Drug Database
ID

idoxuridine (idoxuridine, APR / Apridin C / Apridin)

✓ Approved

Pierre Fabre S.A. · · Small Molecule

What is idoxuridine?

idoxuridine is a small molecule developed by Pierre Fabre S.A.. It is approved for therapeutic indications via topical.

Drug Profile

Brand Namesidoxuridine, APR, Apridin C, Apridin
CompanyPierre Fabre S.A.
Drug ClassSmall Molecule
Molecular Target,
RouteTopical
StatusApproved
Sources: ClinicalTrials.gov, Pierre Fabre S.A.

Mechanism of Action

Molecular Targets

idoxuridine acts on 2 molecular targets:

(UL30)
(UL30)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

idoxuridine is developed for 2 unique indications across 2 therapeutic areas.

Therapeutic AreaConditionPhase
Infections and infestationsHerpes simplex✓ Approved
Congenital, familial and genetic disordersCongenital herpes simplex infection✓ Approved

Related Research Articles

PubMedHealth science reports2026-09-19

Multidimensional Assessment of Nutritional Status Among Hospitalized Older Adults With Pneumonia at a Tertiary Hospital in Ghana: A Descriptive Cross-Sectional Study.

Andoh Theresa T, Owusu Justina S JS, Mohammed Husein H, Kwesi-Maliepaard Eliza M EM et al.

Malnutrition is a common but often overlooked problem among hospitalised older adults, particularly those admitted with acute infections such as pneumonia. Pneumonia can worsen nutritional status through inflammation, fever, poor appetite, breathlessness, fatigue, and reduced food intake, while malnutrition can, in turn, weaken immunity, reduce respiratory muscle strength, and delay recovery. This study assessed the spectrum of nutritional status among hospitalised older adults with pneumonia at the 37 Military Hospital in Accra, Ghana. A descriptive cross-sectional study was conducted among 74 hospitalised adults aged 60 years and above with a confirmed diagnosis of pneumonia. Data were collected on socio-demographic and health-related characteristics, dietary intake, anthropometry, and haemoglobin status. Nutritional status was assessed using Body Mass Index (BMI), the Mini Nutritional Assessment (MNA), mid-upper arm circumference (MUAC), calf circumference, dietary diversity score, and haemoglobin concentration. Associations between nutritional indicators were examined using chi-square and Monte Carlo exact tests, and multivariable prevalence-ratio regression was used to identify factors independently associated with MNA-defined malnutrition and BMI-defined underweight. Participants had a mean age of 72.3 ± 8.6 years, with 38 males and 36 females. Based on BMI, 66.2% were underweight, 31.1% had a healthy weight, and 2.7% were overweight. The MNA classified 39.2% of participants as malnourished, 50.0% were at risk of malnutrition, and only 10.8% as well nourished. Among participants with haemoglobin data, 77.5% were anaemic. MUAC classified 9.5% as underweight and 32.4% as at risk, while 31.1% had a low calf circumference; 56.8% had inadequate dietary diversity. MUAC and calf circumference were significantly associated with both MNA classification (p = 0.0047 and p = 0.0309) and BMI category (p = 0.010 and p = 0.035), whereas MNA classification was not significantly associated with BMI category (p = 0.142). In multivariable analysis, each 5-year increase in age was associated with a 21% higher prevalence of MNA-defined malnutrition (aPR = 1.21, 95% CI: 1.01-1.46, p = 0.040); no factor was independently associated with BMI-defined underweight. Malnutrition was highly prevalent and manifested in multiple, only partly overlapping forms among hospitalised older adults with pneumonia. Because BMI, MNA, MUAC, calf circumference, and dietary diversity captured related but distinct dimensions of nutritional risk, reliance on a single indicator particularly BMI alone may underestimate the true burden of malnutrition. Routine screening with multiple, low-cost indicators should be integrated into pneumonia care for older adults to support early detection, targeted intervention, and improved recovery.

PMID 42761161
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PubMedPeerJ2026-09-18

Prevalence and obstetric risk factors of stress urinary incontinence in parous women: a cross-sectional study in rural areas of Mangaluru, India.

Amin Amisha S AS, Leena Kunnath Chacko KC

Stress urinary incontinence (SUI) is common among parous women, yet community-level data from rural India remain limited. This study estimated the prevalence of SUI among relatively healthy, rural, reproductive-age parous women without major comorbidities. A community-based cross-sectional study was conducted among 412 parous women (aged 25-40 years) using proportionate stratified random sampling across seven rural wards. SUI was assessed using the modified International Continence Society (ICS) Uniform Cough Stress Test (CST) with a standard bladder-fill protocol. Obstetric data were collected via a validated questionnaire. Bivariate and multivariable associations were analysed using modified Poisson regression with robust standard errors to estimate crude prevalence ratios (cPR) and adjusted prevalence ratios (aPR). The prevalence of SUI was 53.4% (n = 220), yet 98.3% (n = 405) of participants had no prior information regarding its management. The relatively high prevalence may reflect the use of an objective modified ICS-based cough stress test, which can identify previously unreported cases. Maternal age was independently associated with higher SUI prevalence in the adjusted modified Poisson regression model (aPR = 1.198 per year; 95% CI [1.168-1.229]; p < 0.001). SUI affects more than half of relatively healthy, reproductive-age parous women in this rural setting; however, these findings represent associations within a clinically screened population and should not be interpreted as causal relationships or generalised to all rural women. Increasing maternal age was independently associated with higher SUI prevalence, supporting consideration of routine pelvic floor assessment and targeted community-based education within primary maternal healthcare services.

PMID 42756861
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PubMedPLOS global public health2026-09-18

Cost and transportation barrier trends related to Affordable Care Act among cancer survivors and atherosclerotic cardiovascular disease patients.

Bega Rabia R, Alizai Qaidar Q, Charalampous Charalampos M CM, Mevawalla Areesh A et al.

The Affordable Care Act (ACA) included major coverage expansions implemented in 2014. However, its association with cost‑related barriers among people with chronic disease remains incompletely described. We analyzed trends in cost and transportation related barriers to care between cancer survivors and adults with atherosclerotic cardiovascular disease (ASCVD) in relation to ACA implementation and expansion. National Health Interview Survey (NHIS) data from 2004-2024 for adults ≥18 years reporting a history of cancer or ASCVD without cancer were obtained. Primary outcomes were overall cost‑barrier and transportation barrier. We used survey weighted interrupted time series analysis (ITSA) with prespecified policy breakpoints and survey weighted modified Poisson regression to estimate associations between policy periods and barriers, adjusting for sociodemographic covariates. The analytic sample included 106,947 respondents: 63,505 cancer survivors and 43,442 adults with ASCVD without cancer. Overall cost barriers were reported by 8.1% of cancer survivors (n = 5,264) and 10.6% of adults with ASCVD without cancer (n = 4,772; p < 0.001). In adjusted models, the prevalence of overall cost barriers in 2022-2024 was lower than in 2004-2009 among both cancer survivors (aPR 0.63; 95% CI: 0.56-0.71) and adults with ASCVD without cancer (aPR 0.73; 95% CI: 0.65-0.82). In ITSA, cancer survivors had an immediate decrease in overall cost barriers at the 2022 breakpoint (-1.98 percentage points; p = 0.006). No substantial 2022 level change in overall cost barriers was observed among adults with ASCVD without cancer. Transportation barriers were higher in the post-pandemic period among years with available data, particularly among adults with ASCVD without cancer, but transportation ITSA findings were exploratory since data were unavailable in 2019-2021. Overall cost related barriers declined among U.S. cancer survivors and ASCVD patients, with the largest improvements observed in the most recent period. Nevertheless, increases in transportation-related delays underscore persistent structural barriers and highlight the need for targeted interventions to improve care accessibility.

PMID 42758753
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PubMedRevista brasileira de epidemiologia = Brazilian journal of epidemiology2026-09-17

Sexual risk behaviors among adolescent men who have sex with men in two Brazilian cities: findings from an RDS-based study.

Leal Marto M, Kendall Carl C, Almeida Rosa Livia Freitas de RLF, Araujo Junior Antonio José Lima de AJL et al.

To estimate the prevalence of sexual risk behaviors among adolescent men who have sex with men and to identify factors associated with these behaviors. Data were collected between December 2020 and July 2022 in Fortaleza and São Paulo, Brazil, using respondent-driven sampling. Study outcomes included inconsistent condom use, multiple sexual partners, and sexualized drug use. The final sample was composed of 287 adolescents. Among participants, 38.0% reported inconsistent condom use, 36.1% reported multiple sexual partners, and 23.8% reported sexualized drug use. Factors associated with inconsistent condom use were not having a steady partner (adjusted prevalence ratio (APR): 0.5), having come out to everyone or almost everyone (APR: 6.3), consuming alcohol weekly (APR: 2.9), looking for family/friends/pharmacy (APR: 0.7), or looking for the public healthcare service when sick (APR: 0.7), and having sexual intercourse with partners of unknown HIV status (APR: 1.6). Factors associated with multiple sexual partners were receiving money in exchange for sex (APR: 1.6), and having sexual intercourse with partners of unknown HIV status (APR: 2.0). Factors associated with sexualized drug use included Catholic religion (APR: 0.2), having a steady partner < 20 years old (APR: 2.0), participating in non-governmental organization activities (APR: 2.5), experiences of violence (APR: 2.7), receiving money in exchange for sex (APR: 1.7), and having sexual intercourse with partners of unknown HIV status (APR: 2.1). These findings highlight the high prevalence of sexual risk behaviors among adolescent men who have sex with men, underscoring the need for targeted prevention strategies and youth-friendly services in diverse urban contexts.

PMID 42752776
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PubMedRevista Cuidarte2026-09-16

Health literacy and knowledge of HIV and sexually transmitted infections among adolescents.

Durand-Granados Kimberly Alison KA, Curisinche-Rojas Maricela M

Inadequate knowledge of sexually transmitted infections (STIs) and the human immunodeficiency virus (HIV) places adolescents at increased risk for infection. Health literacy is an important strategy for reducing this risk. To determine the association between health literacy and knowledge of HIV and other STIs among adolescents. This analytical cross-sectional study included 204 adolescents from public schools. The Health Literacy Questionnaire and the HIV and other Sexually Transmitted Infections Knowledge Scale were used. Descriptive and bivariate analyses were performed using the chi-square test and Poisson regression with robust variance. A total of 51.47% adolescents had inadequate knowledge, and 63.24% had inadequate health literacy. A significant association was found between the two variables (chi-square test, p = 0.009, 95% confidence interval [CI]). The crude prevalence ratio (cPR) was 1.44 (95% CI: 1.119-1.874), and the adjusted prevalence ratio (aPR) was 1.45 (95% CI: 1.123-1.880), adjusted for age, sex, and school grade level. Health literacy equips individuals with the skills to access, understand, and use health information, improving knowledge for informed decision-making and the adoption of protective behaviors against HIV and STIs. Adolescents with adequate health literacy are more likely to have adequate knowledge of HIV and STIs. It is necessary to incorporate health literacy into health plans and promote information and education programs and interventions on these infections and comprehensive sexual health within and outside schools, using a multisectoral approach.

PMID 42746535
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PubMedDrug and alcohol dependence2026-09-16

Use of sedative drugs among adults reporting illicit opioid use or prescription opioid use in the United States, 2017-2024.

Jiang Xinyi X, Zhang Kun K, Strahan Andrea E AE, Guy Gery P GP

Co-use of opioids and sedatives significantly increases the risk of overdose. This study examined associations between person-level characteristics and persons who co-use different types of opioids (prescription and/or illicit opioids) and sedatives. The study population included a large sample of adults aged ≥ 18 years assessed for substance use disorder treatment in the United States. Data were collected between January 2017 and June 2024 using the Addiction Severity Index-Multimedia Version instrument. Co-use was defined as reporting past 30-day use of both opioids and sedatives. Multivariable Poisson regressions were used to examine associations between person-level characteristics and co-use. The percentage of adults reporting sedative co-use was 17.5% among those using prescription opioids only (n = 36,978), 17.5% among those using illicit opioids only (n = 13,492), and 29.9% among those using both prescription and illicit opioid (n = 19,542). Being non-Hispanic White and having psychiatric conditions were associated with increased prevalence of co-use, regardless of opioid type. Adults assessed in the Northeast (adjusted prevalence ratios (aPRs)= 5.88 [95%CI= 4.49-7.97]), or Midwest (aPR=2.52 [95%CI=1.83-3.47]) versus the West were associated with an increased prevalence of co-use of illicit opioids only and sedatives but were not associated with co-use of prescription opioids only and sedatives. Findings provide new insights into co-use of opioids and sedatives and help inform prevention strategies. In addition to checking prescription drug monitoring programs and care coordination, potential opportunities for preventing co-use of illicit opioids and sedatives include disrupting the availability of illicit opioids and checking persons' substance use and overdose history.

PMID 42748644
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