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erythromycin (erythromycin, KV)

✓ Approved

Lumara Health · therapeutic agent

What is erythromycin?

erythromycin is a therapeutic agent developed by Lumara Health. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand Nameserythromycin, KV
CompanyLumara Health
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, Lumara Health

Therapeutic Indications

erythromycin is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Infections and infestationsSalmonellosis✓ Approved

Related Research Articles

PubMedRSC advances2026-07-25

Enhancing broadband electromagnetic wave absorption performance of NZFO/BSTO multiferroic materials in the X and Ku bands.

Tung Do Khanh DK, Son Tung Bui B, Viet Nguyen Van NV, Truong Nguyen Xuan NX et al.

Multiferroic composites with the composition xNi0.5Zn0.5Fe2O4/(1 - x)(Ba0.8Sr0.2TiO3) (denoted as NZFO/BSTO) (where x = 0, 0.1, 0.2, 0.3, 0.4, and 1.0) were fabricated using a solid-state reaction method combined with spark plasma sintering. The obtained materials exhibited an average particle size of approximately 500 nm. X-ray diffraction analysis confirms the co-existence of the ferromagnetic Ni0.5Zn0.5Fe2O4 (NZFO) phase and the ferroelectric Ba0.8Sr0.2TiO3 (BSTO) phase. As the NZFO content increases from x = 0.1 to 0.4, the saturation magnetization (M s) rises from 13.6 to 56.9 emu g-1, while the remanent magnetization (M r) increases from 0.71 to 1.88 emu g-1. Simultaneously, the P-E hysteresis loops become more pronounced, with a significant increase in both the maximum polarization (P m) and remanent polarization (P r). The coercive electric field (E c) also increases markedly from 1.94 kV cm-1 to 3.56 kV cm-1 under an applied electric field of 12.5 kV cm-1. The composite with the ferromagnetic phase fraction x = 0.4 exhibits excellent broadband electromagnetic wave absorption performance. At thicknesses of 2.0 mm and 2.5 mm, the effective absorption bandwidth exceeds 5.4 GHz and 5.7 GHz, respectively. Notably, minimum reflection loss (RLmin) values of -48.3 dB and -43.9 dB are achieved at 15.7 GHz and 12.6 GHz, respectively. These results demonstrate the strong potential of the material for practical applications in electromagnetic wave absorption in the X-band and Ku-band frequency ranges, particularly in radar stealth and military technologies.

PMID 42500411
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PubMedDose-response : a publication of International Hormesis Society2026-07-25

Dose Reconstruction After a WD‒XRF Spectrometer Accident Using Minute-Rate TLD Measurements.

Gao Yiying Y, Wang Haoyu H, He Ling L, He Liangguo L et al.

Accurate dose estimation following radiation accidents remains challenging, particularly when personal dosimeter data are unavailable. This study presents a practical post-accident dose reconstruction approach based on minute-rate thermoluminescent dosimeter (TLD) measurements combined with exposure scenario reconstruction, demonstrated through a wavelength-dispersive X-ray fluorescence (WD‒XRF) spectrometer accident. The exposure scenario was reconstructed by placing LiF(Mg,Cu,P) TLDs at seven representative positions corresponding to head and hand locations, with the spectrometer operated under the recorded technical parameters (40 kV, 7 mA). Minute personal dose equivalent rates, H p'(10), were measured and combined with reconstructed retention times to calculate cumulative doses, from which skin absorbed doses were derived. The measured dose rates ranged from 0.13 to 358.38 mSv/min for the head and from 0.07 to 620.24 mSv/min for the hands. The resulting cumulative skin absorbed doses were 7.58 Gy for the head and 12.52 Gy for the hands, consistent with reported dose ranges associated with localized radiation injury. This approach provides a feasible supplementary strategy for retrospective dose reconstruction under emergency or resource-limited conditions when conventional dosimetric information is unavailable.

PMID 42500306
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PubMedWater research2026-07-25

Scalable nanoconfined GO/SWCNT-OH membranes for efficient high-salinity organic wastewater treatment.

An Yechen Y, Gao Xiaoxu X, Han Jing-Long JL, Ning Yuting Y et al.

Recovering valuable organic compounds from high-salinity organic wastewater is essential for sustainable chemical manufacturing. However, conventional polymeric membranes suffer from insufficient organic/inorganic selectivity, poor solvent resistance, and severe membrane fouling during practical applications. Herein, we developed a hydroxylated carbon nanotube (CNT-OH)-modulated graphene oxide (GO) membrane to address these challenges. By precisely regulating the inner diameter and hydroxyl content of CNT-OH, rapid transport channels for water molecules and hydrated ions were constructed, which simultaneously suppressed interlayer swelling and enhanced the rejection of organic compounds. The optimized GO/single-walled hydroxylated carbon nanotubes (SWCNT-OH) membrane achieved water permeability of 28.7 l m-2 h-1 bar-1 and separation factor above 15 for negatively charged dyes, antibiotics, and per- and polyfluoroalkyl substances (PFASs) relative to inorganic salts (NaCl), outperforming commercial nanofiltration (NF) membranes by one order of magnitude. During one-month continuous treatment of real erythromycin (ERY) fermentation broth, the membrane showed only a 7.1% flux decline and maintained 99.9% ERY rejection. Compared with conventional ultrafiltration-nanofiltration (UF-NF) processes, the system reduced operating costs by 66.4% and CO2 emissions by 76.8%, demonstrating pronounced economic and environmental advantages. Overall, the system demonstrates outstanding application potential, strong scalability and engineering feasibility.

PMID 42497558
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PubMedPhysica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)2026-07-25

Optimising beam quality for chest X-ray imaging: Insights from over two decades of peer reviewed publication.

Devery Ms Clare MC, Sweetman Lorna L, Cody Dervil D

Optimisation of beam quality for chest radiography has been extensively investigated and reported on, but there are few comparisons of the reported study methods, outcomes and recommendations. This work aims to compile the available data on this subject with the objective of identifying and categorising the methods used to optimise chest x-ray (CXR) imaging, and to determine if a particular beam quality can be distinguished as optimal. A literature review was carried out on papers investigating optimisation of beam quality for CXR exposures. The identified studies (n = 29, spanning 2001-2020) were grouped into descriptive categorical variables. Statistical analysis (Fisher's exact testing) was used to investigate the relationships between the materials, methods and results drawn from literature concerning the CXR optimisation process. The primary decisions in each CXR optimisation study concern the type of source image used and the image assessment approach adopted. Across the literature, 240 potential combinations of methodological variables were found. The findings are highly variable, and no standardised optimisation approach emerges. The literature provides no definitive evidence for an optimal beam quality in chest radiography. While the most frequently recommended tube voltages were in the 90-110 kV range, this accounted for only 43% of studies. Only one-third of the analysed studies accounted for the influence of filtration. These findings pose a challenge for medical physicists engaging in optimisation activities in clinical departments and support the case for standardising both the approaches for optimisation of the technical parameters in general radiography, and the reporting of same.

PMID 42497642
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PubMedPesticide biochemistry and physiology2026-07-24

The neurotoxicity of Chlorantraniliprole to Helicoverpa armigera larvae.

Zhang Lingna L, Hou Jiayin J, Li Yuxin Y, Wei Xinghui X et al.

Chlorantraniliprole (CAP) is a mainstream diamide insecticide widely used against lepidopteran pests such as Helicoverpa armigera. Given that most insecticides act via neurotoxic mechanisms, we reasoned that CAP, despite its well-established action on ryanodine receptors (RyRs), may also disrupt nervous system function through additional targets. Insect neurotoxicity is a coordinated process involving neurons and glial cells: voltage-gated sodium (Nav) and potassium (Kv) channels are common insecticide targets, however, their involvement in CAP-induced neurotoxicity has not been established, and glial contributions are poorly understood. We elucidated CAP's multi-target mechanisms by constructing the first single-cell transcriptomic atlas of the H. armigera ventral nerve cord (VNC) using scRNA-seq, validated by whole-cell patch-clamp electrophysiology and RT-qPCR. Results showed that CAP modulated the kinetics of Nav channel in a concentration-dependent manner and suppressed Kv channel currents, confirming both as novel non-canonical targets. scRNA-seq identified VNC cell types, identifying NKCC (perineurial glia-enriched) and UGT39B1 (subperineurial glia-enriched); both were upregulated after 24 h LC30 CAP exposure. These results indicate that CAP modulates Nav and Kv channels at relatively high concentrations. As potential functional targets, these channels supplement the primary RyR-mediated action of CAP, and imply a partial mechanistic similarity to pyrethroids via regulation of Nav channels. Moreover, the VNC atlas facilitated the identification of glial-specific markers (NKCC and UGT39B1), clarifying glial involvement. Collectively, our work advances multi-target understanding of diamide insecticides, provides candidate synergists, and supports "neuron-glial dual-target" strategies for managing H. armigera resistance.

PMID 42493017
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PubMedJournal of developmental biology2026-07-24

Evolutionary Analysis of Vertebrate KCNH Voltage-Gated Potassium Channels and Spatial Expression of kcnh Genes in Zebrafish Embryos.

Wu Kuangyi K, Wang Dingxun D, Dong Ziyu Z, Zhou Alice Yahui AY et al.

Voltage-gated potassium channels (Kv) are a large family of potassium channels composed of 40 members across 12 subtypes. The KCNH genes encode three subfamilies of voltage-gated potassium channels: Kv10 (EAG, ether à go go), Kv11 (ERG, EAG-related gene), and Kv12 (ELK, EAG-like K). Kv channels play prominent roles in neuronal and cardiovascular systems. Mutations in Kv channels have been linked to many human diseases, such as epilepsy, heart arrhythmias, and cancers. Significant progress has been made in understanding protein structures, physiological functions, and pharmacological modifiers. However, the evolutionary history and gene expression of vertebrate KCNH genes during embryonic development remain largely unknown. We systematically identified and cloned 14 kcnh genes in zebrafish. Then, we examined the vertebrate KCNH channel evolution by phylogenetic and syntenic analyses. Our data reveal that the three subtypes of the KCNH gene family had already evolved in invertebrates, long before the emergence of vertebrates. The number of vertebrate KCNH genes increased, most likely due to whole-genome duplications (WGDs). In addition, we examined zebrafish kcnh gene expression during early embryogenesis by in situ hybridization. Each subgroup's genes showed similar but distinct gene expression domains with some exceptions. Most of them were expressed in neural tissues. Notably, kcnh6a showed robust expression in the developing heart, consistent with its conserved role in cardiac repolarization. Additionally, a few kcnh genes were transiently expressed in non-neural tissues, such as somites and the notochord, suggesting they may have a unique role in embryonic development. Our phylogenetic and developmental analyses of KCNH channels shed light on their evolutionary history and potential roles during embryogenesis, in line with their physiological functions and human channelopathies.

PMID 42496271
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