Drug Database
NI

nilotinib

✓ Approved

MolecularMD · ABL1 · Companion diagnostic

What is nilotinib?

nilotinib is a companion diagnostic developed by MolecularMD. It is approved for therapeutic indications via others.

Drug Profile

CompanyMolecularMD
Drug ClassCompanion diagnostic
Molecular TargetABL1, BCR
RouteOthers
StatusApproved
Sources: ClinicalTrials.gov, MolecularMD

Mechanism of Action

Molecular Targets

nilotinib acts on 2 molecular targets:

ABL1ABL proto-oncogene 1, non-receptor tyrosine kinase (c-ABL, bcr/abl)
BCRBCR activator of RhoGEF and GTPase (CML, ALL)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

nilotinib is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Neoplasms benign, malignant and unspecified (incl cysts and polyps)Uterine cancer✓ Approved

Related Research Articles

PubMedVeterinary medicine and science2026-07-25

Green Tea Extract, Keratin Hydrolysate and Vitamin C Exert Anti-Ageing Effects Through the Hippo Signalling Pathway in Feline and Canine Mammary Gland Cells.

Gao Yi Y, Sun Xue X, Ma Yan Y, Li Jiaxi J et al.

Ageing is a progressive decline in organ function and tissue integrity caused by genetic, environmental and physiological factors. With the increasing lifespan of companion animals, effective anti-ageing interventions for elderly felines and canines have attracted growing attention in veterinary medicine. This study aimed to investigate the anti-ageing effects of green tea extract, keratin hydrolysate and vitamin C in feline and canine mammary gland cells and to explore the underlying molecular mechanisms. Feline and canine mammary gland cells were treated with green tea extract, keratin hydrolysate and vitamin C in vitro. Cell proliferation, oxidative stress responses and ageing-associated protein expression induced by actinomycin D were evaluated. The involvement of the Hippo signalling pathway was further analysed to determine the molecular mechanisms underlying the anti-ageing effects. Green tea extract, keratin hydrolysate and vitamin C significantly promoted the proliferation of feline and canine mammary gland cells. These treatments effectively restored the abnormal expression of ageing-related proteins induced by actinomycin D and exhibited protective effects against oxidative damage. Mechanistically, the anti-ageing effects were associated with regulation of the Hippo signalling pathway. Green tea extract, keratin hydrolysate and vitamin C exhibit significant anti-ageing effects in feline and canine mammary gland cells through modulation of the Hippo pathway. These findings suggest their potential as safe and effective anti-ageing interventions for improving health and alleviating geriatric syndromes in ageing companion animals.

PMID 42499304
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PubMedBiochemical and biophysical research communications2026-07-25

Exploring the therapeutic potential of NCX1 in hematological cancers; integration of molecular docking, bioinformatics approaches, and experimental validation.

Misir Sema S, Yaman Serap Ozer SO, Petrović Nina N, Cakmak Isik I et al.

Hematological malignancies are highly heterogeneous diseases characterized by dysregulated signaling pathways and limited durable therapeutic responses. Calcium homeostasis has emerged as a critical regulator of cancer cell fate, yet the role of the sodium/calcium exchanger 1 (NCX1/SLC8A1) in leukemogenesis remains poorly defined. In this study, we comprehensively investigated the biological significance and therapeutic potential of NCX1 across major hematological malignancies by integrating transcriptomic analyses, protein-protein interaction networks, experimental validation, and in silico drug repurposing strategies. NCX1 was highly expressed in HL-60, K-562, and Jurkat cells compared to HaCaT controls. Network analyses revealed that NCX1 interacts with key regulators of calcium signaling, immune response, and signal transduction. In AML and CML patient datasets, a strong positive correlation was observed between NCX1 expression and immune-related pathways, while a negative correlation was observed with translation-related processes. Molecular docking analyses demonstrated that several clinically approved compounds, particularly imatinib and nilotinib, interact with NCX1. Molecular dynamics simulation was performed to evaluate the binding stability and safety of imatinib. Remarkably, the comprehensive analysis showed that imatinib exhibited a stable molecular dynamics profile. All these findings have demonstrated NCX1 as a biologically informative marker of myeloid differentiation and a promising therapeutic weak point within calcium signaling networks in hematological malignancies, providing a rationale for future functional and single-cell validation studies.

PMID 42497834
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PubMedGalen medical journal2026-07-25

Diagnostic Performance and Radio-Pathologic Correlation of Image-Guided Biopsy in Head and Neck Lesions: A Systematic Review : Short title: Diagnostic Performance and Radio-Pathologic Correlation of Image-Guided Biopsy in Head and Neck Lesions.

Al-Hakami Hadi H

Accurate diagnosis of head and neck lesions relies heavily on image-guided biopsy techniques, which facilitate targeted sampling and enable radiologic-pathologic correlation. Increasing use of CT-guided fine-needle aspiration cytology (FNAC) and core-needle biopsy (CNB) necessitates updated evaluation of their diagnostic performance and safety. To systematically identify, appraise, and synthesize published evidence on the diagnostic accuracy, tissue adequacy, and radio-pathologic concordance of image-guided biopsy for head and neck lesions. This review followed PRISMA 2020 guidelines and a protocol registered in PROSPERO (CRD420251181567). Searches were conducted across PubMed/MEDLINE, Scopus, Cochrane Library, Web of Science, and Google Scholar (January 2018-September 2025). Eligible studies included human subjects undergoing image-guided FNAC or CNB with reported diagnostic outcomes. Two reviewers independently screened, extracted data, and assessed quality using QUADAS-2. Due to methodological and clinical heterogeneity, meta-analysis was not performed. From 345 records, eight studies met inclusion criteria. Most were retrospective (8/10), evaluating CT-guided FNAC, CNB, or percutaneous needle biopsy across cervical, suprahyoid, salivary, lymphatic, thyroid, and skull base lesions. Diagnostic sensitivities ranged from 85-95%, specificities from 92-97%, and overall accuracies from 90-96%. Diagnostic yield was high (85-100%), and radio-pathologic concordance consistently exceeded 87%. Complications were uncommon and generally minor, except for hilar lymph node biopsies, which showed higher pneumothorax rates. Image-guided biopsy of head and neck lesions demonstrates high diagnostic accuracy and excellent radio-pathologic concordance across diverse anatomic regions, supporting its role as a reliable, minimally invasive diagnostic tool. Despite strong performance in deep and complex spaces, procedure-specific complication risks-particularly in hilar lymph node sampling-should inform clinical decision-making.

PMID 42499369
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PubMedThe Medical clinics of North America2026-07-25

Diagnostic Tools in Sleep Medicine.

Yuan Nathaniel N, Avidan Alon Y AY

This article presents a structured, clinically grounded approach to the diagnosis of sleep disorders. Key conceptual distinctions are clarified to support accurate symptom characterization and avoid diagnostic misclassification. Validated screening instruments are reviewed. Objective diagnostic modalities are discussed. The role of the physical examination and targeted biomarkers is emphasized as a means of enhancing diagnostic precision in selected patients. Through integration of clinical data, subjective assessments, and objective measures, the experienced clinician can accurately diagnose and manage common sleep disorders including insomnia, hypersomnolence disorders, obstructive sleep apnea, and circadian rhythm sleep-wake disorders while delivering individualized, patient-centered care.

PMID 42498433
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PubMedJournal of molecular biology2026-07-25

Alcohol dehydrogenase D from Pyrococcus furiosus is a thermostable rare earth element binding enzyme: Metal/cofactor interactions modulate the apparent reaction equilibrium constant.

Gokulu Ipek Simay IS, Abeyrathna Sameera S, Banta Scott S

Metals are frequently exploited in the active sites of enzymes; however, the involvement of rare earth elements (REEs) in biocatalysis has been less commonly observed. Here, we show that the alcohol dehydrogenase D (AdhD) from Pyrococcus furiosus can bind REE ions, and the forward activity (alcohol oxidation) is accelerated by the addition of REEs, while, unexpectedly, the reverse reaction is inhibited. In the companion paper, we discovered a REE binding site in the AdhD structure that is distal to the active site. Here, we identified a second REE binding interaction that is only observed in the presence of bound cofactor. The addition of REEs affects the observed equilibrium constant of the reaction, and the binding of the REEs by the enzyme/cofactor complex depends on the redox state of the cofactor. Comparable REE-dependent modulation of catalysis was also observed with human aldose reductase (hAR), suggesting a conserved mechanism of REE interaction among aldo-keto reductase (AKR) family enzymes. REE interactions attenuate the formation of the enzyme cofactor/complexes, which explains the differential impact on the reaction rates and the variable effective reaction equilibrium constant. Together, these results establish a mechanism by which REEs tune catalytic directionality and apparent thermodynamic set points through cofactor-dependent binding and linkage effects, rather than through classical active-site metal catalysis.

PMID 42497915
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PubMedWorld journal of otorhinolaryngology - head and neck surgery2026-07-25

Research Progress on Upper Airway Cough Syndrome.

Huang Wan-Ting WT, Chen Jia J

Upper airway cough syndrome (UACS) has been identified as a significant contributor to chronic cough in various national guidelines. However, the complexity of its pathogenesis, the lack of clarity surrounding its diagnostic criteria, and its overlap with other etiologies of chronic cough present considerable challenges in both diagnosis and treatment. The utilization of nasal and laryngeal endoscopy is crucial in the diagnostic process, and the implementation of a multidisciplinary collaborative approach can markedly enhance diagnostic accuracy and treatment outcomes. This article provides a comprehensive review of the clinical characteristics, diagnostic and therapeutic approaches, and pathophysiological mechanisms associated with UACS, aiming to equip clinicians with a deeper understanding for improved management of this condition.

PMID 42500107
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