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sodium ferrous citrate (SCF, Eisai / Ferromia / Nemiffero)

✓ Approved

Eisai Co., Ltd. · Small Molecule · Small Molecule

What is sodium ferrous citrate?

sodium ferrous citrate is a small molecule developed by Eisai Co., Ltd.. It is approved for therapeutic indications.

Drug Profile

Brand NamesSCF, Eisai, Ferromia, Nemiffero
CompanyEisai Co., Ltd.
Drug ClassSmall Molecule
StatusApproved
Sources: ClinicalTrials.gov, Eisai Co., Ltd.

Therapeutic Indications

sodium ferrous citrate is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Blood and lymphatic system disordersAnaemia✓ Approved

Related Research Articles

PubMedAnalytical chemistry2026-11-11

Simultaneous Visualization of Labile Ferrous Iron Pool and Biothiols Reveals Divergent Pathological Trajectories in Ferroptosis and Alzheimer's Disease.

Yin Guoxing G, Tan Wei W, Wang Donghao D, He Zhiping Z et al.

Alzheimer's disease (AD) and ferroptosis share certain pathobiochemical features, yet the spatiotemporal evolution patterns and metabolic trajectories of their core hallmarks, labile ferrous iron pool and biothiols, and their pathophysiological relationship remain elusive. Herein, we developed a single-molecule dual-site fluorescent probe, FCG, for simultaneous discrimination of Fe2+, Cys/Hcy, and GSH via analyte-specific cascade reaction mechanisms. The probe exhibits rapid kinetics (k = 0.16-1.23 min-1), nanomolar sensitivity (detection limits: 38.8-509.2 nM), and well-separated emission signatures (Δλem ≥ 60 nm), facilitating concurrent visualization of these endogenous species dynamics in living systems. Importantly, application to cellular and mouse models revealed divergent metabolic pathways: ferroptosis displays synchronized labile ferrous iron pool accumulation, catastrophic lipid peroxidation, and global biothiols depletion, whereas AD exhibits modest iron elevation, a unique biothiols profile (elevated total Cys and Hcy but depleted GSH), and protein aggregation that is absent in ferroptosis. Comparative proteomic analysis further elucidated the molecular landscape of these dynamically regulated networks, as well as their distinct pathological metabolic trajectories. This study not only clarifies the mechanistic basis for the fundamentally different pathological trajectories underlying ferroptosis and AD but also provides critical evidence and analytical tools for targeted interventions in neurodegenerative diseases.

PMID 43010452
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PubMedZhonghua nan ke xue = National journal of andrology2026-11-11

[Effect of zinc selenium L-carnitine compound nutrient combined with tamoxifen citrate on routine semen parameters and sperm DNA fragmentation index in male infertility patients].

Xie Yuanzhi Y, Xin Meijiao M, Shi Nanxiang N, Shi Yimin Y et al.

Objective To explore the effect of zinc selenium L-carnitine compound nutrient combined with tamoxifen citrate on routine semen parameters and sperm DNA fragmentation index of male infertility patients with abnormal sperm DNA fragmentation index. Methods A total of 903 male infertile patients with sperm DFI (>15%) were selected and randomly divided into control group (453 cases) and combination group (450 cases). The control group was treated with vitamin E soft capsule, and the combination group was treated with zinc selenium L-carnitine compound nutrient combined with tamoxifen citrate. The percentages of normal morphology sperm, sperm volume, sperm concentration, percentage of forward moving sperm（PR）, percentage of non-forward moving sperm（NP）, and DFI of patients in the two groups were collected before treatment and 1, 2 and 3 months after treatment. The effective rates of combined medication treatment for patients with abnormal DFI in different age groups were compared. Results After 1 month of treatment in the combination group, PR increased significantly and DFI decreased significantly (P<0.01). After 2 months of treatment, compared with before treatment, PR (P<0.01) and NP increased (P<0.05), DFI decreased (P<0.01). After 3 months of treatment, the semen volume increased compared with before treatment (P<0.05), and DFI decreased continuously (P<0.01). However, there was no significant difference in the percentage of normal morphological sperm and sperm concentration compared with before treatment (P>0.05). In the control group, PR increased significantly after 1 and 2 months of treatment compared with before treatment (P<0.01, P<0.05), and DFI decreased significantly (P<0.001, P<0.01). However, there was no statistically significant difference in the percentage of normal morphological sperm, semen volume, sperm concentration, and NP compared with before treatment. There was no significant difference in any parameters after 3 months of treatment compared with before treatment (P>0.05). Before treatment, the differences in various parameters between the two groups were not significant (P>0.05). After 1 and 2 months of treatment, compared with the control group, the DFI of the combination group showed a significant decrease (P<0.01, P<0.05), and the differences in other parameters were not significant (P>0.05). After 3 months of treatment, the differences in various parameters between the two groups were not significant (P>0.05). Among the patients in the combination group with DFI>25%, the treatment effectiveness rate of patients aged ≥35 years was higher than that of those aged <35 years old (P<0.01); while among the patients in the combination group with 15%0.05). Conclusion The zinc selenium L-carnitine compound nutrient combined with tamoxifen citrate can improve PR and sperm DNA integrity of male infertility patients. Meanwhile, patients with higher baseline DFI values combined with older age have better therapeutic effects.

PMID 43012228
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PubMedNature communications2026-11-11

The sodium channel SCN2A regulates cortical excitatory and inhibitory neurogenesis.

Uy Jarryll A JA, Dargaei Zahra Z, Geahchan Sarah S, Botler Laura L et al.

Voltage-gated sodium channels regulate neuronal excitability and synaptic transmission in the postnatal and adult brain. The gene SCN2A, encoding the sodium channel Nav1.2, regulates synaptic development and variants in SCN2A are associated with autism spectrum disorders (ASD) and a broad spectrum of epilepsy phenotypes, including early-onset developmental and epileptic encephalopathies. The expression pattern of SCN2A begins during prenatal cortical development, prior to the onset of synaptic transmission, but it is unknown whether SCN2A regulates early cortical development through mechanisms independent of synaptic transmission. Here we reveal that isogenic and ASD patient-derived human forebrain organoids modelling a loss of SCN2A function display impaired excitatory and inhibitory neurogenesis, leading to a developmental imbalance. Unexpectedly, we find precocious generation of cortical inhibitory neurons is driven by elevated Sonic hedgehog signaling and is reversible through pharmacological inhibition. Functionally, these developmental phenotypes arise due to Nav1.2-dependent sodium channel dysfunction and reduced action potential generation, leading to abnormal neuronal network activity. Our results identify a mechanism for cortical excitatory and inhibitory neurogenesis involving SCN2A, and reveal that early neurogenesis deficits precede postnatal neural circuit dysfunction in SCN2A-associated disorders.

PMID 43009472
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PubMedFrontiers in chemistry2026-11-11

Performance evaluation of sodium-ion batteries for microgrid and off-grid energy storage applications.

Hu Xingyu X

Sodium-ion batteries are increasingly considered for stationary energy storage; however, their application-level performance depends on how experimentally measured electrochemical behavior translates into realistic grid-connected and standalone operating conditions. This study evaluated 24 5.0-Ah sodium-ion pouch cells through baseline electrochemical characterization, identification of a second-order Thevenin electrochemical-thermal model, annual system simulation, and application-specific aging tests. Discharge behavior was characterized at rates of 0.20-2.00 C and temperatures of 10-40 °C. Pulse and impedance measurements were used to parameterize the model across 10%-90% state of charge. The calibrated model was scaled to a 504-kWh grid-connected microgrid and a 120.96-kWh standalone off-grid system, both simulated over 365 days at 15-min resolution. Increasing discharge rate reduced usable capacity and energy efficiency, whereas Coulombic efficiency remained above approximately 99%. The model reproduced measured voltage responses with millivolt-scale prediction errors and captured state-of-charge- and temperature-dependent resistance trends. The grid-connected microgrid achieved 91.6% round-trip efficiency, an 18.7-kW tracking root-mean-square error, and 4.3% renewable curtailment. The standalone system achieved 89.8% round-trip efficiency, a 1.6% annual loss-of-power-supply probability, and 6.4% curtailment. After 500 equivalent full cycles, capacity state of health was 85.2%, 81.9%, and 79.8% under reference, microgrid, and off-grid cycling, respectively, with corresponding resistance growth of 39%, 58%, and 74%. These findings demonstrate that application-specific duty cycles materially influence the efficiency, reliability, and degradation of sodium-ion battery storage systems. Integrating experimentally calibrated electrochemical-thermal models with application-level simulations provides a practical basis for evaluating battery performance under realistic stationary energy-storage conditions.

PMID 43011270
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PubMedBiology direct2026-11-11

The YTHDF1/CAV1 axis regulates clear cell renal cell carcinoma progression through ferroptosis and apoptosis.

Sun Yulin Y, Wang Songbo S, Sun Jinpeng J, Zhu Shouwei S et al.

Sorafenib exerts antitumor activity in clear cell renal cell carcinoma (ccRCC), but its precise mechanisms involving regulated cell death remain incompletely understood. Ferroptosis has emerged as an important effector of sorafenib-mediated antitumor activity; however, the regulatory network controlling ferroptosis in ccRCC, particularly the role of epitranscriptomic regulators such as the N6-methyladenosine reader YTHDF1, remains poorly defined. Sorafenib induced ferroptosis in ccRCC cells, as evidenced by increased intracellular ferrous iron, reactive oxygen species, lipid peroxides, and malondialdehyde levels, and was accompanied by reduced YTHDF1 expression. Genetic silencing of YTHDF1 robustly activated both ferroptosis and apoptosis, characterized by iron accumulation, oxidative stress, lipid peroxidation, mitochondrial damage, an increased Bax/Bcl-2 ratio, Caspase-3 activation, and PARP1 cleavage. These changes significantly suppressed ccRCC cell proliferation, migration, and invasion. Integrated RNA sequencing and RIP sequencing analyses, together with molecular validation, identified Caveolin-1 (CAV1) as a downstream target of YTHDF1. Rescue experiments showed that CAV1 overexpression effectively reversed the ferroptotic and apoptotic phenotypes, as well as the impaired malignant behaviors, induced by YTHDF1 knockdown. In vivo, YTHDF1 depletion markedly inhibited xenograft tumor growth, whereas restoration of CAV1 reversed this tumor-suppressive effect and attenuated the associated ferroptosis- and apoptosis-related changes. This study identifies the YTHDF1/CAV1 signaling axis as a critical regulator that concurrently suppresses ferroptosis and apoptosis in ccRCC, highlighting it as a promising therapeutic target to inhibit ccRCC progression.

PMID 43010063
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PubMedChemSusChem2026-11-11

Aqueous Guar Gum Binder Enables Regulated Surface Structure Evolution and Enhanced Electrochemical Performance of NFPP/Activated Carbon Composite Cathodes for Sodium-Ion Batteries.

Cai Benzhen B, Huang Linran L, Shao Haitao H, Li Lunjie L et al.

Na4Fe3(PO4)2(P2O7) (NFPP) has emerged as a promising low-cost, structurally stable cathode material for sodium-ion batteries. However, the intrinsically low electronic conductivity of NFPP limits NFPP/activated carbon (NFPP/AC) composite performance. Considering that polymer binders control electrode microstructures and sodium-ion reaction kinetics, the authors incorporated an aqueous guar gum (GG) binder into an NFPP/AC cathode and benchmarked it against polyvinylidene fluoride (PVDF) and carboxymethyl cellulose (CMC)/styrene-butadiene rubber (SBR) systems. The GG-based electrode slurry demonstrates superior rheological properties that facilitate electrolyte infiltration, promote uniform particle dispersion and improve electrode structural integrity. This effect is primarily ascribed to the hydroxyl-rich structure of GG, which establishes hydrogen-bond-mediated multipoint interfacial interactions between NFPP and AC particles, enhancing particle dispersion, slurry structural recovery and interparticle contact. GG also promotes a uniform, dense, inorganic-rich cathode-electrode interface, minimizing charge-transfer resistance and activation energy (61.1 kJ·mol-1). Consequently, the GG-based electrode maintains a high Na+ diffusion coefficient during cycling, retaining 73.8 mAh·g-1 at 5C and showing negligible capacity fading after 400 cycles at 1C. Overall, GG constructs a continuous interfacial binding network between NFPP and AC, regulating interfacial chemistry, structural integrity and Na+ transport pathways.

PMID 43010639
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