Drug Database
MF

MF-59 (MF59)

✓ Approved

Novartis AG · Small Molecule · Small Molecule

What is MF-59?

MF-59 is a small molecule developed by Novartis AG. It is approved for therapeutic indications via injectable (others).

Drug Profile

Brand NamesMF59
CompanyNovartis AG
Drug ClassSmall Molecule
RouteInjectable (Others)
StatusApproved
Sources: ClinicalTrials.gov, Novartis AG

Therapeutic Indications

MF-59 is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Surgical and medical proceduresOral appliance application✓ Approved

Related Research Articles

PubMedRevista brasileira de medicina do trabalho : publicacao oficial da Associacao Nacional de Medicina do Trabalho-ANAMT2026-07-25

Epidemiology of work-related musculoskeletal disorders in Brazil, 2007-2021.

Rosa Guilherme Octhávio Rodrigues da Silva GORDS, Hillesheim Danúbia D, Ruiz Roberto Carlos RC, Menegon Fabrício Augusto FA et al.

The intensification of labor exploitation contributes to the occurrence of work-related health conditions. In this context, the increasing prevalence of repetitive strain injuries (RSIs) and work-related musculoskeletal disorders (WMSDs) represents a major concern for the health of Brazilian workers. To describe the epidemiological profile and prevalence rates of RSIs and WMSDs among workers in Brazil based on notification records from the Brazilian Notifiable Diseases Information System (SINAN) between 2007 and 2021. A cross-sectional study was conducted using notification data from SINAN and population information obtained from the Brazilian National Household Sample Survey (PNAD), the Demographic Census, and the Continuous PNAD. Sociodemographic variables were described using absolute and relative frequencies. Prevalence rates were estimated according to year, sociodemographic characteristics, macroregions, and Brazil as a whole using Poisson regression. A total of 102,986 cases were reported during the study period. Over the 15-year period, the states of Piauí, Amapá, Roraima, Acre, and Rondônia each recorded fewer than 4,000 cases. In contrast, São Paulo reported more than 32,000 cases during the same period. The highest prevalence rates were observed in 2017 among women (12.84 per 100,000 workers), self-identified White individuals (8.19 per 100,000 workers), individuals with complete secondary or higher education (4.89 per 100,000 workers), and workers aged 40 to 59 years (10.69 per 100,000 workers). The highest prevalences of RSIs and WMSDs were observed among women, self-identified White individuals, people with complete secondary or higher education, and workers aged 40 to 59 years. In addition, disparities were identified in both notifications and prevalence rates across Brazilian states and macroregions.

PMID 42499562
Read full article →
PubMedJournal of surgical case reports2026-07-25

Malignant priapism as the presenting manifestation of penile metastasis following radical cystoprostatectomy for bladder urothelial carcinoma: a case report.

Nayeri Reza Kaffash RK, Banouei Farshad F

Penile metastasis is a rare but grave complication of systemic malignancies, occasionally manifesting as malignant priapism due to neoplastic infiltration of the corpora cavernosa. We report a 59-year-old male who presented with painful, refractory penile erection 3 years after radical cystoprostatectomy for bladder urothelial carcinoma (pT3bN0M0). Pelvic magnetic resonance imaging revealed a heterogeneous infiltrative mass involving the proximal corpora cavernosa bilaterally. 18F-fluorodeoxyglucose positron emission tomography/computed tomography confirmed multiple metabolically active penile lesions without distant metastasis. Core needle biopsy established the diagnosis of metastatic transitional cell carcinoma. Total penectomy was performed, and adjuvant chemotherapy was recommended. This case highlights the importance of clinical vigilance in urological malignancy survivors.

PMID 42500557
Read full article →
PubMedJournal of environmental sciences (China)2026-07-25

Surfactants promote microbial CO2 fixation by enhancing nutrient utilization.

Wang Jia J, Jiang Piao Yi PY, Liu Jia Bing JB, Tong Wang Kai WK et al.

Surfactants, essential chemicals in daily life, are widely utilized across industries, from pharmaceuticals to agriculture, leading to their extensive presence in soils and aquatic environments. Meanwhile, as microbial metabolites, surfactants play a crucial role in enhancing nutrient utilization and promoting the rapid growth of microorganisms. This study aimed to use anionic, nonionic, and cationic surfactants to promote the growth of autotrophic microorganisms and break through the bottleneck of low microbial CO2 fixation efficiency. Among them, only anionic surfactants exhibited significant and universal promoting effects, with a maximum enhancement of 59 %-95 % on autotrophic strains utilizing the Calvin cycle. Furthermore, anionic surfactants, in combination with autotrophic microorganisms, were applied as amendments to improve soil, effectively increasing soil organic carbon content by 27 %-54 %. The long-term effects of these amendments depend on several mechanisms: promoting the Calvin cycle, enhancing soil organic carbon metabolism, facilitating nutrient transport, and reducing the abundance of genes associated with surfactant-degrading enzymes. This study contributes to a deeper understanding of the impacts of surfactants on the environmental CO2 fixation capacity and introduces a novel approach for enhancing soil carbon sink capacity.

PMID 42498415
Read full article →
PubMedHNO2026-07-25

The European Board Examination in Otorhinolaryngology as a high-quality test instrument: psychometric measures in a long-term comparison.

Neudert Marcus M, Meric Hafiz Aysenur A, Ward Victoria V, Simo Ricard R et al.

The European Board Examination in Otorhinolaryngology, Head and Neck Surgery (EBEORL-HNS) is a Europe-wide specialty examination consisting of a written multiple-choice test and a standardized oral examination. Only limited psychometric analyses have been published to date. This study aimed to evaluate examination data from recent years and assess the formats regarding difficulty, reliability, and pass rates. Aggregated data from 2013-2024 were analyzed. Mean scores, standard deviations, item difficulty, item discrimination, Cronbach's alpha, and Angoff's score were calculated. The written and oral parts were examined descriptively and comparatively. The written examination demonstrated a mean difficulty of 67% (proportion of correctly answered items), a pass rate of 82%, and Cronbach's alpha of 0.83 (internal consistency). The passing cutoff (according to the Angoff method) was 59 points on average. The oral part showed a mean difficulty of 70%, a pass rate of 74%, and an average score of around 3.0 on a four-point scale. Year-to-year variability largely reflected differences in the international candidate cohorts. The findings confirm that the EBEORL-HNS demonstrates stable psychometric quality. Compared to national specialty examinations, it offers high transparency and clearly defined quality criteria. Variations in performance appear more related to heterogeneous training backgrounds than to shortcomings of the assessment tools.

PMID 42498845
Read full article →
PubMedEuropean heart journal. Digital health2026-07-25

Pharmacist-led, digitally enabled transitional care after acute myocardial infarction: design and baseline characteristics of the AMI-HOPE nationwide stepped-wedge trial.

Wang Melody M, Lim Zhi Zhen ZZ, Chan Siew-Pang SP, Teo Zhen-Long ZL et al.

To describe the design of AMI-HOPE, a pharmacist-led, digitally enabled transitional care intervention for patients after acute myocardial infarction (AMI), and its nationwide stepped-wedge cluster-randomized evaluation across Singapore's public healthcare system. AMI-HOPE is designed as a pragmatic, open-label trial across three health clusters (7 hospitals, 18 polyclinics) in which hospitals crossed over from standard cardiologist-led care to intervention at 3 month intervals. We utilize the Health Discovery+ (HD+) platform for remote vital signs monitoring, rule-based alerts, pharmacist-led teleconsultations, and automated patient education. Target N = 1512 (1:1 ratio); primary outcome is a hierarchical win ratio composite (CV death, MI, stroke, CV readmissions, low-density lipoprotein cholesterol, systolic blood pressure, HbA1c, patient-reported outcome measures). Secondary outcomes include guideline-directed medical therapy titration/adherence, LVEF, and cost-effectiveness. Enrolment completed in September 2025 (N = 1634 randomized; 810 control, 824 intervention). Baseline characteristics (N = 1492 in follow-up) showed a median age of 59 years, 12% female, 61% Chinese ethnicity. Twelve-month follow-up will complete on 30 September 2026. AMI-HOPE demonstrates a scalable, digitally enabled model shifting early post-AMI care from specialist-led clinics to pharmacists with remote monitoring. This nationwide trial evaluates its clinical efficacy, implementation, and value at population scale. ClinicalTrials.gov: NCT07443982.

PMID 42499410
Read full article →
PubMedThe American surgeon2026-07-25

Multidisciplinary Management of Recurrent Laryngeal Nerve Injury After Transhiatal Esophagectomy.

Evans Coleton C, Jomy Anish A, Martínez María Del Pilar MDP, Osman Houssam H et al.

Recurrent laryngeal nerve (RLN) injury is a significant morbidity following transhiatal esophagectomy (THE). While surgical platforms have evolved, the clinical burden and longitudinal management of these injuries remain under-characterized. This study evaluates RLN injury incidence and the effectiveness of a multidisciplinary management pathway in a contemporary cohort. A retrospective review of 135 patients undergoing THE with cervical anastomosis between 2017 and 2024 was conducted. The primary outcome was confirmed RLN injury via laryngoscopy and postoperative hoarseness. Predictors of injury and specialty follow-through with Otolaryngology (ENT) and Speech-Language Pathology (SLP) were analyzed. Postoperative hoarseness occurred in 43.7% (n = 59) of patients, while RLN injury was confirmed in 11.9% (n = 16), which falls within the reported national average. Surgical approach was not an independent predictor of injury (MIS vs. Open, P = 0.309). Notably, only 44.1% of symptomatic patients completed an ENT referral. However, 100% of those with confirmed paralysis required surgical intervention (eg, injection laryngoplasty and thyroplasty) to restore laryngeal function. Mean specialty follow-up for the intervention group was 20.8 months. RLN injury is a persistent complication of THE that is likely underdiagnosed by reactive, symptom-triggered screening. The 100% requirement for surgical correction among confirmed cases underscores that these injuries are rarely self-limiting. To bridge the significant gap in specialty follow-through and mitigate complications like aspiration, a standardized, proactive multidisciplinary referral protocol is necessary.

PMID 42498703
Read full article →

+9996 more articles available with a free account

Sign up free to view all articles →

Ask about MF-59