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folic acid + vitamin B6 + vitamin B12 + primorine (Folmor)

✓ Approved

Zylera · Small Molecule · Small Molecule

What is folic acid + vitamin B6 + vitamin B12 + primorine?

folic acid + vitamin B6 + vitamin B12 + primorine is a small molecule developed by Zylera. It is approved for therapeutic indications via unknown.

Drug Profile

Brand NamesFolmor
CompanyZylera
Drug ClassSmall Molecule
RouteUnknown
StatusApproved
Sources: ClinicalTrials.gov, Zylera

Therapeutic Indications

folic acid + vitamin B6 + vitamin B12 + primorine is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Metabolism and nutrition disordersHypercholesterolaemia✓ Approved

Related Research Articles

PubMedFrontiers in medicine2026-07-25

Role of homocysteine, vitamins B12, B6, B1, and folate in Saudi patients with premature acute coronary syndrome.

Alfaraidy Khalid K, Mohamed Ayman A, Woodman Alexander A, Al-Ansari Rehab R et al.

Homocysteine (HCY) has been implicated in cardiovascular disease through adverse effects on vascular endothelium, oxidative stress, and thrombogenic pathways. Saudi Arabia has a young population and an increasing burden of cardiovascular disease, yet regional data on HCY and B-vitamin profiles in premature acute coronary syndrome (ACS) remain limited. This single-center cross-sectional exploratory study evaluated serum HCY, vitamins B12, B6, B1, and folate levels in 80 patients with premature ACS at King Fahd Military Medical Complex (KFMMC), Dhahran, Saudi Arabia. Premature ACS was defined as ACS occurring in men aged <=55 years and women aged <=65 years. Clinical, laboratory, electrocardiographic, echocardiographic, angiographic, and SYNTAX score II 2020 data were collected. Spearman correlation showed a weak but statistically significant inverse association between HCY and folate (rho = -0.254, p = 0.040; approximate R2 = 0.065), whereas correlations between HCY and vitamins B12, B1, and B6 were not statistically significant. Most patients had low SYNTAX score categories, and exploratory ordinal regression suggested associations between selected biomarkers/clinical variables and SYNTAX score category; however, these findings should be interpreted cautiously because of the small sample size, absence of a control group, and risk of model instability. The study provides preliminary descriptive data on HCY and B-vitamin status among Saudi patients with premature ACS and highlights the need for larger, controlled, multicenter studies incorporating dietary assessment and genetic determinants such as MTHFR polymorphisms.

PMID 42500536
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PubMedMedicine2026-07-25

Association between vitamin B6 metabolism and the prevalence of age-related macular degeneration: A cross-sectional analysis of National Health and Nutrition Examination Survey (NHANES).

Tang Mingxia M, Sun Shuai S, Liu Yu Y, Dong Lili L

B vitamins may be involved in the development of age-related macular degeneration (AMD). This investigation intended to examine the association between vitamin B6 catabolic status and the prevalence of AMD. Individuals ≥ 40 years old in the 2005 to 2008 National Health and Nutrition Examination Survey who had complete vitamin B6 measurement and AMD diagnostic data were included in this cross-sectional study. The catabolic status of vitamin B6 was evaluated using serum levels of pyridoxal 5'-phosphate (PLP) (the active form) and its metabolite 4-pyridoxic acid (4-PA). The analysis of 4-PA, PLP, and the 4-PA to PLP ratio (4-PA/PLP) used continuous variables and quartiles (Q1-Q4). The associations of 4-PA, PLP, and 4-PA/PLP with the prevalence of AMD were evaluated via weighted logistic regression, with odds ratio (OR) and 95% confidence interval (CI) estimates provided. Nonlinear relationships were explored utilizing restricted cubic splines. Of these 4202 included individuals, 549 were diagnosed with AMD and 3653 were non-AMD patients. High PLP levels (Q4 [≥ 55.475 nmol/L] vs Q1: OR [95% CI] = 0.69 [0.48-0.97]) were significantly associated with lower odds of AMD, whereas high 4-PA/PLP levels (Q3 [0.668-0.976]: OR [95% CI] = 1.57 [1.07-2.29]; Q4 [≥ 0.976]: OR [95% CI] = 2.00 [1.35-2.96]) were related to higher odds of AMD. The associations of PLP levels (Q4: OR [95% CI] = 0.49 [0.32-0.76]) and 4-PA/PLP levels (Q4: OR [95% CI] = 2.18 [1.27-3.75]) with the prevalence of AMD were observed only in individuals aged ≥ 65 years and not in those aged < 65 years. No significant association was found between 4-PA levels and the odds of AMD (P > .05). The restricted cubic splines curves demonstrated that the nonlinear relationships of 4-PA (Poverall = .002; Pnon-linear = .730) and PLP (Poverall < .001; Pnon-linear = .791) with the prevalence of AMD were not significant, whereas the levels of 4-PA/PLP (Poverall < .001; Pnon-linear < .001) had a significant nonlinear association with the prevalence of AMD. High 4-PA/PLP levels showed an association with high odds of AMD, suggesting that vitamin B6 catabolic status may influence the prevalence of AMD.

PMID 42499120
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PubMedCureus2026-07-25

Myo-Inositol for Cutaneous Manifestations of Polycystic Ovary Syndrome: An International Delphi Consensus Recommendation for Dermatology Practice.

Ganjoo Anil A, Kalra Sanjay S, Kohli Malavika M, Damisetty Rajetha R et al.

Acne and hirsutism are among the most distressing features of polycystic ovary syndrome (PCOS), yet current guidelines largely emphasize metabolic and reproductive aspects, offering limited guidance for dermatologic management. Myo-inositol (MI), an insulin-sensitizing agent with endocrine benefits, has emerged as a promising nonhormonal option; however, its role in managing cutaneous symptoms remains unclear. The purpose of this study was to develop expert consensus on the use of MI alone and in combination with folic acid and vitamin D₃ for PCOS-related dermatologic manifestations. Eleven statements were generated through a rigorous literature review and subsequently evaluated by 133 experts through a two-round online Delphi process. Consensus was defined as ≥70% agreement; statements with 50% to <70% agreement were revised and reassessed. Consensus endorsed MI as an effective and well-tolerated intervention for acne and hirsutism. Continuous MI supplementation at 4 g/day for ≥6 months was recommended. MI + folic acid + vitamin D₃ and MI + D-chiro-inositol were favored for metabolic dysfunction and hyperandrogenism. MI-based therapy, particularly early initiation and strategic combinations, should be integrated into multimodal management of PCOS-related cutaneous manifestations.

PMID 42500779
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PubMedMedicine2026-07-25

Effect of vitamin D supplementation on clinical outcomes of patients with Parkinson disease: A randomized controlled study.

Anamnart Chumpol C, Kitjarak Ram R

Vitamin D deficiency is linked to Parkinson disease (PD) pathogenesis; however, clinical trial results remain inconclusive. Thus, in this study, we aimed to evaluate the prevalence of vitamin D deficiency in Thai patients with PD and the efficacy of vitamin D3 supplementation on clinical outcomes in a tropical, sun-abundant region. In this randomized controlled trial, we enrolled 60 patients with PD and 60 healthy controls. Patients with PD were randomized 1:1 to receive 2000 IU/d of vitamin D3 or no additional treatment (control) for 12 weeks. Primary outcomes included changes in MDS-UPDRS, Hoehn and Yahr (mH&Y), Thai Mini-Mental State Examination, and PDQ-39 scores. The secondary outcome was the prevalence of vitamin D deficiency (25(OH)D < 20 ng/mL). At baseline, vitamin D deficiency was significantly more prevalent in patients with PD than in healthy controls (23.2% vs 10.0%, P = .046). After 12 weeks, the vitamin D group showed a significant increase in serum 25(OH)D levels compared to the control group (P < .001, successfully normalizing levels in the deficiency subgroup (30.96 ± 3.18 ng/mL). Although Thai Mini-Mental State Examination scores improved significantly within the vitamin D group (mean difference 1.37, P < .001), a similar improvement occurred in the control group (mean difference 0.93, P = .010), with no significant difference between groups (P = .378). No significant improvements were observed in motor function (MDS-UPDRS, mH&Y) or quality of life (PDQ-39). Vitamin D deficiency is common among Thai patients with PD, despite equatorial proximity. While 2000 IU/d of vitamin D3 safely corrected nutritional deficiency, it provided no significant short-term motor or cognitive benefits.

PMID 42499083
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PubMedThe Journal of steroid biochemistry and molecular biology2026-07-25

Podophyllotoxin induces testicular toxicity via the microbiota-gut-testis axis based on the toxicological evidence chain concept.

Shao Yuanyang Y, Wang Yu Y, Dai Yihang Y, Wang Lei L et al.

Podophyllotoxin (PPT), a natural lignan with well-established antitumor efficacy and well-documented ovarian toxicity, was first investigated for its potential testicular toxicity in male Sprague-Dawley rats, following the guidance of the Toxicological Evidence Chain (TEC) framework. Through an integrated approach combining physiological and pathological phenotyping, targeted metabolomics of intestinal contents, serum, and testicular tissues, testicular transcriptomics, and 16S rDNA sequencing of gut microbiota, we systematically delineated the injury evidence chain induced by PPT. Oral administration of PPT (20mg/kg/day for 4 days) elicited marked systemic toxicity, including reduced body weight and food intake, alongside clinical signs such as nasal hemorrhage and diarrhea. Testicular toxicity was evident from decreased testicular weight and organ index, histopathological impairments-including seminiferous tubule distortion, fibrosis, and germ cell apoptosis-and compromised sperm quality. Serum levels of testosterone (T), luteinizing hormone (LH), and follicle-stimulating hormone (FSH) were significantly suppressed. Concurrently, colonic injury was observed alongside gut dysbiosis, characterized by a reduction in Lactobacillus and enrichment of Proteus and Escherichia-Shigella. Multi-tissue metabolomics consistently identified disruption of vitamin B6 metabolism, with downregulation of pyridoxine, pyridoxamine, and 4-pyridoxic acid, while transcriptomic analysis revealed suppression of steroidogenic genes (Star, Cyp11a1, Cyp17a1). These findings collectively indicate that PPT induces testicular injury via the microbiota-gut-testis (MGT) axis.

PMID 42498206
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PubMedTurkish journal of medical sciences2026-07-25

Association of vitamin D, oxidative stress markers, and hormonal factors with male infertility: a case-control study in Pakistan.

Tayyab Ihsan Muhammad M, Ali Malick Ayesha A, Khan Sher S, Tahir Khan Muhammad M et al.

Infertility impacts around 15% of couples worldwide, with male factors accounting for approximately 50% of cases. Despite this significant share, male infertility remains understudied, particularly in developing nations such as Pakistan. The present study explores the association between male infertility and seminal plasma concentrations of oxidative stress markers, inhibin B, and vitamin D, along with their relationship with sperm parameters. The dataset of the study consisted of seminal plasma levels from 30 fertile and 60 infertile males. Total antioxidant capacity (TAC), Vitamin D, malondialdehyde (MDA), 4-hydroxynonenal (4-HNE), lipid peroxide (LPO), superoxide dismutase (SOD), and inhibin B levels were assessed using ELISA kits and the data were analyzed using SPSS (v.23) software. Descriptive statistics for quantitative variables were reported as mean ± standard deviation. Correlations among parameters were assessed using Spearman's rank correlation test. In all analyses, p-values of < 0.05 were considered significant, and < 0.001 as highly significant. Fertile males exhibited higher vitamin D and TAC levels than the infertile males (p-values = 0.00 and < 0.01, respectively). In contrast, higher MDA and 4-HNE levels were observed in infertile males (p-value = 0.00). No statistically significant relationship was identified between the inhibin B and LPO values of the two groups. Elevated oxidative stress markers (MDA, 4-HNE) and reduced vitamin D and TAC levels were associated with infertility in the sample. The dual role of SOD in oxidative stress regulation warrants further investigation to determine the thresholds at which sperm integrity is affected. Vitamin D may play a critical function in spermatogenesis, though its exact mechanisms require further exploration. These findings underscore the role of oxidative stress and nutritional factors in fertility, and highlight the need for targeted interventions to improve reproductive outcomes.

PMID 42499447
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