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Ortho-ACI

✓ Approved

Orthocell Pty, Ltd. · Cell-based Therapies · Cell-based Therapies

What is Ortho-ACI?

Ortho-ACI is a cell-based therapies developed by Orthocell Pty, Ltd.. It is approved for therapeutic indications via surgical implantation.

Drug Profile

CompanyOrthocell Pty, Ltd.
Drug ClassCell-based Therapies
RouteSurgical Implantation
StatusApproved
Sources: ClinicalTrials.gov, Orthocell Pty, Ltd.

Therapeutic Indications

Ortho-ACI is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Musculoskeletal and connective tissue disordersChondropathy✓ Approved

Related Research Articles

PubMedChemistry (Weinheim an der Bergstrasse, Germany)2026-07-25

Rhodium-Catalyzed Synthesis of Enantioenriched α-Substituted Primary Amines Through Asymmetric Transfer Hydrogenation.

Liu Chonghuo C, Lefèvre Guillaume G, Yin Qin Q, Phansavath Phannarath P et al.

The preparation of a series of enantioenriched α-substituted primary amines using rhodium-catalyzed asymmetric transfer hydrogenation of ortho-hydroxyaryl N─H imines is reported. The reaction proceeds under mild conditions using a low catalyst loading and ammonium formate as the hydrogen source, delivering the reduced compounds in high yields (up to 99%) and enantioselectivities (up to 99% ee).

PMID 42498498
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PubMedInternational journal of biological macromolecules2026-07-25

Coat protein complex II vesicle transport is involved in tri-o-cresyl phosphate-induced delayed neuropathy.

Sun Yan-Yan YY, Song Xiao-Hua XH, Zhang Di D, Yang Dan D et al.

Tri-ortho-cresyl phosphate (TOCP) is an organophosphorus compounds (OP) known to induce delayed neurotoxicity, called OP-induced delayed neuropathy (OPIDN), which involves multiple pathological processes, including degeneration and demyelination of long axons within the spinal cord and peripheral nerves. In this study, we employed the Schwann cell line (sNF96.2 cells) and adult hens, the classical model animal for OPIDN study, to investigate the mechanism of TOCP-induced myelin damage. The results showed that TOCP (750 mg/kg, p.o.) significantly reduced the number of COPII vesicles in the spinal cord and sciatic nerves of hens; on day 2 after the single exposure, the number of vesicles decreased to 27% and 38% of the control group, respectively, while 4-phenylbutyric acid (4-PBA, 150 mg/kg, i.p.), an inhibitor of endoplasmic reticulum (ER) restored them to 80% and 75% of the control group, respectively. In sNF96.2 cells, cresyl saligenin phosphate (CBDP), the active metabolite of TOCP, inhibited COPII vesicle transport from the ER to the Golgi apparatus, reducing the transport rate of ManII-SBP-mCherry from 76% to 38% and the relocation rate of GalNAc-T2-GFP in the Golgi apparatus from 91% to 26%. 4-PBA partially reversed the effects (restoring them to 62% and 72%, respectively). These results suggested that TOCP/CBDP impairs COPII vesicle transport at least partially by activating ER stress, and that impaired vesicle transport may be an important mechanism by which TOCP induces neuropathy.

PMID 42498192
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PubMedJournal of xenobiotics2026-07-24

Xenobiotic Hazards in Aircraft Cabin Air.

Ramsden Jeremy J JJ

Most airline passengers and crew assume that the air in the cabin is free from harmful or hazardous substances, as is mandated by airworthiness regulations. While fresh air entering the cabin is sterile (and if recirculated is usually efficiently filtered to remove microorganisms), if the fresh air is bled off the turbine compressors (as is the case in about 95% of airliners currently in service), it may be contaminated with traces of engine oil and ultrafine particles abraded from the turbine blades, and possibly traces of hydraulic fluid leaking from servo systems. Engine oil contains tricresyl phosphate (TCP) as an essential antiwear agent, but it is also a well-known neurotoxin, and it has been suggested that there may be no safe lower limit of exposure, not least because of considerable variation among individuals in sensitivity to tri-ortho-cresyl phosphate (ToCP) and other isomers with at least one ortho constituent. This paper reviews current knowledge about these hazards and discusses the medical and economic motivations for diminishing them. A calculation based on maintaining the life quality index shows that eliminating xenobiotic hazards in aircraft cabin air is likely to be affordable.

PMID 42496307
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PubMedACS omega2026-07-24

Experimental and DFT/TD-DFT Insights into Spectroscopic, Solvatochromic, and Nonlinear Optical Properties of Methoxy-Substituted N‑Benzylideneaniline Schiff Base Regioisomers.

Paul Michael Wilson Bosco WB, Abraham Hemamalini H, Senthan Selvam Amudhan SA, Alexander Carlson C et al.

Schiff bases bearing donor-acceptor substituents represent versatile D-π-A systems with tunable electronic and optical properties. Herein, we report combined experimental spectroscopic and DFT/TD-DFT (B3LYP/6-311++G-(d,p)) investigations of methoxy-substituted N-benzylideneaniline Schiff base regioisomers, benchmarked against unsubstituted analogues, revealing substituent position-controlled spectral and nonlinear optical properties. The FT-IR and NMR results demonstrate that substituent identity and position significantly influence the vibrational frequencies of characteristic IR bands and shielding/deshielding patterns of proton and carbon nuclei. UV-Vis and TD-DFT analyses reveal bathochromic shifts of the π → π* transitions in polar media with solvatochromic sensitivity decreasing in the order: ortho > para ≫ meta. Molecular electrostatic potential and Mulliken charge analyses indicate that methoxy substitution on the benzylidene ring enhances resonance donation and conjugation in the ortho- and para-isomers, leading to higher molecular electron polarization and consequently stronger bathochromic shifts and solvatochromic responses than the meta-isomer and unsubstituted analogues. Frontier molecular orbital (FMO) analysis further confirms that substituent position and donor strength critically govern the optical response and chemical reactivity of these systems. DFT-calculated polarizabilities reveal that donor-acceptor strength tuned by π-conjugation significantly enhances the NLO responses of these systems. The positional methoxy substitution provides an effective strategy for tuning the electronic and photophysical properties of Schiff bases, highlighting their potential for nonlinear optical and photonic applications.

PMID 42495300
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PubMedPoultry science2026-07-23

A yeast-based oral vaccine platform reveals antigen-dependent protection against Eimeria tenella.

Han Wenqi W, Chen Lang L, Wang Lu L, Zhao Qiping Q et al.

The development of effective oral mucosal vaccines against intracellular enteric pathogens remains a formidable hurdle, demanding innovative platforms that combine targeted antigen delivery with the induction of potent local immunity. Avian coccidiosis, caused by Eimeria parasites, exemplifies this need, as its control is hampered by drug resistance and limitations of live vaccines. Here, we engineered a novel oral vaccine platform based on Saccharomyces cerevisiae surface display to deliver defined Eimeria tenella rhoptry antigens (EtRON2, its variants EtRON2L1-1 and EtRON2L1-2, and EtROP17). Recombinant yeast strains demonstrated efficient surface antigen localization. In vivo trials in chickens showed that the live yeast vaccine expressing the core invasion antigen EtRON2 conferred the highest level of protection among all tested candidates, characterized by a high anticoccidial index (ACI = 172), a 54% reduction in oocyst shedding, minimized weight loss, and a systemic Th1/Th17-polarized response suggestive of mucosal T-cell recruitment. Protection was dependent on both antigen identity and carrier viability; inactivated yeast or other antigens provided only partial efficacy. Our findings reveal a critical triad for successful mucosal vaccination: functional centrality of the antigen, viability of the delivery vehicle, and induction of a polarized adaptive immune profile. This study establishes a versatile and safe yeast-based oral vaccine platform and provides a generalizable design framework for next-generation mucosal vaccines against intracellular pathogens.

PMID 42486030
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PubMedDalton transactions (Cambridge, England : 2003)2026-07-23

Challenges in ALD precursor design: mechanism of intramolecular C-H activation by internal deprotonation of tin(II) precursors.

Goodall Joe C JC, Morales Agustín A, Foote Samuel H SH, Clark Oliver W S OWS et al.

Di(silylamido)stannylenes find application in chemical synthesis, catalysis and deposition of thin film materials. Homoleptic bis(N-alkyl-substituted-silylamido)stannylenes (i.e. [Sn{NtBu(TMS)}2], TMS = trimethylsilyl) have previously been reported to possess limited thermal stability. Here, we describe the experimental and computational investigation of the thermal decomposition of [Sn{NR(TMS)}2] [R = iPr, Cy, tBu, Ad (Ad = 1-adamantyl), CPh3]. For aliphatic N-alkyl groups, DFT calculations support an intramolecular C(sp3)-H activation by deprotonation of the TMS group via σ-bond metathesis (σBM), which forms a reactive four-membered heterocycle that is followed by disproportionation. When the N-alkyl group is substituted for the trityl group (-CPh3), the homoleptic stannylene could not be isolated, with the deprotonation of a neighbouring ortho-phenyl C(sp2)-H position via σBM occurring at room temperature. The resultant five-membered heterocyclic Sn(II) intermediate rapidly tetramerises into [Sn{κ2-Ph'CPh2N(TMS)}]4, which is stable with respect to disproportionation.

PMID 42487635
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