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ZI

zinc acetate dihydrate (Wilzin / Wilzin)

✓ Approved

Recordati S.p.A. · Small Molecule · Small Molecule

What is zinc acetate dihydrate?

zinc acetate dihydrate is a small molecule developed by Recordati S.p.A.. It is approved for therapeutic indications via unknown.

Drug Profile

Brand NamesWilzin, Wilzin
CompanyRecordati S.p.A.
Drug ClassSmall Molecule
RouteUnknown
StatusApproved
Sources: ClinicalTrials.gov, Recordati S.p.A.

Therapeutic Indications

zinc acetate dihydrate is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Congenital, familial and genetic disordersHepato-lenticular degeneration✓ Approved

Related Research Articles

PubMedVeterinary medicine and science2026-09-20

The Effect of Multi-Strain Probiotics, Zinc and Copper on the Performance of Broiler Chickens Challenged With Clostridium perfringens.

Kazemi Amin A, Kermanshahi Hassan H, Heravi Reza Majidzahe RM, Jouzani Gholamreza Salehi GS et al.

Clostridium perfringens infection is a major cause of necrotic enteritis in broiler chickens, leading to impaired growth performance and intestinal health. Nutritional strategies, such as probiotics and chelated trace minerals, may help mitigate these adverse effects. This study investigated the effects of multi-strain probiotics and chelated forms of zinc and copper on the performance, gut health and physiological responses of broiler chickens challenged with C. perfringens. A completely randomized design with six treatments involving 390 male broiler chickens was used. Treatments included (1) control, (2) control + challenge with C. perfringens, (3) challenge + selected probiotic strains, (4) challenge + chelated zinc, (5) challenge + chelated copper and (6) challenge + a combination of probiotics, zinc and copper. Growth performance, carcass characteristics, gut histomorphology, ileal pH, microbial populations, blood biochemical parameters and volatile fatty acids (VFAs) were evaluated. C. perfringens infection significantly (p < 0.05) impaired growth performance and gut health, as evidenced by reduced body weight gain, poorer feed conversion ratio and alterations in intestinal morphology. Probiotic supplementation significantly improved growth performance, indicated by higher body weight at Days 1-10 (p = 0.048) and 1-21 (p = 0.020). It also enhanced intestinal morphology, including increased villus height and villus width (p < 0.05), and modulated gut microbial balance in the ileum by increasing Bacillus counts (p = 0.004) and decreasing C. perfringens populations (p < 0.001). Furthermore, dietary supplementation with probiotics, chelated zinc and chelated copper, individually or in combination, mitigated the adverse effects of infection by improving growth performance, supporting gut integrity and enhancing antioxidant status, as indicated by reduced malondialdehyde (MDA) levels. Supplementation with probiotics and chelated zinc during necrotic enteritis challenge can serve as an effective nutritional strategy to alleviate the detrimental effects of C. perfringens infection and improve intestinal health in broiler chickens.

PMID 42763419
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PubMedJournal of biomaterials science. Polymer edition2026-09-20

Avian eggshell membrane proteins in bone remodeling and regeneration: molecular mechanisms and therapeutic prospects.

Aggarwal Aakriti A, Dan Siddhartha S, Sah Mahesh Kumar MK

The need for efficient biomaterials that can promote bone regeneration is driven by the fact that bone defects incurred by illness, trauma, or ageing continue to be a significant clinical challenge. Recently, the avian eggshell membrane (ESM) has drawn interest as a protein-rich, sustainable biomaterial for bone restoration. ESM, which is made up of more than 470 proteins, such as collagens, defensins, serpins, histones, and zinc finger proteins, mimics the extracellular matrix and controls cellular processes that are necessary for osteogenesis. Several of these proteins can stimulate pathways that support osteoblast differentiation, matrix formation, and mineralization, whereas the roles of others remain hypothetical and require experimental validation. ESM can be incorporated into immunomodulatory and osteoinductive constructs using bioengineering techniques. In addition to its biological effectiveness, ESM presents a circular bioeconomy model, turning natural waste into a valuable regenerative resource. Using proteins derived from ESM presents a viable, environmental friendly approach to clinical bone defect repair and advanced bone tissue engineering.

PMID 42763429
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PubMedCurrent opinion in clinical nutrition and metabolic care2026-09-19

Evolution of zinc biomarkers and impact on clinical nutrition and public health.

Bochud Murielle M, Berger Mette M MM

Zinc deficiency is a major modifiable nutritional and public health burden worldwide. Because zinc participates in a wide range of biochemical functions, the physiological consequences of deficiency are diverse and nonspecific, complicating the identification of reliable biomarkers of zinc status. The present review summarizes recent evidence regarding zinc status biomarkers, while integrating the impact of novel findings on the genetics of zinc homeostasis. Updated assessment of available zinc biomarkers shows that plasma/serum and urinary zinc excretion respond to changes in zinc intake in humans. Despite the impact of inflammation, plasma/serum zinc remains a good indicator of status. Numerous other putative biomarkers do not meet biomarker efficiency criteria. Zinc homeostasis is tightly controlled through the action of more than 20 membrane transporters belonging to two large families (SLC30 and SLC39). SLC30A2 genetic variants play a key role in controlling urinary zinc excretion, with high geographic variation in allele frequency. The observation from genetic studies that urinary and blood zinc levels are regulated through largely distinct biological pathways suggests that urinary zinc levels may provide relevant complementary information to serum/plasma levels pointing towards urinary-to-plasma ratio as a novel biomarker of human zinc status. The combined assessment of serum (or plasma) zinc concentration and urinary zinc excretion appears to be the most sensitive and specific approach for evaluating zinc status in humans.

PMID 42762104
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PubMedAllergologia et immunopathologia2026-09-19

Products of compound probiotics combined with zinc and vitamin B ameliorate the risk of food allergy.

Lu Hanming H, Zhang Liwen L, Ren Mingxing M, Xue Guochang G et al.

Probiotics have emerged as a promising avenue for modulating immune responses implicated in food allergies, with zinc and vitamin B also exhibiting antiallergic properties. However, the clinical efficacy of compound probiotics combined with these nutrients in mitigating food allergy risk remains to be elucidated. In this randomized controlled trial, 796 children aged 0-6 years with food allergies were assigned to either an experimental group receiving compound probiotics, zinc, and vitamin B products alongside hydrolyzed protein formula milk, or a control group receiving only hydrolyzed protein formula milk. Serum IgE levels, specific food allergies, and key immunological factors were assessed at baseline, posttreatment, and post-follow-up time points. The experimental group demonstrated significantly reduced skin-prick test wheal diameters and serum total IgE levels compared with the control group after the 6-month intervention, with sustained efficacy at the 6-month follow-up. Furthermore, the prevalence of specific food allergies, including egg, milk, crab, shrimp, cashew, beef, mango, and shellfish, was significantly lower in the experimental group posttreatment and post-follow-up, highlighting the therapeutic potential of the intervention. Immunological analysis revealed a favorable modulation of Th1/Th2 balance, with increased IFN-γ levels and decreased IL-4 levels in the experimental group. Additionally, serum zinc and vitamin B2 levels were significantly elevated in the experimental group posttreatment and post-follow-up, indicating improved nutritional status. Compound probiotics combined with zinc and vitamin B represent a promising intervention for reducing the risk of food allergies in children, offering a multifaceted approach to immune modulation and nutritional support in this vulnerable population.

PMID 42760882
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PubMedDNA repair2026-09-19

ZIPPing the gaps: A new class of zinc finger proteins orchestrates the DNA damage response.

Nonfoux Louis L, Gagné Jean-Philippe JP, Kang Bong Gu BG, Kang Sung-Ung SU et al.

Maintaining genomic integrity is fundamental to cellular survival, the prevention of cancer and other pathologies. Central to this protective system is the DNA damage response (DDR), governed by an intricate cascade of post-translational modifications, among which poly(ADP-ribosylation) (PARylation) stands out for its rapid and spatially precise dynamics. Catalyzed by PARP1 and PARP2 at sites of DNA lesions, the resulting poly(ADP-ribose) (PAR) polymer functions as a signaling scaffold that drives repair factor recruitment, chromatin remodeling, and the seeding of liquid-liquid phase-separated repair condensates. This review synthesizes recent evidence to propose and define ZIPPs (Zinc finger proteins Interacting with PAR) as an emerging and functionally coherent class of DDR regulators. Although zinc finger proteins (ZFPs) have historically been associated with transcriptional regulation, a growing body of proteomic, biochemical, and cell biological evidence reveals that a large subset is directly recruited to DNA damage sites through non-covalent PAR interactions, a function entirely distinct from their canonical roles. We posit that this interaction is not merely incidental for the many ZIPPs discussed herein but reflects a dedicated functional relationship for at least a subset of these proteins, with specific ZIPPs possessing PAR-binding domains that enable them to act as readers of the PAR signal and translate it into precise downstream actions. The structural plasticity of zinc finger domains, spanning C2H2-type arrays, PBZ motifs, RING domains and other modules, enables ZIPPs to decode distinct PAR topologies in a temporally ordered fashion. We suggest viewing the DDR as two distinct phases each driven by separate waves of ZIPP activity. Within this framework, ZIPPs govern critical DDR decisions, including repair pathway choice, thereby functioning as essential coordinators rather than general contributors to genome stability. This perspective both challenges and refines current DDR models, and highlights ZIPPs as a promising new class of therapeutic targets for overcoming resistance to PARP inhibitor-based cancer therapies.

PMID 42762747
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PubMedAngewandte Chemie (International ed. in English)2026-09-19

Bio-Inspired Bidirectional Proton Regulatory Mechanisms by Anhydride-Based Hydrogel Electrolytes for High-Performance Aqueous Zinc-Ion Batteries.

Li Jingcheng J, Chu Yuanwei Y, Li Xinpeng X, Luo Tingting T et al.

Aqueous zinc-ion batteries (AZIBs) employing hydrogel electrolytes offer significant advantages in mitigating short-circuit and electrolyte leakage risks. Nevertheless, the sluggish transport kinetics of Zn2 + and severe interfacial instability of zinc anodes still severely restrict their further development. Herein, a bio-inspired hydrogel electrolyte based on poly(acrylamide-co-maleic anhydride) (P(AM-co-MA)) copolymer is fabricated to construct a dual-functional polymer network. The dynamic acid-base equilibrium between carboxyl and amide groups enables reversible bidirectional proton buffering, which effectively suppresses the hydrogen evolution reaction and anode corrosion. Meanwhile, the synergistic Zn2 + hopping sites constituted of carboxylate and amide groups optimize the ion-transport microenvironment and accelerate Zn2 + migration kinetics synchronously, realizing the coordinated regulation of proton activity and Zn2 + transport. Thus, the optimized P(AM-co-MA) hydrogel electrolyte delivers a high Zn2 + transference number of 0.66 and an ionic conductivity of 16 mS cm-1. The assembled Zn||Zn symmetric cells achieve ultra-long and stable cycling for over 2700 h at 1 mA cm-1. Furthermore, the pouch-type Zn||NaV3O8 full cells based on this hydrogel electrolyte exhibit a high specific capacity of 254 mAh g-1 at 1 A g-1, with a capacity retention of 80% after 120 cycles, verifying the great application potential of this rational design for flexible energy storage devices.

PMID 42762445
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