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salbutamol (Proventil HFA / Epaq / Airomir)

✓ Approved

Teva Pharmaceutical Industries Ltd. · ADRB2 · Small Molecule

What is salbutamol?

salbutamol is a small molecule developed by Teva Pharmaceutical Industries Ltd.. It is approved for therapeutic indications via inhaled or topical.

Drug Profile

Brand NamesProventil HFA, Epaq, Airomir
CompanyTeva Pharmaceutical Industries Ltd.
Drug ClassSmall Molecule
Molecular TargetADRB2
RouteInhaled, Topical
StatusApproved

Mechanism of Action

Molecular Targets

salbutamol acts on 1 molecular target:

ADRB2adrenoceptor beta 2 (B2AR, ARB2)
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Therapeutic Indications

salbutamol is developed for 3 unique indications across 1 therapeutic area.

Therapeutic AreaConditionPhase
Respiratory, thoracic and mediastinal disordersAsthma✓ Approved
Respiratory, thoracic and mediastinal disordersBronchitis chronic✓ Approved
Respiratory, thoracic and mediastinal disordersEmphysema✓ Approved

Related Research Articles

PubMedEnvironmental monitoring and assessment2026-11-11

Forecasting of aerosol optical depth over arid and semi-arid regions using time series and machine learning models.

Singh Sukhpal S, Parmar Kulwinder Singh KS, Soni Kirti K, Singh Sarbjit S

Aerosols play a crucial role in the Earth's radiation balance and represent a major source of uncertainty in global radiative forcing estimation. Accurate prediction of aerosol optical depth (AOD), a key parameter for characterizing atmospheric aerosols, is increasingly important due to rising air pollution and its environmental impacts, particularly in desert regions. This study investigates and compares advanced time-series forecasting models for AOD prediction across six major arid regions of Asia, including the Thar, Thal, Karakum, Kutch, Kyzylkum, and Arabian deserts. Considering the temporal variability of desert aerosols, three forecasting approaches were developed and evaluated: the classical statistical Autoregressive Integrated Moving Average (ARIMA), the deep learning-based Long Short-Term Memory (LSTM), and the dynamic Nonlinear Autoregressive with Exogenous Inputs (NARX) model. Initially, statistical analysis was performed to examine the temporal characteristics, variability, and distribution patterns of AOD series. The study used 294 monthly satellite-derived AOD550 observations retrieved using the Deep Blue algorithm, covering the period from February 2000 to July 2024. The performance of three forecasting models was evaluated using the 44-month test set, with root mean square error (RMSE) and the coefficient of determination (R2) used as performance metrics. Subsequently, 6-year-ahead AOD forecasts were generated for the period from August 2024 to July 2030. ARIMA showed capability in representing linear patterns but exhibited comparatively lower forecasting performance, with testing RMSE values ranging from 0.0250 to 0.0400 and testing R2 values between 0.40 and 0.60. LSTM achieved improved prediction accuracy over ARIMA by capturing nonlinear temporal dependencies, reducing testing RMSE to 0.0215-0.0350 and increasing R2 values to 0.53-0.70. The NARX model provided the best forecasting performance, achieving testing RMSE values between 0.0180 and 0.0275 and consistently outperforming ARIMA and LSTM across all desert sites. The Diebold-Mariano test confirmed that the superior performance of NARX was statistically significant. These findings demonstrate that nonlinear neural network-based models, particularly NARX, are more effective for capturing complex aerosol variability and provide a useful modeling framework for long-term AOD forecasting and environmental monitoring in arid regions. However, the moderate prediction accuracy of the models and the exclusion of additional meteorological variables highlight the scope for further improvement through the integration of relevant atmospheric parameters.

PubMedFrontiers in physiology2026-11-11

Comparative oxidative and inflammatory responses to heated tobacco aerosol and cigarette smoke extracts in human lung fibroblasts.

Abelia Xylia Annisa XA, Lesmana Ronny R, Barliana Melisa Intan MI, Caruso Massimo M et al.

Combustible cigarette smoke induces oxidative stress and inflammation in lung cells. Heated tobacco products (HTPs) have been proposed as alternatives with reduced toxicant emissions, but their cellular effects remain incompletely characterized. MRC-5 human lung fibroblasts were exposed to aqueous cigarette smoke extract (CSE; 0.1-1.0 puffs/mL) or heated tobacco aerosol extract (HTE; 1.5-5.5 puffs/mL for viability, 3.0-5.5 puffs/mL for other endpoints). Concentrations were anchored to each product's 24 h IC50 (CSE 0.70 puffs/mL, 95% CI 0.63-0.77; HTE 4.76 puffs/mL, 95% CI 4.39-5.16). Cytotoxicity, oxidation-sensitive dihydroethidium (DHE) fluorescence, intracellular TNF-α and IL-6, and morphology were assessed. ATG5 protein was included as an exploratory endpoint. Both extracts increased DHE fluorescence and intracellular TNF-α and IL-6 in a concentration-dependent manner, with reduced viability and morphological changes. ATG5 findings were inconclusive, as no concentration differed from the untreated control. Nominal puff concentrations were not considered equivalent doses. In an exploratory comparison near each product's 24 h IC50 (CSE 0.7 and HTE 4.75 puffs/mL), CSE produced greater DHE fluorescence (3.17- versus 2.31-fold over vehicle) and greater intracellular IL-6 and TNF-α signals than HTE. Equivalent viability at the 90 min and 4 h endpoints was not established. Under these study-specific conditions, HTE elicited quantitatively smaller oxidative and inflammatory responses than CSE at the selected comparison concentrations.

PubMedAnalytical chemistry2026-11-11

Multimodal Single-Particle Characterization of Airborne Microplastics Reveals Physicochemical Heterogeneity and Aging-Related Features.

Park Jonghyeon J, Kang Cheonwoong C, Lee Kyeong-Eun KE, Park Ji-Won JW et al.

Airborne microplastics (AMPs) have emerged as an important atmospheric contaminant; however, their physicochemical characteristics at the individual particle level remain poorly understood. In this study, a multimodal single-particle analytical approach integrating fluorescence microscopy, Raman microspectrometry (RMS), optical photothermal infrared (O-PTIR) spectroscopy, and SEM/EDX was developed for the characterization of individual AMP particles. Fluorescence microscopy enabled screening of particles with high AMP potential, while RMS and O-PTIR provided complementary molecular and functional characterization, and SEM/EDX further provided morphological information. Among the fluorescent AMP candidates analyzed in a single aerosol sample, 18.0% and 19.7% were identified as AMPs by RMS and O-PTIR, respectively, whereas their combined application increased the identification fraction to 22.0%. The incomplete overlap between the two techniques demonstrates their complementary analytical capabilities and indicates that reliance on either technique alone may result in the underestimation of AMPs. Their combined use further enabled the detailed physicochemical characterization of individual AMPs. Notably, 86% of the identified AMPs exhibited spectral features distinct from those of standard polymers, including peak attenuation, broadening, and additional peaks, accompanied by worn and irregular morphologies. These differences suggest modifications associated with environmental aging processes, including oxidation, chain scission, and changes in aromatic structures. Substantial particle-to-particle variability within the same polymer type and similar size range further indicated heterogeneity in environmental exposure history and sources. Although the present study is limited to a single urban aerosol sample, the results demonstrate that multimodal single-particle analysis can reveal physicochemical heterogeneity and aging-related features of AMPs that may not be readily accessible using conventional single-technique approaches.

PubMedPrecision clinical medicine2026-11-11

Inhaled nucleic acid therapeutics for respiratory diseases: delivery barriers, translational challenges, and emerging solutions.

Yu Leijie L, Zhou Chongrui C, Cheng Xiang X, Zhao Xia X et al.

Pulmonary delivery of nucleic acid therapeutics represents a transformative strategy for treating a broad spectrum of respiratory diseases, including lung cancer, pulmonary fibrosis, chronic obstructive pulmonary disease, and acute lung injury. Despite their promise, effective clinical translation is hampered by a cascade of physiological barriers spanning the airway mucus layer, mucociliary clearance, alveolar macrophage uptake, cellular internalization, and endosomal sequestration. In this review, we adopt a barrier-oriented framework to systematically dissect these extracellular, cellular, and intracellular obstacles, highlighting how disease-specific microenvironments further modulate delivery efficiency. We then critically examine emerging engineering strategies-including nanocarrier surface modifications, biomimetic vesicles, aerosol optimization, and stimuli-responsive formulations that are designed to overcome these barriers. Integrating mechanistic insights with disease-specific considerations, we analyze how distinct pulmonary pathologies necessitate tailored delivery solutions, emphasizing that successful translation requires coupling nanoengineering with the unique cellular and molecular landscapes of target tissues. Finally, we discuss translational challenges, including manufacturing scalability, long-term safety, and regulatory constraints, and outline emerging solutions that may enable next-generation inhaled nucleic acid therapies. By providing a synthesis of barrier-oriented design principles and disease-driven targeting strategies, this review offers a comprehensive roadmap for accelerating the clinical adoption of inhaled nucleic acid therapeutics.

PubMedEnvironmental science & technology2026-11-10

Modeling Decadal Organosulfates in Particulate Matter to Improve Estimations of Aerosol Hygroscopicity in the United States.

Gonzalez Alan R AR, Yim Heewon H, McCary Kyle P KP, Meng Xiangxinyue X et al.

Organosulfates (OSs) can comprise a substantial fraction of secondary organic aerosol and exhibit significantly different hygroscopicity than inorganic sulfates, yet their spatiotemporal prevalence and climatic impacts remain poorly constrained because speciated measurements are sparse and common chemical transport models do not explicitly represent OS formation. This study develops a flexible and robust modeling framework to quantify isoprene-derived OS (iOS) concentrations and OS impacts on aerosol hygroscopicity (κ) across the contiguous United States (U.S.) for summers spanning 2013-2022. Using the Community Multiscale Air Quality (CMAQ) model with updated iOS chemistry, simulations reproduce Interagency Monitoring of Protected Visual Environments (IMPROVE) network-derived organosulfur and inorganic sulfate and agree with speciated iOS measurements from filter analyses. OS concentrations are elevated in the eastern U.S., with summertime mean values up to 0.51 μg m-3. OS formation produces a net 5.6% decrease in κ (direct OS contribution, +2.8%; indirect, -8.4% via sulfate reduction). We apply an interpretable machine-learning surrogate to identify predictive features associated with OS variability and enable efficient estimation without rerunning CMAQ. These results provide the first observation-validated, high-spatial-coverage OS reconstruction and nationwide quantification of OS-driven κ changes, underscoring the importance of representing OS formation and expanded observations to improve aerosol-cloud radiative effect assessments.

PubMedEnvironmental science & technology2026-11-10

Fog Intensity and Droplet Size-Resolved Aqueous Secondary Organic Aerosol (aqSOA) Formation in Polluted Winter Fog: New Insights from a Combined Observational and Modeling Study.

Chakraborty Abhishek A, Pakki Jayaraju J, Anand Megha M, Moosakutty Shamjad P SP

Fog is a chemically active aqueous medium in which dissolved organic gases and particles are converted into highly oxidized aqueous secondary organic aerosol (aqSOA). Its magnitude is difficult to constrain, and most published estimates rely on models. We analyzed size-resolved fogwater collected over two winters at Kanpur, India, by offline high-resolution aerosol mass spectrometry and apportioned by positive matrix factorization (PMF). Three highly oxidized factors (O/C 0.95-1.19) were summed as an aqSOA proxy. Combining this proxy with colocated liquid water content and water-soluble organic carbon yielded 3.1-8.4 μg m-3 aqSOA across seven events. The droplet aqSOA accounts for a median of about 7% of ambient SOA and 5% of ambient OA, reaching 13% of SOA in the densest fogs. Fine droplets carried the largest aqSOA share (43-84%), driven by higher concentrations of dissolved Fe and Cu and longer residence times. Ambient OA was less oxidized during dense than light fog (O/C 0.52 versus 0.61). Returning aqSOA after dissipation gave direct-radiative-effect increments of -0.048 W m-2 (dense) and -0.032 W m-2 (light). These size- and intensity-resolved observational constraints quantify fog-aerosol interactions and their air quality consequences in a heavily polluted region.

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