Drug Database
IB

ibuprofen (Ibuprof von CT 2% / Ibuprof von CT / Ibupan)

✓ Approved

Adare Pharma Solutions · PTGS1 · Small Molecule

What is ibuprofen?

ibuprofen is a small molecule developed by Adare Pharma Solutions. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesIbuprof von CT 2%, Ibuprof von CT, Ibupan
CompanyAdare Pharma Solutions
Drug ClassSmall Molecule
Molecular TargetPTGS1, PTGS2
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, Adare Pharma Solutions

Mechanism of Action

Molecular Targets

ibuprofen acts on 2 molecular targets:

PTGS1prostaglandin-endoperoxide synthase 1 (COX3, PCOX1)
PTGS2prostaglandin-endoperoxide synthase 2 (GRIPGHS, hCox-2)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

ibuprofen is developed for 2 unique indications across 2 therapeutic areas.

Therapeutic AreaConditionPhase
Gastrointestinal disordersAbdominal pain✓ Approved
Hepatobiliary disordersHepatitis✓ Approved

Related Research Articles

PubMedJournal of chromatography. A2026-07-26

TODGA-impregnated extraction chromatographic resin for the separation of U(VI) and Th(IV) from nitric acid media.

Konopkina Ekaterina A EA, Gopin Alexander V AV, Lopatin Dmitrii A DA, Gerasimov Mikhail A MA et al.

The separation of uranium and thorium is a critical task in nuclear fuel cycle management, particularly for the potential use of thorium-based fuels. This work focuses on the development and evaluation of a novel extraction chromatographic resin for the efficient separation of U(VI) and Th(IV) from nitric acid media. A polymeric matrix based on methyl methacrylate (MMA), divinylbenzene (DVB), and diethylene glycol dimethacrylate (DEGDMA) was synthesized via suspension polymerization. The resulting macroporous carrier (DL matrix) was characterized and subsequently impregnated with the commercially available extractant N,N,N',N'-tetraoctyldiglycolamide (TODGA). The synthesized DL-DGA resin was tested in batch and column modes. Batch sorption studies demonstrated high affinity for Th(IV) over U(VI), with a maximum separation factor (SFTh/U) of 196 ± 12 in 0.1 M HNO3. In 3 M HNO3, the distribution coefficients were Kd(Th) = 6100 mL/g and Kd(U) = 65 mL/g (SF = 94). Based on these data, efficient separation of uranium and thorium was achieved using 0.76 mL bed volume columns.

PMID 42501703
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PubMedTransplantation proceedings2026-07-26

Case Report: Falsely Elevated Tacrolimus Concentrations in a Kidney Transplant Recipient.

Teixeira Lucas Nascimento Diniz LND, Cabral Diogo Buarque Cordeiro DBC, Pinto Alexandre de Holanda Cavalcanti AHC, Sena Tatiana Cristina Manzi TCM et al.

Tacrolimus (TAC) is a cornerstone of immunosuppressive therapy after kidney transplantation but has a narrow therapeutic window, requiring strict therapeutic drug monitoring. Several analytical methods are available for serum concentration measurement and methodological interference may lead to clinically misleading results. We report the case of a 67-year-old female kidney transplant recipient who presented with persistently elevated tacrolimus concentrations despite drug discontinuation. TAC concentrations were initially measured using the affinity column-mediated immunoassay (ACMIA), showing markedly supratherapeutic values that prompted repeated suspension of the medication. Given the discrepancy between laboratory results and TAC withdrawal, measurement was repeated using the microparticle enzyme immunoassay (MEIA), which demonstrated undetectable results, confirming false-positive values associated with ACMIA interference. TAC was safely reintroduced at a reduced dose, with subsequent concentrations remaining within the therapeutic range. During follow-up, the patient developed antibody-mediated rejection, which was successfully treated and maintained good graft function. This case highlights the importance of recognizing analytical limitations of TAC assays and emphasizes that unexpected results should prompt confirmatory testing using alternative methodologies. Integration of clinical judgment with laboratory data is essential to avoid inappropriate immunosuppressive management and to ensure graft safety.

PMID 42502012
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PubMedBiotechnology and bioengineering2026-07-26

High Cell Density Cultivation of HEK293 Cells Using a 2L Membrane-Stirred Bioreactor.

Jacobtorweihe Lennart L, van Heuvel Yasemin Y, Scheiermann Kathrina K, Bongartz Patrick P et al.

The use of perfusion systems for the continuous cultivation of animal cells at high cell density (HCD) for the production of recombinant proteins, viruses, and viral vectors has many advantages. Besides an enhancement of volumetric productivity and high cell viability, the product quality can be improved through a steady-state environment. However, the establishment of such a process intensification method using stirred tank bioreactors (STRs) for cultivations at very high cell concentrations (> 50 × 106 cells mL-1) can be challenging. In particular, limitations in the oxygen supply, CO2 stripping, high viscosity, and excessive foam formation can impede cell viability and product yields. In this study, we investigated a novel membrane-stirrer (MemStir) based bioreactor that employs multiple hollow-fiber membrane sheets arranged in a device that facilitates efficient gas transfer through bubble-free diffusion for HCD cultivations. We found that the oxygen transfer rates at different tip speeds and gas flow rates resulted in volumetric mass transfer coefficient (kLa) values of 10-30 h-1 enabling sufficient oxygen supply to support concentrations exceeding 50 × 106 cells mL-1. The functionality of the membrane-stirrer was benchmarked in batch mode against shake flasks and a conventional STR equipped with a pitched-blade impeller and an l-drilled hole sparger. Suspension growth of a human embryonic kidney 293 LTV (HEK-LTV) cell in the MemStir system was comparable to the cell growth in a STR. Using pure oxygen for aeration, a maximum viable cell concentration of 7.6 × 106 cells mL-1 was achieved. As a starting point for further optimization, we investigated the impact of the MemStir system on viable cell concentration, cell viability, dissolved oxygen partial pressure, pH control and foam formation in HCD cultivations in perfusion mode. Using the MemStir system equipped with an alternating tangential flow system, HEK-LTV cells reached concentrations of up to 92 × 106 cells mL-1 with a specific growth rate of 0.022 h-1 in perfusion mode. Moreover, controlling the pH in the range 7.0 to 7.3 was easily achieved, and no foam formation was observed. Overall, these results suggest that the MemStir system is a viable option for HCD cultivation because it can overcome limitations of both aeration and foam formation.

PMID 42502896
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PubMedTurkish journal of medical sciences2026-07-25

vNOTES high uterosacral ligament suspension versus laparoscopic lateral suspension in the management of vaginal vault prolapse: initial experience in a single tertiary center.

Adan Ramazan R, Şahin Fatih F, Üskent Ulya U, Çulha Mehmet Gökhan MG et al.

The optimal technique for vaginal vault prolapse correction has yet to be identified. This study aimed to evaluate the anatomic and functional outcomes of women who underwent vaginal natural orifice transluminal endoscopic high uterosacral ligament suspension (vNOTES HUSLS) or laparoscopic lateral suspension (LLS). This retrospective study included symptomatic women with stage ≥2 vault prolapse who underwent vNOTES HUSLS or LLS between January 2019 and June 2022 at a tertiary center. The surgical efficacy, postoperative outcomes, complication rates, and recurrence frequencies of these procedures were compared. The primary outcomes of the study included anatomical success, patient-reported (subjective) success, and recurrence rates. The study included 64 women, 32 of whom underwent vNOTES HUSLS and 32 of whom underwent LLS. Demographic characteristics and preoperative Pelvic Organ Prolapse Quantification (POP-Q) values were comparable (p > 0.05). The mean Patient Global Impression of Improvement (PGI-I) score did not differ significantly between the groups (1.6 ± 0.8 vs. 1.7 ± 0.7, p = 0.344). Improvements in terms of sexual function scores (p < 0.001) were observed postoperatively in both groups. No difference was observed in postoperative sexual questionnaires scores (p > 0.05). Vault suspension by vNOTES produced better results only for point Ba (most distal portion of the remaining upper anterior side of the vaginal wall) of the POP-Q score (p = 0.03). The incidence rates and types of postoperative complications and recurrences were similar between the groups. Both vNOTES HUSLS and LLS safely support the vault and restore the normal vaginal anatomy with similar effectiveness. Functional results were also similar and satisfactory between the groups.

PMID 42499426
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PubMedArthroscopy techniques2026-07-25

Arthroscopic Allogeneic Bone Strip Grafting for Recurrent Shoulder Dislocation With Critical Glenoid Bone Loss: A Free Graft Suspension Fixation Technique.

Wu Yingbin Y, Guo Jiang J, Liu Weitong W, Wang Changbing C et al.

In patients with recurrent anterior shoulder dislocation and glenoid bone loss between 10% and 20%, isolated Bankart repair remains associated with a certain rate of postoperative redislocation. The optimal management for this patient subset is controversial. We describe an all-arthroscopic technique using allogeneic bone strips for free graft suspension fixation in cases of critical glenoid bone loss (10%-20%). This technique is predicated on the principle that restoring both osseous and soft-tissue anatomy of the glenoid is fundamental to addressing shoulder instability.

PMID 42499863
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PubMedExperiments in fluids2026-07-25

Synchrotron X-ray multi-projection imaging (XMPI) for high-resolution 4D characterization of multiphase flows.

Rosén Tomas T, Yao Zisheng Z, Tejbo Jonas J, Wegele Patrick P et al.

Multiphase flows where particles, bubbles, or droplets are suspended in a fluid govern critical processes in biology, medicine, materials processing, and geophysics. However, observing their microscale dynamics in opaque systems has remained a fundamental challenge. We present Synchrotron X-ray Multi-Projection Imaging (XMPI), a novel approach enabling four-dimensional (3D + time) tracking of microparticles in visibly opaque suspension flows without requiring sample rotation. By capturing simultaneous projections from multiple angles using beam-split X-rays at synchrotron facilities, we resolve instantaneous particle positions and trajectories in opaque fluids such as blood. We demonstrate the potential of XMPI through individual particle tracking velocimetry (3D PTV) in dilute conditions, as well as multi-projection image velocimetry in dense suspensions. The methodology provides otherwise inaccessible experimental validation for particle-resolved computational fluid dynamics models and allows, e.g., observation of inertial focusing effects and microstructural dynamics relevant to suspension rheology and biomedical flows. This work paves the way for high-resolution, time-resolved 4D imaging of complex multiphase flows across a range of scientific and industrial applications. Combining XMPI with recent AI-supported 4D reconstruction algorithms opens a new spatiotemporal frontier for high-speed, rotation-free microtomography. The online version contains supplementary material available at 10.1007/s00348-026-04271-6.

PMID 42499685
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