Drug Database
PI

piperacillin (piperacillin, KRKA / Isipen)

✓ Approved

Krka · Small Molecule · Small Molecule

What is piperacillin?

piperacillin is a small molecule developed by Krka. It is approved for therapeutic indications via unknown.

Drug Profile

Brand Namespiperacillin, KRKA, Isipen
CompanyKrka
Drug ClassSmall Molecule
RouteUnknown
StatusApproved
Sources: ClinicalTrials.gov, Krka

Therapeutic Indications

piperacillin is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Infections and infestationsSalmonellosis✓ Approved

Related Research Articles

PubMedTropical medicine and health2026-09-20

Timing of surgery for a melioidosis-associated abdominal aortic pseudoaneurysm: a case report.

Fu Tianning T, Qiu Xiali X, Zhan Yuefu Y, Chen Jianqiang J

Melioidosis is a tropical infectious disease caused by Burkholderia pseudomallei. Although vascular involvement is rare, melioidosis-associated abdominal aortic pseudoaneurysm can rapidly progress and carries a high risk of rupture and mortality. Due to nonspecific early symptoms and the lack of specific guidelines, the optimal timing of surgery remains unclear. A 62-year-old female farmer from Hainan Province, China, presented with persistent lower abdominal pain for over 10 days, followed by low back pain and fever (maximum 38.0 °C). She was diagnosed with type 2 diabetes mellitus based on persistent hyperglycemia and an HbA1c level of 14.8%. Emergency CTA revealed a focal pseudoaneurysmal lesion of the abdominal aorta at the L3 level, with periaortic inflammatory changes and suspected contained rupture, but no active contrast extravasation. As the patient was hemodynamically stable, empirical piperacillin/tazobactam therapy was initiated with close monitoring. Blood cultures on hospital day 5 suggested gram-negative bacilli, prompting a switch to imipenem/cilastatin. On day 6, cultures confirmed B. pseudomallei, susceptible to imipenem, ceftazidime, and TMP-SMX. Targeted antimicrobial therapy was continued with addition of TMP-SMX. The patient's fever, pain, and inflammatory markers improved significantly. Follow-up CTA on day 21 showed marked resolution of periaortic inflammation, and blood cultures became negative on day 28. Antimicrobial therapy was switched to ceftazidime on day 30, and open vascular reconstruction was performed on day 38. In melioidosis-endemic regions, aortic infection should be considered in diabetic patients with fever and abdominal or back pain. For carefully selected patients with suspected contained rupture, hemodynamic stability, and good response to targeted antimicrobial therapy, delayed elective open reconstruction under strict surveillance and with emergency intervention capability may be a feasible strategy. However, this single case cannot establish the superiority of delayed surgery or define the optimal timing of intervention.

PMID 42763400
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PubMedFrontiers in cellular and infection microbiology2026-09-19

Antibiotic resistance, pathogenicity and genomic characteristics of a novel sequence type 6839 Klebsiella pneumoniae strain isolated from cultured bullfrogs (Rana catesbeiana).

Dou Yafeng Y, Wang Haochen H, Chen Qikai Q, Zhang Bo B et al.

Klebsiella pneumoniae is the most frequently encountered multidrug-resistant bacterial pathogen in humans, but its pathogenic effects on aquatic animals are not well documented. K. pneumoniae has recently been identified as a significant cause of death and illness in American bullfrogs (Rana catesbeiana). In the present study, the dominant bacteria were isolated from a diseased bullfrog with neurological signs in Hanchuan, Hubei Province, China. The ZYRC75 isolate was identified by Gram staining, morphological observations, biochemical assays and 16S rRNA sequencing. Antimicrobial susceptibility testing and artificial infection testing were conducted to determine its resistance phenotype and pathogenicity. The whole genome of the ZYRC75 strain was also sequenced. The isolate ZYRC75 was identified as K. pneumoniae and assigned to ST6839, a novel sequence type. It displayed multidrug resistance against penicillins (carbenicillin, piperacillin, ampicillin, penicillin), chloramphenicol, trimethoprim and tetracycline. Infection experiments confirmed the isolate exhibited significant pathogenicity in bullfrogs. ZYRC75 possessed a single circular chromosome of 5,454,922 bp, carrying 179 virulence‑related genes and 157 antimicrobial‑resistance genes. This investigation presents a detailed phenotypic and genomic profile of ZYRC75, revealing its antimicrobial resistance and virulence, and establishing a basis for future studies on the pathogenicity of K. pneumoniae.

PMID 42761288
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PubMedCase reports in urology2026-09-19

Phosphodiesterase-5 Inhibitor Use Masking a Necrotizing Syphilitic Infection: A Rare Differential Diagnosis of Priapism.

Papadimopoulos Dimitrios M DM, Chasapis Apostolos A, Sitaridis Konstantinos K, Arapis Evangelos E et al.

Acute penile enlargement is often presumed to indicate priapism, particularly after Phosphodiesterase-5 inhibitor use. However, alternative diagnoses, including infectious and necrotizing processes, should be considered-especially in patients with a history of unprotected sex-to avoid delayed or inappropriate management. A 43-year-old male with a history of intravenous drug use presented with acute penile swelling and leukocytosis (20,500/μL) following unprotected sexual intercourse and tadalafil consumption. Although priapism was suspected, corporal blood gas analysis demonstrated oxygenation and pH levels that excluded ischemic priapism. The patient was admitted to the clinic, and empiric intravenous antibiotics (piperacillin/tazobactam and clindamycin) were initiated. Despite laboratory improvement, penile edema and erythema progressed with early necrotic changes. Postoperative history obtained from a relative revealed prior inadequately treated syphilis, subsequently confirmed by serologic testing. Τhe patient underwent surgical debridement of necrotic tissue surrounding the corporal bodies. He was discharged and referred to a specialized center for syphilis treatment. The patient recovered without further complications and demonstrated preserved erectile function at 1-month follow-up. Acute penile enlargement following Phosphodiesterase-5 inhibitor use is not necessarily attributable to priapism and may instead be caused by infectious or necrotizing etiologies. Prompt recognition, initiation of antimicrobial therapy, and timely surgical intervention are critical to preserve penile tissue and erectile function.

PMID 42761209
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PubMedCellular and molecular biology (Noisy-le-Grand, France)2026-09-18

Molecular epidemiology of antimicrobial-resistant Klebsiella pneumoniae in intensive care unit patients, southwestern Saudi Arabia.

Abdullah I Abdullah I AI

Antimicrobial resistance (AMR) in Gram-negative pathogens poses a critical threat in intensive care units (ICUs). This retrospective observational study aimed to determine the prevalence and phenotypic resistance profiles of extended-spectrum β‑lactamase (ESBL)-producing and carbapenem‑resistant Klebsiella pneumoniae among ICU patients at a tertiary hospital in southwestern Saudi Arabia (2020-2021). Clinical specimens (n=179) from patients with hospital‑acquired infections were processed using standard culture, Vitek 2 identification, and phenotypic confirmatory tests (combination disc test for ESBLs and modified carbapenem inactivation method for carbapenemase). Of 543 total samples, 49 (9.0%) were identified as K. pneumoniae. ESBL production was detected in 15/49 (30.6%) and carbapenemase production in 6/49 (12.2%) of isolates. The highest resistance rates were observed against piperacillin‑tazobactam (55.1%), cefotaxime (55.1%), imipenem (53.0%), and meropenem (53.0%), while tigecycline (100% susceptibility) and amikacin (93.9% susceptibility) remained the most effective agents. Notably, susceptibility to trimethoprim‑sulfamethoxazole was 83.7% (corrected figure). Children under 10 years and adults aged 21-40 years showed the highest infection rates. The alarmingly high prevalence of ESBL and carbapenemase phenotypes, coupled with significant multidrug resistance, underscores the urgent need for routine molecular surveillance and targeted antibiotic stewardship in this region. Rapid phenotypic screening combined with genotypic confirmation is essential to guide empirical therapy and curb the spread of these high‑risk clones in critically ill populations.

PMID 42758111
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PubMedFrontiers in cellular and infection microbiology2026-09-18

Trends in pathogens and antimicrobial resistance in culture-proven neonatal sepsis over a decade (2015-2024): the impact of COVID-19 pandemic.

Lin Fatao F, Ma Yushu Y, Li Xiaojuan X, Yan Wenbo W et al.

Neonatal sepsis remains a leading cause of mortality and long-term disability worldwide. The coronavirus disease 2019 (COVID-19) prevention measures effectively curbed viral transmission. However, evidence of their long-term impact on the pathogen spectrum and antimicrobial resistance in neonatal sepsis is limited. In this single-center retrospective observational study at Henan Children's Hospital, 894 neonates with culture-confirmed sepsis (2015-2024) were enrolled. Using pandemic policy time points, we divided the study into three phases and compared pathogen spectrum and antimicrobial resistance. Among neonates with sepsis, preterm proportion increased from 32.5% to 46.2%. The pathogen spectrum shifted from Gram-positive to Gram-negative predominance. Coagulase-negative staphylococci (CoNS) detection declined from 36.6% to 9.8%, a trend consistent across preterm/full-term and early-onset/late-onset subgroups. Klebsiella pneumoniae (K. pneumoniae) maintained high resistance to third-generation cephalosporins, while Escherichia coli (E. coli) showed a numerical increase in ceftazidime resistance. In contrast, CoNS and Enterococcus faecium (E. faecium) remained susceptible to vancomycin and linezolid. E. coli maintained favorable susceptibility to carbapenems and piperacillin-tazobactam, whereas K. pneumoniae showed a fluctuating carbapenem resistance trend that initially increased then declined, though it remained susceptible to tigecycline. All-cause mortality increased from 1.4% to 5.4%, with Gram-negative bacteria predominating in fatal cases. Enhanced hand hygiene and contact isolation are consistent with a sustained decline in CoNS, but show limited association with changes in Gram-negative bacilli. Routine surveillance and optimized empirical therapy remain crucial for improving neonatal sepsis outcomes.

PMID 42755470
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PubMedJournal of clinical microbiology2026-09-18

Optimization of culture read times using full microbiology laboratory automation.

Glover Janiece S JS, Demarest Bailey B BB, Foster Pam J PJ, Bryant Kendall A KA

Clinical microbiology laboratories are increasingly adopting automation to meet testing demands, improve throughput, and accelerate diagnostic turnaround. This study evaluated optimal culture read times using Copan WaspLab microbiology laboratory automation (MLA) to determine if earlier read times affect accuracy and turnaround times as they pertain to microbial identification and antimicrobial susceptibility testing (AST). A total of 374 patient specimens were cultured simultaneously using a conventional incubation method and MLA, with MLA images captured from 10 to 72 h of incubation. Non-urine specimens were ready for workup in over 50% of cases at 16 h, 92% by 24 h, and 100% by 36 h, while 90% of urine cultures were ready for workup by 16 h. Using frozen isolates (127 gram-positive bacteria, 83 gram-negative bacteria, and 12 yeasts), we further evaluated the accuracy of MALDI-TOF identification and AST results for cultures incubated for 10 h and 16 h in MLA. Identification accuracy remained high across all groups, with gram-negative bacteria achieving 98.8% accuracy at 10 h and 97.6% at 16 h, gram-positive bacteria showing 97.6% accuracy at 10 h and 98.4% at 16 h, and yeasts demonstrating 91.6% accuracy at 10 h and 100% at 16 h of incubation, respectively. AST results using cultures at both time points demonstrated essential agreement above 90% for most drugs on Vitek 2 GN-807N, GP75, and ST02 AST cards. Minor and major errors were rare; however, elevated error rates were observed for specific drugs (e.g., cefazolin, piperacillin/tazobactam, nitrofurantoin, and linezolid), largely due to a limited number of susceptible isolates and breakpoint-related challenges. MLA enables earlier culture reads while maintaining ID and AST accuracy. Microbiology laboratory automation (MLA) is increasingly used to address rising test volumes and workforce limitations; however, optimal incubation durations for automated workflows are not well defined. In this study, we demonstrate that cultures from a range of specimen types can be reliably read as early as 16 h and finalized by 36 h without compromising organism identification or antimicrobial susceptibility testing accuracy compared to conventional incubation. These findings support the use of earlier culture read time points in MLA workflows, enabling faster turnaround of clinically actionable results. Implementation of optimized incubation times has the potential to improve laboratory efficiency and accelerate patient care decisions while maintaining diagnostic reliability.

PMID 42757838
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