Drug Database
AB

abuse-deterrent extended release tablet technology

✓ Approved

Inspirion Delivery Technologies · therapeutic agent

What is abuse-deterrent extended release tablet technology?

abuse-deterrent extended release tablet technology is a therapeutic agent developed by Inspirion Delivery Technologies. It is approved for therapeutic indications via others.

Drug Profile

CompanyInspirion Delivery Technologies
RouteOthers
StatusApproved
Sources: ClinicalTrials.gov, Inspirion Delivery Technologies

Therapeutic Indications

abuse-deterrent extended release tablet technology is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Surgical and medical proceduresOral appliance application✓ Approved

Related Research Articles

PubMedFrontiers in cell and developmental biology2026-11-11

Antibiotic and growth factor-loaded hydrogels for infected bone defect repair: mechanisms of spatiotemporal delivery and cellular microenvironment regulation.

Chen Lin L, Zhang Xulin X, Luo Lan L, Lan Jiaping J et al.

The treatment of infected bone defects (IBDs) requires simultaneous infection control and bone regeneration. However, traditional staged treatment protocols have several limitations. These include extended treatment durations, multiple surgical procedures, and low repair efficiency. Bifunctional hydrogels loaded with antibiotics and growth factors (GFs) offer a crucial material platform for integrated treatment strategies. These hydrogels possess excellent biocompatibility, malleability, and the capacity for spatiotemporal drug delivery. This review summarizes the design principles of antibiotic- and GF-loaded hydrogels, with particular attention to sequential and synergistic release strategies and their roles in infection control, immune regulation, vascularization, and osteogenesis. Current in vitro and in vivo evaluation approaches are also discussed, together with remaining challenges in drug stability, release precision, long-term biosafety, and clinical translation. This review may provide a basis for the rational design of multifunctional hydrogel systems and their further development for infected bone defect repair.

PMID 43010935
Read full article →
PubMedNeurourology and urodynamics2026-11-11

Child Abuse and Lower Urinary Tract Symptoms: A Systematic Review.

Gemma Luca L, Bonerba Giuseppe G, Antonietti Michela M, De Donno Antonio A

About 25% of children will encounter child abuse throughout their lifetime. Child abuse, one of the main components of adverse childhood experiences (ACEs), is associated with a variety of physical and mental health problems, such as posttraumatic stress disorder, self-injurious behavior, personality disorder, psychosis, sexually transmitted diseases, and lower urinary tract symptoms (LUTS). The aim of this systematic review was to evaluate prevalence and pattern of LUTS both in childhood and adulthood associated to a history of child abuse. The systematic review was conducted in accordance with the PRISMA statement. A literature search of the Medline, Scopus, and Web of Science databases was performed in May 2026 and included studies published in English up to April 2026. Relevant studies to the review reported the prevalence and urinary symptoms in child and adult patients who have experienced abuse in childhood primarily. The quality of the studies and risk of bias were evaluated using version 2 of ROBINS-I tool. Out of 676 studies, 19 papers met the inclusion criteria. Six studies explored LUTS in children with past child abuse and neglect, while 13 studies evaluated LUTS in adults with a history of child abuse. Up to 12 years after sexual abuse, abused girls had 2.1 times more diagnoses of urinary problems compared to the general population. In children evaluated for suspected sexual abuse, nocturnal enuresis increased with age, from 13% in 5-9 years to 18.2% in 17-18 years. Childhood traumatic event score was significantly associated with overall LUTS severity and frequency, urgency, and incontinence severity, while ACEs predicted the total number of LUTS. In one study, formal mediation analysis suggested that depression, anxiety, and perceived stress partly mediated the association between childhood trauma and LUTS severity, whereas another study found no mediating effect of negative affect. Limitations of the review are the low quality of studies (13 of 19 retrospective; serious overall risk of bias in 13) and the lack of standardized assessment of abuse and LUTS; overall, the certainty of the evidence is low. A history of childhood abuse appears to be associated with LUTS during childhood, which could also manifest in adulthood. However, given the predominantly retrospective design of the included studies and the heterogeneity of abuse definitions and urinary outcomes, the strength of this evidence remains limited.

PMID 43012092
Read full article →
PubMedJournal of interpersonal violence2026-11-11

An Ecological Model of Recognition: Diagnosis as a Relational Process Among Survivors of Childhood Sexual Abuse.

Klein Michal M, Farchi Moshe M, Meir Noam N, Peled-Avram Maya M

While the diagnostic overlap between complex post-traumatic stress disorder (CPTSD) and borderline personality disorder (BPD) has received increasing scholarly attention, there remains a limited understanding of how adult women survivors of childhood sexual abuse (CSA) interpret psychiatric diagnoses within the relational contexts that shape their self-recognition and meaning-making processes. This study investigated the processes by which adult women survivors of CSA, diagnosed with CPTSD and/or BPD, understand their experiences of abuse, interpret their psychiatric diagnoses, and integrate these distinct yet interconnected aspects of their lived experience. Semi-structured interviews were conducted with 19 adult women survivors of CSA, and the resulting data were analyzed employing interpretive description and reflexive thematic analysis. This analysis identified a central theme: making sense of the abuse and its consequences over time. This theme encompassed four subthemes: fragmented memory, containment, and silence; internal struggles of recognition and interpretation; familial validation and invalidation; and institutional responses that either connected or failed to connect trauma to its consequences. Across these domains, psychiatric diagnoses served as relational frameworks, with their meaning being negotiated across intrapsychic, familial, and institutional contexts. These findings propose a preliminary socioecological framework that extends Kelley et al.'s model of traumatic stress to the concept of recognition itself, herein conceptualized as relational and dynamically unfolding. Clinically, these findings underscore the importance of trauma-informed diagnostic communication that collaboratively explores possible links between current difficulties and abuse history while attending to safety, pacing, and readiness. They also highlight the importance of institutional practices that integrate trauma-related information across services and into clinical formulation.

PMID 43010712
Read full article →
PubMedJournal of interpersonal violence2026-11-11

Man Up? Understanding Sexual Distress and Functioning Problems After Childhood Sexual Abuse in Men.

Gewirtz-Meydan Ateret A, Mitchell Kimberly J KJ, Sherer Yael Y, Godbout Natacha N

Childhood sexual abuse (CSA) can have enduring consequences for sexual well-being, yet research on adult sexual distress and functioning has focused predominantly on women. A specific focus on men is needed because masculine expectations of strength, control, and sexual competence may shape how male survivors interpret both victimization and subsequent sexual difficulties. This study examined whether CSA is associated with sexual distress and sexual functioning among men, and whether these associations are moderated by masculine discrepancy stress and intrusiveness during sex. A cross-sectional sample of 586 adult men with a history of CSA completed validated self-report measures assessing all constructs. Hierarchical ordinary least squares regressions were conducted while adjusting for demographic and abuse-related characteristics. CSA severity was initially associated with greater sexual distress and functioning problems, but these associations were no longer significant after accounting for masculine discrepancy stress and intrusiveness during sex. Intrusiveness during sex was consistently associated with both greater sexual distress and more functioning problems, whereas masculine discrepancy stress was independently associated only with sexual distress. Masculine discrepancy stress moderated the association between intrusiveness and functioning problems: contrary to expectations, this association weakened as discrepancy stress increased. No comparable interaction emerged for sexual distress. These findings suggest that men's sexual difficulties following CSA cannot be understood solely as direct consequences of abuse severity. Gender-sensitive, trauma-informed interventions should address both trauma-related experiences during sexual activity and the masculine meanings through which survivors understand their sexual well-being.

PMID 43012333
Read full article →
PubMedJournal of interpersonal violence2026-11-11

Measuring Child Sexual Abuse Myth Acceptance in a Multiprofessional German Sample.

Bayer Lennart L, Cigelski Maike M, Eilfgang Justine J, Mensing Frieda F et al.

Child sexual abuse myths (CSAM) may influence professionals working in the fields of child protection, the judicial sector, and schools. Their acceptance of CSAM is associated with negative effects on prevention and intervention efforts in cases of child sexual abuse (CSA); and individuals who accept CSAM view children and adolescents who disclose their experiences as less credible. Therefore, it is important to assess the CSAM acceptance rate of professionals who frequently deal with children and adolescents in general and cases of CSA in particular. This study used the Child Sexual Abuse Myth Scale-German version to assess CSAM acceptance in a sample of N = 578 German professionals from the fields of child protection, the judicial sector, and schools in five German states. Results showed low CSAM acceptance rates overall-especially in those CSAM subscales that downplay negative effects or shift responsibility from perpetrators to survivors. However, professionals in our sample were more accepting of CSAM about perpetrators and showed the highest CSAM acceptance rates in the subscale focusing on CSAM about CSA disclosures. Additionally, we found higher CSAM acceptance rates on some subscales for men and CSA nonsurvivors compared to women and CSA survivors. There were some significant group differences between professionals from child protection, the judicial sector, and schools: School professionals showed higher CSAM acceptance than both other groups. It is concluded that findings should be used to design and evaluate specific CSA training programs focusing on the CSAM with higher acceptance rates and to apply effective training programs to different professional groups.

PMID 43010721
Read full article →
PubMedNano letters2026-11-11

Nanoscale Mapping of Internal Magnetization Dynamics Reveals How Disorder Shapes Heat Generation in Magnetic Particle Hyperthermia.

Jefremovas Elizabeth M EM, Rooms Pauline P, Gallo-Córdova Álvaro Á, Morales María P MP et al.

Magnetic particle hyperthermia relies on the efficient conversion of magnetic field energy into heat, yet the microscopic mechanisms governing this process within individual particles remain poorly understood. Here, we combine AC magnetometry experiments with dynamic micromagnetic simulations to connect microstructural features, magnetization dynamics, and macroscopic heat dissipation. We resolve heat generation at the intraparticle level, uncovering heterogeneous nanoscale heat-generation bursts with nanometer and nanosecond resolution. At a given particle size, grain size acts as an experimentally tunable parameter, balancing anisotropy disorder and pinning strength, thereby controlling both the magnitude and spatiotemporal distribution of heat release. Experiments show that flux-closure-dominated nanoflower architectures composed by larger grains generate more heat than their smaller-grain counterparts, whose deeper intraparticle pinning landscape redistributes heat generation over extended time windows. Together, our results provide a mechanistic framework linking nanoparticle microstructure to magnetic heating and establish design principles for optimizing nanoflowers as magnetic hyperthermia transducers.

PMID 43012586
Read full article →

+9996 more articles available with a free account

Sign up free to view all articles →

Ask about abuse-deterrent extended release tablet technology