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erythromycin (erythromycin, KV)

✓ Approved

Lumara Health · therapeutic agent

What is erythromycin?

erythromycin is a therapeutic agent developed by Lumara Health. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand Nameserythromycin, KV
CompanyLumara Health
RouteOral (PO)
StatusApproved

Therapeutic Indications

erythromycin is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Infections and infestationsSalmonellosis✓ Approved

Related Research Articles

PubMedMaterials horizons2026-09-18

A ferroelectric-resistive dual-mode capacitor for unified KV-cache and weight storage toward Transformer acceleration.

Lee Youngseo Y, Choi Minki M, Kim Nawoon N, Lee Seonjeong S et al.

This study proposes processing-in-memory (PIM) architecture based on a dual-mode capacitor to address the memory bottleneck and power consumption issues arising from the rapid expansion of large language models (LLMs). In large-scale AI systems, the key-value cache (KV-cache) is essential for handling massive parameters; however, as the cache size increases proportionally with context length, DRAM usage and power consumption surge, leading to memory bottlenecks. To mitigate this, we introduce a PIM architecture that performs computations directly within memory, thereby reducing data transfer overhead. While the conventional analog PIM architecture enables fast and energy-efficient computation, it is unsuitable for dynamic attention operations in Transformer models and suffers from increased power consumption and reduced endurance due to frequent write operations in KV-cache processing. To overcome these limitations, the proposed dual-mode capacitor supports both ferroelectric tunnel junction (FTJ) and resistive random-access memory (RRAM) modes, enabling selective functionality depending on computational demands, providing low-power and high-speed operation in FTJ mode and high-reliability, multilevel data storage in RRAM mode. Experimental results confirmed that the HfZrOx (HZO) device can be irreversibly converted from the FTJ mode to the RRAM mode through a forming process. Accordingly, individual cells within the same array architecture can be preconfigured in either the FTJ or RRAM mode according to their designated functions, thereby enabling the integrated implementation of KV-cache storage, weight storage, and multiply-and-accumulate (MAC) operation.

PubMedJournal of applied clinical medical physics2026-09-18

Commissioning and end-to-end validation of a combined surface-guided and triggered kV imaging workflow for breath-hold SBRT on a Varian TrueBeam.

Osunkwor Offormata E OE, Ndlovu Alois A, Teboh Roland F RF

Respiratory motion introduces significant geometric uncertainty in Stereotactic Body Radiotherapy (SBRT) for thoracic and abdominal tumors. Deep Inspiration Breath-Hold (DIBH) mitigates this, but the surface signal alone may not reflect internal target position, supporting the need for real-time internal-anatomy verification during delivery. To commission a Surface-Guided Radiation Therapy (SGRT) system and validate an integrated SGRT + Image-Guided Radiation Therapy (IGRT) + triggered kV imaging (SITI) workflow for DIBH SBRT. The LAP LUNA 3D SGRT system was commissioned per AAPM TG-302 using phantom-based assessment of static and dynamic localization accuracy, reproducibility, and latency. An end-to-end test using a dynamic phantom validated the SITI workflow. Point dose was measured with an ion chamber under four scenarios: SGRT-only delivery, full SITI delivery, and SITI with induced 1 and 2 mm uncorrected 3D shifts. Static localization accuracy was better than 0.5 mm / 0.3°, with reproducibility within 0.2 mm / 0.1°. Dynamic testing confirmed sub-millimeter spatial accuracy and a 31.6 ms latency, well below the AAPM TG-302 100 ms tolerance. The 1 and 2 mm uncorrected shifts produced point-dose reductions of 0.9% and 2.2% relative to the SITI reference, consistent with the ∼1%/mm local dose gradient. Both shifts were clearly visualized on triggered kV images, confirming detection of sub-tolerance residual displacements undetected by surface guidance alone. The LAP LUNA 3D system meets the technical requirements for SBRT. The SITI workflow is technically feasible and provides real-time visualization of internal target position during delivery, offering a robust motion-management strategy for DIBH SBRT of mobile thoracic and abdominal targets.

PubMedFrontiers in pediatrics2026-09-18

Serotypes, sequence types, and erythromycin resistance of maternal colonizing group B Streptococcus: implications for neonatal early-onset disease prevention.

Sun Xia X, Liu Hua H

Intrapartum antibiotic prophylaxis for maternal group B Streptococcus (GBS) colonization depends on the assumption that a woman identified as colonized receives an antibiotic active against her own isolate, an assumption that routine susceptibility reporting may overestimate when inducible clindamycin resistance is present. This study characterized the capsular serotypes, sequence types, macrolide-lincosamide resistance phenotypes and the intrapartum antibiotic actually administered for maternal colonizing GBS isolates at a single tertiary maternity centre. Banked isolates from antenatal screening were revived and analysed by capsular multiplex PCR, multilocus sequence typing, broth microdilution, D-test and resistance gene PCR, and each isolate was linked to the intrapartum regimen recorded in the corresponding delivery record. Among 120 isolates, serotype III predominated at 35.8%, and the six serotypes included in a hexavalent capsular vaccine accounted for 94.9% of typeable isolates, representing a serotype-based ceiling rather than expected vaccine effectiveness. Thirteen sequence types were resolved, and CC17/ST17 accounted for 11.7% of the collection. All isolates were susceptible to penicillin, ampicillin and vancomycin, whereas erythromycin non-susceptibility reached 63.3%, comprising constitutive (40.0%), inducible (8.3%) and M (15.0%) phenotypes, with a further 3.3% showing the L phenotype. Routine testing classified 56.7% of isolates as clindamycin-susceptible, but effective in-vitro clindamycin availability after reclassification of D-test-positive isolates was 48.3%, an absolute reduction of 8.3 percentage points. The inducible phenotype was more frequent in CC17/ST17 than in other lineages (28.6% versus 5.7%), although this subgroup contained only 14 isolates and should be interpreted as exploratory. Among the women who had actually received clindamycin during labour, half were colonized by isolates against which clindamycin lacked in-vitro activity. These findings support routine D-testing of erythromycin non-susceptible maternal GBS isolates and reporting that states whether clindamycin is suitable for intrapartum prophylaxis.

PubMedRSC advances2026-09-18

Enhanced CO2 conversion via synergistic effect of dielectric barrier discharge plasma and halogen-modified g-C3N4.

Rao Mudadla Umamaheswara MU, Cho Phyu Phyu PP, Vidyasagar Devthade D, Joseph Sneha S et al.

Carbon dioxide (CO2) conversion is a key challenge in addressing global warming and the associated climate change. Non-thermal plasma activation of CO2 is a viable alternative to traditional thermal catalytic routes for converting CO2 into CO and O2. In this study, a dielectric barrier discharge (DBD) plasma reactor operated under ambient conditions was developed and demonstrated for CO2 conversion to CO. The integration of halogen-modified g-C3N4 markedly enhanced CO2 conversion relative to the unpacked condition. The addition of a photocatalyst to the plasma reactor improved plasma discharge parameters, and the synergy present between the catalyst and plasma reactor promoted the conversion. The maximum conversion of CO2 attained was approximately 11% with Br/g-C3N4 at an applied voltage of 22 kV. Additionally, halogen doping enhanced CO selectivity and energy efficiency. Furthermore, the integration of the photocatalyst with DBD avoids coke formation, which is one of the limiting steps in high temperature CO2 activation.

PubMedSocial psychiatry and psychiatric epidemiology2026-09-18

Development of a peer support program for persons with mental health conditions in India: a formative qualitative study with expert validation of program components.

Kundurthi Venkatesh V, K Reddy Shanivaram S, Jagannathan Aarti A, Berigai Parthasarathy Nirmala N et al.

Improving support for persons with long-term mental health challenges is a key concern in global mental health care. In recent years, peer support (PS) has been recognised as a person-centred and recovery-oriented approach for persons with mental health conditions. While most PS research originates from high-income countries, there's a notable gap in the literature and structured programs within low- and middle-income countries, including India. This study aimed to develop and validate a culturally adapted PS program for persons with mental health conditions tailored to the Indian context. An exploratory qualitative design was used, following the three-phase approach: (I) a systematic literature review, (II) qualitative in-depth interviews with diverse mental health stakeholders (N = 31), and (III) development and expert validation. Interviews were conducted by KV in both face-to-face and online settings, using English, between June and December 2023. Each session lasted between 75 and 120 min and was audio-recorded with the participant's consent. A purposive sampling strategy was employed, and data collection continued until data saturation was achieved. The finalised program, validated by experts using Lawshe's CVR (≥ 0.71), is structured around seven key themes: Core Principles of Peer Support, Structure and Process of Peer Support Groups, Content and Focus of Peer Support Interactions, Roles and Responsibilities, Guidelines for Safe and Effective Peer Support, Challenges in Peer Support Groups, and Ethical Considerations. This developed peer support program (PSG) has been systematically designed to help form and facilitate peer support groups for persons with mental health conditions, and it now requires feasibility and effectiveness testing through larger experimental trials.

PubMedMedical physics2026-09-18

Measurement-anchored Monte Carlo prediction of diagnostic x-ray air kerma using HVL-matched spectra and per-electron normalization.

Obara Yusuke Y, Sekimoto Michiharu M, Kato Toyohiro T

Quantitative Monte Carlo (MC) prediction of diagnostic x-ray air kerma is limited by mismatch between theoretical spectra and measured beam quality and by the lack of a reproducible normalization from source-photon tallies to mAs-based exposures. To test whether HVL-matched spectra combined with measurement-anchored per-electron normalization can predict free-in-air and transmitted air kerma under selected radiographic exposure settings and to evaluate the framework in PHITS and EGS5. Birch-Marshall spectra at 50, 80, and 120 kV were adjusted by tuning the Al-equivalent filtration parameter so that the theoretical HVL agreed with the measured HVL. The matched spectra were used as common input for PHITS and EGS5. Free-in-air air kerma was measured for 102 exposure conditions, and transmitted air kerma was measured after 2.0-cm PMMA or 0.5-cm Al for seven conditions at each tube voltage. From measured air kerma and MC air-kerma tallies expressed per source photon, we defined the normalization constant Y ( V , I , t ) , the per-electron correction factor X ( V , I , t ) , and the tube-voltage-averaged coefficient X ' ( V ) . Predictions based on X ' ( V ) were compared with measurements using percentage error. Performance on the full free-in-air dataset was interpreted as agreement within the calibration dataset, whereas held-out-condition performance was assessed by leave-one-out cross-validation (LOOCV) on seven selected radiographic exposure settings at each tube voltage. Combined standard uncertainty was also summarized. After HVL matching, the free-in-air MC air-kerma tallies expressed per source photon differed between PHITS and EGS5, a finding interpreted primarily in relation to differences in source definition and source normalization. After measurement-based normalization with X ' ( V ) , predicted air kerma was generally consistent with measurements under both free-in-air and transmitted conditions. The largest mean percentage error was 7.8%, slightly exceeding the predefined ± 7.5% operational benchmark. The representative combined standard uncertainty was 5.6%; when the nominal tube-voltage setting was used directly as a simulation input, inclusion of the tube-voltage accuracy term increased it to 7.3%. Within the tested radiographic system and slab-transmission geometries, HVL-matched spectra combined with measurement-anchored per-electron normalization enabled prediction of air kerma under actual exposure conditions. Despite differences in the MC air-kerma tallies expressed per source photon, the final predicted values were generally consistent with measurements in both codes under the tested conditions.

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