Drug Database
BL

blood substitute (Volplex / Volplex)

✓ Approved

Sinclair · Cell-based Therapies · Cell-based Therapies

What is blood substitute?

blood substitute is a cell-based therapies developed by Sinclair. It is approved for therapeutic indications via injectable (others) or intravenous (iv).

Drug Profile

Brand NamesVolplex, Volplex
CompanySinclair
Drug ClassCell-based Therapies
RouteInjectable (Others), Intravenous (IV)
StatusApproved

Therapeutic Indications

blood substitute is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Surgical and medical proceduresAdjuvant therapy✓ Approved

Related Research Articles

PubMedInnovation (Cambridge (Mass.))2026-11-11

Coal phaseout undermines co-benefits of fly ash as a clinker substitute.

Li Huaqing H, Chen Bin B, Xie Hongyi H, Yu Huajun H et al.

Replacing clinker with fly ash is a critical CO2 mitigation pathway for cement clinker plants (CCPs), yet this potential may be adversely affected by the phaseout of coal-fired power plants (CFPPs). Here, we draw upon a high-resolution infrastructure-level database encompassing approximately 4,460 CFPP units and 1,540 CCP production lines in China. Through industrial symbiosis simulations and cost-benefit analyses, we evaluate the mitigation performance and adaptation costs of CCPs under various future CFPP retirement and flexible dispatch pathways. Our findings indicate that CCPs could reduce CO2 emissions by 141 Mt and generate 8.2 billion Chinese Yuan (CNY) in economic benefits through clinker substitution with fly ash. However, under the 1.5°C warming target by 2050, the coal power phaseout would undermine these benefits by more than 80%. While deploying adaptation measures could offset 57 Mt of CO2 losses, these measures incur an additional 5 billion CNY in costs for CCPs, potentially turning net economic benefits into an estimated loss of 17 billion CNY. Developing systematic and collaborative decarbonization strategies for highly connected sectors is essential for mitigating transition risks and improving decision-making effectiveness.

PubMedZhonghua nan ke xue = National journal of andrology2026-11-11

[Potential therapeutic mechanism of the blood activation and stasis method for erectile dysfunction: From the perspective of cellular senescence].

Huang Nianwen N, Bai Zunguang Z, Gu Chiming C, Ma Jianxiong J

Cellular senescence plays a significant role in the pathogenesis of erectile dysfunction (ED), which can be induced by affecting various mechanisms such as nitric oxide release, the phenotype of smooth muscle cells, and the secretory function of testicular interstitial cells. Blood stasis is the core pathogenesis of ED in Traditional Chinese medicine. In clinical practice, the use of blood-activating and stasis-removing herbal medicines to treat ED has been recognized for its efficacy. However, the relevant mechanism of action is not yet fully understood. Combining cell biology and basic theories of Traditional Chinese medicine, blood stasis and cellular senescence are pathologically interrelated and mutually causative. Therefore, this article explores the correlation between cellular senescence-mediated ED and the Traditional Chinese medicine theory of "blood stasis induced decline". And the potential mechanism of Chinese herbal medicines that promote blood circulation and remove stasis in treating ED by delaying cell aging will be discussed as well, aiming to provide new breakthroughs for Traditional Chinese medicine treatment of ED.

PubMedMedicine2026-11-11

The influence of robotic assistance on hidden blood loss in the treatment of posterior pelvic ring injuries with sacroiliac screw fixation: A retrospective cohort study.

Xu Ding D, Guo Jing J, Lou Weigang W, Li Ming M et al.

Pelvic posterior-ring injury is a severe traumatic condition accompanied by substantial perioperative hidden blood loss (HBL). Minimally-invasive sacroiliac screw fixation is widely applied for this injury, yet postoperative anemia remains common and is predominantly caused by HBL. Whether robotic-assisted screw placement can reduce HBL in patients with posterior pelvic-ring injuries remains unclear. We retrospectively analyzed the data of 64 patients with posterior pelvic ring injury treated with sacroiliac screw fixation in our hospital from January 2020 to June 2023. Based on the use of intraoperative robot assistance during surgery, the 64 patients were divided into 2 groups. The total blood loss (TBL) and HBL were compared to analyze the difference between the 2 groups. In the robotic surgery group, TBL was 335.51 ± 31.46 mL, and the HBL was 300.96 ± 37.01 mL. In the freehand group, the TBL was 410.57 ± 54.55 mL, and the HBL was 370.34 ± 54.51 mL. The difference between the 2 groups was statistically significant (P < .001). However, there was no statistically significant difference in visible blood loss (VBL) and surgical duration between the 2 groups (P > .05). The robotic group presented a significantly smaller postoperative maximum hemoglobin drop (P < .001), whereas transfusion-related indicators were comparable between the 2 groups (P > .05). In the treatment of posterior pelvic ring injuries with sacroiliac screws, the assistance of surgical robots plays a significant role in reducing intraoperative blood loss, particularly hidden blood loss. Compared to traditional freehand screw placement, we recommend considering the incorporation of robotic assistance during surgery.

PubMedMedicine2026-11-11

A Mendelian randomization analysis of the causal effect of body mass index on biomarkers and renal failure risk.

Liu Xin X, Yang Wenwen W

Renal failure significantly impairs the kidneys' ability to filter waste and maintain fluid balance. This study employed Mendelian Randomization (MR) to investigate the causal effect of BMI on 44 biomarkers related to renal failure. The genetic data were sourced from publicly available genome-wide association studies (GWAS) and biobank datasets, including blood cells, urinary electrolytes, enzymes, liver markers, lipids, and blood pressure. Single-nucleotide polymorphisms (SNPs) were used as instrumental variables (IVs) to assess the causal relationships and to identify significant mediators of the BMI-renal failure pathway. The study found that BMI is a risk factor for renal failure (OR = 1.324, P = .00185). Out of 44 biomarkers, nine were associated with renal failure, and five acted as mediators in the relationship between BMI and renal failure: cystatin C (12.34%), glucose (7.02%), glycated hemoglobin (HbA1c) (6.83%), diastolic blood pressure (6.37%), and systolic blood pressure (7.14%). The findings suggest that reducing BMI could improve renal health by addressing metabolic factors like blood glucose and blood pressure. This study highlights the causal pathways linking BMI to renal failure, underscoring the importance of weight management and metabolic control for prevention.

PubMedCase reports in pulmonology2026-11-11

Management of a Spontaneous Secondary Pneumothorax Complicated by Persistent Air Leak With Autologous Blood Patch Pleurodesis: A Case Report.

Basnet Ashok A, Rajbhandari Bhushan Kumar BK, Rana Ekta Malla EM, K C Rajesh R et al.

Persistent air leak (PAL) in pneumothoraces, especially in underlying structural lung disease, remains a significant challenge leading to prolonged hospitalization and even mortality because of pleural sepsis. Various treatment modalities, such as chemical pleurodesis, autologous blood patch, endobronchial valve, and surgical interventions, have been reported in the literature. We report a case of an 80-year-old male with PAL successfully managed with 100 mL of autologous blood patch pleurodesis (ABPP) as the patient was deemed unsuitable for surgery. In our experience, ABPP has proven to be safe, bedside, low-cost effective procedure with minimal complications. ABPP is still underutilized and is used mostly in resource-limited settings. We believe ABPP should be accepted as a treatment option before considering surgery in selected patients.

PubMedBiotechnology for biofuels and bioproducts2026-11-11

High-throughput biosensor-based platform for semi-quantitative screening of hydrogen-producing microalgae.

Pinon A M AM, Oey M M, Williams H K HK, Ross I L IL et al.

Green hydrogen (H2) is a promising alternative to carbon-based fuels. However, delivering economically viable large-scale renewable H2 production remains challenging. Green microalgae, such as Chlamydomonas reinhardtii, offer a sustainable route to H2 production by coupling water oxidation to the photosynthetic electron transport chain. As a result, considerable effort is being devoted to improving microalgal H2 yields through engineering of metabolic and photosynthetic pathways. Although microalgal H2 production has been studied for over two decades, progress towards application remains constrained by the lack of rapid, reproducible and quantitative phenotypic screening tools. Conventional photobioreactor-based assays are low-throughput, labour-intensive and poorly reproducible, limiting comparative assessment across strains and conditions. We developed a cost-effective, plate-based, semi-quantitative, high-throughput assay for screening microalgal H2 production based on an H2-responsive Rhodobacter capsulatus biosensor that reports H2 via GFP fluorescence. The platform enables simultaneous assessment of H2-producing microalgae across multiple strains and conditions in 96-well plates, with a total workflow time of ~ 6 h from setup to data acquisition. Benchmarking the microplate assay against six well-characterised Chlamydomonas reinhardtii strains demonstrated strong concordance with photobioreactor data, while exhibiting good technical precision and biological reproducibility. Chemical-inhibitor treatments revealed pathway-specific contributions to H2 evolution and highlighted the constraining role of PSII-derived O2 under illuminated conditions. Importantly, the assay supports assessment of H2 production under photoautotrophic conditions, which remain challenging to establish in standard photobioreactor workflows. This assay directly addresses the limited throughput and poor reproducibility that currently constrain phenotypic screening in microalgal H2 research. While not a substitute for larger-scale, long-term photobioreactor-based quantitative studies, it provides a rapid, robust and small-scale upstream screening tool to prioritise strains, mutants, and experimental conditions for downstream analysis, thereby accelerating early-stage phenotypic evaluation in microalgal H2-production workflows. In this role, adoption of this assay provides a basis for standardising H2-phenotyping workflows and supporting the development of next-generation microalgal H2 production processes.

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