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folic acid + vitamin B6 + vitamin B12 + primorine (Folmor)

✓ Approved

Zylera · Small Molecule · Small Molecule

What is folic acid + vitamin B6 + vitamin B12 + primorine?

folic acid + vitamin B6 + vitamin B12 + primorine is a small molecule developed by Zylera. It is approved for therapeutic indications via unknown.

Drug Profile

Brand NamesFolmor
CompanyZylera
Drug ClassSmall Molecule
RouteUnknown
StatusApproved
Sources: ClinicalTrials.gov, Zylera

Therapeutic Indications

folic acid + vitamin B6 + vitamin B12 + primorine is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Metabolism and nutrition disordersHypercholesterolaemia✓ Approved

Related Research Articles

PubMedMedicine2026-06-09

Associations between vitamin B6 and vitamin B12 intake and lung function: A cross-sectional study based on NHANES 2007 to 2012.

Wang Wuzhen W, Gu Yingying Y

Although the benefits of enhanced nutrition on respiratory health are widely recognized, the specific effects of vitamins B6 and B12 on lung function are not fully understood. This study aimed to investigate the potential association between vitamin B6 and B12 intake and lung function. This is a cross-sectional study using data from the National Health and Nutrition Examination Survey from 2007 to 2012. The study assessed the pulmonary function of the subjects by measuring forced expiratory volume in the first second (FEV1), forced vital capacity (FVC), and the FEV1/FVC ratio. In addition, stepwise multiple linear regression, logistic regression modeling, and other analytical methods were used in this study in order to investigate the correlation between vitamin B6 and B12 intake and lung function. A total of 9648 participants were included in this study, and after adjusting for relevant confounders, linear regression analyses showed that for every 1 mg/day increase in vitamin B6 intake, there was an increase in FVC of 22 mL (P = .004). Meanwhile, for every 1 μmg/day increase in vitamin B12 intake, there was an increase of 2.2 mL (P = .006) in FEV1 and 3.8 mL (P < .001) in FVC. In addition, no association was found between vitamin B6 and B12 intake and the FEV1/FVC ratio. There was no gender difference in the effect of vitamin B6 and B12 intake on lung function, and there was a significant trend toward improvement in all relevant indicators with increasing intake. Weighted logistic regression analysis showed that no association was found between vitamin B6 and B12 intake and the risk of airway obstruction. In this regard, we think that higher intake levels of vitamins B6 and B12 may be associated with better lung health.

PMID 42260844
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PubMedTheScientificWorldJournal2026-06-09

Seminal Homocysteine Levels in Men With Asthenozoospermia: Correlation With Sperm Parameters and Vitamin B6 Levels.

Aljabali Shefa S, Bdeir Roba R, Banihani Saleem Ali SA

In this study, we aim to assess the seminal plasma levels of homocysteine in men with asthenozoospermia compared with normozoospermic men and to investigate their correlations with sperm parameters and seminal plasma vitamin B6 levels. The levels of homocysteine and vitamin B6 were measured in 108 asthenozoospermic and 64 normozoospermic semen samples. Homocysteine levels in seminal plasma were determined using high-performance liquid chromatography, whereas vitamin B6 levels were measured by liquid chromatography-tandem mass spectrometry. The results showed that seminal plasma levels of homocysteine were significantly higher in the asthenozoospermic group than in the normozoospermic group (3.08 ± 0.320 vs. 1.23 ± 0.320  μmol/L, p < 0.0001). Notably, the receiver operating characteristic (ROC) curve analysis demonstrated that the area under the curve was 0.999 (p < 0.0001), indicating a strong diagnostic performance of seminal plasma homocysteine in distinguishing asthenozoospermic men from normozoospermic men. In addition, the cutoff value was > 1.87 μmol/L, with a specificity of 100.0% (95% CI: 94.3%-100%) and a sensitivity of 99.1% (95% CI: 94.9%-99.9%). In the normozoospermic group, there was no statistically significant association between seminal plasma levels of homocysteine and progressive motility (p = 0.675, r2 = 0.00286) or total motility (p = 0.178, r2 = 0.0291) of spermatozoa. However, in the asthenozoospermic group, progressive and total motility were inversely correlated with the seminal plasma levels of homocysteine (p = 0.0025, r2 = 0.0827, p = 0.0048, r2 = 0.0725, respectively). No significant correlation was found between homocysteine levels and sperm concentration, semen volume, age, or seminal plasma vitamin B6 levels in either group. These findings suggest that seminal plasma levels of homocysteine are associated with impaired sperm motility and may serve as a potential biomarker for asthenozoospermia. However, further studies are needed to confirm these findings.

PMID 42262176
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PubMedMedicine2026-06-09

Uric acid, vitamin D, and left ventricular hypertrophy: Unveiling cardiovascular risks - a retrospective cross-sectional study.

Abdallah Eman Ali EA, Elzorkany Khaled M A KMA, AlSahlawi Muthana M, Alruzaihan Sarah A SA et al.

Hyperuricemia is increasingly recognized as being associated with adverse cardiovascular outcomes. The connection between serum uric acid (SUA) levels, vitamin D levels, and cardiovascular risk factors, particularly in the Middle Eastern population, is a subject that requires further exploration. This study aimed to explore the association between high uric acid levels and low vitamin D levels in adults to identify independent predictors of left ventricular hypertrophy (LVH). A retrospective cross-sectional study was conducted using medical records from the rheumatology and cardiology departments at King Faisal University Polyclinics in Al Ahsa, Saudi Arabia, between May 2024 and June 2025. According to the National Health and Nutrition Examination Survey criteria, hyperuricemia was defined. Demographic, biochemical, and echocardiographic factors were examined. Multivariate logistic regression was performed to identify independent predictors of LVH. A total of 803 participants, including 207 individuals with hyperuricemia, were analyzed. Patients with hyperuricemia had significantly higher fasting blood glucose, glycated hemoglobin, total cholesterol, low-density lipoprotein, triglycerides, body mass index (BMI), and left ventricular mass index (all P < .001). The prevalence of LVH was markedly higher in the hyperuricemic group (43.5% vs 1.2%, P < .001). A strong negative correlation was found between SUA and vitamin D levels (r = -0.466, P < .001). SUA and BMI were independently associated with LVH (P < .05). The study found that hyperuricemia was significantly associated with LVH and lower vitamin D levels. However, only SUA and BMI showed independent associations with LVH. This highlights the substantial impact on cardiac and metabolic health linked to high levels of uric acid in the Saudi population.

PMID 42260814
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PubMedCureus2026-06-09

Association Between Neutrophil-to-Lymphocyte Ratio and Vitamin D Deficiency in Patients With Sickle Cell Disease: A Cross-Sectional Study in Central Uganda.

Muwanguzi Enoch E, Tumusiime Jazira J, Salamu Geofrey G, Nkubi Bagenda Charles C et al.

Vitamin D deficiency and chronic inflammation are prevalent in individuals with sickle cell disease (SCD), contributing to disease severity. Hematological ratios are simple inflammatory markers that can have various clinical outcomes. The main aim of our study was to assess the association between hematological ratios and vitamin D deficiency among patients with SCD in Central Uganda. We conducted a cross-sectional study among patients with SCD attending Mengo Hospital, Central Uganda. Data were collected using a researcher-administered questionnaire supplemented with information from participants' medical records. Anthropometric measurements were taken, and a blood sample was drawn for laboratory measurement of hematological parameters and serum vitamin D levels. Out of the 213 participants, 101 (47.4%) had serum 25-hydroxyvitamin D (25(OH)D) concentrations <20 ng/mL, indicating vitamin D deficiency, while 68 (31.9 %) had levels between 20-30 ng/mL, consistent with vitamin D insufficiency. Participants with vitamin D deficiency had a higher neutrophil-to-lymphocyte ratio (NLR) (0.27, IQR: 0.13-0.88) compared to those without vitamin D deficiency (0.22, IQR: 0.10-0.63), although the difference was not statistically significant (p=0.45). However, after adjusting for potential confounders, both the second (adjusted prevalence ratio (aPR)=1.83; 95% CI: 1.25-2.68; p=0.002) and third tertiles (aPR=1.74; 95% CI: 1.04-2.91; p=0.033) of the neutrophil-to-lymphocyte ratio were significantly associated with increased prevalence of vitamin D deficiency. Vitamin D deficiency is prevalent among patients with SCD in Central Uganda. High NLR is potentially associated with vitamin D deficiency among patients with SCD.

PMID 42261508
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PubMedGinekologia polska2026-06-09

Vitamin D deficiency in pregnant women: obstetric implications and clinical management.

Tadros-Zins Monika M, Krekora Michal M, Zych-Krekora Katarzyna K, Drosdzol-Cop Agnieszka A

Vitamin D deficiency in pregnant women constitutes a significant obstetric concern, affecting 40-98% of gravid populations worldwide. Adequate vitamin D status is essential for successful pregnancy outcomes, fetal development, and maternal health. This review analyzes current evidence regarding vitamin D deficiency during pregnancy from an obstetric perspective, focusing on pregnancy complications, fetal outcomes, and evidence-based supplementation strategies for clinical practice. A systematic review of PubMed, Scopus, and Cochrane databases was conducted, encompassing publications from 2020-2025. Randomized controlled trials, meta-analyses, and prospective cohort studies examining vitamin D status and pregnancy outcomes were included. Analysis demonstrated significant associations between vitamin D deficiency (< 50 nmol/L) and elevated risk of preeclampsia (OR 0.65), gestational diabetes mellitus (OR 1.61), preterm birth (RR 0.67), and small-for-gestational-age neonates (RR 0.61). Supplementation with 2000-4000 IU/day appears safe and efficacious in achieving optimal concentrations. Vitamin D assessment and individualized supplementation should be integrated into routine prenatal care. Obstetricians should implement screening protocols particularly for high-risk pregnant women.

PMID 42261719
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PubMedPediatrics international : official journal of the Japan Pediatric Society2026-06-09

Vitamin K Deficiency Associated With Low Vitamin K Intake During Antibiotic-Associated Diarrhea in Two Disabled Patients.

Mitsui Yoshitaka Y, Fujisawa Reiko R, Sato Hitoshi H, Ikawa Yasuhiro Y

PMID 42260978
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