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erythromycin (erythromycin, KV)

✓ Approved

Lumara Health · therapeutic agent

What is erythromycin?

erythromycin is a therapeutic agent developed by Lumara Health. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand Nameserythromycin, KV
CompanyLumara Health
RouteOral (PO)
StatusApproved

Therapeutic Indications

erythromycin is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Infections and infestationsSalmonellosis✓ Approved

Related Research Articles

PubMedMedical physics2026-05-24

Monte Carlo modeling of the field size dependency for thin window plane-parallel chambers in kilovoltage X-ray reference dosimetry.

Kadeer Fayz F, Healy Brendan B, Butler Duncan D

Clinical dosimetry for kV X-ray radiotherapy beams requires calibrated ionization chambers. When the clinical field size differs from the field size used for chamber calibration, in-air measurements result in a different magnitude of scatter from the detector stem or body housing affecting the sensitive volume. This results in a field size dependency based on how much of the chamber body is irradiated, which can be corrected for using the factor Pstem,air. This factor is challenging to characterize, and published data is recommended for this correction. This study aims to use Monte Carlo (MC) modeled factors as a function of field size and beam quality to establish Pstem,air correction factor values for the PTW 23342 and 23344 chambers (PTW Freiburg GmbH, Freiburg, Germany) and validate these results with measurements. Calculations of the Pstem,air correction factors were made using the egs_chamber user code of the EGSnrc MC package for the full suite of low energy X-ray beams which Australia's Primary Standards Dosimetry Laboratory (PSDL) use to calibrate these chamber types (20-100 kV, half value layer [HVL] 0.11-6.53 mm Al). The field size diameters ranged from 1 to 12 cm. To validate the modeling, measurements of the field size dependency were conducted on a subset of the Australian PSDL medium energy X-ray beams. The Pstem,air correction values were normalized to the results corresponding to the 5 cm field size diameter. Pstem,air correction factors are a function of circular field size diameter and HVL. The MC modeled correction factors agreed with the measured factors, for both chamber types, within the calculated ± 1.7% (k = 2) combined uncertainty. The results in this study agreed within uncertainties with the measurements of Austerlitz et al. (2004) and the IAEA TRS398 CoP (2024) for the PTW 23342 chamber in a 100 kV beam and field size diameters from 3 to 5 cm. However, disagreement up to 3.0% was observed when comparing the results of this study with the IAEA TRS398 CoP (2024) measured data at 10 cm relative to 3 cm, for the 100 kV beam. Higher differences may be attributed to differences in the 100 kV beam qualities, and the unknown scatter contribution effect from the physical chamber holder with the measurement data. It is acknowledged that comparisons with the literature at 100 kV were made at beam qualities which exceeded the recommended upper HVL limit of 2.2 mm Al for these chambers. We consider the MC modeled data to be the more accurate characterization of the Pstem,air correction factor, since the results are not affected by additional scatter from a chamber holder. Physical measurements would not be immune from this effect and would be variable between holder designs. MC modeled Pstem,air correction factor values for in-air measurements of kilovoltage radiotherapy beams using the PTW 23342 and 23344 ionization chambers were determined and validated with experimental measurements. This work provides field size correction factors for these ionization chambers, improving kV X-ray radiation therapy treatment accuracy with more accurate dosimetry.

PubMedScientific reports2026-05-24

Impact of atmospheric electrical charges on ryegrass pollen rupture and sub-pollen particle release.

Venkatesan Sudharsun S, Zare Ali A, Ristovski Zoran D ZD, Alinaghipour Behnaz B et al.

Thunderstorm asthma (TA) is a significant health concern, recorded in 26 instances globally, primarily linked to ryegrass pollen. Existing research has shown that physical forces such as wind and rain can cause pollen to rupture during thunderstorms, creating micronic, inhalable allergen-rich fragments called sub-pollen particles (SPPs). However, little is known about the role of electrical charges in storm clouds, such as those associated with lightning, in triggering pollen rupture. This study presents the first simulation-based evidence that the static electric fields typical of storm clouds (105-870 kV/m) can fragment pollen into SPPs. The results reveal a clear increase in pollen fragmentation and dispersal when exposed to these charges - especially at higher electric field strengths and higher humidity. Under discharge conditions, such as simulated lightning (arcing), fragmentation intensifies, generating abundant, irregularly shaped ruptured pollen particles, as confirmed by scanning electron microscopy. The results identify both static and discharge electrical processes in storm clouds as drivers of pollen rupture, advancing the mechanistic understanding of TA. In the context of climate change-driven increases in severe storm frequency and intensity, this dual-mechanism insight has important implications for forecasting TA risk and mitigating respiratory health impacts.

PubMedMetabolomics : Official journal of the Metabolomic Society2026-05-24

Integrated GC-MS and UHPLC-HRMS/MS profiling of bioactive compounds from Streptomyces sp. BPA-6 isolated from bees-collected pollen.

Belhadj Hani H, Mokhnache Mohamed M, Alien Ahmed Mohamed Bachir AMB, Pellegrini Marika M et al.

Antimicrobial resistance is one of the most current global health challenges, due to the increasing ineffectiveness of antibiotics and the increasing difficulty in treating infections. Approximately two-thirds of microbial antibiotics are produced by actinomycetes, of which approximately 74% come from the genus Streptomyces. In this study, a novel actinomycete strain, Streptomyces sp. BPA-6, isolated from pollen collected by Algerian bees, was investigated for its antimicrobial potential and chemical composition by GC-MS and HPLC-MS analyses. The strain showed strong antimicrobial activity against Staphylococcus aureus, Bacillus subtilis, and Candida albicans, with minimum inhibitory concentrations (MICs) ranging from 62.5 to 250 µg/mL. Molecular identification using 16S rRNA gene sequencing and scanning electron microscopy confirmed the affiliation of the isolate to the genus Streptomyces. GC-MS analysis of the ethyl acetate extract revealed a complex mixture of volatile organic compounds, including fatty acid methyl esters, long-chain hydrocarbons, and sesquiterpenes, many of which are associated with antimicrobial, antioxidant, or anti-inflammatory properties. Complementary HPLC-MS profiling identified more than 40 nonvolatile bioactive compounds, including macrolides (erythromycin), polyethers (nigericin), aminoglycosides (netilmicin), polyketides (cytosporone C), and various sugar and lipid derivatives. The chemical diversity of the extract highlights the rich biosynthetic capacity of BPA-6 and its potential as a source of novel natural products.

PubMedLangmuir : the ACS journal of surfaces and colloids2026-05-23

Interfacial Polarization Engineering in MXene-Polymer Nanofibers for High-Output Triboelectric Nanogenerators.

Gong Chenbo C, Song ZhaoHong Z, He Zixu Z, Liu He H et al.

In mechanical energy harvesting and sensing, triboelectric nanogenerators (TENGs) have garnered significant attention for effectively extracting energy from low-frequency, irregular motion and directly transducing it into sensing signals. However, poly(vinylidene fluoride)-based (PVDF-based) TENGs frequently exhibit limitations, including low power density, low output current, and high matched load resistance during operation. Herein, we report a TENG based on MXene, hydroxypropyl methylcellulose (HPMC), and PVDF-HFP composite nanofibers membrane (MHPm) as the negative tribo-layer and Al foil as the counter tribo-layer/electrode for low-frequency mechanical energy harvesting and real-time, ultrasensitive respiratory monitoring. HPMC acts as a synergistic regulator that promotes interfacial interactions among MXene, HPMC, and PVDF-HFP, reduces the coherent stacking scale of MXenes, and facilitates the maintenance of a discrete conductor-polymer-conductor structure, thereby strengthening interfacial polarization and electrical output performance. Under the drive of 70 N and 6 Hz, this device achieves a peak-to-peak (p-p) open-circuit voltage of 1.02 kV, a p-p short-circuit current density of 0.133 A·m-2, and a peak power density of 27.40 W·m-2 at a matched load resistance of 20 MΩ, while maintaining a stable current output over 15,000 contact-separation cycles. Moreover, the electrical outputs also provide well-differentiated breathing waveforms, enabling direct self-powered signal acquisition and supporting integrated wearable functionality.

PubMedBMC nephrology2026-05-23

Staphylococcus aureus carriage among hemodialysis outpatients: risk factors, antimicrobial resistance, and molecular characterization.

Kirkliauskienė Agnė A, Vitkauskaitė Monika M, Vankevičienė Karolina K, Bratchikov Maksim M et al.

Staphylococcus aureus (S. aureus) carriage is prevalent among hemodialysis outpatients and may be associated with frequent healthcare contact and vascular access use. The aim of the study was to determine the prevalence of S. aureus carriage, factors associated with carriage, antimicrobial resistance patterns, and selected resistance and virulence genes among hemodialysis outpatients. A cross-sectional observational study was conducted in 2018-2021. Eighty-one hemodialysis outpatients and 81 age-matched adults without kidney disease were included. S. aureus isolates were identified using standard microbiological methods, and antimicrobial susceptibility testing was performed according to EUCAST criteria. Multiplex real-time PCR was used for the detection of resistance genes (ermA, ermC, mecA, tetM, tetK) and the lukF-PV associated virulence gene. Factors associated with carriage were assessed using structured interviews and electronic medical records. Categorical variables were compared using chi-square or Fisher's exact tests, and continuous variables using Mann-Whitney U-test. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. Significance level - p < 0.05. Eighty-one hemodialysis outpatients (39.5% female; mean age 62.0 years) were enrolled. S. aureus carriage was detected in 38.3% and was significantly higher than in controls (p = 0.041). In univariable analyses, S. aureus carriage was associated with hemodialysis access type, dialysis vintage, recent hospitalization, antimicrobial use, gastroesophageal reflux disease, atrial fibrillation, anemia, and secondary hyperparathyroidism (all p < 0.05). In exploratory multivariable analysis, only atrial fibrillation remained associated with carriage. Resistance to penicillin was observed in 69.7% of isolates, tetracycline in 6.1%, and erythromycin/clindamycin in 3.0%. No methicillin-resistant S. aureus (MRSA) isolates were detected; pvl was detected in 1/33 (3.0%) hemodialysis isolates and in 3/52 (5.8%) isolates overall. Compared to healthy controls, hemodialysis patients were more frequently colonized with S. aureus. The observed resistance and virulence profiles provide local epidemiological data from Lithuania. The selected resistance and virulence gene profiles provide descriptive molecular data but do not allow conclusions regarding lineages or transmission patterns.

PubMedJournal of food science2026-05-22

Co-Occurrence of Biofilm Formation and Disinfectant-Antimicrobial Resistance in Staphylococcus spp. Along the Dairy Production Chain.

Karadal Fulden F, Ertas Onmaz Nurhan N, Bagci Cemalettin C, Ucar Yeliz Y et al.

This study aims to investigate the co-occurrence of biofilm formation and resistance to disinfectants and antimicrobial agents in Staphylococcus spp. isolated from different stages of the dairy production chain, and to assess the contribution of these traits to persistence in dairy processing environments. A total of 51 Staphylococcus isolates, including coagulase-positive and coagulase-negative species, were recovered from raw milk, dairy products, and food-contact surfaces after disinfection. Biofilm and slime formation were assessed phenotypically, while biofilm-associated (icaA, icaD, bap) and disinfectant resistance-associated genes [qac (A, B, C, G, H, J), mdeA, lmrS, and norA] were detected by PCR. Antimicrobial susceptibility was determined by disk diffusion, and disinfectant resistance by broth microdilution. Biofilm and/or slime formation was detected in 52.9% of isolates, including 89% of Staphylococcus aureus and 45.2% of coagulase-negative staphylococci. Resistance to oxacillin was highly prevalent (94.1%), followed by tetracycline (29.4%) and erythromycin (17.6%). Reduced susceptibility was most frequently observed for quaternary ammonium compound-based disinfectants (62.7%), whereas resistance to phosphate-acid-, chlorine-, and peracetic acid-based disinfectants ranged from 17.7% to 35.3%. According to the study results, Staphylococcus species combine biofilm-forming capacity with decreased susceptibility to commonly used disinfectants and high levels of antimicrobial resistance, with oxacillin and QACs resistance being particularly prevalent. Overall, the findings highlight the presence of resistant staphylococci in the dairy production chain and underscore the need for optimized hygiene and control strategies.

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