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umeclidinium bromide + vilanterol (642444+573719 / Anoro / GSK573719/GW642444)

✓ Approved

Innoviva, Inc. · ADRB2 · Small Molecule

What is umeclidinium bromide + vilanterol?

umeclidinium bromide + vilanterol is a small molecule developed by Innoviva, Inc.. It is approved for therapeutic indications via inhaled.

Drug Profile

Brand Names642444+573719, Anoro, GSK573719/GW642444
CompanyInnoviva, Inc.
Drug ClassSmall Molecule
Molecular TargetADRB2, NR3C1
RouteInhaled
StatusApproved
Sources: ClinicalTrials.gov, Innoviva, Inc.

Mechanism of Action

Molecular Targets

umeclidinium bromide + vilanterol acts on 2 molecular targets:

ADRB2adrenoceptor beta 2 (B2AR, ARB2)
NR3C1nuclear receptor subfamily 3 group C member 1 (GR, GCCR)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

umeclidinium bromide + vilanterol is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Respiratory, thoracic and mediastinal disordersChronic obstructive pulmonary disease✓ Approved

Related Research Articles

PubMedMedicine2026-06-09

Adverse event mining for Breztri and Trelegy Ellipta based on the three international pharmacovigilance databases.

Wang Junyu J, Chen Kexu K, Yun Lu L, Xu Dexiang D

This study aimed to identify adverse drug reaction (ADR) risk signals associated with budesonide/glycopyrrolate/formoterol (Breztri) and fluticasone furoate/umeclidinium/vilanterol (Trelegy Ellipta) to support clinical decision-making and risk management. ADR reports related to Breztri and Trelegy Ellipta from the FDA Adverse Event Reporting System (FAERS) database, Japanese Adverse Drug Event Report (JADER) database and Canada Vigilance Adverse Reaction database (Q3 2004 to Q2 2024) were analyzed. After deduplication, reports were categorized using Medical Dictionary for Regulatory Activities (MedDRA) to obtain System Organ Class (SOC) and preferred terms (PTs). Disproportionality analysis was conducted using reporting odds ratio (ROR) and proportional reporting ratio methods. Analysis of 394 Breztri and 18,866 Trelegy Ellipta FAERS reports (predominantly consumer-submitted, U.S.-originated) identified 47 signals across 11 SOCs for Breztri (e.g., "Drug delivery system issue" ROR = 411.16, "Intentional device misuse" ROR = 410.69) and 160 signals across 15 SOCs for Trelegy (e.g., "Chronic eosinophilic rhinosinusitis" ROR = 187.65, "Foreign body in mouth" ROR = 107.67), revealing unlabeled risks like administration errors and packaging confusion. JADER data reinforced respiratory risks (Breztri: Chronic obstructive pulmonary disease (COPD) ROR = 516.8; Trelegy: gastrointestinal fungal infection ROR = 413.11) and device-independent safety signals (e.g., Trelegy urinary retention ROR = 28.81), while CVARD highlighted region-specific concerns including Trelegy-associated vasculitis (pulmonary vasculitis n = 29) and Breztri hypertension (ROR = 7.82). Cross-database convergence confirmed core anticholinergic/cardiopulmonary risks, yet divergent signals, FAERS' device errors, JADER's infection prominence, and CVARD's immunological events, underscore geographic heterogeneity in adverse reaction profiles, necessitating tailored risk management strategies for inhaler therapies. Inhalation device-related ADRs were observed, with Breztri showing higher incidence than Trelegy Ellipta, likely due to its more complex device usage. These findings highlight the need for enhanced patient education by healthcare providers to ensure proper device use in COPD treatment. Although core respiratory and anticholinergic risks are globally relevant, infection profiles, device complications, and rare immunological events exhibit significant geographic heterogeneity, necessitating tailored risk mitigation strategies aligned with regional pharmacovigilance patterns.

PMID 42260824
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PubMedScientific reports2026-06-09

Bromide is a surprisingly potent larvicide for Anopheles gambiae in the laboratory.

Ikuzwe Stella M SM, Raji Joshua I JI, Potter Christopher J CJ, Rokita Steven E SE

Mosquito-borne diseases remain a major global health burden, and novel approaches to vector control are urgently needed as resistance to conventional insecticides spreads. Most mosquitoes breed in freshwater but can tolerate low levels of halogen salts. Whether specific halides exhibit selective toxicity toward mosquito larvae has not been systematically investigated. We now report on a survey focusing on Anopheles gambiae, the primary vector for malaria in sub-Saharan Africa. Bromide is selectively and potently toxic to Anopheles larvae with an LC50 below 10 µM for its sodium potassium salt. This sensitivity is more than 10-fold greater than that observed for the sodium salts of fluoride, chloride and iodide. Bromide toxicity is stage-specific with An. gambiae larvae displaying 300-fold greater sensitivity than adults while eggs and pupae remain unaffected by 5 mM sodium bromide. Anopheles stephensi larvae exhibit similar sensitivity, whereas Aedes aegypti and Culex quinquefasciatus larvae are approximately 10-fold more tolerant of sodium bromide. Mechanistically, bromide toxicity operates independently of pathways targeted by conventional insecticides. Co-administration of diflubenzuron or spinosad neither suppressed nor enhanced bromide's effects. Bromide exposure induced overexpression of GluCl and CCC-2 ion channels without affecting Rdl, Best, or KCC expression. Chloride also protected against bromide toxicity, suggesting these halides share a common receptor. Thoracic swelling in dying larvae indicates that bromide disrupts osmotic or hydration balance. These findings are unexpected given that bromide is generally considered non-toxic to aquatic and terrestrial organisms, revealing a previously unknown vulnerability specific to Anopheles mosquitoes. The selective toxicity of bromide toward Anopheles larvae, combined with its independence from existing insecticide resistance mechanisms, may serve as a new lead for controlling malaria vectors. Targeting this bromide-sensitive pathway may complement current larvicidal approaches and provide an alternative for populations resistant to standard insecticides. The use of bromide itself will still require significant environmental and field-based studies prior to its possible application.

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PubMedSmall (Weinheim an der Bergstrasse, Germany)2026-06-09

Combining Underpotential Deposition and Soft-Template to Construct Ordered Mesoporous PdSb Nanocubes for Selective Ethylene Glycol Oxidation.

Zhou Junjie J, Xia Shiyu S, Guo Xiaoyun X, Gao Wenping W et al.

Rational design of bimetallic nanocrystals with ordered mesoporous architectures and precise compositional control is critical for high-performance electrocatalysis, yet it remains a significant challenge. Herein, we report the synthesis of PdSb ordered mesoporous cubes (PdSb OMCs) via a seed-mediated growth strategy, driven by the synergistic interplay between Sb underpotential deposition (UPD) and hexadecyltrimethylammonium bromide (CTAB) soft-template. Mechanistic studies reveal that the Sb ions and CTAB play decisive roles in directing the ordered self-assembly of surfactant micelles on the Pd surface, enabling the controlled growth of a uniform mesoporous alloy shell. Consequently, the resulting PdSb OMCs exhibit reliable and steady electrocatalytic performance for the ethylene glycol oxidation reaction, directing the conversion of ethylene glycol to glycolic acid with a selectivity of ∼95%. Experimental investigations suggest that this enhancement stems from the unique ordered mesoporous architecture, which facilitates mass transport, and the electron-rich Pd surface modulated by Sb, which suppresses C─C bond cleavage. This work provides a promising approach for UPD-assisted soft-template synthesis and offers insights into designing electrocatalysts for value-added chemical production.

PMID 42261213
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PubMedPakistan journal of pharmaceutical sciences2026-06-09

Chemical composition, antioxidant, antifungal, antibacterial and anticancer activities of essential oils of Berberis balochistanica Ahrendt.

Taj Rukhsana R, Ali Samar S, Khan Shafiullah S, Taj Naila N

In Balochistan, the biotechnological potential of medicinal plants has not been widely investigated. Thus, searching medicinal plants for novel compounds is vital source for developing emerging and new medications. The present study aims to describe the chemical profile and evaluate the antimicrobial, antioxidant and anticancer effects of the essential oil (EO) of Berberis balochistanica. Gas Chhromatography-Mass Spectrometry (GC-MS) analyzed the chemical constituents. Antioxidant potential was evaluated by 2-2-diphenyl-1-picylhydrazyl (DPPH) assay. Antifungal action was evaluated using agar well and disc diffusion methods. The antibacterial screening was evaluated against Gram-positive and Gram-negative bacterial strains through the disc diffusion technique and by determining minimal inhibitory concentration (MIC). To investigate anticancer activity, an 3-(4,5-dimetylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) colorimetric assay was used. GC-MS analysis revealed 19 components accounting for 99.9% of the total EO. The EO exhibited a substantial effect against the fungal strain Alternaria alternate and remarkable antibacterial activity against Staphylococcus aureus, while showing no cytotoxic activity. These results show that B. balochastanica based EO has the potential to be evaluated in clinical applications and pharmaceutical industries as an antimicrobial agent for the treatment of various ailments. It may serve as a preservative in food stuffs, serving as a natural replacement for harmful synthetic antioxidants.

PMID 42262185
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PubMedLangmuir : the ACS journal of surfaces and colloids2026-06-09

Asymmetrical Two-Headed Linear Cationic Surfactants with Halogenoferrate Magnetic and Bromide Counterions: Synthesis, Thermal Behavior, Magnetic Performance, and Surface Properties.

Lamch Łukasz Ł, Korabik Maria M, Szarpak Dawid D, Szklarz Przemysław P et al.

A series of multicharged surfactants with magnetic counterions (Mag-D-Surfs) containing one hydrophobic tail and two hydrophilic groupings, and comprising exclusively carbon atoms in the hydrophobic part, i.e., 2-alkyl-N,N,N,N',N',N'-hexamethylpropan-1,3-ammonium salts (ferrates; alkyl: decyl, dodecyl, and tetradecyl, abbreviated, respectively, as C10-DCMe3Mag, C12-DCNMe3Mag, and C14-DCNMe3Mag), were first synthesized and characterized by FT-IR, Raman, X-ray fluorescence (XRF), and FIR spectra as well as elemental analyses. Thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC), supported by optical polarization microscopy, showed that the coexistence of isotropic and anisotropic subphases depended on cooling rates. Surface activity of Cn-DCNMe3Mag at the air/water interface was evaluated by measuring the surface tension of their solutions by the pendant drop technique and compared with surfactants without magnetic function. Moreover, surface tensiometry in a magnetic field demonstrated that the studied Mag-D-Surfs exhibited magnetically induced changes in the drop shape. Their magnetic behavior in the solid state was determined by superconducting quantum interference device magnetometry (SQUID). All findings related to the aforementioned double-headed Mag-D-Surfs were compared to linear magnetic ionic liquids surfactants (MILSs), i.e., alkyltrimethylammonium halogenoferrates (alkyl: dodecyl [DTA][FeClxBr4-x-], tetradecyl [TTA][FeClxBr4-x-], and cetyl [CTA][FeClxBr4-x-]). Magnetic tests confirm the paramagnetic nature of the studied compounds and the 1:1 molar ratio (surface active cation:Fe3+) for all the studied surfactants. Their unique physicochemical properties demonstrate exceptional performance, particularly in the development of new stimuli-responsive materials.

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PubMedActa crystallographica. Section E, Crystallographic communications2026-06-08

Synthesis and crystal structure of catena-poly[[[aqua-(2,3-di-methyl-pyrazine-κN)cadmium(II)]-di-μ-bromido] 2,3-di-methyl-pyrazine monosolvate hemihydrate].

Näther Christian C

Crystals of the title compound, {[CdBr2(C6H8N2)(H2O)]·C6H8N2·0.5H2O} n (C6H8N2 = 2,3-di-methyl-pyrazine), were obtained accidentally by the reaction of cadmium bromide with 2,3-di-methyl-pyrazine in water. The asymmetric unit consists of one Cd cation, two bromide anions, one 2,3-di-methyl-pyrazine ligand, one non-coordinating 2,3-di-methyl-pyrazine mol-ecule, and one water mol-ecule in general positions as well as an additional water mol-ecule that is located on a twofold rotation axis. The cadmium cations are octa-hedrally coordinated by four bromide anions, one 2,3-di-methyl-pyrazine ligand and one water mol-ecule, and are linked by pairs of μ-1,1-bridging bromide anions into chains that propagate in the a-axis direction. These chains are further connected into layers by inter-molecular hydrogen bonding. The coordinated water ligand is hydrogen bonded to the 2,3-di-methyl-pyrazine, and the water solvate mol-ecule and the 2,3-di-methyl-pyrazine mol-ecules of crystallization are linked by O-H⋯N hydrogen bonding via the water solvate mol-ecules into chains along the c-axis direction. The water solvate mol-ecule therefore acts as donor for two O-H⋯N and as acceptor for two O-H⋯O hydrogen bonds.

PMID 42254789
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