Drug Database
MF

MF-59 (MF59)

✓ Approved

Novartis AG · Small Molecule · Small Molecule

What is MF-59?

MF-59 is a small molecule developed by Novartis AG. It is approved for therapeutic indications via injectable (others).

Drug Profile

Brand NamesMF59
CompanyNovartis AG
Drug ClassSmall Molecule
RouteInjectable (Others)
StatusApproved
Sources: ClinicalTrials.gov, Novartis AG

Therapeutic Indications

MF-59 is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Surgical and medical proceduresOral appliance application✓ Approved

Related Research Articles

PubMedUltrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology2026-09-20

Prenatal findings and postnatal outcomes in cases of closed spinal dysraphism: 10-year two-center cohort study.

Athiel Y Y, Van Den Eede E E, De Saint Denis T T, Blondiaux E E et al.

To characterize prenatal ultrasound findings in fetuses with prenatally diagnosed closed spinal dysraphism (CSD) and report their postnatal management and functional outcomes at 18 and 36 months. This retrospective cohort study included all fetuses with a prenatal diagnosis of CSD assessed between January 2014 and December 2024 at two tertiary centers (Fetal Medicine Department of Trousseau Hospital, Paris, France, and Department of Obstetrics and Gynecology, University Hospitals Leuven, Leuven, Belgium). Lesions were reassessed and classified according to the updated Orphanet classification system for dysraphisms. Cases of open dysraphism, intermediate forms, Currarino syndrome, caudal regression syndrome and postnatally diagnosed cases were excluded. Prenatal imaging findings, pregnancy outcomes, postnatal diagnostic concordance, neurosurgical management and functional outcomes were analyzed. Seventy fetuses with a prenatal diagnosis of CSD were included. Saccular forms of CSD accounted for 85.7% (n = 60) of cases, including 33 (47.1%) cases of limited dorsal myeloschisis, 18 (25.7%) cases of posterior meningocele and nine (12.9%) cases of conus spinal cord lipoma. Most (85.7%) lesions were located at the lumbar or sacral level. Associated structural cerebral anomalies were identified prenatally in 17.1% (n = 12) of cases. There were 59 (84.3%) live births and 11 (15.7%) terminations of pregnancy, including eight cases with major cerebral anomalies. Among liveborn infants with available data on postnatal surgical interventions (n/N = 44/59), postnatal surgery was performed in 90.9% of cases. The prenatal diagnosis was adjusted postnatally in 4/39 (10.3%) cases with available postnatal outcome data. At 36 months, independent ambulation was achieved in 94.4% (17/18) of children with follow-up data available at this time point. In contrast, urinary dysfunction was present in 38.9% of cases at 36 months, while gastrointestinal disorders were less frequent (22.2%). Using the Orphanet classification, prenatal ultrasound examination allows reliable anatomical characterization of CSD in 89.7% of cases. Motor outcomes are generally favorable, whereas urological morbidity is observed in nearly half of cases at 18 months. These are important elements to consider in prenatal counseling. © 2026 The Author(s). Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.

PMID 42763785
Read full article →
PubMedCurrent health sciences journal2026-09-20

Diagnostic Performance of Diffusion-Weighted MRI and ADC Values in Differentiating Atypical Leiomyomas from Uterine Sarcomas.

Rizescu Ramona-Andreea RA, Salcianu Iulia Alecsandra IA, Ionescu Alexandre A, Iana Gheorghe G et al.

Leiomyomas are the most common benign uterine tumors, whereas uterine sarcomas are rare malignant neoplasms associated with high morbidity and mortality. Differentiation using imaging remains challenging because of overlapping radiologic features. To evaluate magnetic resonance imaging (MRI) characteristics of atypical leiomyomas and uterine sarcomas, with emphasis on diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) values. In this retrospective study, 22 patients with histopathologically confirmed uterine leiomyoma or sarcoma underwent MRI for atypical or suspicious uterine lesions. MRI assessment included T2-weighted imaging, DWI with ADC maps, and fat-suppressed T1-weighted sequences before and after gadolinium administration. Thirteen atypical leiomyomas (59%) and nine sarcomas (41%) were analyzed. Mean patient age was similar between groups. Abnormal vaginal bleeding was more frequent in sarcomas (89% vs. 38%). Sarcomas more commonly showed irregular margins (89% vs. 69%) and T2 hyperintensity (89% vs. 15%). Heterogeneous enhancement and cystic or hemorrhagic changes occurred in both tumor types, while extrauterine disease was observed only in sarcomas. All sarcomas demonstrated high DWI signal intensity exceeding that of the endometrium, whereas most leiomyomas showed intermediate signal intensity. Mean ADC values were significantly lower in sarcomas (0.813 × 10⁻³mm²/s) than in leiomyomas (1.050 × 10⁻³ mm²/s), with an optimal cutoff of 0.892 × 10⁻³mm²/s. MRI, particularly DWI and ADC analysis, provides valuable differentiation between atypical leiomyomas and uterine sarcomas, with sarcomas demonstrating higher DWI signal intensity and significantly lower ADC values.

PMID 42763695
Read full article →
PubMedBMC musculoskeletal disorders2026-09-20

Rectus femoris stiffness is associated with aerobic capacity in healthy young men: a comparative shear wave elastography study among lower-limb muscles.

Kara Hasan H, Kaplan Hüseyin H, Cengiz Gizem G, Cüce İsa İ et al.

This study aimed to comparatively investigate the relationships between the ultrasonographic architectural and viscoelastic properties of the soleus, medial gastrocnemius (MG), and rectus femoris (RF) muscles and objectively measured aerobic capacity in healthy young adult males. This observational cross-sectional study included 59 healthy male medical students aged 18-30 years. The muscle thickness, pennation angle, fascicle length, and shear wave elastography (SWE) stiffness of the right lower-extremity RF, MG, and soleus were measured ultrasonographically. Aerobic capacity was evaluated using cardiopulmonary exercise testing (CPET) with the Bruce protocol, and VO₂max was recorded as the primary outcome. Participants were stratified into low- and high-aerobic capacity groups based on the median VO₂max value (29.4 mL·kg⁻¹·min⁻¹). Associations were examined using correlation analysis and multiple linear regression. No significant between-group differences were observed in any ultrasonographic or SWE parameter (low vs. high aerobic capacity groups). Conventional architectural parameters (muscle thickness, pennation angle, and fascicle length) showed no significant correlations with VO₂max across all assessed muscles. RF SWE velocity demonstrated a significant positive correlation with VO₂max (r = 0.364, p = 0.005), designated a priori as the primary comparison; RF Young's modulus showed a smaller, exploratory correlation (r = 0.274, p = 0.036) that did not survive multiplicity correction, and no soleus or MG SWE parameters correlated with aerobic capacity. In multiple linear regression analysis, RF SWE velocity (β = 0.280, p = 0.021) and BMI (β=-0.555, p < 0.001) were independently associated with VO₂max (R²=0.310). RF shear wave velocity is independently associated with aerobic capacity (VO₂max) in healthy young men, whereas no significant association was detected for the soleus or MG. These associations were not formally compared between muscles.

PMID 42763388
Read full article →
PubMedCureus2026-09-20

Thymic Carcinoma Presenting as Diffuse Bone Marrow Infiltration Mimicking Lymphoma.

Mateus Farias Krystel P KP, Reyes Mayaute Edgar R ER, Tarazona Cervantes Walmer M WM, Pozo Morales Carmen R CR et al.

Thymic epithelial tumors (TETs) represent the most common primary neoplasms of the anterior mediastinum, yet thymic carcinoma (TC) stands out as an exceptionally rare and biologically aggressive subtype. Unlike thymomas, TCs exhibit marked cytologic atypia, early invasive potential, and a high predisposition for extrathoracic metastasis. We report the case of a 59-year-old male who presented with a seven-month history of progressive, refractory lumbar pain and functional limitation. Initial clinical and laboratory evaluation revealed normocytic anemia, leukocytosis, elevated inflammatory markers, and increased lactate dehydrogenase and beta-2 microglobulin levels. These findings, combined with systemic bone marrow infiltration observed on spinal magnetic resonance imaging, initially suggested a lymphoproliferative disorder. A subsequent thoracic computed tomography scan identified an anterior mediastinal mass with lymphadenopathy. A bone marrow biopsy evidenced infiltration by a poorly differentiated malignant neoplasm, and an immunohistochemical profile of the mediastinal mass confirmed the diagnosis of stage IVb TC, showing positivity for pan-cytokeratin, tumor protein p63, cluster of differentiation 5 (CD5), epithelial membrane antigen (EMA), and cluster of differentiation 117 (CD117), with a Ki-67 proliferation index of 20%, while remaining negative for hematolymphoid, neuroendocrine, and lung-specific markers. The patient was managed through a multidisciplinary approach with systemic palliative chemotherapy. This case highlights a critical diagnostic challenge where TC mimicked a hematological malignancy. The systemic dissemination of TC, particularly the diffuse bone marrow infiltration, is a rare clinical phenotype that obscures the primary mediastinal origin. Our report emphasizes the necessity of including TC in the differential diagnosis of patients presenting with refractory bone pain and systemic hematological abnormalities, even in the absence of respiratory symptoms. Early diagnostic recognition through strategic immunohistochemical profiling is imperative to avoid clinical bias, prevent the initiation of inappropriate therapies, and facilitate a prompt, evidence-based management strategy for patients with advanced, non-resectable disease.

PMID 42763745
Read full article →
PubMedJournal of the American Academy of Audiology2026-09-20

Relationship Between Age, Auditory Performance, and Quality of Life in Middle-Aged and Older Cochlear Implant Users.

Deniz Hüseyin H

Aging can result in hearing loss, and cochlear implants (CIs) provide an effective means for auditory rehabilitation. We evaluated the impact of age on CI outcomes. This study aimed to examine the effects of aging on auditory performance and quality of life in individuals who underwent unilateral cochlear implantation. This study was designed as a cross-sectional study. Participants included individuals with postlingual, profound sensorineural hearing loss who had undergone unilateral cochlear implantation. Two groups were formed: those aged 40-59 years (Group 1) and those aged ≥60 years (Group 2). There were 31 participants in Group 1 and 33 participants in Group 2, totaling 64 participants (30 women [46.88 percent] and 34 men [53.13 percent]). Quality of life was measured using the Turkish version of The World Health Organization Quality of Life Brief Version (WHOQOL-BREF), and depression levels were assessed using Beck's Depression Inventory. To assess auditory performance, free-field audiometry included pure-tone threshold at 0.5-4 kHz, speech recognition threshold, speech discrimination, and spectral-temporally modulated ripple test measurements. The Shapiro-Wilk test was used to assess the normality of the numerical variables. The Mann-Whitney U test was used to compare WHOQOL-BREF scores and auditory performance between groups, and the chi-square test was used for categorical variables. Relationships between numerical variables were assessed using Spearman's correlation coefficient. The older group exhibited significantly poorer auditory performance and quality of life scores across multiple dimensions (p < 0.05). However, no significant differences in depression levels were observed between the groups (p = 0.198). Age considerably influences auditory performance and quality of life in CI users. These findings underscore the importance of tailored rehabilitation approaches for this population. The results of this study show that aging negatively affects the auditory performance and quality of life of CI users. Moreover, CI alone is insufficient to fully improve quality of life in older individuals, highlighting the need for a comprehensive, multidisciplinary approach to address aging-related neurological and sensory changes.

PMID 42763618
Read full article →
PubMedCureus2026-09-20

Knowledge-Attitude-Practice Gap Among Mothers of Under-Five Children With Iron-Deficiency Anemia and the Association of Maternal Knowledge With Hemoglobin Levels: A Cross-Sectional Study at a Rural Tertiary Care Center in Haryana.

Loomba Ashiya A, Kumar Surendra S, Sharma Vishal V, Mohammad Abdur Rahman Sheikh S et al.

Anemia is the third leading cause of disability globally, with iron deficiency as the most common nutritional cause. India accounts for nearly half of the global anemia burden in children under five years of age. Given that mothers play a critical role in child care, this study aimed to identify gaps in their knowledge, attitudes, and practices (KAP) regarding anemia prevention. A hospital-based cross-sectional study was conducted among 102 mothers of anemic children aged 6-59 months diagnosed with iron-deficiency anemia (IDA) and presented to a rural tertiary care center in Haryana. Participants were selected by systematic random sampling after obtaining written informed consent. Data were collected using a prevalidated, interviewer-administered, semistructured questionnaire comprising sociodemographic characteristics, knowledge, attitude, and preventive practice domains. Open-ended responses were categorized using qualitative content analysis. Knowledge scores were calculated for each participant. Pearson's correlation was used to assess the relationship between maternal knowledge scores and children's hemoglobin levels. One-way analysis of variance (ANOVA) with Tukey's honestly significant difference (HSD) post hoc test compared mean knowledge scores across anemia severity groups. Statistical significance was set at p < 0.05. Most mothers had secondary or higher education (n = 75; 73.5%) and were homemakers (n = 85; 83.3%). Over half of the participants failed to recognize the role of antenatal iron-folic acid supplementation (n = 56; 54.9%) and diet (n = 63; 61.8%) in anemia prevention. In addition, several other important knowledge gaps and misconceptions were identified. Only 41 (40.2%) recognized worm infestation as a cause of anemia, 20 (19.6%) incorrectly considered milk and milk products to be iron-rich, and only three (3%) were aware of government anemia prevention programs. Mothers generally demonstrated positive attitudes toward childhood anemia; however, preventive practices such as deworming (n = 39; 38.2%), iron supplementation (n = 25; 24.5%), and cooking in iron utensils (n = 15; 14.7%) were suboptimal. Maternal knowledge scores showed a significant positive correlation with children's hemoglobin levels (r = 0.30, p = 0.002). Mean knowledge scores differed significantly according to anemia severity (ANOVA: F(2,99) = 5.54, p = 0.005), with mothers of children with mild anemia demonstrating significantly higher knowledge scores than those of children with severe anemia (Tukey's HSD, adjusted p = 0.004). Higher maternal knowledge was associated with better hemoglobin levels in their children. Despite generally favorable attitudes, substantial gaps exist between maternal knowledge and preventive practices regarding childhood IDA. This emphasizes the need for targeted educational interventions, especially in rural areas, to reduce anemia prevalence and its associated health impacts.

PMID 42763774
Read full article →

+9996 more articles available with a free account

Sign up free to view all articles →

Ask about MF-59