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COVID-19 vaccine (ZF2001 / Zifivax / ZF 2001)

✓ Approved

Anhui Zhifei Longcom Biopharma · Recombinant Proteins · Recombinant Proteins

What is COVID-19 vaccine?

COVID-19 vaccine is a recombinant proteins developed by Anhui Zhifei Longcom Biopharma. It is approved for therapeutic indications via injectable (others) or intramuscular (im) injection.

Drug Profile

Brand NamesZF2001, Zifivax, ZF 2001
CompanyAnhui Zhifei Longcom Biopharma
Drug ClassRecombinant Proteins, Vaccine
RouteInjectable (Others), Intramuscular (IM) Injection
StatusApproved
Sources: ClinicalTrials.gov, Anhui Zhifei Longcom Biopharma

Therapeutic Indications

COVID-19 vaccine is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Infections and infestationsCOVID-19✓ Approved

Related Research Articles

PubMedHealth communication2026-11-11

Spiritual Health Locus of Control and COVID-19 Booster Intentions Among Hispanic Americans: A Culturally Grounded Extension of the Extended Parallel Process Model.

Kim Joon J, Jun Jungmi J, Zambrano Rodriguez Viviana Carolina VC

Declining uptake of COVID-19 boosters poses significant public health concerns. Hispanic Americans, who have experienced disproportionate pandemic impacts, report lower uptake of updated boosters than non-Hispanic White adults, partly attributable to vaccine hesitancy. Although religiosity plays a central role in Hispanic communities, little is known about how spiritually grounded beliefs shape cognitive and emotional responses to vaccination. This study integrates the extended parallel process model (EPPM) with spiritual health locus of control (SHLOC) to examine how exposure to faith-based and governmental vaccine information influences booster intention through spiritually grounded efficacy appraisals. Using an online survey of Hispanic American adults (N = 349), we tested a structural equation model linking SHLOC, perceived threat, efficacy beliefs, fear, and vaccination intentions. Results indicated that active SHLOC, reflecting beliefs in divine partnership in health, increased response efficacy and indirectly promoted booster intention and vaccine advocacy, whereas passive SHLOC, reflecting divine determinism, reduced self-efficacy and indirectly discouraged booster intention. Perceived threat was positively associated with fear, and efficacy beliefs emerged as the strongest predictors of booster intention. Mediation analyses supported serial pathways from message exposure to SHLOC to efficacy to intention, identifying spiritually grounded control beliefs as a culturally embedded mechanism in vaccine decision making. Findings suggest that faith-based engagement can function as either a protective or risk communication channel, depending on whether messages reinforce divine partnership or determinism. The study advances EPPM by identifying SHLOC as a culturally grounded antecedent to efficacy appraisal and offers implications for culturally responsive vaccine communication in Hispanic communities.

PMID 43012739
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PubMedFrontiers in public health2026-11-11

Study on the clinical outcomes of COVID-19 infection and immune responses following the third booster dose of inactivated COVID-19 vaccine in hematologic disease patients.

Zhang Haiying H, Wang Xin X, Zhang Runling R, Liu Feng F et al.

Patients with hematologic diseases may have impaired immunity owing to their underlying diseases and immunosuppressive treatments. Evidence on documented SARS-CoV-2 RT-PCR outcomes and responses to inactivated COVID-19 vaccines remains limited. This retrospective study analyzed three independently identified populations: 20,813 individuals tested by SARS-CoV-2 RT-PCR, 2,438 tested for anti-SARS-CoV-2 IgG, and 1,946 adults tested after two or three vaccine doses. Intervals to documented RT-PCR negativity were analyzed only among positive individuals with subsequent negative results. Vaccination analyses were adjusted for age, sex, testing interval, and disease group. Monthly comparisons were cross-sectional. Serial antibody measurements were analyzed separately. Recorded RT-PCR positivity was lower among tested individuals with hematologic diseases (4.77% vs. 10.74%; p < 0.001). Among 64/64 positive individuals with and 381/2,091 without hematologic diseases who had documented subsequent negative results, median intervals to negativity were 5.05 versus 3.99 days (difference, 1.06 days; 95% CI, 0.73-2.21; p < 0.001). Within the hematologic disease group, longer intervals were observed after prior immunosuppressive treatment (5.99 vs. 3.97 days); haploidentical allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients had the longest descriptive median interval (6.97 days). In the separate IgG-testing population, positivity did not differ significantly (86.00% vs. 90.16%; p = 0.174). Three versus two doses were associated with higher neutralizing antibody (NAb) positivity (94.1% vs. 77.3%; adjusted prevalence ratio [aPR], 1.281; 95% CI, 1.232-1.332) and IgG positivity (97.2% vs. 83.4%; aPR, 1.229; 95% CI, 1.189-1.271). Among 20 paired participants, 19 had higher NAb levels after the third dose. Among three-dose recipients, NAb positivity was 25/32 (78.13%) with hematologic diseases, 36/42 (85.71%) with solid tumors, and 743/780 (95.26%) without documented hematologic disease or solid tumors (overall p < 0.001). Among RT-PCR-positive individuals with documented subsequent negativity, intervals were modestly longer with hematologic diseases. Within this group, median intervals were longer after immunosuppressive treatment, and longest among haploidentical allo-HSCT recipients. Differential availability of negative results warrants caution. Three inactivated vaccine doses were associated with higher NAb and IgG positivity overall. Among three-dose recipients, NAb positivity was lower with hematologic diseases than without documented hematologic disease or solid tumors.

PMID 43011357
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PubMedFrontiers in psychology2026-11-11

The mediating role of social distance on the association between audience-protagonist similarity and fear: a case of fear of COVID-19.

Levy Inna I, Razpurker-Apfeld Irene I, Shamoa-Nir Lipaz L, Cohen-Louck Keren K

This study examined the effects of news content on fear of COVID-19 by examining perceived social distance and audience-protagonist similarity. Participants (N = 78) read a fictitious news story about a COVID-19 patient (similar/dissimilar protagonist) and then rated social distance regarding this protagonist and their fear of COVID-19. The results showed that participants exposed to a similar protagonist reported significantly lower perceived social distance, and that social distance was moderately negatively correlated with fear of COVID-19. Social distance mediated the association between audience-protagonist similarity and fear of COVID-19. These findings provide insights into how exposure to health-related news content can impact fear of disease.

PMID 43011287
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PubMedJournal of intensive care medicine2026-11-11

COVID-19 Is Not an Independent Risk Factor for Post-Intensive Care Syndrome: A Retrospective Cohort Study.

Antinoro Alberto A, Leder Antonia A, Grunow Julius J JJ, Steinecke Karin K et al.

BackgroundPost-intensive care syndrome (PICS) affects many ICU survivors, leading to persistent physical, cognitive, and mental health issues. The COVID-19 pandemic raised concerns about whether SARS-CoV-2 infection increases PICS risk. This study aimed to evaluate whether COVID-19 is an independent risk factor for PICS and to identify other contributing factors.MethodsThis retrospective cohort included 92 patients treated for respiratory failure in three ICUs at Charité - Universitätsmedizin Berlin between July 2020 and September 2021. Patients were divided into COVID-19 (n = 49) and non-COVID-19 (n = 43) groups. At three months post-discharge, outpatient assessments consisted of demographic data, ICU-related variables, and evaluations of physical (handgrip dynamometry, Timed Up and Go test), cognitive (Mini-Cog, Animal Naming Test), and psychological health (PHQ-4). PICS was defined as at least one abnormal test; severity was graded by the number of affected domains. Logistic and ordinal regression analyses assessed whether COVID-19 was independently associated with PICS prevalence and severity.ResultsPICS was present in 71.4% of COVID-19 and 62.8% of non-COVID survivors (p = 0.378). Multivariable analysis showed no significant association between COVID-19 and PICS or its severity (OR = 1.46; 95% CI 0.50-4.23; p = 0.486; and OR = 1.09; 95% CI 0.45-2.68; p = 0.845, respectively).ConclusionsCOVID-19 was not independently associated with PICS in ICU survivors. Both groups experience high rates of long-term impairments, highlighting the importance of rehabilitation and follow-up care for all ICU survivors.

PMID 43012546
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PubMedThe Permanente journal2026-11-11

Predictors of Preterm Delivery in the COVID-19 Era: A Retrospective Cohort Study of a Large, Integrated HealthSystem.

Raisler Katharine K, Jefferson Celeena R CR, Kim Seohyun S, Bishop R Clayton RC et al.

Preterm delivery is the leading cause of perinatal mortality and long-term neonatal morbidity in the United States, and rates are rising. Research has shown that COVID-19 infection may increase the possibility of preterm delivery. However, these studies disproportionately focus on third trimester and iatrogenic cases, often overlooking risk across the entire pregnancy or without adjusting for prior preterm delivery and sociodemographic factors. To address these gaps, the authors investigated the association between COVID-19 at any point in pregnancy and preterm delivery while exploring other predictors of preterm delivery. The authors conducted a retrospective cohort study of members pregnant between March 2020 and March 2021, comparing odds of preterm delivery for those with and without COVID-19. Using logistic regression and χ2 tests, the authors explored associations between preterm delivery and other sociodemographic and clinical characteristics. Data were abstracted from electronic medical records. Of 14,250 participants, 994 (7%) experienced COVID-19 infection during pregnancy. Overall, 1313 (9%) had preterm delivery. In univariate logistic regression analyses, those with COVID-19 were more likely to be < 35 years old, Hispanic or Black, non-English-speaking, obese, and multiparous. COVID-19 infection during pregnancy was associated with increased odds of preterm delivery in the authors' unadjusted model but not in the multivariable adjusted model. Being ≥ 35 years old, Hispanic, Black, nulliparous, hypertensive, immunocompromised, or having a prior preterm delivery or gestational or chronic diabetes were significantly associated with higher odds of preterm delivery in the authors' multivariable model. COVID-19 infection throughout pregnancy was not associated with increased odds of preterm delivery. Racial disparities and other key covariates like history of preterm delivery may confound the reported increase in preterm delivery.

PMID 43010853
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PubMedCurrent medical imaging2026-11-11

Brain MRI Abnormalities in COVID-19: A Narrative Review of Neuroimaging Findings, Pathophysiological Mechanisms, and Clinical Correlates.

Faizo Nahla L NL

Coronavirus disease 2019 (COVID-19) has been associated with a wide range of neurological complications, highlighting the importance of neuroimaging in clinical evaluation. This review aimed to evaluate magnetic resonance imaging (MRI)- detected brain abnormalities in patients with COVID-19 comprehensively and correlate these findings with neurological manifestations. We searched PubMed, Web of Science, and Google Scholar for studies published between 2019 and 2024. Studies reporting brain MRI findings in living patients with COVID-19 were included, while postmortem imaging, non-MRI studies, and non-English publications were excluded. Data were synthesized qualitatively. MRI demonstrated a broad spectrum of brain abnormalities, particularly in patients with severe COVID-19. The most frequently reported findings were ischemic stroke, hemorrhagic stroke, encephalitis, cerebral microbleeds, and leukoencephalopathy. Ischemic stroke was mainly associated with hypercoagulability and inflammation, whereas hemorrhagic stroke was linked to endothelial dysfunction and anticoagulation therapy. Encephalitis and leukoencephalopathy were primarily related to immune-mediated and hypoxic mechanisms, while cerebral microbleeds were common in critically ill patients and associated with blood-brain barrier disruption. Available evidence suggests that vascular, inflammatory, immune-mediated, and hypoxic mechanisms may contribute substantially to COVID-19- associated neurological injury, although the relative contribution of direct viral neuroinvasion remains incompletely defined. MRI is valuable for detecting these complications and guiding clinical management, although study heterogeneity and variations in imaging protocols limit direct comparisons. MRI plays a pivotal role in identifying neurological complications of COVID-19. Prospective longitudinal studies with standardized imaging protocols are needed to clarify long-term neurological outcomes and optimize diagnostic and management strategies.

PMID 43012279
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