Drug Database
AB

abuse-deterrent extended release tablet technology

✓ Approved

Inspirion Delivery Technologies · therapeutic agent

What is abuse-deterrent extended release tablet technology?

abuse-deterrent extended release tablet technology is a therapeutic agent developed by Inspirion Delivery Technologies. It is approved for therapeutic indications via others.

Drug Profile

CompanyInspirion Delivery Technologies
RouteOthers
StatusApproved
Sources: ClinicalTrials.gov, Inspirion Delivery Technologies

Therapeutic Indications

abuse-deterrent extended release tablet technology is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Surgical and medical proceduresOral appliance application✓ Approved

Related Research Articles

PubMedInternational journal of pharmaceutics2026-07-25

Development of propranolol hydrochloride extended-release lipid matrix tablets for pediatric use.

Broocks Stefanie S, Gebhardt Melanie M, Klein Sandra S

Although solid oral dosage forms are widely used in adult drug therapy, age-appropriate formulations for pediatric patients remain limited. The development of suitable dosage forms is challenged by specific requirements regarding excipient safety, tablet size, and dose flexibility, as well as the need to improve therapy adherence in the context of frequent dosing. This study aimed to develop a pediatric-appropriate extended-release matrix tablet based on lipid matrix formers, with particular attention to the use of safe excipients and the selection of excipients based on sustainability considerations. Lipid-based excipients, selected due to their natural origin and similarity to dietary fats, were investigated and compared with conventional matrix formers. A formulation screening approach was applied to identify promising candidates based on drug release after one hour, followed by further evaluation of manufacturability, tablet hardness, and extended-release performance. In addition, the influence of a physiological pH-gradient, bile salts, and long-term storage on drug release was assessed. The selected formulations showed good manufacturability, uniformity, and sustained drug release. Overall, several lipid-based matrix formulations suitable for pediatric use were identified, providing a promising basis for the development of solid oral extended-release dosage forms for children.

PMID 42497932
Read full article →
PubMedJournal of controlled release : official journal of the Controlled Release Society2026-07-25

Simple hybrid predictive model for point-of-care pharmaceutical tablet disintegration.

Leung Chi Ki CK, Bawuah Prince P, Spiesshofer Nicolas N, Kottlan Andreas A et al.

Ensuring the consistent disintegration performance of immediate-release oral solid dosage (OSD) forms throughout their shelf life is critical for therapeutic efficacy, yet predicting point-of-care performance from manufacturing data remains a significant challenge. Current predictive approaches often rely on empirical correlations or high-dimensional black-box models that lack mechanistic insight and longitudinal validity. To address this, a simple hybrid model that predicts longitudinal disintegration times tdisint,T solely from at-line porosity measurements fat-line is established. The framework is anchored in United States Pharmacopoeia <701> standards to ensure regulatory compliance and reproducibility, while maintaining an architecture that is agnostic to the specific porosity characterisation technique. Utilising a five-year real-time stability dataset with different formulations and tablet geometries, global models are established and demonstrate exceptional predictive accuracy (R2>0.92) across all longitudinal time points. The operating range lies in fat-line∈[0.1,0.3], which is the typical porosity range of pharmaceutical OSDs. The model's longitudinal validity is predicated on the physicochemical stability of the formulation, allowing the model parameters to serve as quantitative indicators in stability assessments. The simplicity and adaptability of this mechanistically grounded model offer a pragmatic path to demonstrating dosage form efficacy at the point-of-care, providing a robust alternative to traditional, destructive end-point testing. By relating at-line structural attributes to long-term performance, this model facilitates Quality by Design in development, seamless technical transfer, and robust real-time release testing. Ultimately, this framework ensures that the rigorously designed quality standards are demonstrably preserved until the moment of patient administration.

PMID 42498232
Read full article →
PubMedInternational journal of biological macromolecules2026-07-25

Controlled release network hydrogel based on zein/sodium alginate-stabilized chrysanthemum essential oil Pickering emulsions for prolonged preservation of fresh-cut Gastrodia elata.

Zhang Lihui L, Liu Jieni J, Law Chung Lim CL, Sun Qing Q et al.

Browning and microbial proliferation are major factors driving quality deterioration in fresh-cut Gastrodia elata. This study developed a zein/sodium alginate-stabilized chrysanthemum essential oil (CEO) Pickering emulsion and incorporated it into gelatin-konjac glucomannan hydrogels for fresh-cut G. elata preservation. The emulsion exhibited nanoscale droplets (194.53-515.00 nm) with exceptional stability (zeta potential: -82.85 to -95.92 mV), confirming effective encapsulation of CEO. The optimized hydrogel (GK-8%) formed a dense network with uniform pore structure, demonstrating superior water retention and sustained release properties, achieving 73.30% CEO release over 390 h. Application tests revealed that GK-8% significantly reduced weight loss (≤ 0.15%) and browning index (26.72% reduction), maintained firmness and total phenolic content, while decreasing antioxidant enzyme activities, indicating reduced oxidative stress. Visual observations showed that GK-8% treatment delayed visible browning by approximately 3 days compared to the control. The hydrogel extended shelf life through synergistic effects of microbial inhibition and oxidative stress alleviation, providing an effective, eco-friendly strategy for fresh-cut product preservation.

PMID 42498190
Read full article →
PubMedJournal of cardiology2026-07-25

Self-care interventions using mobile applications in heart failure management.

Yokota Takashi T

Digital therapeutics using mobile technology offer potential advantages for facilitating patient-centered care. Driven by an increasing demand for digital health in the care of individuals with heart failure (HF), numerous mobile health applications (mHealth apps) have been developed to enhance self-care behaviors in patients with chronic HF. The key functional elements of HF apps include self-monitoring support, medication tracking and reminders, lifestyle modification guidance, sensor device connectivity and data transmission, educational materials, automated health status checks with alerts for potential HF exacerbation, and motivational support and feedback. Several randomized clinical trials (RCTs) have evaluated the efficacy and feasibility of self-care interventions for patients with chronic HF that use smartphone- or tablet-based apps designed as standalone or near-standalone systems. Although it has been observed that mHealth apps can improve patients' self-care behaviors, the evidence regarding the apps' impact on hard clinical endpoints (e.g. mortality and hospitalization) remains limited and inconsistent. The results of RCTs have demonstrated potential benefits, but it remains essential to address barriers to mHealth app adoption among both patients and healthcare professionals in order to successfully implement such apps into routine clinical practice. This narrative review examines mobile app-based self-care interventions and evaluates the evidence concerning their efficacy and feasibility in chronic HF patient populations.

PMID 42498001
Read full article →
PubMedNational science review2026-07-25

Smart symbiotic lithium-sulfur batteries under extremely low-temperature conditions.

Mao Runyue R, Pei Mengfan M, Jin Xin X, Qu Dejian D et al.

Lithium-sulfur batteries (LSBs) fail catastrophically under ultralow temperature due to frozen polysulfide conversion kinetics, with no existing technology achieving high-energy-density operation below -40°C. Here, we report a self-regulating LSB system, the 'smart symbiosis' cell, that activates multifield synergy at interface reaction sites to overcome kinetic barriers under low temperature. This directly modulates the transport of ions/electrons and the spin electron states of reaction sites at the quantum level, enabling wave-shaped charge/discharge profiles and achieving a ratio of 3.11 between the first plateau and the second plateau (theoretical value 3.0). The ultratheoretical capacity mechanism is revealed-magnetic field-induced enhancement of kinetics and interfacial reactions. The pouch cell achieves an energy density of 454.5 Wh kg-1 (based on total system mass) and 219.1 Wh kg-1 (with device consumption) at -80°C. This technology could increase the capacity of batteries by 9.5 times at low temperatures with an energy consumption of ∼0.091% °C-1 of the battery energy, while the conversion retention rate remains as high as 87% after 200 cycles (∼2800 h), and breaks the lowest temperature record. This new battery system opens the door to extremely wide temperature applications for LSBs and could be extended to other batteries.

PMID 42500739
Read full article →
PubMedSmart molecules : open access2026-07-25

Transparent, solvent-free, and pressure-tolerant antifouling coatings via molecular nanocomposite engineering.

Li Jieran J, Xu Xiubin X, Liang Yueyan Y, Mu Hongchun H et al.

Traditional solvent-based antifouling coatings face critical limitations including application onto miscible organic substrates and volatile organic compound (VOCs) pollution. Herein, this work presented a solvent-free, transparent antifouling coating through room temperature vulcanization, based on a strategy of molecularly engineered nanocomposite networks. This strategy utilizes hydroxy-terminated polydimethylsiloxane (HO-PDMS-OH) as functional segments to enable dynamic liquid repellency, isocyanatopropyltriethoxysilane (IPTS) and 3-(2-aminoethylamino) propylmethyldimethoxysilane (AEAPS) as dual cross-linkers for rapid curing and robust network, and hydrophobic nano-SiO2 as reinforcing fillers for anti-fouling and mechanical robustness. The coating exhibited low VOC release through solvent-free processing, high visible-light transmittance (91% at 500 nm), and broad-spectrum repellency with excellent durability against abrasion/chemical exposure/long-term oil immersion. This unique coating strategy makes it possible for the ready application of antifouling technology onto heat-sensitive, solvent-sensitive, and flexible substrates such as flexible display devices. This work establishes an eco-friendly paradigm for multifunctional protective coating through molecular nanocomposite engineering.

PMID 42500725
Read full article →

+9996 more articles available with a free account

Sign up free to view all articles →

Ask about abuse-deterrent extended release tablet technology