Drug Database
FR

Fraction F (Fraction F / Ateroid / Ateroid 200)

✓ Approved

Gentium · therapeutic agent

What is Fraction F?

Fraction F is a therapeutic agent developed by Gentium. It is approved for therapeutic indications via injectable (others) or intravenous (iv) or oral (po).

Drug Profile

Brand NamesFraction F, Ateroid, Ateroid 200
CompanyGentium
RouteInjectable (Others), Intravenous (IV), Oral (PO)
StatusApproved
Sources: ClinicalTrials.gov, Gentium

Therapeutic Indications

Fraction F is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Nervous system disordersDementia Alzheimer's type✓ Approved

Related Research Articles

PubMedNMR in biomedicine2026-09-19

Assessment of Cerebral Perfusion Asymmetry in Chronic Migraine Patients Using Intravoxel Incoherent Motion (IVIM)-Derived Pseudodiffusion Coefficient and Perfusion Fraction.

Senturk Yunus Emre YE, Peker Ahmet A, Yuzkan Sabahattin S, Ergin Huseyin Ekin HE et al.

Chronic migraine (CM) is associated with neurobiological alterations beyond episodic attacks, yet cerebral microvascular perfusion changes during the interictal phase of CM remain underexplored. Intravoxel incoherent motion (IVIM) magnetic resonance imaging (MRI) provides diffusion-derived pseudoperfusion parameters that reflect regional microvascular alterations in the brain parenchyma. Accordingly, this study aimed to investigate right-to-left hemispheric asymmetry of IVIM-derived perfusion parameters in migraine-implicated cortical and subcortical regions during the interictal phase of CM. Thirty patients with CM imaged during the interictal phase, along with 30 age- and sex-matched healthy controls, underwent IVIM imaging. IVIM parameters, including the pseudodiffusion coefficient (D*), perfusion fraction (f), and their composite metric (fD*), were estimated using a Bayesian probability-based fitting algorithm. Region-of-interest (ROI) analysis was performed bilaterally in migraine-implicated cortical and subcortical regions. Hemispheric asymmetry indices (HAIs) of IVIM parameters were calculated and compared between groups using Benjamini-Hochberg (FDR) false discovery rate correction. No absolute IVIM parameter showed significant interhemispheric differences in either group after FDR correction. In addition, no significant group differences in HAI of IVIM parameters were identified across the six cortical regions or pontine tegmentum. In contrast, posterior thalamic fD* asymmetry was significantly greater in patients with CM than in controls (median HAI: 27.91 vs. 10.43; p = 0.002, q = 0.017). Exploratory analysis confirmed greater separation between bilateral posterior thalamic fD* measurements in CM versus control subjects (0.429 vs. 0.151 × 10-3 mm2/s; p = 0.002), whereas leave-one-out analysis showed that this outcome was not driven by any single participant. Interobserver agreement for HAI measurements was good for D* (ICC = 0.81) and moderate for f and fD* (ICC = 0.70 and 0.69, respectively). These findings indicate that CM is associated with increased hemispheric asymmetry of IVIM-derived microvascular perfusion in the posterior thalamus during interictal phase, suggesting lateralized thalamic microvascular alterations in CM.

PMID 42760639
Read full article →
PubMedFrontiers in psychology2026-09-19

Contextual and cultural influences on preschoolers' aesthetic experience: evidence from a situational teaching intervention in China.

Fang Fei F, Li Xiangyu X, Yan Lin L, Zhu Jian J et al.

Contextual and cultural influences play an important role in shaping young children's learning, meaning-making, and emotional engagement. In early childhood education, art appreciation provides a valuable context for examining how children perceive, interpret, and emotionally respond to culturally and pedagogically structured learning environments. However, empirical evidence remains limited regarding how culturally grounded contextual teaching approaches influence preschoolers' aesthetic experience. Drawing on situated learning theory and Li Jilin's situational teaching framework in China, this study examined the effects of a situational teaching intervention on preschoolers' aesthetic experience in art appreciation. A quasi-experimental pretest-posttest control group design was adopted. Sixty preschool children from two intact classes in a public kindergarten in Beijing, China, participated in the study. One class was assigned to the experimental group, and the other served as the control group. Over an eight-week period, the experimental group participated in situational art appreciation activities organized around life-related scenarios, storytelling, role-play, multisensory exploration, and reflective dialogue, whereas the control group received conventional art appreciation instruction. Children's aesthetic experience was assessed across three dimensions: aesthetic perception, aesthetic understanding, and aesthetic emotion. Repeated-measures ANOVAs revealed Group × Time interactions for visual perception and verbal expression, F(1, 58) = 8.12, p = 0.01, ηp 2 = 0.12; aesthetic understanding, F(1, 58) = 9.32, p < 0.001, ηp 2 = 0.14; facial expression, F(1, 58) = 5.14, p = 0.03, ηp 2 = 0.08; and preference explanation, F(1, 58) = 4.78, p = 0.03, ηp 2 = 0.08. No significant Group × Time interaction was found for viewing duration, F(1, 58) = 0.54, p = 0.46, ηp 2 = 0.01. After Bonferroni correction, robust intervention effects remained for visual perception and verbal expression and aesthetic understanding, while effects on aesthetic emotion were suggestive and should be interpreted with caution. The results suggest that culturally grounded situational teaching can support preschoolers' aesthetic-cognitive and socio-emotional engagement by embedding artworks within meaningful, interactive, and emotionally resonant learning contexts. This study provides educational psychological evidence for the role of contextualized teaching in promoting young children's perception, meaning-making, and emotional expression. It also extends research on contextual and cultural influences by showing how a Chinese situational teaching model may function as a developmentally appropriate contextual learning approach in early childhood art education.

PMID 42761055
Read full article →
PubMedVeterinary research communications2026-09-19

Macroscopic and ultrasonographic anatomy of the brachial plexus in the American kestrel (Falco sparverius).

Morel Ana Paula AP, Rösler Maria Lúcia ML, de Souza Ana Júlia Fazenda AJF, da Silva Luana Célia Stunitz LCS et al.

The American kestrel (Falco sparverius) is a small raptor frequently admitted to wildlife rehabilitation centers, often due to traumatic injuries requiring surgical intervention. Regional anesthesia techniques, particularly brachial plexus blocks, may improve perioperative management; however, species-specific anatomical and ultrasonographic data remain limited. This study aimed to characterize the macroscopic and ultrasonographic anatomy of the brachial plexus in F. sparverius and to assess the distribution of injectate following ultrasound-guided administration. Nineteen kestrels were allocated into three groups: anatomical dissection (n = 6), ultrasonographic evaluation (n = 8), and cadaveric ultrasound-guided dye injection 0.5 mL kg⁻¹ of a lidocaine-methylene blue solution resulted in consistent dye distribution within the plexus location (n = 5). The brachial plexus was formed by the ventral rami of spinal nerves C13-T2, organized into dorsal and ventral fascicles. Ultrasonographically, the brachial plexus appeared as small hypoechoic structures beneath the superficial and deep pectoral muscles using a ventral approach. These findings demonstrate that the brachial plexus of F. sparverius follows a typical avian pattern with species-specific variations and that the ventral ultrasonographic approach allows reliable visualization and accurate injectate delivery. This study provides anatomical and imaging data to support the development of regional anesthesia techniques in small raptors.

PMID 42760395
Read full article →
PubMedJournal of food science2026-09-19

Physicochemical Insights Into Structuring Olive Oil With Dry-Fractionated Anhydrous Milk Fat.

Zampouni Konstantina K, Prodromidis Prodromos P, Andriotis Elefterios G EG, Katsanidis Eugenios E et al.

Anhydrous milk fat (AMF) and its dry-fractionated derivatives were evaluated as structurants for olive oil oleogels designed to reduce the overall saturated fat content compared to conventional solid fats. AMF was subjected to sequential dry fractionation at temperatures ranging from 5°C to 30°C to produce liquid and solid fractions differing in fatty acid composition and thermal behavior. The fractions were characterized using GC-FID, Raman and ATR-FTIR spectroscopy, polarized and confocal microscopy, rheological measurements, and thermal analysis. Based on their distinct physicochemical properties, the 30°C fractions (S30 and O30) were further investigated as oleogelators in olive oil. The S30 fraction was enriched in saturated fatty acids, exhibited higher melting temperatures and formed dense microstructures composed of numerous fine crystals. Rheological measurements revealed that the S30 generated robust oleogels at significantly lower concentrations than unfractionated AMF, demonstrating high structuring efficiency through the formation of a strong crystalline network. However, these oleogels also exhibited greater brittleness, consistent with their denser crystal packing. Overall, dry-fractionated AMF effectively structured olive oil into stable oleogels. Despite its higher saturated fatty acid content, the S30 fraction formed self-supporting oleogels at a structurant concentration of only 25% (w/w). Consequently, oleogels containing 25% S30 and 75% olive oil may provide structured lipid systems with a lower overall saturated fatty acid content than formulations based entirely on AMF or conventional solid fats while maintaining desirable mechanical and functional properties. These findings highlight the potential of dry-fractionated AMF as a natural, food-grade oleogelator for developing alternative structured lipid systems.

PMID 42760796
Read full article →
PubMedJournal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine2026-09-19

Diagnostic Accuracy of Quantitative Ultrasound Liver Fat Estimation with MRI-PDFF as the Reference Standard.

Roccarina Davide D, Ferraioli Giovanna G, Hidalgo Ronald R, Barr Richard G RG

To assess the performance of 3 ultrasound-based liver fat quantification algorithms-tissue attenuation imaging (TAI), tissue scatter imaging (TSI; Nakagami parameter), and ultrasound-derived fat fraction (USFF)-using magnetic resonance imaging-derived proton density fat fraction (MRI-PDFF) as the reference standard. In this prospective, IRB-approved, HIPAA-compliant study conducted at 2 North American centers, adults with or at risk for hepatic steatosis underwent quantitative ultrasound and same-day MRI-PDFF. The US examinations were performed with the Samsung RS85 system (Samsung Medison, Seoul, South Korea) using a C1-5S transducer. The software version utilized was 2.08.01.3538. Correlations were assessed using Spearman's rho. Diagnostic performance for steatosis grades S > 0, S > 1, and S > 2 was evaluated using AUROC analysis. Overall accuracy across grades was also assessed with the Obuchowski measure. Correlations and AUROCs were compared using Steiger's and DeLong's tests, respectively. Among 181 participants (113 women; median age, 57 years), MRI-PDFF correlated strongly with TAI and USFF (rho, 0.77 and 0.79) and moderately with TSI (rho, 0.57). For S > 0, AUROCs were 0.92 for TAI, 0.78 for TSI, and 0.93 for USFF; for S > 1, 0.88, 0.77, and 0.89; and for S > 2, 0.81, 0.73, and 0.83, respectively. Obuchowski measures were 0.87, 0.76, and 0.88. TAI and USFF were significantly more accurate than TSI (p = .03 and p = .02), with no significant difference between them (p = .79). TAI and USFF showed high, comparable performance for detecting hepatic steatosis and outperformed TSI. USFF was numerically superior to TAI, without significant incremental benefit. Discrimination between moderate and severe steatosis remained limited in the US evaluation.

PMID 42760613
Read full article →
PubMedJournal of fluorescence2026-09-19

Modulation of Optoelectronic Performance in N-alkyl-dithieno[3,2 b:2',3' d]pyrrole based Organic Dyes: Insights from DFT/TD-DFT.

Panigrahi Ananta A, Sahu Prabhat K PK

The present study focuses computational design and theoretical evaluation of ten different donor-π-acceptor (D-π-A) organic dyes F (1-10), for dye-sensitized solar cell (DSSC) applications. The dye molecules are incorporated using 4-methyl-4H-dithieno[3,2-b:2',3'-d]pyrrole π-bridge combined with different electron-donating groups, including amino, dimethylamine, methoxy, and diphenylamine, along with electron-withdrawing acceptors such as nitro (-NO₂), cyano (-CN), cyanoacrylic acid (CAA), 4,5-dicyanoimidazole (DCI), and 5,6-dicyanobenzoimidazole (DCBI). Density functional theory (DFT) and time-dependent DFT (TD-DFT) calculations have been performed to investigate the electronic, optical, and photovoltaic properties. The optimized dyes exhibit narrow energy gaps (2.67- 4.00 eV) and strong intramolecular charge-transfer (ICT) characteristics with absorption maxima ranging from 312.5 nm to 564.3 nm. Organic dyes with CAA, DCI and DCBI units significantly enhance ICT strength, red-shifts absorption spectra, and improve electron injection efficiency. The calculated open-circuit voltages ([Formula: see text]) span from 1.18 V to 1.41 V, while light-harvesting efficiencies (LHE) reach up to 96.57%. The photovoltaic analysis shows outstanding device performance, with short-circuit current densities ([Formula: see text]) reaching 32.3 mA cm⁻2 and power conversion efficiencies (PCE) up to 37.8%. Collectively, these results underscore the potential of the proposed dyes as high-efficiency sensitizers for next-generation DSSC applications.

PMID 42760452
Read full article →

+9996 more articles available with a free account

Sign up free to view all articles →

Ask about Fraction F