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montmorillonite (Diarrafin)

✓ Approved

Beijing Holley-Cotec Pharma · Small Molecule · Small Molecule

What is montmorillonite?

montmorillonite is a small molecule developed by Beijing Holley-Cotec Pharma. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesDiarrafin
CompanyBeijing Holley-Cotec Pharma
Drug ClassSmall Molecule
RouteOral (PO)
StatusApproved

Therapeutic Indications

montmorillonite is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Gastrointestinal disordersDiarrhoea✓ Approved

Related Research Articles

PubMedACS omega2026-07-24

Hydration-Induced Transition from Site-Controlled to Diffusion-Controlled Ion Transport in Montmorillonite Interlayers.

Nugraha Irwan I, Izadifar Mohammadreza M, Emmerich Katja K, Ukrainczyk Neven N et al.

Ion transport in clay minerals is governed by hydration (interlayer water content), yet the underlying molecular mechanisms remain insufficiently understood. Specifically, it is unclear whether water simply reduces migration barriers or fundamentally alters the nature of transport. Here, we combine density functional theory (DFT) with two-dimensional potential energy surface (PES) mapping to investigate the mobility of Na+ and K+ in montmorillonite interlayers as a function of water content. In water-free conditions, the energy landscape is strongly corrugated, exhibiting pronounced minima and large migration barriers (∼several eV) that localize ions at specific adsorption sites, defining a site-controlled regime. Upon hydration, migration barriers decrease nonlinearly, and the energy landscape progressively flattens. At sufficiently high water content, well-defined adsorption sites disappear, signaling a transition to a diffusion-controlled regime. We further demonstrate that the topology of the tetrahedral framework acts as a physical sieve, proving as decisive for ion localization as the electrostatic charge distribution. While Na+ mobility remains sensitive to the local structural vacancy arrangement, the larger K+ ion experiences a spatially averaged potential due to steric restrictions that decouple its transport from local lattice heterogeneity. These findings reveal that hydration does not merely enhance mobility but fundamentally alters the topology of the energy landscape, acting as a molecular "switch" between localized and delocalized ion behavior in confined nanoporous materials.

PubMedEFSA journal. European Food Safety Authority2026-07-24

Assessment of the feed additive consisting of bentonite (dioctahedral montmorillonite) as an anticaking agent for all animal species and as a substance for reduction of the contamination of feed by mycotoxins for pigs, poultry and ruminants for the renewal of its authorisation (BASF SE).

EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Villa Roberto Edoardo RE, Azimonti Giovanna G, Bonos Eleftherios E et al.

Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the renewal of bentonite as a technological feed additive in the functional groups of anticaking agents for all animal species and of substances for reduction of the contamination of feed by mycotoxins for pigs, poultry and ruminants. The applicant has provided evidence that the additive currently on the market complies with the existing conditions of authorisation. There is no evidence that would lead the FEEDAP Panel to reconsider its previous conclusions. Thus, the Panel concluded that the additive remains safe for the target species, consumers and the environment under the authorised conditions of use. Regarding user safety, the Panel concludes that bentonite is not irritant to skin but mildly irritant to eyes and is a skin and respiratory sensitiser. Exposure of users by any route is considered a risk and should be minimised. There is no need for assessing the efficacy of the additive in the context of the renewal of the authorisation.

PubMedEnvironmental science & technology2026-07-23

Iron-Rich Clay Minerals Mediate Abiotic Methane Formation through Distinct Fe Coordination Environments.

Yan Ying Y, Zou Jianlong J, Wang Hao H, Yu Menghan M et al.

Methane (CH4) plays a central role in the global carbon cycle, yet the contribution of abiotic processes to natural CH4 emissions remains poorly constrained, particularly in iron-rich sedimentary environments. Here, we demonstrate that ubiquitous iron-rich clay minerals, including Fe3+-exchanged montmorillonite (Fe3+-MMT) and ferric nontronite (NAu), catalyze abiotic CH4 formation from methylated organic substrates under environmentally relevant redox conditions. Both minerals enhance CH4 formation relative to dissolved Fe3+ but exhibit contrasting formation kinetics and product selectivity arising from differences in Fe coordination and mineral structure. Fe3+-MMT generates rapid CH4 pulses through interlayer-confined redox cycling, whereas NAu supports slower yet sustained CH4 formation through gradual activation of structural Fe. Spectroscopic analyses combined with density functional theory calculations reveal that mineral structure regulates Fe(IV)═O generation and stabilizes methyl radicals, thereby suppressing overoxidation. Compared with homogeneous Fe3+ systems, clay-catalyzed reactions reduced CO/CO2 formation by 42-62%. CH4 yields are further modulated by pH, temperature, inorganic cations, and organic ligands. These findings identify iron-rich clays as mineralogical controls on abiotic CH4-forming pathways and highlight their potential role in sedimentary carbon cycling and methylated organic compound transformation.

PubMedRSC advances2026-07-23

Synergistic adsorption-oxidation of phenol by a magnetically recoverable LNC/MMT-stabilized NZVI composite.

Baiyun Zhao Z, Ling Meng M, Bo Zhang Z, Li Wang W

Phenolic wastewater remains a critical environmental concern owing to its high toxicity and resistance to natural attenuation. To overcome the inherent drawbacks of bare nano-zero-valent iron (NZVI)-namely severe agglomeration and rapid surface passivation-we designed a novel ternary composite (LNC/MMT@NZVI) by immobilizing NZVI particles onto a lignocellulose/montmorillonite (LNC/MMT) binary support via liquid-phase reduction. This strategy achieved excellent NZVI dispersion and generated a mesoporous architecture with markedly enhanced thermal stability, as confirmed by N2 adsorption-desorption, XRD, FTIR, SEM-EDS, TEM, TG-DSC, and VSM analyses. The composite exhibited an outstanding phenol adsorption capacity of 127.58 mg g-1 under optimized conditions (pH 8, 50 °C, 240 min). Kinetic and isotherm studies revealed that phenol removal follows the pseudo-second-order model (R 2 = 0.9857) and Langmuir isotherm (R 2 = 0.9999), indicating a chemisorption-dominated monolayer process. XPS and EPR spectroscopic evidence unambiguously demonstrated that the embedded Fe0 initiates a sustained Fenton-like redox cycle, generating hydroxyl radicals (·OH) as the predominant reactive species, while the LNC/MMT support concurrently enriches phenol molecules near the active sites via hydrogen bonding and surface complexation. This synergistic integration of adsorptive enrichment and catalytic oxidation not only overcomes the intrinsic limitations of standalone NZVI but also provides a highly efficient, magnetically recoverable platform for treating recalcitrant organic wastewater.

PubMedEnvironmental geochemistry and health2026-07-16

Adsorption behavior and isotopic effect of boron on montmorillonite in the presence of Ca2.

Zhu Zihao Z, Hao Xiaodong X, Dong Ruixue R, Chen Xuejun X et al.

Owing to the high solubility of boron, it is prone to migration in aqueous environments, which may consequently affect its geochemical processes in soil systems. To better understand the role of clay minerals and coexisting cations in the adsorption and isotopic fractionation of boron, montmorillonite (Mmt) was selected as a model mineral, and batch adsorption experiments were conducted in aqueous solution to explore the kinetic and equilibrium adsorption behavior of boron in the presence of Ca2+. The results showed that the dynamic adsorption process could be well described by the Freundlich isotherm model (R2 > 0.8). The isotopic composition of adsorbed boron on Mmt decreased with increasing pH when boron existed predominantly as B(OH)3, which indicated the preferential enrichment of 10B on the surface of Mmt. Moreover, the presence of Ca2+ enhanced the adsorption of boron and led to more negative δ11B values on Mmt, which suggested the formation of a surface-associated Ca10B(OH)4+ complex and was further supported by negative zeta potentials measured. These findings provide fundamental insights into the adsorption of boron on clay minerals in aqueous systems and offer a basis for future investigations into the regulation of boron-containing fertilizers and the leaching behavior of boron in different types of soils.

PubMedPolymers2026-07-15

Organo-Montmorillonite (OMMT) Modified SiC/Hydrogenated Epoxy Micro-Nanocomposites for Enhanced Corona Aging Resistance.

Hu Haitao H, Dong Hailiang H, He Mingpeng M, Ma Boxin B et al.

The concentration of electric fields at the end region of stator bars in large generators can readily induce corona discharge. Under long-term operation, corona discharge may cause drift in the surface conductivity and nonlinear coefficient of anti-corona materials, thereby weakening their capability to homogenize the tangential electric field. In severe cases, this can lead to charring failure of the anti-corona material. To improve the electrical-parameter stability and surface morphological resistance to corona aging of silicon carbide (SiC)-based anti-corona materials under long-term corona exposure, epoxy-resin-based anti-corona materials were investigated in this study. Scanning electron microscopy (SEM) and Fourier-transform infrared spectroscopy (FTIR) were first employed to analyze the effects of corona aging on the microstructure and chemical structure of the anti-corona layer, thereby revealing its failure mechanism. Subsequently, the evolution of surface conductivity, nonlinear coefficient, and surface morphology of bisphenol A epoxy resin (EP)- and hydrogenated bisphenol A epoxy resin (H-EP)-based anti-corona materials during 120 h of corona aging was comparatively investigated. On this basis, different mass fractions of organically modified montmorillonite (OMMT) were introduced into the H-EP-based anti-corona material for synergistic modification. The OMMT used in this study had a particle size of approximately 5 μm and an interlayer spacing of 2.6 nm, and its lamellar morphology and dispersion state in the epoxy matrix were characterized by cross-sectional SEM. Meanwhile, the trap-regulation mechanism of the OMMT-modified anti-corona materials was analyzed using isothermal surface potential decay (ISPD). The results show that erosion of the epoxy resin matrix by corona discharge is the primary cause of internal conductive-pathway disruption and anti-corona layer failure. Compared with the EP-based material, the H-EP-based material exhibited better conductivity and nonlinear stability during aging, although a certain degree of drift still occurred. The incorporation of an appropriate amount of OMMT further improved the corona resistance of the material. Among the investigated samples, the material containing 1 wt% OMMT showed the best performance, with its conductivity stabilized within the range of 10-13-10-11 S, the lowest variation rate of 104.76%, a relatively stable nonlinear coefficient, and slight surface damage. The ISPD results indicate that the interfaces introduced by OMMT increase the deep-trap density and suppress carrier migration, thereby stabilizing the conductive network. Overall, the synergistic effect of the H-EP matrix and 1 wt% OMMT can effectively enhance the corona resistance of SiC-based anti-corona materials.

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