Drug Database
NI

nilotinib

✓ Approved

MolecularMD · ABL1 · Companion diagnostic

What is nilotinib?

nilotinib is a companion diagnostic developed by MolecularMD. It is approved for therapeutic indications via others.

Drug Profile

CompanyMolecularMD
Drug ClassCompanion diagnostic
Molecular TargetABL1, BCR
RouteOthers
StatusApproved
Sources: ClinicalTrials.gov, MolecularMD

Mechanism of Action

Molecular Targets

nilotinib acts on 2 molecular targets:

ABL1ABL proto-oncogene 1, non-receptor tyrosine kinase (c-ABL, bcr/abl)
BCRBCR activator of RhoGEF and GTPase (CML, ALL)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

nilotinib is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Neoplasms benign, malignant and unspecified (incl cysts and polyps)Uterine cancer✓ Approved

Related Research Articles

PubMedThe Journal of chemical physics2026-06-09

WMS-Rot: From quantum-chemical predictions to rotational spectral assignment and refinement.

Lazzari Federico F, Barone Vincenzo V

We present WMS-Rot and its fitting companion WMS-FitRot as an integrated framework for the early stages of rotational spectral analysis, starting from spectroscopic parameters obtained from electronic-structure computations and progressing to assignment-aware local refinement driven by the same theoretical catalog used for prediction. The framework provides a practical and internally consistent route connecting modern composite quantum-chemical predictions to first-pass assignments and controlled refinement. More fundamentally, it reformulates the incorporation of theoretical information into the spectroscopic inverse problem: calculated parameters act not only as initial guesses but also as active constraints that stabilize assignments and guide early-stage refinement within a unified simulation-fit cycle. Applications to nicotinic acid and thiopronine show that accurate composite inputs markedly improve starting points compared to low-level models, enabling robust assignment, reliable conformer discrimination, and consistent refinement. The approach reproduces matched reduced-Hamiltonian fits while remaining fully compatible with standard SPCAT/SPFIT practice and provides diagnostic insight into parameter correlations, identifiability, and model conditioning.

PMID 42262045
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PubMedMedicine2026-06-09

Factors influencing anxiety levels in colon cancer patients undergoing chemotherapy after arm venous port implantation: An exploratory study of risk factors.

Zhang Jiemin J, Wang Xiaomei X, Han Jing J

There are currently few studies on the association between arm venous port implantation and anxiety levels in colorectal cancer chemotherapy patients, and there is a lack of systematic analysis of related risk factors. Further research is urgently needed to provide scientific evidence for clinical practice. To investigate the risk factors for anxiety in patients with arm venous access ports after chemotherapy and established a predictive model. A total of 245 patients were enrolled in this study, among whom 94 patients developed anxiety symptoms after chemotherapy. The enrolled patients were randomly divided into a training set and a validation set in a 7:3 ratio, with 171 patients in the training set and 74 patients in the validation set. Demographic and disease-related data were collected from the patients. The study investigated the factors associated with anxiety after chemotherapy in patients with arm venous access ports and established a predictive model. Factors potentially associated with anxiety were included in a univariate logistic regression analysis. The results indicated that 5 factors - educational attainment, marital status, presence of a bedside companion, distant metastasis, and chemotherapy-related adverse reactions - had P values < .2, making them potential risk factors for anxiety in patients with an arm-based intravenous port following chemotherapy. Further analysis using a multivariate regression model revealed that marital status, presence of a bedside companion, distant metastasis, and chemotherapy-related side effects were identified as independent risk factors for post-chemotherapy anxiety in patients with an arm venous access port (P < .05). This study confirmed that marital status, bedside companions, distant metastasis, and chemotherapy side effects are 4 independent risk factors for anxiety in patients with arm venous access ports after chemotherapy. The predictive model established in this study provides a powerful tool for clinicians to identify high-risk patients for post-chemotherapy anxiety at an early stage, enabling them to provide timely interventions such as symptomatic treatment and alleviation of chemotherapy side effects, thereby reducing the incidence of post-chemotherapy anxiety in patients.

PMID 42260797
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PubMedBMC nursing2026-06-09

Children's near-death experiences: tales from nurses - a content analysis study.

Moradi Poria P, Abdi Alireza A, Kolehjoubi Ameneh Amiri AA

Near-death experiences (NDEs) are rare but profound phenomena that have also been reported in children. However, most existing research has focused primarily on adults, and evidence regarding pediatric NDEs remains limited. This study explored pediatric nurses' observations and accounts of children's NDEs using a qualitative approach. A conventional qualitative content analysis design was employed. Thirteen nurses working in pediatric oncology and intensive care units of a children's referral hospital in Kermanshah, Iran, were recruited through purposive and snowball sampling. In-depth semi-structured interviews were conducted between May and August 2025. Data were analyzed using the Graneheim and Lundman (2004) approach and managed with MAXQDA 2020 software. Three main categories emerged from the data: soothing perceptions, encounters with individuals, and emotional reactions. These were further organized into six subcategories: enveloped in light, secure companion, unknown observer, invitation to play, seeking security, and anxiety. Children's NDEs, as reported by nurses, are multidimensional phenomena involving feelings of peace, perceived interactions with figures, and emotional responses. These findings highlight the importance of recognizing the psychological and spiritual dimensions of children's end-of-life experiences and supporting nurses in responding to them with empathy and understanding.

PMID 42260495
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PubMedJoint Commission journal on quality and patient safety2026-06-09

Diagnostic Safety Policy and Practice: Advocacy Drivers and Challenges-Key Recommendations from a Qualitative Interview Study with US and Australian Experts.

Dahm Maria R MR, Chien Laura J LJ

Diagnostic errors are a global patient safety threat, with emergency settings particularly vulnerable. It remains poorly understood how diagnostic safety is incorporated into policy and reflected in practice. This study compares policy trajectories in the United States and Australia to offer insights into embedding diagnostic safety as a core patient safety priority over the past 25 years. Data collection was guided by "information power," where sample size is determined by the relevance and richness of the information participants provide. Qualitative semistructured interviews (n = 29) were conducted with experts from the United States (n = 15) and Australia (n = 14) to capture system-level and frontline perspectives across diagnostic safety research and policy (n = 14), emergency medicine (n = 9), and health consumer advocacy (n = 6). Transcribed interviews were analyzed using thematic analysis. Eight themes were identified: four advocacy cycle drivers progressing the evolution of diagnostic safety policy in the United States and four persistent challenges impeding progress in the United States and Australia. Diverging evolutionary pathways showed that the United States developed a pioneering and increasingly coordinated approach to diagnostic safety, although threatened by limited federal funding and policy reach, while in Australia diagnostic safety is kept at the policy margins due to fragmentation and underfunding. Key recommendations are provided to address persistent challenges constraining diagnostic safety in policy and practice. Coordinated action is required to drive recognition and solutions for diagnostic safety as a health policy issue and wicked practice problem and to achieve measurable impact toward sustained diagnostic excellence.

PMID 42259689
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PubMedActa radiologica (Stockholm, Sweden : 1987)2026-06-09

Diagnostic performance of contrast-enhanced ultrasound for thyroid nodule characterization: a systematic review and meta-analysis.

Huo Xiang X, He Jianlin J, Sun Yijun Y, Ren Yanhong Y

BackgroundDifferentiating benign from malignant thyroid nodules is essential for effective patient management.PurposeTo evaluate the diagnostic performance of contrast-enhanced ultrasound (CEUS) for thyroid nodule characterization based on currently available evidence.Material and MethodsWe conducted a systematic review and meta-analysis of studies evaluating the diagnostic accuracy of CEUS for thyroid nodules. PubMed, Scopus, and Web of Science were searched through 31 March 2025. Studies using histopathologic or cytologic reference standards were included. Pooled estimates of sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy were calculated using random-effects models. Subgroup analyses and meta-regression were performed to explore potential effect modifiers. Studies evaluating contrast-enhanced computed tomography were included in the qualitative synthesis but were not incorporated into the quantitative meta-analysis.ResultsA total of 59 studies were included in the systematic review. Among these, 54 CEUS studies provided sufficient data for quantitative synthesis. CEUS demonstrated pooled sensitivity of 78.6% and specificity of 82.6%, with an overall diagnostic accuracy of 81.6%. Subgroup analyses indicated that examiner experience significantly influenced diagnostic performance, with higher sensitivity observed in studies involving more experienced operators. Meta-regression did not identify statistically significant independent associations between examined covariates and diagnostic outcomes.ConclusionThe available literature indicates that CEUS demonstrates favorable diagnostic performance for differentiating benign from malignant thyroid nodules. Further prospective studies using standardized imaging protocols and reporting frameworks are needed to better define the role of CEUS in thyroid nodule evaluation.

PMID 42262145
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PubMedNature communications2026-06-09

A disease-centric vision-language foundation model for precision oncology in kidney cancer.

Tao Yuhui Y, Zhao Zhongwei Z, Wang Zilong Z, Luo Xufang X et al.

The non-invasive assessment of renal masses remains a critical challenge in urologic oncology, where diagnostic uncertainty frequently causes overtreatment. Here, we develop RenalCLIP, a vision-language foundation model for precision oncology in kidney cancer. Utilizing 27,866 computed tomography scans from 8809 patients across diverse multi-center cohorts, we employ a two-stage pre-training strategy to align domain-specific visual and textual representations. RenalCLIP achieves enhanced performance and generalizability across ten core clinical tasks, spanning anatomical assessment, diagnostic classification, and survival prediction, significantly outperforming state-of-the-art general-purpose foundation models. Furthermore, RenalCLIP demonstrates strong data efficiency in diagnostic classification, achieving peak baseline performance using only 20% of the training data. The model also exhibits robust zero-shot diagnostic capabilities, effective image-text retrieval, and high-quality medical report generation. Our findings establish RenalCLIP as a powerful, generalizable tool to enhance diagnostic precision, refine prognostic stratification, and personalize the management of renal masses.

PMID 42259830
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