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terbinafine hydrochloride (MOB015B / MOB 015 / MOB015)

✓ Approved

DongKoo Bio & Pharma · SQLE · Small Molecule

What is terbinafine hydrochloride?

terbinafine hydrochloride is a small molecule developed by DongKoo Bio & Pharma. It is approved for therapeutic indications via topical.

Drug Profile

Brand NamesMOB015B, MOB 015, MOB015
CompanyDongKoo Bio & Pharma
Drug ClassSmall Molecule
Molecular TargetSQLE
RouteTopical
StatusApproved
Sources: ClinicalTrials.gov, DongKoo Bio & Pharma

Mechanism of Action

Molecular Targets

terbinafine hydrochloride acts on 1 molecular target:

SQLEsqualene epoxidase ()
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

terbinafine hydrochloride is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Infections and infestationsOnychomycosis✓ Approved

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A decade of decline and regional disparity: Trends and associated factors in use of ritodrine hydrochloride for threatened preterm labor in Japan, a nationwide ecological study.

Yorozu Kazuma K, Hinotsu Shiro S, Matsuura Motoki M, Someya Masayuki M et al.

Ritodrine hydrochloride is a commonly used tocolytic agent for threatened preterm labor in Japan, despite its serious adverse events and limited use in many other countries. National obstetric guidelines have shifted toward restricting its use, but the evidence-practice gap remains unclear. The aim of this study is to determine usage trends for ritodrine at nationwide and prefectural levels and identify factors associated with usage. We conducted an ecological study linking nationwide aggregated medical claims data and statistical survey records across all 47 prefectures. We investigated 10-year trends in ritodrine use from fiscal year (FY) 2014 to 2023. Choropleth maps and spatial statistics illustrated geographic relationships among neighboring prefectures. We also conducted a cross-sectional study to identify factors associated with ritodrine injection use. The usage rate of ritodrine injection per 1000 deliveries decreased by more than 45% over 10 years. Joinpoint regression analysis identified FY2017 as a turning point, after which the decline accelerated. However, prefectural usage varied up to 13.58-fold, with spatial clustering of high-use regions. Factors associated with injection usage included the density of Perinatal Medical Centers (PMCs), hospital admissions for threatened preterm labor and preterm birth per 1000 deliveries, and the proportion of hospitals among delivery facilities. This study showed that nationwide use of ritodrine injection decreased by half over a decade, along with regional disparities among prefectures in Japan. These variations might reflect localized treatment policies influenced by differences in healthcare resources and geographical accessibility.

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In response to the ecological and health risks posed by Tetracycline Hydrochloride (TCH) residues in the environment, this study develops a microwave-induced catalytic system using ZnFe2O4/C/SiO2 nanocomposites for efficient TCH degradation. The composites were prepared by anchoring ZnFe2O4 nanoparticles onto a rice husk-derived C/SiO2 support, leveraging both the thermal and non-thermal effects of microwave irradiation to synergistically enhance catalytic performance. Our results showed that the porous structure of C/SiO2 effectively dispersed ZnFe2O4 nanoparticles, reduced agglomeration, and significantly improved microwave absorption by balancing dielectric loss and magnetic loss, with a reflection loss reaching -41.97 dB. Under optimized conditions (microwave power: 1000 W, catalyst dosage: 100 mg, reaction time: 21 min), the degradation rate of 60 ppm TCH exceeded 99%. Free radical trapping and EPR analyses confirmed that holes (h+) are the dominant active species responsible for degradation, and oxygen vacancies promote electron-hole separation. Recycling experiments showed that the catalyst maintained a degradation efficiency of over 75% after four cycles, indicating good stability. This study offers an efficient and sustainable microwave catalytic technology for organic wastewater treatment, with the added environmental benefit of utilizing agricultural waste.

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Effects of anion excipients on the viscosity of high-concentration mAb solution.

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High protein concentrations often lead to high viscosity, necessitating reduced solution viscosity. We investigated the effects of eight anionic excipients commonly used in biopharmaceutical formulations on the solution viscosity of high-concentration monoclonal antibodies using three antibodies with different isoelectric points. The three antibodies exhibited attractive or repulsive protein-protein interaction tendencies in histidine buffer without anionic excipients. The effect of adding anionic excipients on solution viscosity differed by interaction tendencies. Preferential interaction coefficients revealed differences in the extent of interaction between individual anionic excipients and antibodies. Comparison with chloride, positioned in the middle of the Hofmeister series, suggested that the observed viscosity behavior could only be partially explained by the previously reported Hofmeister anion effects on solution viscosity. We examined the effects of combining L-arginine with each anionic excipient as a counter anion. Formulations containing L-arginine and other anionic excipients contributed more strongly to reducing solution viscosity than L-arginine hydrochloride. The effects of anionic excipients on viscosity can be understood in terms of protein-protein interactions of an antibody in the presence of anionic excipients; whether anionic excipients strengthen or weaken the intrinsic protein-protein interactions is important, underscoring the key indicator for selecting the optimal anionic excipients when designing high-concentration formulations with lower viscosities.

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PubMedDanish medical journal2026-09-18

Increasing use of azoles combined with corticosteroids in Denmark.

Gupta Aditya K AK, Economopoulos Vasiliki V, Saunte Ditte Ml DM

Superficial fungal infections are of growing concern, especially with the emergence of antifungal-resistant infections. Antifungal stewardship is important for preventing further resistance, and understanding how these medications are used will advise public health policy. Our objective was to determine antifungal prescribing patterns in Denmark's primary care sector. We analysed data from the Danish Health Data Bank Medstat website. We examined the number of individuals per 1,000 who received triazole/corticosteroid combinations, miconazole, topical and oral terbinafine, ketoconazole, fluconazole and itraconazole. Data were analysed for both males and females across the following age groups: 0-24 years, 25-44 years, 45-64 years and > 65 years. When analysing topical medications, we found high rates of triazole/corticosteroid prescriptions in all age groups. Topical ketoconazole was the most prescribed topical monotherapy across all ages; topical terbinafine prescription tended to decrease over time. When analysing oral medications, terbinafine was most commonly prescribed in males until age 65 years, after which fluconazole and terbinafine were prescribed at similar rates. Fluconazole prescriptions were highest among females of all age groups. Antifungal prescribing patterns in Denmark have shifted substantially over time, with persistently high use of azole/corticosteroid combination therapies highlighting the importance of ongoing antifungal stewardship. None. Not relevant.

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Majocchi's granuloma of the scalp caused by Trichophyton tonsurans in an immunosuppressed adolescent with Crohn's disease: a case report.

Turk Gaja G, Hurych Jakub J, Lzicarova Daniela D, Onderkova Eliska E et al.

Majocchi's granuloma (MG) is a rare invasive dermatophytosis characterised by invasion of hair follicles and perifollicular granulomatous inflammation. Scalp involvement is uncommon, and Trichophyton tonsurans is an unusual aetiological agent of MG. A 16-year-old boy with Crohn's disease treated with infliximab and azathioprine developed a painful inflammatory occipital scalp lesion with colliquation, pustulation, and regional lymphadenopathy shortly after a haircut-related injury. Initial antibacterial and antiviral therapy was ineffective. Dermatological assessment suggested an unusually severe tinea capitis/kerion-like presentation. Biopsy showed periodic acid-Schiff-positive fungal elements in the dermis with granulomatous suppurative inflammation. Culture yielded a weakly growing dermatophyte consistent with Trichophyton sp. Bidirectional sequencing of the ITS2 region showed 100% similarity to members of the Trichophyton mentagrophytes series and did not discriminate between T. tonsurans and Trichophyton equinum; T. tonsurans was considered the most likely species based on the combined clinical and epidemiological context. Terbinafine 250 mg once daily failed to control disease progression. The patient improved after switching to itraconazole 200 mg twice daily, combined with repeated surgical debridement, topical antifungal treatment, and temporary interruption of immunosuppression. The lesion healed completely and hair regrowth was restored. This case highlights the need for early microbiological and histopathological assessment of severe scalp lesions in immunosuppressed patients, especially after skin-barrier disruption. It also raises awareness of possible dermatophyte transmission related to hairdressing and of a lack of clinical response to terbinafine in dermatophyte infections.

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