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Fraction F (Fraction F / Ateroid / Ateroid 200)

✓ Approved

Gentium · therapeutic agent

What is Fraction F?

Fraction F is a therapeutic agent developed by Gentium. It is approved for therapeutic indications via injectable (others) or intravenous (iv) or oral (po).

Drug Profile

Brand NamesFraction F, Ateroid, Ateroid 200
CompanyGentium
RouteInjectable (Others), Intravenous (IV), Oral (PO)
StatusApproved
Sources: ClinicalTrials.gov, Gentium

Therapeutic Indications

Fraction F is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Nervous system disordersDementia Alzheimer's type✓ Approved

Related Research Articles

PubMedFrontiers in pediatrics2026-11-11

The effects of physical games on memory and attention in children aged 5-6 years: a preliminary study.

Zhang Huihui H, Liu Yucheng Y, Zuo Yifan Y, Cui Jiabao J

This pilot study with class-level random assignment examined preliminary evidence on the associations between a structured physical game intervention and memory and attention in children aged 5-6 years. A 12-week physical game program based on cognitive load theory was designed and implemented, consisting of three 60-minute training sessions per week. The program included various game activities designed to promote memory and attention development supplemented by smart interactive motion data collection devices. A pilot study with class-level random assignment was conducted among 59 children aged 5-6 years. Two intact kindergarten classes were included, with one class assigned to the experimental group (n = 30) and the other to the control group (n = 29). The experimental group received the structured physical play intervention, whereas the control group participated in routine kindergarten physical activities. The class, rather than the individual child, was the unit of randomization. Before and after the intervention, children's memory and attention levels were assessed using the Wechsler Memory Scale (measuring picture memory, visual reproduction, visual recognition, digit span forward, and digit span backward) and the Schulte Grid test. A 2 × 2 repeated-measures ANOVA showed significant Group×Time interactions for total short-term memory (F(1,57) = 14.33, p < .001, ηp2 = .20), total immediate memory (F(1,57) = 7.84, p = .007, ηp2 = .12), picture memory (F(1,57) = 6.10, p = .017, ηp2 = .10), visual reproduction (F(1,57) = 18.40, p < .001, ηp2 = .24), and digit span forward (F(1,57) = 5.26, p = .026, ηp2 = .08). A significant Group×Time interaction was also observed for attention performance (F(1,57) = 8.17, p = .006, ηp2 = .13). These findings indicated greater pre-post changes in the experimental condition than in the control condition for the outcomes examined. These findings provide preliminary evidence that a structured physical game intervention was associated with improvements in memory-related task performance and task-related attentional processing in children aged 5-6 years.

PMID 43011067
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PubMedEnvironmental geochemistry and health2026-11-11

Metal(loid) and rare earth element patterns in road- and railway-affected urban soils: comparative source apportionment using total soil concentrations and the PM10 fraction.

Sycheva Daria G DG, Kosheleva Natalia E NE, Dubchak Irina A IA, Rosenberg Igor N IN et al.

Overlapping road- and railway-related inputs and lithogenic material can complicate source apportionment of trace elements in transport-affected soils, particularly when total soil concentrations integrate fine particles and coarser mineral components. This study compared total element concentrations in soil and concentrations in the soil PM10 fraction in transport-affected zones of Ulan-Ude and Severobaikalsk using geochemical indices, Positive Matrix Factorization (PMF), and health risk assessment. Cd, Sb, and Pb showed the most consistent accumulation in transport-affected areas. In Ulan-Ude, railway and roadside zones showed comparable patterns of elemental accumulation, and several transport-associated elements were preferentially concentrated in the PM10 fraction. In Severobaikalsk, Cd, Sb, and Pb showed the clearest anthropogenic accumulation, whereas HREEs were more strongly associated with the coarser mineral fraction. Their distribution relative to the local background, NASC-normalized patterns, and PMF results indicate a predominantly lithogenic origin, with a possible contribution from mineral material associated with railway infrastructure. Comparison of four PMF models showed that source profiles differed between total soil concentrations and the soil PM10 fraction. Several REEs were more strongly associated with lithogenic components in the PM10-based models, whereas transport-related factors were characterized by metal associations consistent with mechanical wear. These results indicate that analysis of the soil PM10 fraction can complement total-soil geochemistry in distinguishing transport-related and lithogenic contributions. Non-carcinogenic risks to adults remained below the screening threshold in all samples, with mean HI values of 0.163-0.263; mean carcinogenic risks were moderate, reaching 3.66 × 10-5 in Severobaikalsk and 3.94-5.18 × 10-5 in Ulan-Ude.

PMID 43009646
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PubMedJournal of agricultural and food chemistry2026-11-11

Polysaccharide A1 from Bran-Fried Atractylodes lancea Regulates Cyclophosphamide-induced Intestinal Immune Injury in Mice via the Faecalibaculum rodentium-Mediated IAA-AHR/RORC Axis.

Nie Wenlv W, Xiao Yangxin Y, Zhong Lijiao L, Wu Kehong K et al.

Cyclophosphamide-induced intestinal injury is often characterized by gut microbiota dysbiosis and metabolite imbalance. Bran-fried Atractylodes lancea polysaccharide (FALP-A1) protects against cyclophosphamide-induced intestinal injury by significantly modulating Faecalibaculum rodentium abundance. However, the mechanism of FALP-A1-mediated F. rodentium regulation remains unclear. Ex vivo digestion confirmed FALP-A1 is stable in the simulated upper gastrointestinal tract, while fermentation showed it is degradable and enriches F. rodentium. Nontargeted fecal metabolomics of in vivo mice co-treated with the FALP-A1 and Faecalibaculum rodentium, together with ex vivo coculture systems, identified Indoleacetic acid (IAA) as a potential metabolite. We further validated that IAA protects the intestinal barrier in cyclophosphamide-induced intestinal injury by modulating nuclear transcription factor RORC mRNA expression. However, these effects were reversed by an AHR inhibitor. This study elucidates the central role of "FALP-A1-F. rodentium-IAA-AHR/RORC" axis in protecting against cyclophosphamide-induced intestinal injury, providing evidence for pharmacological potential of FALP-A1 and indole-3-acetic acid.

PMID 43012691
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PubMedAnalytical chemistry2026-11-11

Single-Particle ICP-MS Enabled Multiplex Digital Detection of Nucleic Acids via Feedback Recombinase Polymerase Amplification.

Dai Feng F, He Man M, Yuan Guolin G, Cui Zewei Z et al.

Digital droplet assays, with their single-molecule sensitivity, hold great promise for early disease diagnosis by enabling precise biomarker quantification and the generation of patient-specific molecular profiles. Inductively coupled plasma mass spectrometry (ICP-MS) has shown its great potential in the quantification of biomolecules with elemental labeling strategies. However, the development of ICP-MS-based digital assays has been limited, primarily due to the challenge of efficiently anchoring elemental labels within droplets. To address this, we developed a feedback recombinase polymerase amplification (F-RPA)-based digital analyzer via a facile droplet generator and combined it with single particle (sp)-ICP-MS for the quantitative analysis of human papillomavirus (HPV) genetic markers. In this system, HPV DNA molecules are randomly partitioned across tens of thousands of agarose droplets, following a Poisson distribution. Individual encapsulated target DNA molecules initiate on-demand F-RPA amplification and anchoring of elemental tags for subsequent signal transduction. Leveraging the discrete event counting characteristics and multi-element analytical capabilities of sp-ICP-MS, the digital F-RPA assay achieved highly sensitive and multiplexed analysis, with detection limits as low as 20 copies/μL for HPV16 and 9 copies/μL for HPV18 DNA. The method was validated by quantifying the HPV DNA load in cervical cancer cell lines and further applied to clinical cervical swab samples, where it identified 26 HPV16-positive and 20 HPV18-positive cases with 100% precision. This digital F-RPA sp-ICP-MS system emerges as a robust diagnostic platform for trace biomarker analysis, significantly advancing the role of sp-ICP-MS in digital droplet detection and clinical diagnosis.

PMID 43010514
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PubMedJournal of human lactation : official journal of International Lactation Consultant Association2026-11-11

The Effect of Breast Crawl on Breastfeeding Success and Maternal Feeding Attitudes: A Randomized Controlled Trial.

Çimen Coşkun Kevser K, İlçioğlu Kevser K

Breastfeeding difficulties often begin with the first feeding after birth. Although infant-led approaches that support newborns' instinctive feeding behaviors are considered beneficial, experimental evidence on their effectiveness and mechanisms is limited. This study aimed to evaluate the effect of the breast crawl intervention on breastfeeding success and maternal feeding attitudes, and to examine whether maternal attitudes and duration of the first breastfeeding episode mediate this relationship. This study used a randomized controlled trial design with 63 mother and infant dyads. Newborns in the intervention group initiated breastfeeding through breast crawl, while routine breastfeeding care was provided in the control group, and outcomes were analyzed using adjusted and mediation models. After adjusting for breastfeeding experience, the intervention group demonstrated significantly longer duration of the first breastfeeding episode (F = 83.89, p < .001), higher LATCH scores (F = 8.99, p = .004), and more positive IIFAS scores (F = 4.34, p = .041) compared to the control group. Parallel mediation analysis indicated that the intervention had a significant direct effect on breastfeeding success (LATCH), but this relationship was not mediated by maternal attitudes or breastfeeding duration (p > .05). Breast crawl is an effective, low-cost, and non-invasive intervention that supports early breastfeeding success through primarily direct mechanisms and can be integrated into routine postpartum care.

PMID 43010687
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PubMedInternational journal of heart failure2026-11-11

Clinical Profiles and Guideline-Directed Therapy Patterns in Heart Failure With Preserved Versus Reduced Ejection Fraction: A Single-Center Retrospective Cohort Study From Pakistan.

Sethi Sher M SM, Umer Abdullah A, Batool Zainab Z, Jitender Kabir K et al.

Heart failure (HF) poses a growing global burden with regional and phenotypic variations. This study compared clinical characteristics, biomarker profiles, and guideline-directed medical therapy (GDMT) use between HF subtypes in a Pakistani tertiary-care population. We conducted a retrospective cohort study of 575 adults admitted with HF at a tertiary hospital in Karachi, Pakistan (2020-2023). Patients were classified as HF with preserved ejection fraction (HFpEF; ≥50%), mildly reduced ejection fraction (HFmrEF; 41-49%) and reduced ejection fraction (HFrEF; ≤40%). Demographic, clinical, laboratory, and treatment data were extracted from electronic records. GDMT score (0-4) reflected use of β-blocker, angiotensin-converting enzyme inhibitor/angiotensin receptor blocker/angiotensin receptor-neprilysin inhibitor, mineralocorticoid receptor antagonist, and sodium-glucose co-transporter 2 inhibitor. Outcomes were in-hospital mortality and 30-day HF readmission. Mean age was 67.67±13.12 years; 46% were male. 18 (3.1%) had HFmrEF; these patients were described descriptively because of limited sample size. HFpEF patients were mostly female (78.9% vs. 39.7%, p<0.001). HFrEF had more ischemic heart disease (58.6% vs. 37.7%, p<0.001). Pro-B-type natriuretic peptide levels were higher in HFrEF than HFpEF (9,142 [3,938-20,308] vs. 4,102 [1,410-9,758] pg/mL; p<0.001). GDMT scores were greater in HFrEF (1.72±1.22 vs. 1.12±0.92, p<0.001). Mortality (6.3%) and 30-day readmission (31.0%) did not differ by phenotype. HFpEF and HFrEF show distinct clinical and biomarker patterns, but GDMT uptake remains suboptimal. Despite similar short-term outcomes, strengthening evidence-based therapy is essential to improve HF care in resource-limited settings.

PMID 43011175
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