Drug Database
MF

MF-59 (MF59)

✓ Approved

Novartis AG · Small Molecule · Small Molecule

What is MF-59?

MF-59 is a small molecule developed by Novartis AG. It is approved for therapeutic indications via injectable (others).

Drug Profile

Brand NamesMF59
CompanyNovartis AG
Drug ClassSmall Molecule
RouteInjectable (Others)
StatusApproved
Sources: ClinicalTrials.gov, Novartis AG

Therapeutic Indications

MF-59 is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Surgical and medical proceduresOral appliance application✓ Approved

Related Research Articles

PubMedAnalytical chemistry2026-11-11

Improving Molecular Formula Assignment of Nitrogen- and Sulfur-Rich DOM in Ultrahigh-Resolution Mass Spectrometry: Validation of Oligopeptides.

Herzsprung Peter P, Lechtenfeld Oliver J OJ, von Tümpling Wolf W, Kamjunke Norbert N et al.

Molecular formula (MF) assignment in ultrahigh-resolution mass spectrometry (UHRMS) analyses of dissolved organic matter (DOM) containing multiple non-oxygen heteroatoms (e.g., nitrogen and sulfur) is highly environmentally relevant yet remains challenging. Recent studies of DOM composition in aquaculture systems with protein-rich surface sediments have reported numerous CHNO (N1-8), CHOS (S1-3), and even CHNOS MFs containing multiple N and S atoms, suggesting the presence of oligopeptide-like molecules. Due to insufficient mass resolution, multiple formula assignments (MultiAs) caused by interchangeable replacement pairs, within a mass error threshold of 1 ppm, complicate the validation of MF assignments. While N5S2 formulas are known as likely false-positive assignments of 13C1 isotopologue peaks, the multiple N-containing MFs in MultiAs of potential oligopeptide origins involving replacement pairs with N6 ↔ S1 and S2 ↔ N4 could not be validated properly. Here, we introduce a new chemically informed validation approach based on the elemental composition and stoichiometry of typical peptides with atomic ratios 0.2 < O/C < 0.65 and 1.5 < H/C < 2. Amino acid combinations matched about 36% N-rich MF (n = 960) among N6 ↔ S1 related MultiAs (N7 ↔ N1S1, N8 ↔ N2S1··· N8S2 ↔ N2S3) and 30% N-rich MF (n = 1040) among S2 ↔ N4 related MultiAs (N1S2 ↔ N5, N2S2 ↔ N6···N4S3 ↔ N8S1), supporting the true assignments of N-rich MFs based on oligopeptide stoichiometry. Overall, the chemical complexity of heteroatom-rich DOM warrants advances in MF assignment for UHR mass spectra by expanding the analytical window to include multiple-heteroatom formulas, which would especially benefit protein-rich samples from aquaculture systems or wastewater.

PMID 43010462
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PubMedMenopause (New York, N.Y.)2026-11-11

Validation of the Perimenopause Symptom Scale (Peri-SS) for digital self-assessment: psychometric evaluation among US women aged 35 to 59 years.

Xu Yihan Y, Ilyich Irina I, Prentice Carley C, Hewings-Martin Yella Y et al.

Perimenopause is an under-recognized transition poorly measured by existing tools, which often overlook symptoms characteristic of this phase. To address this, we developed and validated the Perimenopause Symptom Scale (Peri-SS): a concise, phase-specific, psychometrically robust instrument for digital self-assessment and research use among US women aged 35-59 who self-reported being in perimenopause. We conducted a longitudinal validation study with 1,255 US women aged 35-59 (633 self-identified as perimenopausal) recruited via Prolific. Participants completed the Peri-SS, Menopause Rating Scale (MRS), and EuroQol 5-Dimension, 5-Level (EQ-5D-5L) questionnaire at baseline and 7-14 days later. Following COSMIN guidelines, we assessed structural validity, internal consistency, test-retest reliability, criterion and construct validity, and responsiveness to change. The Peri-SS demonstrated strong psychometric performance. Confirmatory factor analysis confirmed a four-domain structure (vasomotor, psychological, sexual, physical), with excellent model fit (CFI=0.932, RMSEA=0.069). Internal consistency was excellent (α=0.90 overall; domain range 0.73-0.86), and test-retest reliability was high (ICC=0.82). Criterion validity was strong, with Peri-SS scores highly correlated with Menopause Rating Scale (r=0.88). Construct validity was supported through moderate correlations with EQ-5D-5L utilities (ρ=-0.50) and effective discrimination between groups by age, reproductive stage, and hormone therapy use. The scale was also responsive to symptom changes over time (η²=0.277). The Peri-SS is a reliable, valid, responsive tool for assessing perimenopausal symptom burden. Its concise format and strong psychometric performance make it well-suited for research, clinical care, and digital health applications.

PMID 43012501
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PubMedActa veterinaria Scandinavica2026-11-11

First detection of Rumenfilaria andersoni in semi-domesticated reindeer (Rangifer tarandus tarandus) in Norway.

Byrne Jason J, Buhler Kayla J KJ, Nymo Ingebjørg H IH, Sundset Monica A MA et al.

Filarioid nematodes, including Rumenfilaria andersoni and Setaria tundra, are vector-borne parasites of cervids in Fennoscandia. We screened blood samples collected December 2024 - February 2025 from three herds of semi-domesticated reindeer (Rangifer tarandus tarandus) in middle and northern Norway (Trøndelag; n = 27, Nordland; n = 16; Finnmark; n = 28). Samples were examined for microfilariae using a Modified Knott's Assay, followed by PCR and Sanger sequencing of a partial mitochondrial COX1 gene for species confirmation. Microfilariae morphologically consistent with R. andersoni were detected in three animals from Finnmark (n = 3/28, 10.7%, [95% confidence interval (CI) 3.7-27.2]) with a mean intensity of 353 microfilaria per mL (mf/mL, range 63-881). There was no evidence of S. tundra microfilariae in the same animals (n = 0/28, 0% [95% CI 0.0-12.1]). No microfilariae were detected in the animals from Trøndelag (n = 0/27, 0% [95% CI 0.0-12.5]) or Nordland (n = 0/16, 0% [95% CI 0.0-19.4]). COX1 sequencing confirmed R. andersoni and showed 100% identity with a reindeer-derived isolate previously reported from Finland. These findings provide the first confirmed record of R. andersoni in Norway and expand the known distribution of this climate-sensitive parasite, underscoring the need for targeted surveillance to clarify its occurrence, transmission dynamics, and potential health and management implications for semi-domesticated reindeer.

PMID 43009969
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PubMedInternational journal for equity in health2026-11-11

Reaching zero-dose children through the Big Catch-Up initiative in the Eastern Mediterranean Region.

Elmahdy Eman E, Mere Osama O, Farrukh Saadia S, Alyousfi Mohamad Nihad MN et al.

Routine immunization (RI) is one of the most effective public health interventions for reducing childhood morbidity and mortality. However, recent disruptions to RI have created immunity gaps in the Eastern Mediterranean Region (EMR), increasing the number of zero-dose (ZD) and under-immunized children, particularly in countries affected by conflict, displacement, service disruption, and ongoing vaccine-preventable disease outbreaks. The Big Catch-Up (BCU) initiative aimed to identify and vaccinate missed children, close immunity gaps, and strengthen RI systems. In the six Gavi-supported EMR countries included in this study (Afghanistan, Pakistan, Somalia, Sudan, Syria, and Yemen), implementation targeted children aged 12-59 months. This study assessed progress in reaching ZD children during BCU implementation in these six countries. A descriptive, multi-country programmatic analysis was conducted using quantitative and qualitative data from BCU quarterly reports covering implementation from Q4 2024 to Q1 2026. Additional data sources included World health Organization (WHO and United Nations Children's Fund (UNICEF) Estimates of National Immunization Coverage (WUENIC), Gavi-approved vaccine dose data, and UNICEF vaccine shipment data. Quantitative analysis summarized administered doses, zero-dose targets, BCU coverage, vaccine consumption, and performance by country and antigen among children aged 12-59 months. Age-disaggregated analyses were conducted for children aged 12-23 months and 24-59 months. Qualitative information from country reports on implementation successes, challenges, and lessons learned was summarized by country and thematic area. During the BCU implementation period, 3.5 million zero-dose children were reached with Penta1 across the six countries, representing 53% of the estimated cumulative population of 6.6 million ZD children. Of the 57 million Gavi-approved vaccine doses, 98% were shipped to countries, and 47.7 million doses were administered, equivalent to 84% of approved doses. Implementation success was supported by targeted identification of areas with high numbers of zero-dose children, integrated outreach, integration with other health services, and recruitment of vaccinators and deployment of community health workers. Key challenges included insecurity, population movement, inaccessible districts, community refusal, and limited community engagement. Substantial progress in reaching missed children was reported during BCU implementation in high-priority EMR countries. Lessons learned highlight the importance of integrating catch-up vaccination with RI, strengthening microplanning, ensuring timely vaccine supply and financing, improving community engagement, and institutionalizing catch-up vaccination.

PMID 43009985
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PubMedAnalytical chemistry2026-11-11

A Novel sMRMHR Pseudotargeted Method for Rapid Chemome Comparison Among Herbal Medicines: from Metabolome to Exposome.

Wang Xing X, Shen Chen-Xi CX, Shao Si-Min SM, Ma Tian-Bo TB et al.

The metabolomic comparison of closely related herbal species, both the intrinsic plant metabolome and the subsequent in vivo exposome, is vital for ensuring drug safety and elucidating therapeutic mechanisms. However, such a comparison is challenging because medicinal plants within the same genus share similar chemical profiles with minor chemical or abundance differences, and their in vivo exposure levels are typically low and are affected by complex biological matrices. In this study, Curcumae Radix (CR), a traditional Chinese medicine derived from the roots of four Curcuma species, was used as a case study. A pseudotargeted workflow based on scheduled high-resolution multiple reaction monitoring (sMRMHR) was established to compare the metabolites and plasma exposure profiles of these species, using a transition library constructed from the four plant species. The sMRMHR pseudotargeted method showed acceptable linearity, repeatability, and stability in QC samples and 12 reference standards, with performance comparable to that of SWATH and TOF MS1 while maintaining stable coefficients of variation (CVs) at low concentrations. Specifically, 95.2% of metabolomic features showed linearity with R2 ≥ 0.8, 98.16% showed a CV ≤ 30%. In exposomics, 83.14% of exposures had matrix effect factor (MF) CVs below 30%, and over 300 exposures showed MFs within 70%-130%. Finally, the application results of CR demonstrate its capability for chemome comparison of metabolites and exposures. In conclusion, this approach provides a practical HRMS-based strategy for the integrated comparison of plant metabolite profiles and plasma exposure-related profiles across closely related medicinal species, and may support subsequent studies of interspecies chemical differences and in vivo exposure characteristics after oral administration.

PMID 43010515
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PubMedFaraday discussions2026-11-11

High-voltage gel polymer electrolyte integrated laser-induced graphene flexible micro-supercapacitors for wearable and sustainable aerospace electronics.

Ray Apurba A, Mitra Sangha S, Georgopoulou Vasiliki V, Sygellou Labrini L et al.

The global trend towards flexible, portable and wearable electronics, such as smartwatches, fitness trackers, and healthcare monitors etc., has intensified the demand for high-performance flexible energy storage systems. Supercapacitors (SCs) have recently emerged as promising, robust power management solutions for various space applications, including CubeSats, very low earth orbit (VLEO) satellites, electromechanical thrust vector actuation and interplanetary devices. However, their low energy density (<10 Wh kg-1) compared to current lithium-ion batteries (LIBs) and high self-discharge rate limit their widespread use. This work demonstrates the fabrication of high-voltage gel polymer electrolyte (GPE) and laser-induced graphene (LIG) electrode based flexible micro-supercapacitors (FMSCs) to address the current challenges. The GPE, designated as [EMIM][TFSI]/PPC/PC, is synthesized by entrapping the ionic liquid 1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide [EMIM][TFSI] into a matrix of polypropylene carbonate (PPC) and polycarbonates (PC). FMSCs (active device area: 1.6 cm2) are fabricated using interdigital LIG electrodes and the GPE, which demonstrated excellent electrochemical performance with an areal capacitance of 2.5 mF cm-2 at 3.2 V and 70 µA (0.04 mA cm-2), and an energy density of 3.5 µWh cm-2. Long-term charge-discharge stability was also evaluated up to 10 000 cycles at a fixed current of 100 µA and it also showed promising capacitance retention of more than 91%. This work presents a novel FMSC utilizing a high-voltage [EMIM][TFSI]/PPC/PC gel polymer electrolyte and LIG-interdigitated electrodes, engineered to address the stringent demand of space-terrestrial boundaries. The integrated gel polymer structure conceptually suppresses vacuum evaporation and eliminates phase separation under extreme vibrational or high-g loading, highlighting its future utility in unpressurized aerospace environments.

PMID 43012316
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