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Ortho-ACI

✓ Approved

Orthocell Pty, Ltd. · Cell-based Therapies · Cell-based Therapies

What is Ortho-ACI?

Ortho-ACI is a cell-based therapies developed by Orthocell Pty, Ltd.. It is approved for therapeutic indications via surgical implantation.

Drug Profile

CompanyOrthocell Pty, Ltd.
Drug ClassCell-based Therapies
RouteSurgical Implantation
StatusApproved
Sources: ClinicalTrials.gov, Orthocell Pty, Ltd.

Therapeutic Indications

Ortho-ACI is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Musculoskeletal and connective tissue disordersChondropathy✓ Approved

Related Research Articles

PubMedLipids in health and disease2026-11-11

Associations between nut and seed intake and non-traditional lipid indices: a cross-sectional study from the isfahan cohort study 2.

Kakavand Nasim N, Mohammadifard Noushin N, Shamsi Khadijeh K, Haghighatdoost Fahimeh F et al.

Emerging evidence suggests that novel lipid indices may enhance cardiovascular risk prediction beyond conventional measures; however, their associations with dietary factors such as nut and seed consumption remain understudied. This cross-sectional study investigated associations between nut and seed intake and novel lipid indices among Iranian adults. Using baseline data from 2514 participants in the Isfahan Cohort Study 2, nut and seed intake were assessed using a validated food frequency questionnaire. Novel lipid indices, including Atherogenic Index of Plasma (AIP), Castelli's Risk Indices (CRI-I/II), Atherogenic Coefficient (AC), Atherogenic Combined Index (ACI), Remnant Lipoprotein Cholesterol (RLPC), Triglycerides to High-density lipoprotein Cholesterol ratio (TG/HDL-C), Lipoprotein Combined Index (LCI), and Non-High-density lipoprotein Cholesterol (NHC) were calculated from fasting blood samples. Multivariable adjusted linear and logistic regression models evaluated relationships across nut and seed intake quartiles. Participants in the highest quartile of nut and seed intake had significantly lower odds of elevated AIP (odds ratio (OR) = 0.58, 95% confidence interval (CI): 0.37-0.92), ACI (OR = 0.67, 95% CI: 0.50-0.91), CRI-I (OR = 0.46, 95% CI: 0.28-0.75), NHC (OR = 0.75, 95% CI: 0.54-1.03), LCI (OR = 0.72, 95% CI: 0.53-0.97), and TG/HDL-C (OR = 0.70, 95% CI: 0.51-0.95) compared to the lowest quartile after adjustment for potential confounders. The risk reductions for RLPC, AC, and CRI-II did not consistently reach statistical significance. This cross-sectional analysis indicated that higher nut and seed intake was associated with favorable lipid profiles. These findings support the potential role of nuts and seeds in cardiovascular health. However, due to the study's observational design, causal relationships cannot be established. Further prospective studies and randomized controlled trials are needed to confirm these associations and explain the underlying mechanisms.

PMID 43009954
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PubMedAnalytical chemistry2026-11-11

A Versatile Aza-BODIPY-Based Activatable Probe for High-Contrast NIR-II Biosensing.

Yao Chenzhi C, Huang Liwen L, He Qian Q, Guo Jiahao J et al.

Activatable molecular probes in the second near-infrared (NIR-II, 900-1700 nm) window are sought-after for in vivo optical imaging and biosensing. However, current molecular skeletons are confined to a limited range of dye systems, including cyanine, hemicyanine, and xanthene derivatives. Herein, we report a series of ortho-halogenated phenol-conjugated aza boron dipyrromethene platforms (OBDP-xOH, where X = H, F, Cl, Br, or 2Cl) that achieve bright NIR-II emission through a pH-regulated intramolecular charge transfer mechanism. The optimized scaffold, OBDP-2ClOH (pKa = 6.1), concurrently demonstrates the NIR-II emission maximum at approximately 905 nm, a large Stokes shift of 117 nm, high NIR-II brightness (εmaxΦf>1000 nm ≈ 38.46 M-1 cm-1), and excellent photochemical stability. To validate the broad applicability of this platform, we further designed three target-activatable NIR-II nanoprobes responsive to UV light, H2S, and Cu2+, respectively. Each nanoprobe exhibited a high fluorescence turn-on ratio exceeding 29-fold and limits of detection below 10.3 nM. Leveraging these probes, we achieved rapid (<30 min) dynamic imaging of labile Cu2+ in the brains of Parkinson's disease models, as well as high-fidelity in vivo early detection of acute liver injury within 5 min, which is substantially faster than conventional clinical serum analysis that requires approximately 90 min. Collectively, these findings underscore the translational potential of the OBDP-2ClOH scaffold as a versatile and generalizable platform for the development of advanced activatable NIR-II probes.

PMID 43010463
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PubMedChemical science2026-11-11

Azobenzene-mediated reversible conformational switching in 9,9'-bifluorenylidene-based molecular machines.

Mahajan Sohail S, Rich Reese R, Jiao Lin L, Zhang Duhan D et al.

Intrinsically dynamic molecules offer attractive building blocks for molecular machines, yet controlling their conformational motion with external stimuli remains a fundamental challenge. Here, we report Azo-BF-Azo, a visible-light-driven molecular machine in which an intrinsically dynamic 9,9'-bifluorenylidene (BF) core is coupled to two photoswitchable tetra-ortho-fluorinated azobenzene (Azo) units that act as molecular actuators. By using variable-temperature NMR spectroscopy and UV-vis spectroscopy, together with computational studies, we demonstrate that irradiation at 525 nm induces Azo trans-cis photoisomerization and shifts the BF conformational equilibrium from the closed toward the open state, whereas 456 nm irradiation reverses Azo isomerization and promotes recovery of the BF-closed state. DFT calculations reveal that the extended trans-Azo units favor intramolecular π-π interactions that stabilize the closed BF conformation, while their conversion to the folded cis state disrupts these interactions and alters the steric environment surrounding the BF core. Variable-temperature NMR spectroscopy provides experimental support for the role of these intramolecular interactions in regulating the BF conformational equilibrium. The photoinduced metastable state further undergoes spontaneous thermal relaxation in the dark, recovering approximately 65% of the initial state. Together, these results demonstrate that local photoisomerization can reshape the conformational energy landscape of a second, intrinsically dynamic molecular degree of freedom through switchable noncovalent interactions. This work provides a strategy for converting intrinsic molecular dynamics into externally programmable motion and establishes a design principle for constructing integrated molecular machines in which one type of molecular motion regulates another.

PMID 43011982
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PubMedFrontiers in systems neuroscience2026-11-10

Transient peripheral compression induces persistent central pain: the acute constriction injury model.

Luo Kaixuan K, Feng Xiangjun X, Liu Yang Y, Li Guanchen G et al.

Traditional neuropathic pain models such as chronic constriction injury (CCI) induce permanent peripheral nerve damage and cannot mimic persistent pain after resolved transient nerve compression. We established an acute constriction injury (ACI) model on male C57BL/6 J mice with 2-h sciatic nerve constriction followed by complete ligature removal, and performed a 250-day multimodal longitudinal comparison of Control, CCI and ACI mice using behavioral pain assays, somatosensory evoked potentials (SEPs), sciatic function index (SFI), nerve histology, muscle atrophy measurement, open field test, and serial 9.4 T pain-evoked BOLD-fMRI. ACI and CCI mice developed comparable long-lasting ipsilateral and delayed contralateral mechanical allodynia and thermal hyperalgesia over the 250-day observation period. Nonetheless, ACI mice achieved robust peripheral nerve structural and functional recovery without muscle atrophy, whereas CCI mice suffered irreversible peripheral nerve lesions. Serial fMRI revealed distinct brain activation trajectories: ACI mice exhibited spatially restricted response reductions relative to Controls and widespread suppression relative to CCI mice at day 3, isolated hypothalamic activation at day 12, and widespread bilateral activation of brainstem descending modulatory networks at day 250; in contrast, CCI mice showed cerebellar and somatosensory cortical activation at early/mid time points and significant deactivation of striatal-limbic circuits at late chronic stages. Anxiety-like behaviors were detected in both CCI and ACI mice at 12 day post-surgery but only in ACI mice at 7 months post-injury. These data support the pain centralization hypothesis: Brief peripheral nerve insult triggers self-maintained central sensitization that sustains chronic pain after peripheral anatomical and functional recovery. The ACI model may facilitate translational research on central-targeted therapeutics for compression-induced persistent neuropathic pain.

PMID 43005336
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PubMedBMC plant biology2026-11-10

Chickpea responsiveness to contrasting P fertilization reveals agro-physiological and genotypic variability in P use efficiency and rhizosphere microbial communities.

Ndiaye Pape Alioune PA, Saidi Rym R, Sellami Wafae W, Ibnyasser Ammar A et al.

Phosphorus (P) is crucial for grain legumes including chickpea, however P use efficiency (PUE) for both chickpea symbiosis and plant growth strongly relies on chickpea genotypic variability and responsiveness to contrasting P conditions including source, availability and application rate. In this study, three winter Moroccan chickpea (Cicer arientinum L.) varieties (Arifi, Bochra and Taounate) were assessed for plant growth, PUE and rhizosphere soil-associated microbiome composition under both available "ortho-P" and unavailable P sources (rock-P) at increasing rates (0, 40, 80 and 120 kg P2O5 ha- 1). Chickpea growth traits related to shoot dry weight (SDW), leaf area index (LAI), branches number and plant height were significantly enhanced under ortho-P (120 kg ha- 1). The highest pod DW (PDW) (108%) and Harvest Index (HI) (55%) were obtained under rock-P (120 kg ha- 1) as compared to unfertilized treatment, which is the case of Taounate variety that exhibited the highest PDW (2.33 g plant- 1), pod number (9.5 per plant), LAI (321), high PUE and P harvest index (PHI) as a consequence of improved root traits (biomass, length and surface-area). Meanwhile, Bochra variety responded more favorably to rock-P (40, 80 and 120 kg ha- 1) showing a higher PUE concomitantly to a lower root traits. Furthermore, chickpea varieties and P sources influenced the rhizosphere-associated microbial community with a notable abundance of Actinobacteria under rock-P in Bochra variety and Chytridiomycota phylum in Taounate variety under ortho-P, while Bochra and Arifi varieties had more Basidiomycota and Mortierellomycota under ortho-P. Findings revealed that ortho-P-fertilized Taounate and rock-P-fertilized Bochra exhibited high PUE and yielded superior agro-physiological performance concomitantly with specific rhizosphere microbial modifications. Such a genotype-P specific pattern indicates a differential responsiveness to P fertilization suggesting tight relationships between chickpea genotypic diversity, responsiveness to P and modulation of the rhizosphere microbiota that needs to be deciphered.

PMID 43004160
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PubMedPhysical chemistry chemical physics : PCCP2026-11-10

Double halogenation controls the conformation of benzyl alcohol: does DFT fail to predict it even qualitatively?

Hasselhorn Jannes N JN, Sennert Elisabeth E, Suhm Martin A MA, Obenchain Daniel A DA

Benzyl alcohol and its derivatives can occur in chiral and in more elusive mirror-symmetric structures. ortho-Halogenation (X) couples this structural duality with distorted OH⋯X vs. very weak CH⋯O/CH⋯X hydrogen bonding. We show by a combination of infrared and rotational spectroscopy in supersonic jets that additional para-halogenation introduces a particularly interesting halogen-sensitive conformational preference. While ortho-para-difluorobenzyl alcohol prefers the chiral OH⋯X arrangement, ortho-para-dichlorobenzyl alcohol favors the achiral structure with CH⋯O/CH⋯X contacts. Density functional (exemplified by dispersion corrected B3LYP) calculations fully support the infrared and rotational spectra of the competing conformations, but fail in predicting the energetic switch from F to Cl substitution, even when harmonic zero point energy is added or the electronic energy is replaced by its DLPNO-CCSD(T) counterpart. Only the combined effect of vibrational zero point energy and correlated wavefunction energetics is able to correctly predict the switch to mirror symmetry for Cl. Is there a density functional approach out there that predicts the correct structural switch on its own?

PMID 43006202
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