMID 42760453
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PubMedOcular immunology and inflammation2026-09-19

Bilateral Maculopathy in an Infant Following Measles, Mumps, Rubella, and Varicella-Zoster (MMRV) Vaccination.

Ben-Avi Ravid R, Amer Radgonde R

To report on the long-term clinical outcome of a healthy infant who presented with posterior uveitis following the administration of the combined measles, mumps, rubella, and varicella (MMRV) vaccine. Descriptive case report. A 13-month-old infant presented with bilateral visual loss two weeks after receiving the MMRV vaccine. Ophthalmic examination revealed bilateral retinitis and retinal vasculitis with exudative retinal detachment. Extensive infectious work-up was conducted including serologic exams and PCR testing of blood, aqueous humor, cerebrospinal fluid and urine. Serological tests for measles yielded positive IgM and IgG titers. PCR testing for measles in the aqueous humor and urine was negative. Neurologic assessment and neuroimaging were unremarkable, excluding central nervous system involvement. Empiric systemic antiviral and corticosteroid therapy was initiated. Gradual resolution of posterior uveitis ensued, culminating in bilateral macular scars. Over a six-year follow-up period, the patient demonstrated stable ocular findings with no evidence of recurrent inflammation or systemic autoimmune disease. Final visual acuity was 6/9 in each eye. This case represents a rare occurrence of non-necrotizing retinitis following MMRV vaccination. To our knowledge, this is the first report describing the sequential OCT characteristics of presumed measles vaccine-associated retinitis. The prolonged follow-up period supports the absence of an alternative etiology and provides valuable insight into the long-term course and visual prognosis of vaccine-associated retinopathy.

PMID 42760840
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PubMedMedScience2026-09-19

Neoantigen cancer vaccines for gastrointestinal tumors: opportunities and challenges.

Zhao Zixuan Z, Du Xinyu X, Gao Xiaoliang X, Zhao Sheng S et al.

Gastrointestinal tumors are characterized by high global incidence and mortality rates. Although immune checkpoint inhibitors (ICIs) have achieved breakthroughs in some of these cancers, their overall response rate remains low. Neoantigen cancer vaccines have emerged as a promising new strategy for immunotherapy in gastrointestinal tumors due to their high specificity and strong immunogenicity. These vaccines effectively activate specific T-cell immunity and can produce synergistic effects when combined with ICIs. Various vaccine platforms offer distinct advantages, and clinical trials have shown encouraging potential in inducing immune responses and extending progression-free survival. Meanwhile, current challenges and future directions cannot be ignored. Key challenges primarily involve the accuracy of neoantigen prediction, tumor heterogeneity, and optimal treatment timing. Future directions include artificial intelligence (AI)-assisted multi-omics screening, the development of universal vaccines, optimization of novel delivery systems, and multimodal combination strategies. These advances are expected to promote the application of neoantigen cancer vaccines in postoperative recurrence prevention and early-stage treatment, ultimately moving toward personalized precision immunotherapy. This article systematically reviews the clinical progress and prospects of neoantigen cancer vaccines in treating gastrointestinal tumors, aiming to provide insights for immunotherapy in this field and offer new perspectives for further optimization of such vaccines.

PMID 42760419
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PubMedVeterinary surgery : VS2026-09-19

Complete surgical excision of a type V-variant dermoid sinus (V/VI overlap) associated with spina bifida in a Shiba Inu dog: A case report.

Jeong Ji-Eun JE, Kim Sun-Young SY, Kim Jong-In JI

To describe the clinical, imaging, surgical, and histopathologic features of a type V/VI overlap dermoid sinus (DS), and highlight diagnostic and therapeutic considerations. Case report. A 16-month-old spayed female Shiba Inu dog. The Shiba Inu initially presented at 4 months of age with a dorsal thoracic hair tuft. Radiography and ultrasonography suggested a DS; contrast-enhanced computed tomography (CT) and magnetic resonance imaging (MRI) were declined. The dog presented 12 months later for malodor, erythema, pruritus, focal pain on palpation, intermittent discomfort, and decreased appetite, although neurologic status remained normal. CT and MRI revealed spina bifida at T12 and a sinus tract extending from the skin to the dorsal dura mater, with mild dorsal displacement of the dura. Surgical excision via dorsal laminectomy and partial durectomy allowed en bloc removal of the tract and fibrous dural attachment. Histopathology confirmed a keratin-filled dermoid cyst lined by adnexal epithelium with pyogranulomatous inflammation and a fibrous dural connection, consistent with a type V/VI overlap DS. Recovery was uneventful, with no recurrence or neurologic deficits at the 12-month follow-up. Dural attachment may lead to clinical discomfort, even if neurological deficits are not present. Intraoperative assessment, histopathology, and advanced diagnostic imaging modalities such as CT and MRI are essential for surgical planning and accurate classification. This is the first report of a Shiba Inu with a type V/VI overlap DS and thoracic spina bifida. Early surgical intervention based on an integrated approach can lead to a good long term patient outcome.

PMID 42760277
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PubMedSurgical case reports2026-09-19

Thoracoscopic Right S4 Segmentectomy for Pulmonary Arteriovenous Fistula Involving an Aberrant Bronchus: A Case Report.

Kato Hirohisa H, Abiko Masami M

Although pulmonary arteriovenous fistulas (PAVFs) have often been treated with embolization, surgical approaches including segmentectomy might also play a curative role. Furthermore, a near-infrared fluorescent (NIF) imaging has been widely used as an assisting tool during surgery and has been useful for identifying the intersegmental plane during pulmonary segmentectomy. We describe a thoracoscopic right S4 segmentectomy for a PAVF case involving a rare aberrant bronchus in the middle lobe bronchus using NIF imaging to identify the intersegmental plane and target the segmental bronchus. A 66-year-old woman presented with a PAVF consisting of dilated feeding and draining vessels (A4 and V4) in the right S4, the percutaneous oxygen saturation was 94%, and thoracoscopic right S4 segmentectomy was planned. Preoperatively, a bronchial CT simulation revealed a middle lobe bronchus involving a rare aberrant bronchus (B7a), and the target segmental bronchus (B4) was bronchoscopically marked with indocyanine green (ICG). Intraoperatively, the B4 was identified with NIF imaging and divided following division of the dilated vessels. The PAVF was completely removed with the dilated vessels, while the aberrant bronchus was preserved. Segmentectomy can contribute to a curative resection of PAVF, bronchial CT simulation helps to recognize the variant bronchus, and NIF imaging can identify not only the intersegmental plane but also the target segmental bronchus for division in PAVF cases with aberrant bronchus requiring thoracoscopic segmentectomy.

PMID 42760960
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PubMedOral and maxillofacial surgery2026-09-19

Transoral robotic reconstruction of a posterior palatal defect using an upper arm flap following polymorphous adenocarcinoma resection: a novel minimally invasive approach.

Wieker Henning H, Wagner Juliane J, Wiltfang Jörg J, Gülses Aydin A et al.

Surgical management of malignant tumors in the orofacial region frequently necessitates extensive resection, resulting in significant functional and aesthetic morbidity. In younger patients, these sequelae carry a substantial psychosocial burden, emphasizing the need for minimally invasive reconstructive strategies that preserve quality of life while maintaining oncological safety. A 36-year-old female patient presented with a small 1 × 1 cm swelling at the junction of the hard and soft palate on the left side. Incisional biopsy confirmed a malignant minor salivary gland tumor but did not permit definitive subtyping. The final diagnosis of a polymorphous adenocarcinoma (PAC), conventional subtype, was established only on the complete resection specimen. Following oncologically adequate resection, including partial hard palate and tuberosity removal, a 3 × 4 cm defect was reconstructed with a free upper arm flap. Supermicrovascular anastomoses to the superior labial and facial arteries (vessel diameter ~ 0.2 mm) were performed via a transoral approach using the Symani® robotic surgical system with 20× motion scaling. Venous anastomoses to the facial vein were completed end-to-end and end-to-side via the same intraoral access. Selective lymph node sampling of the four radiologically prominent ipsilateral level II lymph nodes through a minimal cervical incision showed no metastases, both on frozen section and on final histopathology (0/4). Final histopathology demonstrated a 15 mm low-grade PAC resected in sano, without lymphovascular invasion, without unequivocal perineural infiltration and without bone invasion, classified as pT1 pN0 (0/4) cM0, R0. Postoperative course was uneventful; functional rehabilitation including speech and swallowing therapy is ongoing. Robotic-assisted supermicrosurgery using the Symani® system enabled safe transoral free flap reconstruction of a posterior palatal defect with anastomoses at the sub 0.2 mm scale. This approach minimizes donor-site morbidity and demonstrates the feasibility of intraoral robotic supermicrosurgery as a novel reconstructive modality in head and neck oncology.

PMID 42760403
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