dutasteride + tamsulosin (Jalyn / Combodart / Duodart)

[Efficacy of human umbilical cord mesenchymal stem cells in the treatment of chronic nonbacterial prostatitis in rats].

DU Haiyan H, Zhang Kun K, Zhang Qin Q, Li Linghui L et al.

Objective To investigate the efficacy of human umbilical cord mesenchymal stem cell (hUCMSC) for the treatment of chronic nonbacterial prostatitis (CNP) model rats. Methods Thirty-two male Sprague-Dawley rats were randomized into four experimental subgroups: control, model, tamsulosin, and hUCMSC, with eight animals allocated to each group. CNP models were induced in all subgroups, except the control. After 28 days of modeling, the hUCMSC group was injected weekly with 1×106 cells/kg P5 hUCMSC cell suspension by tail vein for 4 weeks. In the control and model groups, equivalent volumes of normal saline were administered via injection. And the tamsulosin group was given daily gavage of 0.022 mg/kg tamsulosin solution for 28 days. After 4 weeks of treatment, the basic indexes including body weight, intake and water intake, and prostate index were analyzed in each group, HE staining was performed to characterize the histopathological features of the prostate. The levels of serum TNF-α, IL-1β, and IL-10 in rats were detected by ELISA. qRT-PCR was used to detect the mRNA expression of TNF-α and IL-1β in prostate tissues. And Western blot was performed to detect the protein expression of the NF-κB inflammatory pathway. Results At the end of treatment, compared with the model group, the body weight and water intake of the rats in the tamsulosin group and hUCMSC group increased significantly (P<0.05). There was a significant decline in prostate indexes and prostate wet weight (P<0.01). And interstitial inflammatory cells in prostate tissues were reduced. The levels of serum TNF-α and IL-1β and the expression of TNF-α and IL-1β mRNA in prostate tissues were significantly reduced (P<0.01). An opposite tendency was observed in IL-10 levels (P<0.01). p-IκBα/IκBα and p-NF-κB p65/NF-κB p65 ratios were significantly reduced (P<0.01). Conclusion hUCMSC improve the pathological state of rat prostate, inhibit the overexpression of pro-inflammatory factors, down-regulate the phosphorylation level of NF-κB signaling pathway, and alleviate the inflammatory response in CNP rats.

[Effects of biofeedback electrical stimulation integrated with Chinese medicine emotional care on alleviating symptoms in the patients with chronic prostatitis/chronic pelvic pain syndrome].

Tang Xue X, Wu Hui H, Ning Gang G, Peng Ajian A et al.

Objective To evaluate the efficacy of biofeedback electrical stimulation combined with Chinese medicine emotional nursing in improving symptoms among patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). Methods Seventy patients who met the inclusion criteria of CP/CPPS were randomly divided into the conventional group and the combined intervention group, with 35 cases in each group. The control group received oral tamsulosin sustained-release capsules along with routine care. In addition to the conventional treatment, the patients in combined intervention group received biofeedback electrical stimulation combined with Chinese Medicine emotional nursing. Biofeedback electrical stimulation was administered three times per week for a total of 8 weeks. The National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI), International Prostate Symptom Score (IPSS), Hamilton Anxiety Rating Scale (HAMA), and Hamilton Depression Rating Scale (HAMD) were used to assess patients at baseline, 4 weeks, and 8 weeks of intervention. Results No significant differences in baseline data were observed between the two groups before the intervention (P>0.05). After 4 and 8 weeks of intervention, both groups showed significant improvements in NIH-CPSI, IPSS, HAMA and HAMD scores compared to baseline (P<0.05). Compared to the control group, the combined intervention group demonstrated significantly greater reductions in the total NIH-CPSI score, its pain subscore, IPSS score, and HAMA score at both 4 and 8 weeks (P<0.05). By the 8th week, the combined intervention group also showed a significantly greater reduction in the NIH-CPSI urination subscore and HAMD score (P<0.05). However, no statistically significant intergroup difference was found in the NIH-CPSI quality of life subscore (P>0.05). Furthermore, the combined intervention group achieved significantly higher rates of nursing satisfaction (97.05%) and overall efficacy (91.18%) compared to the control group (P<0.05). Conclusion The combined intervention of biofeedback electrical stimulation and Chinese Medicine emotional nursing can significantly alleviate urinary symptoms, pelvic pain, and anxiety-depression moods in patients with CP/CPPS. Although there was no statistically significant difference in the quality of life scores between the two groups, the combined intervention may provide potential benefits for the long-term improvement of patients' quality of life in terms of the improvement of core clinical symptoms and emotional states.

Response: Long-term use of dutasteride to treat androgenic alopecia in young men may lead to persistent abnormalities in semen parameters.

Yu Young Dong YD

Letter: Long-term use of dutasteride to treat androgenic alopecia in young men may lead to persistent abnormalities in semen parameters.

Corona-Rodarte Eduardo E, Fuentes-Mendez Alejandro A, Zubirán Rafael R, Tosti Antonella A et al.