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Ortho-ACI

✓ Approved

Orthocell Pty, Ltd. · Cell-based Therapies · Cell-based Therapies

What is Ortho-ACI?

Ortho-ACI is a cell-based therapies developed by Orthocell Pty, Ltd.. It is approved for therapeutic indications via surgical implantation.

Drug Profile

CompanyOrthocell Pty, Ltd.
Drug ClassCell-based Therapies
RouteSurgical Implantation
StatusApproved
Sources: ClinicalTrials.gov, Orthocell Pty, Ltd.

Therapeutic Indications

Ortho-ACI is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Musculoskeletal and connective tissue disordersChondropathy✓ Approved

Related Research Articles

PubMedBiodegradation2026-09-19

Biodegradation and metabolic assimilation of poly (butylene adipate-co-terephthalate) (PBAT) by Gordonia sp. CN2K.

Swamy T M Chandramouli TMC, Nagarathna S V SV, Reddy Pooja V PV, Nayak Anand S AS

The increasing environmental burden of biodegradable plastics such as poly (butylene adipate-co-terephthalate) (PBAT) necessitates a detailed understanding of their microbial degradation mechanisms. In this study, Gordonia sp. CN2K utilized PBAT as the sole carbon and energy source, with cell density increasing from 1.26 × 108 to 6.26 × 108 CFU mL⁻1 over 90 days. PBAT degradation, determined by weight loss measurements, reached 52.8% within 45 days. ATR-FTIR analysis indicated ester bond cleavage and polymer backbone disruption, demonstrating chemical modifications in the PBAT polymer. SEM analysis revealed progressive surface erosion, confirming morphological deterioration during biodegradation. Metabolite profiling identified terephthalic acid (TPA), adipic acid (AA), and oligomeric intermediates, all of which supported bacterial growth as individual substrates. Notably, 1,4-butanediol was not detected in the medium, suggesting rapid uptake and metabolism. Enzyme assays revealed that esterase activity was induced exclusively in PBAT-grown cultures, with higher activity in the extracellular fraction, indicating surface-associated depolymerization. Intracellular enzyme analysis showed the presence of protocatechuate 3,4-dioxygenase and catechol 1,2-dioxygenase, supporting the involvement of ortho-cleavage pathways in aromatic intermediate metabolism. Overall, the results demonstrate a coordinated degradation mechanism involving extracellular depolymerization and intracellular assimilation under substrate-dependent enzyme regulation. These findings highlight Gordonia sp. CN2K as a promising candidate for the biodegradation of PBAT and related copolyesters.

PMID 42762365
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PubMedChemical communications (Cambridge, England)2026-09-18

Racemization mechanism of axially chiral sym-tetraacetylethane: axial rotation vs. intramolecular proton migration.

Liu Mingyue M, Zhang Bao B, Chen Mingliang M, Wang Shuo S et al.

Despite a high rotational barrier from ortho-methyl groups, sym-tetraacetylethane-a distally axially chiral molecule with intramolecular hydrogen bonds-cannot be resolved by chiral HPLC. DFT reveals an unusual racemization pathway via hydrogen-bond-assisted intramolecular proton migration (barrier 1.33-3.00 kcal mol-1) that interconverts enantiomers without axial rotation or bond breaking, supported by NMR and UV-vis spectra.

PMID 42758087
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PubMedEnzyme and microbial technology2026-09-18

Functional characterization of Corynebacterium glutamicum catechol 2, 3-dioxygenase induced by aromatic compounds.

Si Meiru M, Shao Meng M, Wang Shuli S, Shi Qimiao Q et al.

In bacteria, phenolic compounds are usually metabolized via the catechol pathway, in which catechol undergoes ring-opening reactions catalyzed by catechol 1, 2-dioxygenase (C12O, ortho cleavage) or catechol 2, 3-dioxygenase (C23O, meta cleavage), eventually entering central carbon metabolism. Corynebacterium glutamicum can utilize phenol as the sole carbon and energy source. The function of its C12O (encoded by ncgl2319) has been confirmed, whereas the putative C23O (encoded by ncgl2007, designated cgc23o) remains uncharacterized. In this study, we functionally characterized CgC23O, a protein conserved among Corynebacteria. This enzyme exhibited C23O activity toward catechol (Km=5.38 ± 0.32 µM, kcat=2.61 ± 0.12 s-1, kcat/Km=4.85 ×105 M-1s-1), displayed preferential catalytic activity against 4-methylcatechol and 4-chlorocatechol, and acted as a Fe2+-dependent metalloprotein. Transcription of cgc23o was inducible by a broad spectrum of aromatic compounds. At low catechol or phenol concentrations, CgC23O and NCgl2319 were co-expressed and catalytically active; by contrast, at high substrate concentrations, CgC23O served as the dominant enzyme. These results clarify the significant role of CgC23O in the decomposition and assimilation of aromatic compounds in C. glutamicum.

PMID 42759214
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PubMedACS omega2026-09-18

Combining X‑ray Diffraction, Solid-State NMR, and Computational Chemistry for Structural Insights and Performance Evaluation of GIPAW/GIAO 13C Chemical-Shift Calculations for Lamivudine and Three Pharmaceutical Salts.

Dias-Silva Jefferson R JR, Ferreira Vinícius S VS, Martins Felipe T FT, Lacerda Júnior Valdemar V et al.

The increasing prevalence of polymorphism and multicomponent crystal forms in active pharmaceutical ingredients demands rigorous structural characterization tools for quality control. Here, lamivudine and three pharmaceutical salts, hydrochloride, salicylate monohydrate, and hydrogen phthalate, were investigated by combining powder X-ray diffraction, 13C solid-state NMR spectroscopy, and two DFT-based methods for theoretical chemical-shift prediction: gauge including projected augmented wave (GIPAW) and gauge including atomic orbital (GIAO). In statistical comparison of experimental and theoretical chemical shifts, the GIPAW method consistently outperformed GIAO for all four crystalline forms, as evidenced by lower median errors and higher Kendall's τ correlation coefficient values, a rank-order metric that proved more discriminating than Pearson's R alone. The superior performance of GIPAW is attributed to its explicit treatment of periodic boundary conditions, which faithfully reproduces the crystallographic environment of the solid state. In addition, QTAIM topological analysis and natural bond orbital (NBO) second-order perturbation theory were used to characterize all inter- and intramolecular hydrogen bonds in each form. Two strong, nearly symmetric O···H···O interactions in the hydrogen phthalate salt are reported here for the first time, consistent with the anomalously low pK a2 of ortho-phthalic acid. These results demonstrate that the combined use of periodic GIPAW NMR calculations with QTAIM/NBO analysis constitutes a powerful, generally applicable strategy for the unequivocal structural characterization of pharmaceutical solid forms, with direct implications for the physicochemical quality control of drug substances.

PMID 42756740
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PubMedAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026-09-17

Unlocking the Alkynyl Bromide Radical Anion With Alternating Current for Inverse Sonogashira C─H Coupling.

Wang Junya J, Wang Xiaozhou X, Choy Pui Ying PY, Cheung Chi-Wai CW et al.

Carbon-bromine bond cleavage is a fundamental step in many chemical transformations. Over the past two decades, the reductive cleavage of C(Ar)─Br bonds (via a stepwise pathway) and C(alkyl)─Br bonds (via a concerted pathway) has been extensively studied. In contrast, the cleavage of the C(alkynyl)─Br bond remains unreported. We hypothesized that this bond may follow a distinct dissociation pathway, diverging from the established mechanisms. Indeed, the possible generation of reactive alkynyl bromide radical anion intermediates could significantly enrich the synthetic toolbox. However, chemical additives are less attractive than an electrochemical approach. Herein, we report an alternating current (AC)-promoted, Pd-catalyzed ortho-aryl C─H alkynylation employing unprecedented alkynyl bromide radical anion species. This "inverse" Sonogashira synthetic scheme accommodates a broad substrate scope, delivering alkynylated stilbene derivatives with excellent arene site selectivity. Mechanistic investigations, EPR spectroscopy, and DFT calculations suggest the involvement of a Pd(II)/Pd(III) pathway assisted by transient alkynyl bromide radical anion intermediates. This work opens a new method for bromoalkyne activation, demonstrates the capability of electrochemistry to enable efficient electrophilic alkynylation, and expands the synthetic toolkit for constructing complex stilbene-based frameworks.

PMID 42750140
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PubMedEar, nose, & throat journal2026-09-16

Leveraging Artificial Intelligence Chatbot to Generate Cochlear Implant Insurance Appeal Letter.

Washington Caretia J CJ, Lobo Brian C BC, Zeitler Daniel M DM, Hall Melissa M et al.

ObjectivesCochlear implant (CI) denial letters are a time-consuming and repetitive task that could benefit from artificial intelligence (AI)-powered large language model (LLM) chatbots. This study assesses ChatGPT's accuracy in creating insurance appeal letters compliant with the American Cochlear Implant (ACI) Alliance guidelines for CI necessity.MethodsChatGPT was prompted to generate zero-shot appeal letters for asymmetric hearing loss or single-sided deafness (AHL/SSD) CI denials. Thirty prompt variations were created, and responses were scored for guideline concordance by three CI providers. Accuracy and relevance of citations were assessed. One output error was excluded, yielding 29 unique responses and 87 total scores.ResultsAlmost all (96.6%) ChatGPT-generated responses included multiple benefits of CI for AHL/SSD, with 79.3% partially aligning with the ACI Alliance guidelines. However, 51.7% contained hallucinated benefits. Of the 96 citations, only six (6.3%) accurately referenced peerreviewed sources; the rest were hallucinated (57.3%), erroneous (24%), or irrelevant (10%).ConclusionChatGPT inconsistently produced accurate CI insurance appeal letters, often mixing correct guideline-based content with erroneous or misinterpreted information. CI providers should exercise caution and verify AI-generated materials before clinical or advocacy use.

PMID 42745584
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