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articaine hydrochloride + epinephrine (Septocaine)

✓ Approved

GC corporation · Small Molecule · Small Molecule

What is articaine hydrochloride + epinephrine?

articaine hydrochloride + epinephrine is a small molecule developed by GC corporation. It is approved for therapeutic indications via injectable (others).

Drug Profile

Brand NamesSeptocaine
CompanyGC corporation
Drug ClassSmall Molecule
RouteInjectable (Others)
StatusApproved
Sources: ClinicalTrials.gov, GC corporation

Therapeutic Indications

articaine hydrochloride + epinephrine is developed for 2 unique indications across 1 therapeutic area.

Therapeutic AreaConditionPhase
Nervous system disordersAnaesthesia✓ Approved
Nervous system disordersSensory loss✓ Approved

Related Research Articles

PubMedActa paediatrica (Oslo, Norway : 1992)2026-11-11

Management and Outcome of Paediatric Septic Shock Requiring Vasoactive Therapy: A Multicentre Prospective Observational Study.

Üdürgücü Muhammed M, Yener Nazik N, Akyüz Betül Demir BD, İnce Büşra Daştan BD et al.

Although vasoactive drugs are recommended for paediatric septic shock requiring vasoactive therapy (PSSRVT), evidence on optimal agent selection remains limited. This study aimed to describe clinical characteristics, vasoactive drug use, adjunctive treatments, and outcomes of patients with PSSRVT. This multicentre, prospective study was conducted between 1 October 2024 and 30 April 2025, across 16 Paediatric Intensive Care Units (PICUs). The study included 225 PSSRVT patients treated with vasoactive agents, with a PICU frequency of 5%. Normal saline was administered in 93% of cases (mean 29.6 ± 14.0 mL/kg). A single vasoactive drug was used in 23% of patients, while 45% received two. Epinephrine was the most common first-line drug (70%), followed by norepinephrine (27%). Corticosteroids were used in 53% of vasopressor-resistant cases, with a median vasoactive inotrope score (VIS) of 60 (40-100). Among patients requiring intubation due to escalating sepsis severity, the median (IQR) VIS at the time of intubation was 50 (30-70). Overall mortality was 59%. Multiple vasoactive drugs were required in most patients, with usage patterns differing from previous reports. The median VIS at corticosteroid initiation was close to the VIS threshold associated with increased mortality. Further studies are needed to optimize vasoactive agent selection and sequencing.

PMID 43012742
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PubMedZhonghua nan ke xue = National journal of andrology2026-11-11

[Effect of esketamine on anesthesia and postoperative analgesia in patients with prostate resection: Based on oxidative stress response].

Liu Dapeng D, Feng Lingling L, Yao Qun Q, Li Jianwei J et al.

Objective To investigate the effects of esketamine on postoperative analgesia, cognitive function, oxidative stress and safety in patients with electroprostatectomy. Methods One hundred and twenty patients who underwent electroprostatectomy in Zaozhuang Municipal Hospital from October 2021 to May 2022 were selected and divided into experimental group and control group according to the different treatment, with 60 cases in each group. The patients in control group were treated with routine sufentanil during the operation. And esketamine hydrochloride was used in the experimental group at the dosage of 0.2 mg/kg 10 minutes before the end of the operation. VAS score and MMSE score were recorded at 0.5, 2, 4 and 12 h after surgery. The levels of oxidative stress indexes including NE and GSH-Px were compared between the two groups, and the postoperative urinary tract irritation and adverse reactions were analyzed. Results There was significant difference in VAS score between the two groups at 0.5 h and 2 h after surgery (P<0.05), but no significant difference at 4 h and 12 h (P>0.05). There was significant difference in MMSE score at 0.5 h after operation (P<0.05). The scores of urethral irritation in the experimental group were significantly lower than those in the control group at 0.5 h and 2 h after operation (P<0.05), and the inhibition effect on urethral irritation was significant. After anesthesia, the levels of NE and GSH-Px in experimental group showed a more dramatic improvement compared to control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion Esketamine has good postoperative analgesic effect in elderly patients undergoing transurethral resection of prostate with a temporary effect on early postoperative cognitive function, which alleviates symptoms of urinary duct irritation and oxidative stress caused by surgery.

PMID 43012260
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PubMedZhonghua nan ke xue = National journal of andrology2026-11-11

[Clinical efficacy and mechanism of Liniao Tonglin decoction in treating UU-infected oligoasthenospermia with dampness-heat pouring down syndrome].

Zhu Fanyu F, Li Ninghua N, Yang Wentao W

Objective To explore the clinical effect and mechanism of Liniao Tonglin decoction on oligoasthenospermia caused by Ureaplasma urealyticum (UU) infection with dampness-heat pouring down syndrome. Methods Eighty-eight patients were randomly divided into control group and observation group, with 44 cases in each group. The patients in control group were treated with doxycycline hydrochloride enteric-coated capsules and doxycycline tablets. While the patients in observation group were treated with Liniao Tonglin decoction on the basis of the treatment given to the control group. Both groups were treated for 14 days. Sperm concentration, total sperm count, progressive motility sperm rate(PR%), sperm motility rate（［PR+NP］%）, seminal plasmic elastase, interleukin-6(IL-6), interleukin-17(IL-17) levels TCM syndrome score and negative conversion rate of UU were compared between the two groups before and after the treatment. Results The overall efficacy rate of the observation group was significantly higher than that in the control group (86.05% vs 66.67% , χ2=4.435, P<0.05). UU negative conversion rate was also superior in the observation group (95.35% vs 88.10%，P>0.05). The increases in sperm concentration, total count, PR%, and （PR+NP）% (P<0.05) exhibited in both of two groups after the treatment, with significantly greater improvements in the observation group (P<0.05). The levels of seminal elastase, IL-6, IL-17 and TCM syndrome scores declined in both groups (P<0.05), with greater improvements in the observation group as well (P<0.05). Conclusion Liniao Tonglin decoction combined with antibiotics improves the count and motility of sperm and TCM syndrome score of oligoasthenospermia induced by UU infection with dampness-heat pouring down syndrome, increases the negative rate of UU, inhibits the expression of inflammatory factors, and changes the patency of reproductive tract and the living environment of sperm.

PMID 43012219
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PubMedZhonghua zhong liu za zhi [Chinese journal of oncology]2026-11-11

[Mitoxantrone hydrochloride liposomes combined with R-GDP regimen in the treatment of relapsed/refractory diffuse large B-cell lymphoma: a single-arm, multicenter, exploratory clinical study].

Ma L L, Zhao J J, Wang J R JR, Zheng M J MJ et al.

Objective: To evaluate the efficacy and safety of the mitoxantrone liposome combined with R-GDP regimen (R-GDP-Mito regimen) in the treatment of relapsed or refractory diffuse large B-cell lymphoma (DLBCL). Methods: From May 2023 to September 2025, a total of 33 patients with relapsed/refractory DLBCL(R/R DLBCL) were enrolled from multiple centers, including Shanxi Provincial Cancer Hospital, Jincheng People's Hospital of Shanxi Province, Heping Hospital Affiliated to Changzhi Medical College, and Datong Second People's Hospital of Shanxi Province. All patients received 2 to 6 cycles of the R-GDP-Mito regimen. The short-term and long-term efficacy as well as adverse events were analyzed. Results: Among the 33 patients, 16 achieved complete remission (CR), 11 achieved partial remission (PR), 3 had stable disease (SD), and 3 experienced disease progression (PD). The objective response rate (ORR) was 81.8% (27/33), with a 95% CI of 61.4% to 92.3%. The median time to best response was 1.9 months. With a median follow-up of 4.8 months, disease progression was observed in 4 patients, and 5 patient deaths were recorded, attributed to disease progression and severe pulmonary infection, respectively. The median progression-free survival (PFS) was not reached, while the median overall survival (OS) was 16.1 months. The 1-year PFS and OS rates were 56.6% and 90.5%, respectively. All 33 patients experienced adverse events (AEs). Hematological AEs occurred in 60.6% (20/33) of patients, and non-hematological AEs occurred in 81.8% (27/33) of them. Conclusion: The R-GDP-Mitoregimen demonstrates high antitumor activity and well-controlled safety profile in R/R-DLBCL patients, offering a promising new therapeutic option, particularly for those unable to immediately access or tolerate novel targeted or immunotherapy regimens.

PMID 43010748
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PubMedJournal of endodontics2026-11-10

Efficacy of Preoperative High-Power Diode Laser Irradiation in Reducing Local Anesthetic Volume: A Randomized Clinical Trial.

Leonardi Renato de Toledo RT, Berbert Fabio Luiz Camargo Villela FLCV, Aranda Jesus J, Herrera Henry H et al.

Local anesthesia is fundamental in dental practice to ensure patient comfort and pain control during invasive procedures. This study evaluated whether preoperative high-power diode laser (HPDL) irradiation reduces the volume of local anesthetic required to achieve effective anesthesia during endodontic treatment of teeth with symptomatic irreversible pulpitis (SIP) without compromising clinical efficacy or patient comfort. Sixty patients (ASA I-II, aged 18-60 years) diagnosed with SIP in mandibular posterior teeth were randomly allocated into two groups (n = 30): Control Group (CG)- 1.8 mL 4% articaine with epinephrine, and Experimental Group (EG)- HPDL irradiation (810 nm; 1.2 W) at the puncture site prior to administering a volume of 0.9 mL. Primary outcomes were anesthetic success rate and onset latency. Pain intensity (VAS 0-10) was measured during needle insertion, coronal access, and instrumentation. In the CG, mean VAS scores were 4.27 at puncture, 2.74 during coronal access, and 1.56 during instrumentation. Anesthetic success was achieved in 76.7% of CG, with 23.3% requiring supplemental anesthesia. The EG demonstrated a 100% anesthetic success rate with 0% requiring supplemental reinforcement (P< .05). Mean VAS scores in the EG were significantly lower: 2.33 at puncture, 1.50 during coronal access, and 0.20 during instrumentation. Profound anesthesia onset within 3 minutes was observed in 60% of EG compared to 40% in CG. Preoperative HPDL irradiation effectively halves the required local anesthetic volume while maintaining 100% clinical efficacy and superior patient comfort during endodontic treatment of mandibular teeth with SIP.

PMID 43008848
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PubMedChemphyschem : a European journal of chemical physics and physical chemistry2026-11-10

Interconversion Among Different Forms of Lumichrome in Aqueous Pluronic P84 Solutions: Effects of Glucose, Urea, and Guanidine Hydrochloride.

Giri Suman Kalyan SK, Manna Sagar Kumar SK, Seth Debabrata D

This work represents a detailed photophysical investigation of Lumichrome (LuC) in a hydrophobic triblock copolymer, Pluronic P84, as a function of the kosmotropic osmolyte, glucose, and the chaotropic osmolytes, urea and guanidine hydrochloride (GH). The spectral characteristics of LuC demonstrate that, addition of glucose lowers the critical micelle temperature (CMT) of P84, suggesting that dehydration of poly (propylene oxide) (PPO) blocks of P84 through the "sugaring-out" phenomena promotes micellization. In contrast, urea and GH increase the CMT of P84, indicating enhanced polymer hydration and weakened hydrophobic interactions that hinder micellization. Fluorescence spectra of LuC illustrate that osmolytes and temperature modulate the microenvironment of LuC. This was confirmed by finding different forms of LuC in P84 micelles with help of steady state and time resolved fluorescence emission studies. The emission spectrum shows a blueshift as temperature increases. The addition of glucose produced no significant shift in the dominant ~460 nm emission band, while additional emission features/shoulders appeared around ~530 and ~436 nm. Fluorescence lifetime data suggest that, along with 7,8-dimethylalloxazine (DMAL) form, A10, A3 and 7,8-dimethylisoalloxazine (DMIS) species of LuC may also exist within the P84 micelle. Fluorescence anisotropy measurements revealed distinct osmolyte-dependent rotational dynamics, indicating changes in the microenvironment surrounding LuC.

PMID 43004135
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