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diphtheria +tetanus + acellular pertussis + polio + haemophilus influnzae type B vaccine (KD370 / KD 370 / Quintovac)

✓ Approved

Meiji Holdings · Vaccine · Vaccine

What is diphtheria +tetanus + acellular pertussis + polio + haemophilus influnzae type B vaccine?

diphtheria +tetanus + acellular pertussis + polio + haemophilus influnzae type B vaccine is a vaccine developed by Meiji Holdings. It is approved for therapeutic indications via injectable (others) or intramuscular (im) injection.

Drug Profile

Brand NamesKD370, KD 370, Quintovac
CompanyMeiji Holdings
Drug ClassVaccine
RouteInjectable (Others), Intramuscular (IM) Injection
StatusApproved
Sources: ClinicalTrials.gov, Meiji Holdings

Therapeutic Indications

diphtheria +tetanus + acellular pertussis + polio + haemophilus influnzae type B vaccine is developed for 4 unique indications across 2 therapeutic areas.

Therapeutic AreaConditionPhase
Infections and infestationsDiphtheria✓ Approved
Infections and infestationsPertussis✓ Approved
Infections and infestationsTetanus✓ Approved
Surgical and medical proceduresPolio immunisation✓ Approved

Related Research Articles

PubMedTherapeutic advances in respiratory disease2026-09-19

Blood eosinophils in COPD: are biologics for everyone?

Vanetti Marco M, Visca Dina D, Ardesi Francesco F, Taglioretti Antonia M AM et al.

Type 2 (T2) biologics represent a promising treatment option for chronic obstructive pulmonary disease (COPD) patients with eosinophilic inflammation. To evaluate the prevalence of stable COPD patients who may be eligible for T2 biologics. Real-world, retrospective, monocentric study in COPD patients undergoing inpatient pulmonary rehabilitation. Clinical, functional, and inflammatory data were collected. Patients were considered eligible for T2 biologic therapy whether they were receiving optimized inhaled therapy and had a history of ⩾2 moderate and/or ⩾1 severe exacerbations in the previous year, together with a blood eosinophil count ⩾300 cells/μL. Among 441 patients, 21.5% had blood eosinophil counts ⩾300 cells/μL and 6.8% fulfilled the combined eligibility criteria. A high burden of respiratory and cardiometabolic comorbidities and increased cardiovascular risk was observed in the overall population. Only a subgroup of patients seems eligible for biologics, treatment escalation should be based on optimized standard care management and patient phenotyping.

PMID 42760892
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PubMedF1000Research2026-09-19

Understanding the key factors influencing knowledge management in business environments: a systematic review.

Mardian Muhammad Taufik MT, Musadieq Mochammad Al MA, Iqbal Mohammad M, Ruhana Ika I

This study aims to identify and synthesise the main factors that influence knowledge management (KM) in business environments. Using the PRISMA approach, a systematic review of 44 empirical and conceptual articles published between 2020 and 2024 was conducted. The findings indicate eight key variables that are critical for strengthening KM: leadership, technology, entrepreneurial orientation, strategic orientation, learning orientation, innovation, human resource management, and high-performance work systems. The findings show that leadership promotes collaboration and trust, creating a supportive environment for KM. Technological advancements facilitate efficient knowledge sharing and application, while strategic alignment ensures KM supports organizational goals. Human resource practices engage employees in knowledge processes, and high-performance work systems enhance knowledge acquisition and utilization. Innovation drives the generation of new ideas, and entrepreneurial orientation encourages a proactive approach to leveraging knowledge for competitive advantage. Despite the growing interest in KM, challenges such as resistance to change, inadequate infrastructure, and varying employee readiness hinder its effective implementation. This study emphasizes the need for an integrated KM approach that addresses these barriers while aligning KM strategies with organizational needs. Future research should investigate how these factors interact across different industries and cultural contexts to optimize KM practices and improve organizational performance.

PMID 42760914
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PubMedAAPS PharmSciTech2026-09-19

Comprehensive Stability Assessment of Squalene in a Nanoemulsion Adjuvant and the SpiN-Tec Vaccine: HPLC Quantification, Stress Testing, and Stability Studies.

Gomes Isabela Pereira IP, Rivelli Graziella Gomes GG, Bagno Flávia Fonseca FF, Hojo-Souza Natália Satchiko NS et al.

Squalene-based nanoemulsions are widely used as adjuvants in vaccine formulations, but their stability can be affected by environmental factors such as pH, oxidative stress, temperature, and light. We have produced a squalene nanoemulsion (CTVad1) to support the clinical development of new vaccines. This study aimed to develop and validate an HPLC method for squalene quantification in SpiN-Tec, a recombinant protein vaccine against COVID-19. We also aimed to evaluate the stability of the CTVad1 adjuvant and SpiN-Tec under controlled storage conditions. A reversed-phase HPLC method was developed and validated, and comprehensive forced degradation studies were performed on the raw material and SpiN-Tec under acidic, basic, oxidative, thermal, and photolytic conditions to demonstrate the stability-indicating capability of the method. Physicochemical, morphological, and biological characteristics were assessed, and stability studies of both the vaccine and the CTVad1 adjuvant were performed under accelerated and long-term conditions. The HPLC method was selective, precise, accurate, linear, and robust. Squalene raw material degraded under all tested conditions, whereas formulation in nano-sized globules improved its stability, with degradation observed only under hydrogen peroxide and light exposure. CTVad1 remained stable over time, exhibiting only minor, non-critical changes within the specification limits in both accelerated and long-term stability studies, regardless of the glass packaging used (clear or amber). In addition, the SpiN-Tec vaccine maintained its physicochemical and biological integrity under all tested conditions, with all evaluated parameters remaining within the established specification ranges. Our findings demonstrate that proper formulation, packaging, and storage conditions can preserve squalene stability in nanoemulsion-based vaccines, ensuring the quality, safety, and efficacy of the SpiN-Tec vaccine and its adjuvant throughout shelf life.

PMID 42760453
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PubMedOcular immunology and inflammation2026-09-19

Bilateral Maculopathy in an Infant Following Measles, Mumps, Rubella, and Varicella-Zoster (MMRV) Vaccination.

Ben-Avi Ravid R, Amer Radgonde R

To report on the long-term clinical outcome of a healthy infant who presented with posterior uveitis following the administration of the combined measles, mumps, rubella, and varicella (MMRV) vaccine. Descriptive case report. A 13-month-old infant presented with bilateral visual loss two weeks after receiving the MMRV vaccine. Ophthalmic examination revealed bilateral retinitis and retinal vasculitis with exudative retinal detachment. Extensive infectious work-up was conducted including serologic exams and PCR testing of blood, aqueous humor, cerebrospinal fluid and urine. Serological tests for measles yielded positive IgM and IgG titers. PCR testing for measles in the aqueous humor and urine was negative. Neurologic assessment and neuroimaging were unremarkable, excluding central nervous system involvement. Empiric systemic antiviral and corticosteroid therapy was initiated. Gradual resolution of posterior uveitis ensued, culminating in bilateral macular scars. Over a six-year follow-up period, the patient demonstrated stable ocular findings with no evidence of recurrent inflammation or systemic autoimmune disease. Final visual acuity was 6/9 in each eye. This case represents a rare occurrence of non-necrotizing retinitis following MMRV vaccination. To our knowledge, this is the first report describing the sequential OCT characteristics of presumed measles vaccine-associated retinitis. The prolonged follow-up period supports the absence of an alternative etiology and provides valuable insight into the long-term course and visual prognosis of vaccine-associated retinopathy.

PMID 42760840
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PubMedActa obstetricia et gynecologica Scandinavica2026-09-19

Dual acellular subnormothermic machine perfusion for enhanced uterus preservation in a swine model.

Cabanel Lucile L, Oubari Haïzam H, Ellis Bradley W BW, Dion Ludivine L et al.

Machine perfusion has rapidly developed in the last decade and demonstrated improved preservation of conventional and marginal organs by reducing ischemia and hypoxia injuries. The aim of this study was to assess whether subnormothermic machine perfusion improves graft preservation compared with SCS in a porcine uterus model. Swine uteri were procured from circulatory-dead donors and allocated into two groups. In the experimental group, the organs were preserved with 4 h-dual subnormothermic machine perfusion (n = 4) while the control group (n = 4) underwent 4 h-static cold storage. After preservation, all uteri received ex vivo whole blood normothermic reperfusion (NMP) to simulate transplantation. Perfusate samples were analyzed from uterine arteries and veins every 30 min for gas and metabolic analysis, and weight variations were recorded continuously during perfusion. Following simulated transplantation, uterine contraction was assessed after oxytocin injection, and macrovascular perfusion was evaluated using contrast angiography. Several biopsies were procured from different parts of the uterus for histological and immunohistochemistry analysis. In the experimental group, the weight of the uteri and lactate difference between vein and artery decreased during subnormothermic machine perfusion. Weight gain was significantly higher in the control group (p = 0.03), which was consistent with interstitial edema observed on histological sections in this group. Uterine contraction evaluated through semi-quantitative scoring was higher in the experimental group (p = 0.02). In this porcine model, subnormothermic machine perfusion reduces edema and preserves contractility more effectively than static cold storage. We demonstrate its particular interest in recovering organs procured from deceased donors. In addition, subnormothermic machine perfusion may enable other applications, including graft assessment, treatment and tolerance induction.

PMID 42760625
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PubMedBritish dental journal2026-09-19

Where NHS dental access in England is least resilient.

Devlin Hugh H

Aims Demographic change may affect access to National Health Service (NHS) dentistry unevenly. This study assessed how fixed provider geography performs under population growth, ageing, and deprivation-focused growth.Methods A scenario-based spatial analysis was conducted using lower layer super output area-level population, age, and index of multiple deprivation (IMD) data. Dental deserts were defined as areas located >5 km from the nearest NHS provider; high-need deserts were those in IMD deciles 1-3. Three scenarios were modelled: 5% general population growth, ageing, and 10% growth concentrated in IMD deciles 1-3.Results At baseline, 2.34 million residents lived in dental deserts, including 189,542 in high-need deserts. General growth increased desert population by 117,135 and high-need desert population by 9,477. Ageing had minimal impact. Concentrated deprived-area growth increased high-need desert population by 18,960, approximately double that seen under general growth. The largest increases occurred in rural and semi-rural authorities.Conclusions Population growth expands exposure to dental deserts, while growth in deprived areas disproportionately increases high-need burden. NHS dental access appears unevenly resilient to demographic change.

PMID 42760347
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