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doxycycline (Perio Product / Atridox / doxycycline, Atrix)

✓ Approved

Pharmascience, Inc. · Small Molecule · Small Molecule

What is doxycycline?

doxycycline is a small molecule developed by Pharmascience, Inc.. It is approved for therapeutic indications via oral (po) or topical.

Drug Profile

Brand NamesPerio Product, Atridox, doxycycline, Atrix
CompanyPharmascience, Inc.
Drug ClassSmall Molecule
RouteOral (PO), Topical
StatusApproved
Sources: ClinicalTrials.gov, Pharmascience, Inc.

Therapeutic Indications

doxycycline is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Infections and infestationsPeriodontitis✓ Approved

Related Research Articles

PubMedZhonghua nan ke xue = National journal of andrology2026-11-11

[Clinical efficacy and mechanism of Liniao Tonglin decoction in treating UU-infected oligoasthenospermia with dampness-heat pouring down syndrome].

Zhu Fanyu F, Li Ninghua N, Yang Wentao W

Objective To explore the clinical effect and mechanism of Liniao Tonglin decoction on oligoasthenospermia caused by Ureaplasma urealyticum (UU) infection with dampness-heat pouring down syndrome. Methods Eighty-eight patients were randomly divided into control group and observation group, with 44 cases in each group. The patients in control group were treated with doxycycline hydrochloride enteric-coated capsules and doxycycline tablets. While the patients in observation group were treated with Liniao Tonglin decoction on the basis of the treatment given to the control group. Both groups were treated for 14 days. Sperm concentration, total sperm count, progressive motility sperm rate(PR%), sperm motility rate（［PR+NP］%）, seminal plasmic elastase, interleukin-6(IL-6), interleukin-17(IL-17) levels TCM syndrome score and negative conversion rate of UU were compared between the two groups before and after the treatment. Results The overall efficacy rate of the observation group was significantly higher than that in the control group (86.05% vs 66.67% , χ2=4.435, P<0.05). UU negative conversion rate was also superior in the observation group (95.35% vs 88.10%，P>0.05). The increases in sperm concentration, total count, PR%, and （PR+NP）% (P<0.05) exhibited in both of two groups after the treatment, with significantly greater improvements in the observation group (P<0.05). The levels of seminal elastase, IL-6, IL-17 and TCM syndrome scores declined in both groups (P<0.05), with greater improvements in the observation group as well (P<0.05). Conclusion Liniao Tonglin decoction combined with antibiotics improves the count and motility of sperm and TCM syndrome score of oligoasthenospermia induced by UU infection with dampness-heat pouring down syndrome, increases the negative rate of UU, inhibits the expression of inflammatory factors, and changes the patency of reproductive tract and the living environment of sperm.

PMID 43012219
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PubMedIrish veterinary journal2026-11-11

Endemic Ehrlichia canis infection in a dog from Ireland: case report.

McCarthy Julia J, Large Thomas Peter TP, Cuq Benoît B

Canine monocytic ehrlichiosis, caused by Ehrlichia canis, is a tick-borne disease of dogs. We report the first confirmed case of endemic Ehrlichia canis infection in a dog from Ireland, with no travel history. A six-year-old female neutered lurcher, presented with chronic fever, lethargy, polyuria, polydipsia, weight loss, thrombocytopenia, non-regenerative anaemia, hyperglobulinaemia, proteinuria, and ocular abnormalities including chorioretinitis and partial retinal detachment. Diagnosis was confirmed by enzyme-linked immunosorbent assays, indirect fluorescent antibody, and polymerase chain reactions. Treatment consisting of doxycycline with systemic corticosteroids resulted in resolution of associated clinical and clinicopathological abnormalities. This case underscores the importance of comprehensive diagnostics, tick surveillance, and a One Health approach to identify, prevent, and manage vector-borne pathogens in Ireland. The presence of potentially endemic Ehrlichia canis in this dog raises concern for local transmission, potentially via Rhipicephalus sanguineus tick.

PMID 43010099
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PubMedMedicine2026-11-11

Syphilitic proctitis with profuse rectal bleeding in an HIV-infected patient with preserved CD4 count (case report).

Mosi Mohamad H MH, Alfarra Hisham H, Davi Chandni C, Saaki Shaila S et al.

Syphilitic proctitis is an uncommon and frequently under-recognized manifestation of Treponema pallidum infection that can closely mimic inflammatory, infectious, or neoplastic rectal disease. We report an unusually severe, hemorrhagic presentation in a patient with human immunodeficiency virus (HIV) and a preserved cluster of differentiation 4 (CD4) count, a setting in which overlapping etiologies often delay the diagnosis. A heterosexual man in his early 50s with untreated HIV infection and chronic hepatitis B-related cirrhosis (Child-Pugh class B) presented with sudden onset of profuse hematochezia, watery diarrhea, abdominal cramping, and fatigue. Computed tomography angiography revealed pronounced rectal wall thickening with deep ulceration. Colonoscopy demonstrated an indurated, ulcerated rectal lesion, and biopsy showed dense lymphoplasmacytic inflammation, with spirochetes confirmed by T pallidum immunohistochemistry. Negative cytomegalovirus (CMV) immunohistochemistry, undetectable CMV DNA in plasma and rectal tissue, and a preserved CD4 count (445 cells/µL) made CMV proctitis unlikely. The overall clinical, endoscopic, and histologic findings supported a diagnosis of syphilitic proctitis. Management included doxycycline 100 mg twice daily for 2 weeks, selected because of the patient's documented penicillin allergy. Antiretroviral therapy with bictegravir/tenofovir alafenamide/emtricitabine was initiated to treat HIV and provide concurrent hepatitis B coverage. Within 2 weeks, the patient experienced complete resolution of hematochezia and diarrhea. At 3-month follow-up, the CD4 count had risen to 570 cells/µL, HIV RNA was undetectable (<20 copies/mL), and the rapid plasma reagin titer had declined from 1:512 to 1:32. This case underscores that syphilitic proctitis may manifest with severe ulcerative disease even in patients with relatively preserved immune function. Clinicians should maintain vigilance for syphilis in individuals with HIV who present with rectal bleeding or proctitis to prevent diagnostic delays and ensure timely therapy.

PMID 43012798
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PubMedFrontiers in medicine2026-11-11

Case Report: When infection wears a rheumatic mask: probable systemic brucellosis mimicking seronegative inflammatory arthritis with sicca symptoms and suspected cervical spondylitis.

Zou Yadan Y, Zhang Jing J, Zhang Xiaoying X, Zhang Qiaolin Q et al.

Brucellosis is a zoonotic infection with protean manifestations. Osteoarticular disease is common, but presentation as seronegative inflammatory arthritis with sicca symptoms, generalized lymphadenopathy, and cervical spondylitis may be mistaken for autoimmune rheumatic disease. A 58-year-old male cattle farmer presented with intermittent chills, sicca symptoms, symmetric polyarthritis, weight loss, anemia, hypoalbuminemia, and elevated inflammatory markers. Autoimmune serology was negative. Ultrasonography confirmed synovial hyperplasia and tenosynovitis. 18F-FDG PET/CT showed generalized lymphadenopathy and focal C5 uptake; MRI showed C5 marrow edema. Lymph-node biopsy demonstrated non-necrotizing granulomatous inflammation with negative acid-fast and periodic acid-Schiff stains. Positive Rose Bengal and Brucella IgG tests, a standard tube agglutination titer of 1:100, and the clinical context prompted a working diagnosis of probable systemic brucellosis. Blood and bone marrow cultures were negative; paired serology was unavailable. At telephone follow-up, the patient reported taking outpatient rifampicin and doxycycline for 2 years, near-resolution of cervical pain at approximately 3 months, and normalization of inflammatory markers and hemoglobin after more than 6 months. A negative local agglutination result reported by his daughter at approximately 3 months could not be verified. Intermittent bilateral hip and knee pain persisted, requiring as-needed etoricoxib and, at the latest follow-up, a walking aid. Treatment had been extended because symptoms persisted, but the cause of the functional impairment remained undetermined. Probable systemic brucellosis merits consideration in exposed patients with seronegative inflammatory arthritis, sicca symptoms, and granulomatous lymphadenopathy. Occupational seropositivity, incomplete microbiological confirmation, and unverified follow-up testing limit diagnostic certainty. Symptomatic improvement during antibiotics does not establish the etiology or microbiological cure, and persistent disability warrants reassessment for infection, structural disease, and coexisting rheumatic pathology.

PMID 43011368
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PubMedEuropean journal of case reports in internal medicine2026-11-11

Tropheryma Whipplei Infection Mimicking Sarcoidosis with an Atypical Course: A Molecularly Confirmed Diagnosis without PAS-Positive Intestinal Disease.

Bohinikova Lucia L, Seneghini Marco M, Fischer Michael Benjamin MB, Wermke Marc Daniel MD et al.

The bacterium Tropheryma whipplei causes Whipple's disease, a rare chronic infection that can involve virtually any organ, especially in the late phase, and mimic inflammatory or neoplastic conditions. The interval from first symptoms to diagnosis is typically several years. A 68-year-old man was referred for pulmonary re-evaluation 2 years after a non-caseating hilar lymph-node granuloma had led to a diagnosis of stage I (nodal) sarcoidosis. His records revealed a 3-year history of lymphadenopathy with persistently elevated C-reactive protein and a two-year history of recurrent fever and fatigue. Corticosteroid therapy for ankle synovitis caused symptomatic worsening, prompting further investigation. Extensive infectious, oncological, rheumatological and tropical-medicine workup was unrevealing. Detailed history-taking revealed a 6 kg weight loss and epigastric discomfort, and a prior short antibiotic course for incipient pneumonia had produced transient improvement, making an atypical infectious aetiology, specifically Whipple's disease, plausible. An endobronchial ultrasound-guided lymph-node aspirate and subsequently a stool sample were both positive for T. whipplei by quantitative polymerase chain reaction (qPCR), whereas cerebrospinal fluid PCR was negative, establishing systemic disease without central nervous system involvement. Oral doxycycline plus hydroxychloroquine produced fast and sustained clinical and biochemical remission at 1 year. Surveillance duodenal histology was periodic acid-Schiff-negative and structured clinical follow-up was arranged. Whipple's disease is a great mimicker, but a treatable one, and should be considered in cases of chronic inflammation without evidence of a pathogen in primary microbiological analysis and in cases of sarcoidosis with an atypical course, particularly if symptoms do not improve or worsen while on corticosteroids. Consider Whipple's disease in any chronic, culture- and serology-negative systemic inflammatory syndrome, particularly when a diagnosis of "sarcoidosis" based on non-caseating granulomas fails to respond to, or clinically worsens under, corticosteroids, because immunosuppression can accelerate the infection.The diagnosis can be established by Tropheryma whipplei-specific quantitative polymerase chain reaction (qPCR) on tissue (here, an endobronchial ultrasound-guided lymph-node aspirate) and on non-invasive samples (typically stool, less frequently saliva), even when classic gastrointestinal symptoms and periodic acid-Schiff-positive duodenal histology are absent. Confirmation on a second specimen and cerebrospinal fluid testing to exclude central nervous system involvement should precede the prolonged antibiotic course.Untreated Whipple's disease is progressive and potentially fatal. Prolonged combination antibiotic therapy with structured follow-up is curative in most patients, and persistent stool-PCR positivity in an otherwise asymptomatic patient with normal duodenal histology may reflect residual deoxyribonucleic acid or colonisation rather than treatment failure.

PMID 43011990
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PubMedClinical journal of gastroenterology2026-11-10

Doxycycline-induced esophageal ulcer: three cases and a reminder of a preventable adverse event.

Okamura Masamichi M, Andoh Akira A, Tamura Akio A, Takata Yuya Y et al.

We report three cases of doxycycline-induced esophageal ulcer in young women. In all cases, doxycycline was prescribed for treatment of acne vulgaris and was taken at bedtime. Endoscopy revealed various ulcerative lesions. Discontinuation of doxycycline resulted in rapid resolution of symptoms and healing of the ulcerative lesions. These cases highlight the importance of obtaining a detailed medication history and considering drug-induced esophageal injury in the differential diagnosis of dysphagia and odynophagia in young patients. Patient education regarding the proper administration of doxycycline may help prevent this avoidable adverse event.

PMID 43007533
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