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DTwP-HepB-Hib-IPV vaccine (Easysix)

✓ Approved

Panacea Biotec Limited · Recombinant Proteins · Recombinant Proteins

What is DTwP-HepB-Hib-IPV vaccine?

DTwP-HepB-Hib-IPV vaccine is a recombinant proteins developed by Panacea Biotec Limited. It is approved for therapeutic indications via injectable (others) or intramuscular (im) injection.

Drug Profile

Brand NamesEasysix
CompanyPanacea Biotec Limited
Drug ClassRecombinant Proteins, Vaccine
RouteInjectable (Others), Intramuscular (IM) Injection
StatusApproved
Sources: ClinicalTrials.gov, Panacea Biotec Limited

Therapeutic Indications

DTwP-HepB-Hib-IPV vaccine is developed for 5 unique indications across 2 therapeutic areas.

Therapeutic AreaConditionPhase
Infections and infestationsDiphtheria✓ Approved
Infections and infestationsHepatitis B✓ Approved
Infections and infestationsPertussis✓ Approved
Infections and infestationsTetanus✓ Approved
Surgical and medical proceduresPolio immunisation✓ Approved

Related Research Articles

PubMedBMC psychiatry2026-11-11

The association between childhood exposure to inter-parental violence and depression in middle-aged and older adults: an empirical analysis from China.

Li Dongxu D, Li Wenhui W, Zhang Weile W, Zhang Tianjiao T et al.

The association between exposure to inter-parental violence (IPV) and depression remains to be further explored. This study aimed to explore the association between childhood exposure to IPV and depression in middle-aged and older adults, and to explore the mediating roles between the two. Using data from the 2011, 2013, 2015, 2018, and 2020 China Health and Retirement Longitudinal Study (CHARLS), and the 2014 Life History Survey Questionnaire. Generalized estimating equation was used to investigate the relationship between childhood exposure to IPV and depression in middle-aged and older adults, the bootstrap method was used to analyse the mediating roles between the two, and multi-group analysis was used to examine the gender differences in their relationship. A total of 9,909 sample were included in the study. This study found 18.6% of the sample exposure to IPV in childhood. IPV was positively associated with depression (β = 0.804,95%CI: 0.592,1.015), father-to-mother violence was positively associated with depression (β = 0.777,95%CI: 0.564,0.991), mother-to-father violence was positively associated with depression (β = 0.796,95%CI: 0.434,1.157), and father-and-mother violence was positively associated with depression (β = 0.731,95%CI: 0.351,1.112). IPV and depression may operate partly through smoking and drinking. The association between IPV and depression (P = 0.017), and between father-to-mother violence and depression (P = 0.023), were both weaker among males than among females. Childhood exposure to IPV was positively associated with depression in middle-aged and older adults. The association between IPV and depression may operate partly through smoking and drinking. The associations between IPV and depression, and between father-to-mother violence and depression, were stronger among female respondents. There is a need to pay attention to depression among those who exposure to IPV in childhood.

PMID 43009861
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PubMedWomen's health (London, England)2026-11-11

Psychometric properties of the German WHO violence against women instrument (WHO-VAWI) in postpartum women: Results from the INVITE study.

Mojahed Amera A, Seefeld Lara L, Schellong Julia J, Garthus-Niegel Susan S

BackgroundThe presence of intimate partner violence (IPV) during the postpartum period can have serious consequences for the health and well-being of both the mother and the child. This period is characterized by heightened vulnerability and unique psychosocial and healthcare-related factors. Different interpretations of IPV can create challenges in research and clinical practice. Accurate and reliable measurement tools are therefore essential to assessing IPV experiences after childbirth.ObjectivesThis study aimed to evaluate the psychometric properties of the German WHO Violence Against Women Instrument (WHO-VAWI) in postpartum women.DesignCross-sectional study.MethodsThis investigation used data from the INVITE study, which was conducted in Germany. Of 9,372 postpartum women approached, 44.4% (n=4,160) responded. In the final sample (n=3,452), the primary outcomes were self-reported exposure to four IPV types using the multidimensional WHO-VAWI. It included controlling behaviors (7 items), psychological (4 items), physical (6 items), and sexual IPV (3 items).ResultsConfirmatory factor analysis showed that the unidimensional model did not fit well (RMSEA = 0.058, CFI = 0.909, TLI = 0.898, SRMR = 0.163). However, the multidimensional WHO-VAWI model without the latent factor "IPV" demonstrated a good fit (RMSEA = 0.016, CFI = 0.993, TLI = 0.992, SRMR = 0.055), as did the model with the latent factor "IPV" (RMSEA = 0.016, CFI = 0.994, TLI = 0.993, SRMR = 0.058). Cronbach's alpha coefficients for subscales ranged from 0.65 to 0.81, and McDonald's omega ranged from 0.68 to 0.82. The instrument discriminated well between groups exposed to physical/sexual IPV and child abuse (χ2(1, N=3,446) = 127.5, p<0.001).ConclusionsThe German WHO-VAWI showed acceptable to good psychometric properties for measuring IPV among postpartum women, confirming IPV as a multidimensional construct. Future studies should explore its integration into routine postpartum care and investigate the cultural adaptation of specific items within the controlling behaviors and psychological violence subscales.

PMID 43012298
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PubMedJournal of interpersonal violence2026-11-11

"I Took the Charge": Coercive Control, Legal Vulnerability, and Intimate Partner Violence Service Navigation Among Black Women Under Community Supervision: A Qualitative Study.

Richer Ariel A, West Brooke S BS, Goddard-Eckrich Dawn D, El-Bassel Nabila N et al.

Black women under community supervision who use drugs experience disproportionately high rates of intimate partner violence (IPV), yet little research has examined how intersecting identities related to race, sexual behavior, substance use, and criminal-legal involvement shape their experiences of IPV and access to services. Guided by Minority Stress Theory, this nested qualitative study explored patterns of IPV and service utilization among Black women under community supervision who have sex with women and men and participated in a prior randomized controlled trial in New York City. Fifteen in-depth, semi-structured interviews were conducted between July and September 2022 via Zoom with women who reported lifetime IPV and drug use. Interviews were transcribed verbatim and analyzed using a grounded, two-cycle coding approach. Participants described severe and overlapping forms of IPV perpetrated primarily by male partners, including physical, sexual, psychological, and financial abuse. Women also identified coercive tactics not routinely captured in standard IPV measures, including spiritual abuse and "taking a charge" for a partner to avoid his incarceration. Violence within relationships with female partners was often described as mutual or bidirectional. Criminal-legal supervision functioned as both a barrier and facilitator to help-seeking: fear of arrest, probation violations, and prior negative police interactions discouraged reporting, whereas supportive probation or parole officers sometimes facilitated access to services. Participants emphasized that traditional IPV services were insufficient without structural support such as housing, employment, and mental health care. Findings suggest that IPV among Black women under community supervision is embedded within intersecting structural vulnerabilities that shape both coercive control and service navigation. Implications include the need for culturally responsive IPV assessment tools, trauma-informed and holistic service models, and alternative pathways to safety that reduce reliance on law enforcement systems.Trial Registration: ClinicalTrials.gov Identifier: NCT02391233 (https://clinicaltrials.gov/study/NCT02391233).

PMID 43010699
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PubMedJournal of marriage and the family2026-11-11

Intimate Partner Violence, Ambiguous and Non-Consensual Non-Monogamy, and Breaking Up During Young Adulthood.

Barber Jennifer S JS, Kusunoki Yasamin Y

This study examines how intimate partner violence (IPV) and two types of non-monogamy- ambiguous consent non-monogamy (ACNM; concurrent sexual partners in relationships without an explicit agreement about monogamy or non-monogamy) and non-consensual non-monogamy (NCNM; cheating in relationships committed to monogamy)-co-occur and shape the probability of dissolution. Ending a relationship can be normative and healthy, particularly when it reflects a response to harmful dynamics. Data are from the Relationship Dynamics and Social Life study, including 27,924 weekly surveys from 895 young women and in-depth interviews with 58 young women. Descriptive statistics assess clustering of IPV types and their co-occurrence with ACNM and NCNM. Relationship-level fixed effects models estimate the weekly probability of dissolution across 2,529 intimate relationships. A narrative thematic analysis of in-depth interviews assesses the logics underlying decisions to remain in or dissolve relationships. Non-monogamy (both NCNM and ACNM) and partner-perpetrated IPV frequently co-occurred. The probability of relationship dissolution was much higher following either NCNM or ACNM. The probability of dissolution was somewhat higher following some types of IPV but not following assault or threats. Findings, interpreted through expectancy violations theory, suggest NCNM and ACNM function as powerful relational breaches, while physical IPV (assault) may operate differently from chronic psychological IPV in predicting dissolution. Researchers and sexuality educators should address adverse experiences as a relational system.

PMID 43011640
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PubMedFrontiers in public health2026-11-11

Person-centered, trauma-informed care and support for resilience after intimate partner violence: an integrative review through a neurobiological lens.

Kerekes Nóra N, Ackemo Caroline C, Alfredsson Erika E, Sfendla Anis A

Intimate partner violence (IPV) is a major global public health concern with severe physical, psychological, and social consequences, strongly associated with chronic stress and diminished wellbeing. IPV often remains under-identified within healthcare and social care settings, with shame, guilt, and stigma acting as barriers to help-seeking. Resilience-the capacity to regulate emotion, adapt, and recover following adversity-has emerged as a central concept in understanding recovery after IPV exposure. Person-centered, trauma-informed care facilities recovery by grounding care in the individual's needs, experiences, and resources and by accounting for how trauma affects the body and the capacity to trust care practitioners. The aim of this study was to analyze person-centered care and support interventions aimed at strengthening resilience in individuals exposed to IPV. An integrative literature review was conducted following Whittemdore and Knafl's methodology. It included 12 peer-reviewed studies published between 2015 and March 2026, retrieved from CINAHL and APA PsycInfo. Nine studies were qualitative, two quantitative, and one mixed methods; all appraised using the CASP framework. Findings were based on 544 participants exposed to IPV (537 women, 7 men, aged 15-73 years), alongside the perspectives of 31 care and support professionals, drawn from studies conducted across eight countries. Three main themes were identified: a safe, trusting, and accessible care relationship as a foundation for resilience; empowerment through participation, autonomy, and reclaiming control; and the mobilization of individual and social resources for long-term recovery, encompassing strength-based coping and supportive networks. Person-centered, trauma-informed care characterized by safety, trust, and genuine participation was central to strengthening resilience. Organizational barriers, along with gendered dynamics affecting autonomy could hinder access to support and recovery. Person-centered, trauma-informed care and support can strengthen resilience by fostering trust, participation, and empowerment. Resilience emerged as a dynamic, nonlinear process shaped by individual resources, relationships with care and support staff, and structural conditions. Trauma's effects on the nervous system offer a neurobiological basis for why consistency, predictability, and genuine attentiveness are prerequisites for effective care, not merely good practice. These findings underscore the need for training in trauma-informed, person-centered approaches across all professions supporting individuals exposed to IPV.

PMID 43011069
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PubMedBMC psychiatry2026-11-11

Assessing the psychometric properties of the Symptom Checklist Five-Items (SCL-5) instrument in a clinical setting for treating intimate partner violence.

Nesset Merete Berg MB, Palmstierna Tom T, Whittington Richard R, Lara-Cabrera Mariela Loreto ML

Research suggests that the Symptom Checklist Five Items (SCL-5) instrument is a reliable and valid scale for assessing mental health in a range of populations. Yet, to date, the SCL-5 has not been validated in a population of perpetrators of intimate partner violence (IPV) and their partners. Hence, the current study aimed to examine the psychometric properties of the SCL-5 within a clinical IPV context characterized by elevated mental health symptoms. This validation study is part of a randomised controlled trial evaluating a group intervention for men voluntarily seeking treatment for IPV in Norway. The study was conducted in accordance with the guidelines Consensus-based standards for the selection of health measurement instruments (COSMIN). We evaluated floor and ceiling effects, internal consistency and estimated the area under the curve to determine optimal diagnostic sensitivity and specificity. Additionally, we explored scale responsiveness using data from a subsample of participants. The highest percentage of respondents with the lowest possible score (value 1) across the 5 items was 8.7%, indicating no floor effect assuming the 15% criterion. The highest percentage with the highest possible score (value 4) across the 5 items was 1.9%, indicating no ceiling effect either. Cronbach's alpha was 0.86 for the total sample (N = 161), 0.83 for perpetrators only (n = 118) and 0.89 for partners only (n = 44). The area under the curve was 94.6% (95% CI 0.913-0.978) for the total sample, 93.5% (95% CI 0.893-0.977) for the perpetrators and 96.9% (95% CI 0.922-1.017) for the victims. Regarding responsiveness, we set a criterion of a statistically significant reduction in mean scores over time as a test of the adequate responsiveness of the SCL-5 from the baseline to the one-year follow-up point. As predicted, it fell from 1.98 to 1.74 and the mean change was significant (t -4.021, CI -0.360 to -0.121; p < 0.001). The mean total SCL-5 score decreased in 54% of cases (n = 43). The results provide evidence that the SCL-5 has adequate psychometric properties in a Norwegian sample of perpetrators and victims of IPV. Not applicable.

PMID 43009897
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