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ZI

zinc acetate dihydrate (Wilzin / Wilzin)

✓ Approved

Recordati S.p.A. · Small Molecule · Small Molecule

What is zinc acetate dihydrate?

zinc acetate dihydrate is a small molecule developed by Recordati S.p.A.. It is approved for therapeutic indications via unknown.

Drug Profile

Brand NamesWilzin, Wilzin
CompanyRecordati S.p.A.
Drug ClassSmall Molecule
RouteUnknown
StatusApproved
Sources: ClinicalTrials.gov, Recordati S.p.A.

Therapeutic Indications

zinc acetate dihydrate is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Congenital, familial and genetic disordersHepato-lenticular degeneration✓ Approved

Related Research Articles

PubMedChemphyschem : a European journal of chemical physics and physical chemistry2026-07-25

Novel Triazine Derivatives Efficiently Regulate the Interfacial Behavior of Metallic Zinc in Sulfuric Acid Electrolyte.

Li Zhuohui Z, Yu Kaixuan K, Ming Weixing W, Xu Ge G

To investigate the corrosion and interfacial behavior of acidic zinc-based battery systems, this study employed 1 mol/L H2SO4 as a model electrolyte and focused on the severe corrosion and hydrogen evolution of zinc anodes in strongly acidic environments. A triazine derivative designed (ZBZ) was selected as a candidate organic inhibitor, and its inhibition performance and mechanism in the Zn / SO 4 2 - system were systematically examined. Electrochemical testing, surface morphology and composition analyses, and theoretical calculations reveal that ZBZ forms a dense, stable organic film on the zinc surface via multisite strong adsorption and a rigid conjugated skeleton, effectively suppressing zinc anodic dissolution and cathodic hydrogen evolution. As a result, the electrochemical stability and reversibility of the zinc electrode in strong acid are markedly enhanced. This work provides fundamental data on zinc anode corrosion in sulfuric acid and represents the extension of triazine-based organic inhibitors to highly reactive Zn / SO 4 2 - strong-acid systems, offering a basis for electrolyte optimization in acidic zinc-based batteries and for the molecular design of highly active zinc anode corrosion inhibitors.

PMID 42498512
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PubMedRSC advances2026-07-25

Retraction: Engineering the optical properties of nickel sulphide thin films by zinc integration for photovoltaic applications.

Younus Junaid J, Shahzad Warda W, Ismail Bushra B, Fazal Tanzeela T et al.

[This retracts the article DOI: 10.1039/D3RA04011A.].

PMID 42500408
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PubMedFrontiers in nutrition2026-07-25

Correction: Enhanced accumulation of phenolics in pea (Pisum sativum L.) seeds upon foliar application of selenate or zinc oxide.

Malka Maksymilian M, Du Laing Gijs G, Kurešová Gabriela G, Hegedüsová Alžbeta A et al.

[This corrects the article DOI: 10.3389/fnut.2023.1083253.].

PMID 42500244
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PubMedTissue & cell2026-07-25

Ameliorative potential of silymarin against lead-induced parotid gland injury: Exploring key mechanistic insights.

Essawy Asmaa Saeed AS, Taha Medhat M, Abubakr Sara S, Arida Dina Abdalla DA et al.

Lead is a widespread environmental contaminant that induces multi-organ toxicity primarily through oxidative damage and inflammatory responses. Salivary glands particularly the parotid are increasingly recognized as vulnerable targets of metal-induced injury, with significant implications for oral and digestive health. This study investigated the protective effect of silymarin, a flavonolignan antioxidant extracted from milk thistle seeds, against lead acetate-induced parotid gland damage in rats. Forty adult male Wistar rats were allocated into four groups: untreated controls, silymarin only (100 mg/kg), lead acetate only (50 mg/kg), and a combined treatment group receiving silymarin (100 mg/kg) and lead acetate (50 mg/kg). Treatments were administered orally for six consecutive weeks. Parotid tissues were evaluated using histology, immunohistochemistry, ELISA, qRT-PCR, and transmission electron microscopy (TEM). Lead acetate exposure caused extensive tissue injury, including acinar vacuolation, ductal dilation, and vascular congestion, accompanied by elevated lipid peroxidation, depletion of endogenous antioxidant enzymes, activation of inflammatory signaling pathways, and upregulation of pyroptotic, apoptotic, and ferroptotic markers. TEM revealed swollen mitochondria with fragmented cristae in lead-exposed glands, hallmarks of ferroptosis. Fibrotic remodeling with collagen accumulation was also evident. Silymarin co administration was associated with significant attenuation of these pathological alterations, correlating with enhanced antioxidant defenses, reduced inflammatory mediators, lowered expression of markers linked to multiple programmed cell death pathways, and decreased fibrosis. TEM confirmed silymarin preserved mitochondrial cristae integrity. In summary, these findings suggest that silymarin may exert broad cytoprotective effects against lead induced parotid gland injury, potentially involving coordinated effects on oxidative stress, inflammation, cell death pathways, and fibrotic responses. This points to its potential therapeutic value in heavy metal toxicity, pending further validation.

PMID 42497779
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PubMedEnvironmental microbiology reports2026-07-25

Metabolic Flux and Growth Profiling of Megasphaera cerevisiae for Medium-Chain Fatty Acid Synthesis.

Sabra Wael W, Villotti Sonia S, Fensterle Joachim J, Zeng An-Ping AP et al.

Megasphaera cerevisiae is a well-known beer spoilage organism, capable of producing undesirable flavours and turbidity. Although the biosynthesis of medium-chain fatty acids (MCFAs) has been extensively studied in different Megasphaera species, the metabolic behaviour of M. cerevisiae in controlled environments remains largely unexplored. This study examines the MCFAs production from diverse substrates and reports flux analyses of core metabolism for the first time using a genome-scale model. The results suggest that acetate stimulates butyrate production but not caproic acid production. Butyrate supplementation, either alone or in combination with acetate, promoted CA synthesis. Lactate supplementation primarily led to the formation of propionic acid and acetic acid. The metabolic network model was manually curated and validated against the different experimental data. The metabolic flux results showed that butyrate production facilitated via the reverse β-oxidation (RBO) pathway, with a minor contribution from the fatty acid synthesis (FAS) pathway. Conversely, CA synthesis was mainly synthesised through the FAS pathway, irrespective of the substrate used. The pathway analyses results highlighted the critical role of hydrogen production in M. cerevisiae metabolism, particularly under conditions where lactate is utilised. Collectively, these findings offer novel insights into the metabolic versatility and pathway preferences of M. cerevisiae.

PMID 42498683
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PubMedChemical science2026-07-25

Current-density-dependent interphase formation and V4+/V5+ activation unlocking low-rate durability of VO2 (B) toward commercializable aqueous zinc-ion batteries.

Xu Dan D, Zhang Shujia S, Jia Xiaolong X, Jia Minyu M et al.

Aqueous zinc-ion batteries (AZIBs) are promising for large-scale energy storage, but their practical application is limited by rapid capacity fading particularly at low current densities-a phenomenon driven by cathode dissolution and structural degradation. Herein, we report ultrathin single-crystalline VO2 (B) nanobelts that overcome this challenge through a synergistic dual mechanism. The unique nanostructure promotes the in situ formation of a reversible, current-density-dependent Zn x (CF3SO3) y (OH)2x-y ·nH2O interphase that suppresses vanadium dissolution, while progressive activation of the V4+/V5+ redox couple compensates for capacity loss from the V3+/V4+ couple. This enables an exceptional capacity retention of 113.8% after 2000 cycles at 0.5 A g-1, and even under a high mass loading (10.1 mg cm-2), it can still achieve stable cycling for 200 cycles. Critically, post-mortem analyses reveal that the cell performance failure originates from anode degradation, rather than the cathode collapse. By introducing a dimethyl sulfoxide-modified electrolyte to stabilize Zn deposition, we achieve 150 stable cycles under challenging conditions: high mass loading (10.3 mg cm-2), low current density (0.2 A g-1), and a low negative-to-positive electrode capacity ratio (≈2.5). The contribution here demonstrates that engineering ultrathin single-crystalline cathodes, combined with anode stabilization, provides a promising pathway toward commercializable AZIBs.

PMID 42499573
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