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DTwP-HepB-Hib-IPV vaccine (Easysix)

✓ Approved

Panacea Biotec Limited · Recombinant Proteins · Recombinant Proteins

What is DTwP-HepB-Hib-IPV vaccine?

DTwP-HepB-Hib-IPV vaccine is a recombinant proteins developed by Panacea Biotec Limited. It is approved for therapeutic indications via injectable (others) or intramuscular (im) injection.

Drug Profile

Brand NamesEasysix
CompanyPanacea Biotec Limited
Drug ClassRecombinant Proteins, Vaccine
RouteInjectable (Others), Intramuscular (IM) Injection
StatusApproved
Sources: ClinicalTrials.gov, Panacea Biotec Limited

Therapeutic Indications

DTwP-HepB-Hib-IPV vaccine is developed for 5 unique indications across 2 therapeutic areas.

Therapeutic AreaConditionPhase
Infections and infestationsDiphtheria✓ Approved
Infections and infestationsHepatitis B✓ Approved
Infections and infestationsPertussis✓ Approved
Infections and infestationsTetanus✓ Approved
Surgical and medical proceduresPolio immunisation✓ Approved

Related Research Articles

PubMedLancet regional health. Americas2026-09-20

Assessing methodological differences in estimating exposure to intimate-partner violence against women in Brazil: a multi-source observational analysis.

Stein Caroline C, Vasconcelos Nádia Machado de NM, Coll Carolina Vn CV, Murray Joseph J et al.

Intimate partner violence (IPV) is a global public health issue. However, prevalence estimates vary depending on the data source and methodology used. This study aimed to assess methodological differences in estimating the prevalence and age distribution of physical and sexual IPV across multiple Brazilian data sources. We assessed and analyzed seven Brazilian data sources: five surveys and two administrative datasets. Surveys used either the World Health Organization (WHO) instrument on violence against women and adaptations or an adapted version of the Revised Conflict Tactics Scales. The analysis included only women aged 16 years or older, and race was not examined. Recall periods varied from 12 to 24 months. We estimated prevalence and age distribution of physical and sexual IPV with 95% confidence intervals (CIs). The seven sources represented national, regional, and local populations. Methodological differences, including questionnaires, interview settings, data collection methods, and recall periods, may explain variation across data sources. Among national-level estimates, physical IPV prevalence ranged from 0.4% (0.3-0.7) to 13.0% (8.3-17.8) across data sources and age strata, with all sources consistently showing higher prevalence and proportions among younger women. For sexual IPV, no age group pattern emerged in prevalence or proportions. This study revealed substantial heterogeneity in estimates of IPV prevalence and age distribution. Without a gold standard for IPV measurement, these findings underscore the need to interpret available estimates in light of the methodological context in which they were generated. The Gates Foundation.

PMID 42763548
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PubMedAdvances in virology2026-09-20

Comparative Sequence Analysis of the Envelope Gene of Kyasanur Forest Disease Virus Vaccine Strain With Currently Circulating Field Strains.

Kaje Keerthi K, Marinaik Chandranaik B CB, Gomes Amitha Reena AR, Rizwan Apsana A et al.

The present study was undertaken with the objective of performing comparative sequence analysis of the envelope (E) gene of Kyasanur forest disease virus (KFDV) vaccine strain P9605 with the circulating field strains. The study was taken up as the currently used KFDV vaccine strain, KFDV P9605, was isolated in the 1960s. For this study, we designed two sets of primers targeting the complete amplification of the E gene of KFDV. The sequencing was performed by the Sanger method, and the deduced sequence of the vaccine virus was deposited in GenBank with accession number PX067005. This sequence obtained for the vaccine virus was aligned and compared with sequences of GenBank-deposited circulating field strains. We also performed comparative sequence analysis of the Kyasanur forest disease (KFD) vaccine seed virus having passaged twice in mouse brain with the vaccine seed virus passaged six times in mouse brain to investigate whether multiple passages in mouse brain will lead to genetic mutation in the immunologically important E gene. The phylogenetic analysis revealed seven amino acid mutations in the field strains at positions A123T, S158N, D178E, D239N, A313S, M429I, and G479A when compared with the vaccine strain. We did not find any mutations at the critical fusogenic segment (residues 98-113) in the E gene of currently circulating field strains compared to the vaccine seed virus. The study found no genetic variations in the E gene of the KFD virus passed two times and passed six times in mouse brain. We performed SWISS-MODEL homology modeling, AlphaFold protein analysis, and Ramachandran plot analysis to study the E protein structures and stability. The observations made in this study suggest slow evolutionary drift and conserved structural stability of the envelope gene of KFDV ever since its emergence 7 decades ago; however, the functional implications of these amino acid substitutions need further studies on their roles in viral infectivity, transmission, and impact on immunity.

PMID 42763584
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PubMedAnnals of epidemiology2026-09-19

A methodological examination of intimate partner violence-related traumatic brain injury in a national panel survey.

Daugherty Jill J, Friar Norah N, Smith Sharon G SG, Siordia Carlos C et al.

Despite challenges in assessing the true prevalence, survivors of intimate partner violence (IPV) are believed to be at a uniquely high risk of traumatic brain injury (TBI). This study examines the feasibility of using a national internet panel survey to capture the frequency of experiencing IPV-related TBI. Data were obtained in 2024 from CDC's National Center for Health Statistics' Rapid Survey System. Adult respondents self-reported experiences with select forms of physical IPV and any IPV-related head or face injuries. Frequency of physical violence, injury to the head or face due to physical violence, IPV-related TBI, TBI symptoms, and healthcare evaluation patterns after TBI were compared by sex of respondent. Estimates with non-overlapping 95% confidence intervals were considered statistically significant differences. Approximately 9.0% (95% CI 7.8,10.2) of women and 2.7% (95% CI 2.1,3.3) of men reported a possible or probable IPV-related TBI in their lifetime. Three-quarters of adults who reported an IPV-related TBI indicated that they were not examined by a healthcare professional after their most severe injury to their head or face. A national internet panel survey can sufficiently capture the frequency of IPV-related TBI and important related information, including symptoms and healthcare seeking, to inform prevention and response efforts. These findings suggest that millions of Americans have experienced IPV-related TBI, with women disproportionately affected.

PMID 42763087
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PubMedEClinicalMedicine2026-09-19

Effectiveness of the 2025-2026 seasonal influenza vaccine among U.S. veterans: an observational study.

Xie Yan Y, Choi Taeyoung T, Al-Aly Ziyad Z

Annual vaccination is the primary strategy for preventing adverse clinical outcomes associated with seasonal influenza, but vaccine effectiveness varies by season with the degree of antigenic match and the predominant circulating subtype. The 2025-2026 season has been dominated by a newly emerged, antigenically distinct influenza A(H3N2) subclade K that arose after the vaccine strain was selected, raising concern about a vaccine mismatch and reduced effectiveness. Contemporary, season-specific evidence on effectiveness against clinically important outcomes is needed. We used U.S. Department of Veterans Affairs (VA) electronic health records to emulate a series of 24 sequential 7-day target trials among VA users with an in-person primary care visit between September 15, 2025, and February 28, 2026, comparing those who did and did not receive a seasonal influenza vaccine at the visit. The final analytic cohort comprised 1,401,492 participant-trials (526,350 vaccinated and 875,142 unvaccinated). Exposure was defined as receipt of the 2025-2026 seasonal influenza vaccine on the date of an eligible primary care visit, compared with no seasonal influenza vaccination at that visit or during follow-up. The primary outcome was a composite of seasonal influenza-associated emergency department visit or hospitalization. Individual components were also evaluated. Vaccine effectiveness (VE), defined as 1 minus the risk ratio, was estimated as the per-protocol effect among vaccinated participants using discrete-time survival models with inverse-probability-of-treatment and inverse-probability-of-censoring weighting. Marginal cumulative risks, and risk differences (RDs) per 10,000 persons, together with risk ratios, were estimated. Compared with no vaccination, receipt of the 2025-2026 vaccine was associated with a lower risk of the composite outcome (VE, 21.95%; 95% CI, 16.08%-27.65%; RD per 10,000 persons, -4.94; 95% CI, -6.49 to -3.47), influenza-associated emergency department visits (VE, 22.25%; 95% CI, 16.38%-27.94%; RD, -5.01; 95% CI, -6.55 to -3.53), and influenza-associated hospitalizations (VE, 31.84%; 95% CI, 14.77%-46.27%; RD, -1.08; 95% CI, -1.82 to -0.44). Vaccination was associated with lower risk of the composite outcome across prespecified subgroups defined by age (≤65 and >65 years) and immunocompromised status. Results were consistent across multiple sensitivity analyses, and negative outcome controls (all-cause hospitalization and all-cause death within 14 days) showed no association with vaccination. In analyses applying the same design to the 2024-2025 season, vaccine effectiveness was lower in 2025-2026 than in 2024-2025 for every outcome (composite, 21.95% vs 32.15%; approximately 30% lower in relative terms). The 2025-2026 seasonal influenza vaccine was associated with reductions in influenza-associated emergency department visits and hospitalizations, but its effectiveness was lower than in the immediately preceding season. These findings provide contemporary, season-specific evidence supporting the continued use of seasonal influenza vaccination to prevent clinically important influenza outcomes. U.S. Department of Veterans Affairs.

PMID 42761462
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PubMedMedical microbiology and immunology2026-09-19

Pneumococcal vaccine serotype-specific antibody levels among PCV-unvaccinated children in Karnataka, India.

Ramakrishnan Shincy M SM, Ranjith R H RH, Mavuppadi Akhila M AM, Yashoda Honnamachanahalli T HT et al.

The immunogenicity of pneumococcal vaccines is commonly assessed using post-vaccination serotype-specific IgG antibody concentrations. Therefore, characterization of baseline antibody levels in vaccine-naïve populations is essential for understanding naturally acquired immunity and accurately interpreting vaccine responses. However, data on baseline serotype-specific IgG levels in healthy, unvaccinated Indian children remain limited. This study aimed to measure baseline serotype-specific pneumococcal IgG antibody levels in healthy vaccine-naïve Indian children. Baseline serotype-specific IgG antibody concentrations against 24 pneumococcal vaccine serotypes were measured in 600 healthy PCV-unvaccinated Indian children aged ≤ 5 years using the WHO-recommended ELISA method. Geometric mean concentrations (GMCs) were calculated for each pneumococcal serotype, and variations in antibody levels were analyzed according to age, gender, and season. Baseline IgG GMCs varied widely across serotypes, ranging from 0.14 µg/mL for serotype 12 F to 5.65 µg/mL for serotype 14. Overall, 71% of serotypes exhibited GMCs above the proposed protective threshold of 0.35 µg/mL. Age-dependent increases in antibody concentrations were observed, with peak GMCs in children aged > 36-≤48 months. Gender-based differences were minimal, with significantly higher GMCs observed in females only for serotype 9 N, whereas seasonal variation was evident for selected serotypes. Healthy Indian children demonstrate considerable heterogeneity in baseline serotype-specific pneumococcal IgG levels prior to vaccination. These findings provide important baseline immunological data on serotype-specific pneumococcal IgG levels in healthy, PCV unvaccinated Indian children and may serve as a useful reference for interpreting future pneumococcal vaccine immunogenicity studies and seroepidemiological investigations.

PMID 42762261
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PubMedAsia-Pacific journal of public health2026-09-19

Advancing Vaccine Security in Pandemic Preparedness: Malaysia's Growing Role, Opportunities and Challenges.

Md Hamzah Nurhafiza N, Mahmood Jemilah J, Renganathan Elil E

The COVID-19 pandemic underscores the need to promote and protect well-being by strengthening prevention, preparedness and response to global health threats. It also demonstrated the need for coordinated national and international efforts, particularly to ensure equitable access to vaccines during public health crises. Malaysia has implemented robust pandemic preparedness measures, although its COVID-19 experience highlighted the need to improve access to life-saving vaccines and to take urgent action towards achieving vaccine security to safeguard public health. Recent initiatives have demonstrated a commitment to this goal, but additional efforts are required to ensure sustainability. In this article, we examine Malaysia's efforts to strengthen vaccine security and the role of international partnerships in supporting this agenda. Malaysia has significant opportunities to promote its biopharmaceutical industry and advance vaccine security. However, the long-term success of these efforts will depend on sustainable investment, stronger coordination, and strategic alignment between domestic capability and international partnership-building.

PMID 42762057
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