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pseudoephedrine sulfate + loratadine (Claritin D24)

✓ Approved

Merck & Co. · HRH1 · Small Molecule

What is pseudoephedrine sulfate + loratadine?

pseudoephedrine sulfate + loratadine is a small molecule developed by Merck & Co.. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesClaritin D24
CompanyMerck & Co.
Drug ClassSmall Molecule
Molecular TargetHRH1
RouteOral (PO)
StatusApproved

Mechanism of Action

Molecular Targets

pseudoephedrine sulfate + loratadine acts on 1 molecular target:

HRH1histamine receptor H1 (HH1R, H1R)
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Therapeutic Indications

pseudoephedrine sulfate + loratadine is developed for 2 unique indications across 2 therapeutic areas.

Therapeutic AreaConditionPhase
Respiratory, thoracic and mediastinal disordersRhinitis allergic✓ Approved
Immune system disordersSeasonal allergy✓ Approved

Related Research Articles

PubMedEnvironmental science & technology2026-06-09

Single Particle Investigation Supports Interfacial Pathway for SO2-NO2 Heterogeneous Reaction.

Zhang Kaiqi K, Yishake Jumabubi J, Zhao Yue Y, Xiao Hua-Yun HY et al.

The reaction between SO2 and NO2 is a key atmospheric sulfate formation pathway, yet its kinetics and mechanisms remain contentious. Here, we employ an aerosol optical tweezer to probe this reaction on microdroplets at the single-particle level. Two competing mechanistic frameworks were used for data interpretation─an aqueous and an interfacial reaction model. Accounting for intraparticle NO2 depletion, the aqueous reaction model explains the data given composition-dependent reaction rate constants. However, our experiments show that chloride ions accelerate sulfate production by more than an order of magnitude compared to sulfate ions, which cannot be explained by the aqueous reaction framework. With data extracted from previous nanoparticle experiments and this work, the interfacial reaction model provides a good fit across studies, yielding an interfacial rate constant that exponentially decreases with particle pH. To further probe the effect of organics, we modified the particle composition with ionic surfactants and polyethylene glycol (PEG). The surfactants can slow down or even completely inhibit the reaction, strengthening the hypothesis that the reaction proceeds via an interfacial pathway. Yet for the water-soluble PEG, the reaction rate decreases almost linearly with its mass fraction among solutes. Finally, under atmospherically relevant conditions, a comparison of the rate constants emphasizes using the full particle size distribution to calculate sulfate formation rates. By evaluating the SO2-NO2 reaction across a wide particle size range under different frameworks, this work provides a holistic picture of this reaction, underscoring the need to resolve this critical atmospheric process for compositionally complex particles.

PubMedBrain and behavior2026-06-09

Elucidating Immune Cell Mediated Causal Pathways Linking Blood Metabolites to Major Depressive Disorder: A Mediation Mendelian Randomization Analysis.

Xu Zhiwei Z, Zhou Yining Y, Zhang Xuecheng X, Chen Xiaowen X et al.

Metabolic and immune alterations have been reported in patients with major depressive disorder (MDD), yet the biological pathways linking these changes to MDD remain incompletely understood. This study aims to examine the association between blood metabolites and the risk of MDD, investigate the mediating role of immune cells, and explore their causal relationships. We analyzed genome-wide association study (GWAS) summary statistics for 1400 circulating metabolites and 731 immune-cell traits, together with an MDD GWAS comprising 135,458 cases and 344,901 controls, all obtained from the GWAS Catalog and the Psychiatric Genomics Consortium. Causal effects of each metabolite on MDD were estimated with seven Mendelian randomization (MR) approaches: inverse variance weighted, MR-Egger, weighted median, debiased inverse variance weighted method (IVW), Bayesian weighted MR, Mendelian randomization robust adjusted profile score (MR-RAPS), and constrained maximum likelihood and model averaging. Horizontal pleiotropy was evaluated with Mendelian Randomization Pleiotropy RESidual Sum and Outlier method (MR-PRESSO), RadialMR, and the MR-Egger intercept, whereas Cochran's Q statistic and leave-one-out analyses assessed heterogeneity and sensitivity. Finally, MR-based mediation analysis quantified the extent to which immune-cell traits mediate the metabolite-MDD associations. MR analyses provided evidence consistent with potential causal effects of 10 metabolites, including 1-(1-enyl-stearoyl)-2-linoleoyl-GPE, 2-linoleoylglycerol, kynurenine, spermidine-to-histidine ratio, 1-linoleoylglycerol, 4-vinylguaiacol sulfate, dopamine 4-sulfate, N-acetyl-aspartyl-glutamate, sphingomyelin and taurine to glutamate ratio and MDD. Mediation analyses identified three immune-cell-mediated pathways: CD8dim T cells mediated 5% of the effect of 2-linoleoylglycerol on MDD risk; CD11b expression on basophils mediated 19% of the effect of dopamine 4-sulfate on MDD risk; and CD4 expression on resting regulatory CD4 T cells mediated 14% of the effect of the spermidine-to-histidine ratio on MDD risk. Our findings suggest that specific metabolites may affect the risk of MDD via immune-related pathways.

PubMedBiotechnology and applied biochemistry2026-06-09

Isolation and Characterization of a Novel Microbacterium takaoensis Lipase for Nutritional and Textural Improvement of Pizza Dough.

Goswami Hetsi H, Bishoyi Ashok Kumar AK, Sanghvi Gaurav G

Lipases are industrially important enzymes with broad applications in food processing, particularly in enhancing dough quality. In the current work, a lipase-producing strain was collected from oil-contaminated soil and recognized as Microbacterium takaoensis through 16S rRNA gene sequencing. Optimal lipase production was achieved under submerged fermentation using olive oil (2.0%) as the carbon and yeast extract (0.5%) as the nitrogen source at pH 7.0. The purification of lipase was carried out by ammonium sulfate precipitation along with size exclusion chromatography. Molecular weight by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) analysis demonstrated the weight of lipase for approximately 40 kDa. Biochemical characterization showed that the lipase exhibited optimal activity at 37°C and pH 7.0 and was significantly enhanced by Zn2+, Fe2+, and Cd2+. Functional application studies of the purified lipase in pizza dough show improved nutritional content, increased protein and lipid levels, and reduced fiber content. Textural analysis revealed enhanced softness and elasticity, whereas scanning electron microscopy (SEM) imaging confirmed improved microstructural uniformity in treated dough. These findings suggest that M. takaoensis derived lipase holds strong potential for clean-label applications in functional food development.

PubMedIndian journal of orthopaedics2026-06-09

Preoperative Intravenous Ferric Carboxymaltose versus Oral Ferrous Sulfate in Total Knee Arthroplasty: Effects on Hemoglobin Levels and Transfusion Rates.

Lee Hyeon-Joon HJ, Lim Doo-Ho DH, Lee Chae-Chil CC, Jeon Young Dae YD et al.

This retrospective case-control study aimed to determine the effectiveness of preoperative intravenous ferric carboxymaltose (FCM) administration compared to oral ferrous sulfate (FS) supplementation in patients undergoing primary unilateral total knee arthroplasty (TKA). This retrospective comparative cohort study included a total of 183 patients with 87 in the FCM group receiving 1000 mg FCM 2 weeks before TKA and 96 in the FS group receiving 1024 mg FS daily for 4 weeks preoperatively. Hemoglobin (Hb) levels were measured at baseline and postoperatively. The primary endpoint was the change in Hb levels relative to baseline. The secondary outcomes were the transfusion rate and volume. Subgroup analysis was performed for patients without preoperative anemia. At all postoperative time points, the Hb levels were significantly higher in the FCM group than in the FS group. The FCM group demonstrated a significantly lower transfusion rate (1.1 vs. 9.4%, P = 0.01) and mean transfusion volume (3.7 vs. 34.5 cc, P = 0.01). Among the patients without preoperative anemia, the FCM-A group had significantly higher Hb levels and lower Hb changes postoperatively than the FS-A group. Preoperative intravenous FCM can help restore postoperative Hb levels and reduce transfusion requirements in patients undergoing primary unilateral TKA, even in those without preoperative anemia.

PubMedEnvironmental science and pollution research international2026-06-09

Eco-friendly water treatment: performance and safety of Moringa oleifera versus aluminum sulfate coagulants.

Nabet Noura N, Galal Mansour M, Mousa Amany A, Sheir Sherin S

Coagulants are vital in surface water purification. This study compares the coagulation efficiency of natural Moringa oleifera seed extract and conventional aluminum sulfate (alum) in treating drinking water, specifically addressing free-living protozoa-a previously understudied area, unlike research on M. oleifera which often focuses on parasitic protozoa. Water samples from Shebeen El-Koum treatment plant underwent analysis before and after coagulation for physicochemical and biological parameters. Results demonstrated that M. oleifera seed extract significantly reduced turbidity, total coliforms, fecal coliform, algae, and free-living protozoa. At concentrations of 550 and 600 mg/L, the efficiency of M. oleifera without addition of chlorine ranged between 68 and 98.6%. While M. oleifera effectively removed most contaminants, it slightly increased some parameters (notably nitrates), though remaining within permissible limits and needing further study. The study concludes that M. oleifera seed extract is an effective, cost-effective, and safer alternative to alum for water purification. Its natural origin eliminates risks from residual aluminum, making it eco-friendly and safe. Additionally, local availability in developing regions boosts cost-effectiveness, indicating strong potential for sustainable water treatment. However, varying effects on certain water quality indicators highlight the need for additional research to optimize its application. The findings support integrating M. oleifera into existing systems, especially in resource-limited areas, but more research is needed on long-term effects, scalability, and wider contaminant removal.

PubMedThe Journal of nutrition2026-06-09

Protective effect of apiaceous vegetables against Total Western Diet- and dextran sulfate sodium-induced colitis in mice.

Lee Hee-Seop HS, Ibarra Laura E LE, Zuo Bin B, Zhao Jiangchao J et al.

Western-style dietary patterns are associated with colitis and colon cancer. Existing data indicate intake of apiaceous vegetables (API; e.g., celery, parsnip) may prevent inflammation-associated diseases. We investigated in mice the effect of API supplementation to the Total Western Diet (TWD) against dextran sulfate sodium (DSS)-induced colitis. Male C57BL/6J mice (8-week-old; 15/group) were fed TWD supplemented with 21% or 42% fresh API (w/w) and given 2% DSS to induce colitis. Diet intake, body weight, and disease activity index (DAI) were monitored. Serum was collected for cytokine/chemokine analysis and colonic tissues for histology and Western blot. Fecal samples were analyzed by 16S rRNA gene sequencing and targeted/untargeted metabolomics. Phenotypic data were analyzed by ANOVA with Tukey's test. Microbiome data were Centered-Log Ratio (CLR) transformed and analyzed using linear mixed models with adjusted pairwise comparisons. API supplementation attenuated colitis phenotypes including weight loss (44% recovery; P < 0.001), colon shortening (57% recovery; P < 0.01), disease activity (59% lower; P < 0.001), cytokine/chemokine release (35-73% reductions; P < 0.05), and mucosal F4/80+ cells infiltration (80% reduction; P < 0.001). API also improved gut microbiota diversity and composition, increasing alpha diversity metrics (4.4%-13.8%; P <0.05), suppressing pathogenic bacteria (Paraclostridium, Enterococcus, Eubacterium; estimated CLR difference: -1.8 to -6.7; P < 0.001), and enriching beneficial bacteria (Lachnospiraceae and Blautia; estimated CLR difference: +1.6 to +3.0; P < 0.05). Furthermore, metabolomics indicated TWD consumption increased arachidonic acid and aliphatic aldehydes (by 109%-510%; P < 0.001), and decreased short-chain and unsaturated fatty acids (by 30%-91%; P < 0.001). API supplementation also mitigated TWD-derived functional metabolites (including bile acids; P < 0.05). These data indicate that API intake is beneficial for risk reduction of diseases associated with Western diets. However, further investigations are warranted to determine the mechanism behind these beneficial effects.

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