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PT

PT-007

✓ Approved

Pediatrix Therapeutics · Unknown · Unknown

What is PT-007?

PT-007 is a unknown developed by Pediatrix Therapeutics. It is approved for therapeutic indications via unknown.

Drug Profile

CompanyPediatrix Therapeutics
Drug ClassUnknown
RouteUnknown
StatusApproved
Sources: ClinicalTrials.gov, Pediatrix Therapeutics

Therapeutic Indications

PT-007 is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Congenital, familial and genetic disordersHereditary haemochromatosis✓ Approved

Related Research Articles

PubMedAngewandte Chemie (International ed. in English)2026-06-09

Redirecting Excited-State Proton Transfer Through Supramolecular Polymerization in Nanoconfinement.

Pantaleone Luis C LC, Hutchings Robert R, Reus Bente B, Martinelli Jacopo J et al.

The photoluminescence of photoacids in supramolecular assemblies provides crucial insights into proton transfer (PT) processes within biologically relevant confinement. In this work, we present a strategy to activate intermolecular excited-state PT within the hydrophobic cavities of cyclodextrin-based nanotubes. Activation is achieved using a specifically designed amphoteric emitter which undergoes a pKa inversion in the photoexcited state. Despite this photophysical behavior, intramolecular PT does not occur due to the spatial separation between the proton donor and acceptor sites in the compound. However, in the presence of γ-cyclodextrin, the photoacid assembles into guest pairs, enabling pre-organized PT between neighboring molecules. The effects of confinement on photostability, emission lifetime, and quantum yield indicate a mechanistic shift from excited-state protolytic dissociation to intermolecular excited-state PT. Spectroscopic investigation of the assembly mechanism and solvent isotope effect further supports the role of a template effect, reminiscent of enzymatic activation, in facilitating PT in the excited state.

PMID 42259609
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PubMedColloids and surfaces. B, Biointerfaces2026-06-09

Construction of colorimetric and fluorescence dual-mode sensing platform based on FeSnO(OH)5/Pt NPs and CsPbBr3@DMSNs for sensitive detection of TBHQ.

Wei Zhiyuan Z, Wang Hanbo H, Lv Yuntai Y, Liang Qing Q et al.

Tert-butylhydroquinone (TBHQ) as a cost-effective synthetic and efficient antioxidant is extensively added to food products, excessive intake of TBHQ is associated with potential health risks. Herein, a colorimetric and fluorometric detection method integrating FeSnO(OH)5/Pt nanoparticles (Pt NPs) and CsPbBr3@DMSNs for the sensitive detection of TBHQ was developed. CsPbBr3@DMSNs nanocomposites were prepared by embedding CsPbBr3 nanocrystals (NCs) within dendritic mesoporous silica nanoparticles (DMSNs), resulting in excellent aqueous stability and enhanced luminescence properties. Pt NPs were in situ grown on FeSnO(OH)5 nanocubes with a favorable specific surface area by a coprecipitation method, yielding the FeSnO(OH)5/Pt NPs with excellent peroxidase-like activity. 3,3',5,5'-tetramethylbenzidine (TMB) could be catalyzed by FeSnO(OH)5/Pt NPs to produce oxTMB, thereby quenching the fluorescence of CsPbBr3@DMSNs by inner filter effect. TBHQ has potent antioxidant properties and could prevent TMB from being oxidized, thereby recovering the fluorescence of CsPbBr3@DMSNs. Hence, a colorimetric and fluorescence dual-signal detection system for TBHQ detection was developed, with LODs of 3.52 µM and 2.12 µM, respectively. Moreover, this sensing platform was successfully used for the TBHQ determination in edible oils, indicating good practicability.

PMID 42259175
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PubMedThe journal of physical chemistry. B2026-06-09

Synergistic Singlet-Triplet Regulation in Platinum(II)-Acetylide Triads with Strong Two-Photon Absorption and Optical Power Limiting.

Zhao Yibo Y, Li Shufei S, Zhou Xingtong X, Liu Taihong T et al.

Unveiling the intramolecular photophysical transitions and intrinsic excited-state dynamics of organometallic complexes is of critical importance yet remains challenging. Herein, two platinum (II)-acetylide triads, namely Pt-1 bearing the triethylphosphine ligands and Pt-2 with the triphenylphosphine ligands, were rationally synthesized and investigated comprehensively. The NMR shielding phenomena of Pt(II) atoms with dense extranuclear electrons are elucidated properly through comparative studies on a reference analogue, BDT-TPA. The rigid planar molecular geometries endow the triads with extended π-conjugation, which promotes efficient ligand-to-metal charge transfer (LMCT) and ligand-to-ligand charge transfer (LLCT). Furthermore, a significant effect of Pt(II)-acetylide d-π coordination, ligand aromaticity, and steric hindrance on the steady state and nonlinear optical properties are also elucidated comparatively. Benefiting from strong spin-orbit coupling and ligand-mediated conjugation, both Pt(II)-acetylide triads exhibit enhanced intersystem crossing rates and prolonged triplet-state lifetimes. Notably, Pt-2 displays a maximum two-photon absorption cross-section of 1830 GM in THF upon femtosecond excitation at 650 nm, which is obviously higher than that of 980 GM at 775 nm observed for BDT-TPA. High-performance optical power limiting assessments based on the two-photon absorption mechanism reveal that both triads possess low onset thresholds around 0.06 J·cm-2 and favorable limiting thresholds around 0.25 J·cm-2. Theoretical calculations further correlate the superior nonlinear optical performance with efficient excited-state absorption as well as prominent LMCT characteristics. This study not only affords mechanistic insights into the intrinsic photophysics of the Pt(II)-acetylide complexes but also sheds light on the potential nonlinear optical applications.

PMID 42262246
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PubMedMedicine2026-06-09

Comparative study of piperacillin-tazobactam versus ampicillin in the treatment of severe pneumonia in children: A retrospective study.

Wang Jiangjiang J, Cao Junyi J, Zhang Lei L

Severe pneumonia remains a leading cause of pediatric mortality, with increasing β-lactamase-producing pathogens challenging traditional penicillin efficacy. This study compared the clinical efficacy and safety of piperacillin-tazobactam (PT) versus ampicillin (AMP) in children with severe community-acquired pneumonia (CAP). This retrospective cohort study with propensity score matching (PSM) enrolled children aged 6 months to 5 years with severe CAP from January 2022 to June 2024. After 1:1 PSM, 95 children per group received either PT or AMP. Primary endpoints included early clinical failure rate, end-of-therapy clinical cure rate, and sustained clinical success at test of cure (TOC). Secondary endpoints encompassed symptom resolution time, pathogen eradication rate, and safety profile. The PT group demonstrated significantly lower early clinical failure rate (2.11% vs 9.47%, P = .030; RR = 0.22, 95% CI: 0.05-0.98) and higher end-of-therapy clinical cure rate (88.17% vs 76.74%, P = .044) compared with AMP. PT achieved superior overall pathogen eradication (88.73% vs 73.13%, P = .019), particularly for Haemophilus influenzae (95.83% vs 68.00%, P = .012) and Pseudomonas aeruginosa (100.00% vs 40.00%, P = .038). Hospital stay was shorter in the PT group (8.65 ± 2.30 vs 9.81 ± 2.73 days, P = .002). Adverse event rates were comparable (10.53% vs 9.47%, P = .809). Piperacillin-tazobactam demonstrated superior efficacy over ampicillin for severe pediatric CAP, with comparable safety. These findings suggest PT offers a favorable benefit-risk profile for severe pediatric CAP, particularly in areas with documented β-lactamase-producing bacterial prevalence.

PMID 42260869
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PubMedACS applied materials & interfaces2026-06-09

Disentangling Degradation Mechanisms of Noble Metal-Coated Titanium Porous Transport Layers for Water Electrolyzers.

Lee Jeongah J, Nam Seongwoo S, Kim Hyunseung H, Lee Pilyoung P et al.

The shift toward a carbon-neutral society hinges on efficient green hydrogen production through proton exchange membrane water electrolysis. While noble metal (especially platinum (Pt))-coated titanium (Ti)-based porous transport layers (PTLs) offer superior robustness, the Pt coating remains unstable under harsh operating conditions. We established a three-electrode evaluation platform that enables precise control over potential, temperature, and pH, allowing a systematic investigation on PTL. Electrochemical and surface analyses reveal that degradation behavior varies with temperature and pH following three mechanisms: (i) defect-induced physical detachment, (ii) Pt particle agglomeration, and (iii) Pt surface passivation. Degradation proceeds most rapidly when passivation and corrosion occur in a balanced manner, with potential pulses of 5 s duration inducing the most severe deterioration. Furthermore, we highlight that short- and long-term degradation follow distinct mechanisms. This study provides a comprehensive understanding of noble metal-coated Ti PTL degradation, presenting essential design principles for developing highly durable electrolyzer components.

PMID 42261701
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PubMedAngewandte Chemie (International ed. in English)2026-06-09

Ordered Pt3Mn Intermetallic Nanoparticles Supported on Atomically Dispersed Mn-N-C as Electrocatalysts for Fuel Cells.

Chen Gongjin G, Wang Tianshuai T, Qiu Xiaoyi X, Liu Shiyuan S et al.

Compared with conventional solid-solution alloy nanoparticles with disordered atomic structures, platinum (Pt)-based intermetallic compounds (IMCs) are recognized as highly promising electrocatalysts for practical fuel cell applications, on account of their long-range periodically ordered atomic arrangements. Nevertheless, the rational development of Pt-based catalysts featuring both high intrinsic activity and long-term durability remains a key challenge in this field. In this work, by simultaneously introducing manganese (Mn) with low-electronegativity into both the active component and the support, we report an efficient electrocatalyst toward the oxygen reduction reaction (ORR), composed of L12-ordered Pt3Mn nanoparticles on Mn single-atom nitrogen-doped carbon support (L12-Pt3Mn@Mn-N-C). The incorporation of Mn, the strong anchoring effect arising from the hierarchically porous structure of the support, and the directional interfacial electron transfer between L12-Pt3Mn and Mn-N-C synergistically mitigate the adsorption strength of key oxygen intermediates and suppress the dissolution of surface Pt sites. Superior catalytic performance and durability are validated in proton exchange membrane fuel cells (PEMFCs), achieving a peak power density of 1.15 W cm-2 under H2/air conditions. After 30 000 square-wave cycles, the voltage loss at 0.8 A cm-2 is only 19 mV, ranking it among the top-performing Pt-based cathode catalysts reported to date.

PMID 42261958
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