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ethyl icosapentate (MND2119 / MND 2119 / icosapent, Mochida)

✓ Approved

Sumitomo Pharma Co., Ltd. · Small Molecule · Small Molecule

What is ethyl icosapentate?

ethyl icosapentate is a small molecule developed by Sumitomo Pharma Co., Ltd.. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesMND2119, MND 2119, icosapent, Mochida
CompanySumitomo Pharma Co., Ltd.
Drug ClassSmall Molecule
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, Sumitomo Pharma Co., Ltd.

Therapeutic Indications

ethyl icosapentate is developed for 2 unique indications across 1 therapeutic area.

Therapeutic AreaConditionPhase
Metabolism and nutrition disordersHyperlipidaemia✓ Approved
Metabolism and nutrition disordersHypertriglyceridaemiaPhase III

Related Research Articles

PubMedDrugs in R&D2026-05-24

A Combination of the Tryptophan Hydroxylase Inhibitor Telotristat with the mTOR Inhibitor Everolimus as an Effective Strategy Against Neuroendocrine Tumors.

Molina-Cerrillo Javier J, Sierra-Ramirez Arantzazu A, López-Aceituno José L JL, Méndez-Pertuz Marinela M et al.

Neuroendocrine tumors are a rare and heterogeneous group of neoplasms that frequently cause carcinoid syndrome, characterized by diarrhea, flushing, and carcinoid heart disease. A recent therapy for carcinoid syndrome involves inhibition of tryptophan hydroxylase, the rate-limiting enzyme in serotonin synthesis, using telotristat ethyl. Telotristat has demonstrated clinical control of carcinoid syndrome; however, its potential antitumoral effects remain unclear. This study aimed to evaluate the antitumor activity of telotristat ethyl alone and in combination with everolimus in neuroendocrine tumor models. Cell viability was assessed in three neuroendocrine tumor cell lines of pancreatic (BON-1, QGP-1) and intestinal (HROC57) origin following treatment with telotristat ethyl. Combination treatments with telotristat ethyl and everolimus or other antitumoral agents were evaluated for effects on cell viability, apoptosis, and cell cycle distribution. In vivo efficacy was examined in nude mice bearing BON-1-derived xenografts treated with telotristat ethyl, everolimus, or the combination. Tumor growth, toxicity, proliferation (Ki67), and apoptosis (active caspase-3) were analyzed. Telotristat ethyl reduced cell viability in all three neuroendocrine tumor cell lines. Combination with everolimus, but not with other antitumoral treatments, synergistically decreased cell viability, induced apoptosis, and reduced the proportion of cells in the G2/M phase. In nude mice bearing BON-1 xenografts, combined treatment with telotristat ethyl and everolimus arrested tumor growth without signs of toxicity compared with single treatments. At the end of treatment, tumors from combination-treated mice showed a reduction in proliferation (Ki67) comparable to single-treated groups and an increase in apoptosis as indicated by active caspase-3. Telotristat ethyl exhibits antitumoral activity in neuroendocrine tumor models in vivo. Moreover, the combination of telotristat ethyl and everolimus, two therapies already used in clinical practice, may represent a safe and effective therapeutic strategy for neuroendocrine tumors.

PMID 42177741
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PubMedTalanta2026-05-24

Enrichment and highly sensitive detection for the chemical agent markers via the rare earth metal ion-modified magnetic nanomaterials.

Li Kexuan K, Zhao Yuxin Y, Wu Jina J, Li Xiaosen X et al.

The rapid detection and trace analysis of the chemical warfare agents (CWAs) are of great practical importance due to the threat influence to global security. Herein, the magnetic nanomaterial as Fe3O4@SiO2-IDA-Eu3+ has been successfully synthesized and utilized for the enrichment of ethyl methylphosphonate (EMPA), the primary marker for the nerve agent VX. Comprehensive characterization by XPS, FT-IR and EDS confirmed the successful synthesis of Fe3O4@SiO2-IDA-Eu3+. The synthesized materials were applied for the sensitive detection of EMPA combined with liquid chromatography-tandem mass spectrometry (LC-MS/MS). The material exhibited rapid adsorption equilibrium (8.0 min) following the pseudo-second-order kinetic model (R2=0.9802) and the high capacity (8.24 mg/g) for the Langmuir isotherm. When coupled with liquid chromatography-tandem mass spectrometry (LC-MS/MS), the method achieved the detection limit of 1.0 ng/mL for EMPA in plasma, with recoveries ranging from 96% to 114%. Compared with commercial materials, the synthesized material exhibited higher adsorption capacity. The method was successfully validated by the actual plasma samples in the Organization for the Prohibition of Chemical Weapons Biomedical Proficiency Test, demonstrating the practical applicability for chemical weapons verification.

PMID 42176518
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PubMedMetabolomics : Official journal of the Metabolomic Society2026-05-24

Integrated GC-MS and UHPLC-HRMS/MS profiling of bioactive compounds from Streptomyces sp. BPA-6 isolated from bees-collected pollen.

Belhadj Hani H, Mokhnache Mohamed M, Alien Ahmed Mohamed Bachir AMB, Pellegrini Marika M et al.

Antimicrobial resistance is one of the most current global health challenges, due to the increasing ineffectiveness of antibiotics and the increasing difficulty in treating infections. Approximately two-thirds of microbial antibiotics are produced by actinomycetes, of which approximately 74% come from the genus Streptomyces. In this study, a novel actinomycete strain, Streptomyces sp. BPA-6, isolated from pollen collected by Algerian bees, was investigated for its antimicrobial potential and chemical composition by GC-MS and HPLC-MS analyses. The strain showed strong antimicrobial activity against Staphylococcus aureus, Bacillus subtilis, and Candida albicans, with minimum inhibitory concentrations (MICs) ranging from 62.5 to 250 µg/mL. Molecular identification using 16S rRNA gene sequencing and scanning electron microscopy confirmed the affiliation of the isolate to the genus Streptomyces. GC-MS analysis of the ethyl acetate extract revealed a complex mixture of volatile organic compounds, including fatty acid methyl esters, long-chain hydrocarbons, and sesquiterpenes, many of which are associated with antimicrobial, antioxidant, or anti-inflammatory properties. Complementary HPLC-MS profiling identified more than 40 nonvolatile bioactive compounds, including macrolides (erythromycin), polyethers (nigericin), aminoglycosides (netilmicin), polyketides (cytosporone C), and various sugar and lipid derivatives. The chemical diversity of the extract highlights the rich biosynthetic capacity of BPA-6 and its potential as a source of novel natural products.

PMID 42177685
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PubMedEnvironmental research2026-05-24

A case-control study of the association between per- and polyfluoroalkyl substances (PFAS) and risk of postmenopausal breast cancer in the Danish Diet Cancer and Health cohort.

Jensen Tina Kold TK, Hvidtfeldt Ulla A UA, Tjønneland Anne A, Batzella Erich E et al.

Exposure to per- and polyfluoroalkyl substances (PFAS) has been associated with breast cancer, however findings have been conflicting and few studies have examined cancer subtypes or risk among subgroups of women. We used an individually matched case-control design, nested within the Danish Diet Cancer and Health cohort. We identified 500 incident breast cancer cases with available plasma samples among postmenopausal women aged 50 to 64 years in the Danish Cancer Registry and for each case, we randomly selected from the study base one control woman enrolled within 180 days of the case and of the same age with an available sample. Plasma samples, taken at enrollment in 1993-97, were identified in the biobank and concentrations of PFAS were measured in 2025. Data were analysed using logistic regression. No association between PFAS exposure and overall breast cancer was found with odds ratios per interquartile range of perfluorooctanoic acid (PFOA) = 0.89 (0.76-1.05), of perfluorohexane sulfonic acid (PFHxS) = 1.02 (0.98-1.06), of perfluorononanoic acid (PFNA) = 0.94 (0.87-1.02), of perfluoroheptanesulfonic acid (PFHpS) = 0.94 (0.79-1.11), of perfluorooctane sulfonate (PFOS) = 0.93 (0.78-1.11), and of N-ethyl perfluorooctane sulfonamido acetic acid (N-EtFOSAA) = 0.93 (0.79-1.09). Likewise, no clear association was observed for subtypes of breast cancer (ER, PR and HER2 status) nor with tumor size, or lymph node involvement. PFHpS, PFOS and N_EtFOSAA exposure was associated with a non-significant increased risk of breast cancer among current and previous hormone therapy (HT) users, whereas no association was found for never users. We found no association between exposure to six commonly used PFAS and overall breast cancer risk in postmenopausal women. The results indicated that exposure to some PFAS might be associated with increased risk of breast cancer among current/previous HT users. These results warrant replication in future prospective studies.

PMID 42176938
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PubMedPlant physiology and biochemistry : PPB2026-05-24

Transcriptome and volatile analyses identify key genes involved in ester biosynthesis in durian (Durio zibethinus) during fruit ripening.

Hiraiwa Naoki N, Luengwilai Kietsuda K, Yamane Hisayo H, Sirikantaramas Supaart S et al.

Durian (Durio zibethinus), which is an important economic crop in Southeast Asia, is known for its distinct aroma combining sulfurous and fruity notes. Volatile esters are the main contributors to the sweet, fruity aroma of ripe durian fruit. Volatile ester contents in fruit are generally regulated by the activities of alcohol acyltransferase (AAT) and enzymes that metabolize amino acids, fatty acids, and carbohydrates into aroma volatiles. However, the molecular regulation of ester biosynthesis in durian remains unexplored. In this study, we aimed to identify key durian genes involved in ester biosynthesis and investigate the association between their expression and volatile profiles. We analyzed the volatile profiles of 'Monthong' pulp samples from four ripening stages (unripe, midripe, ripe, and overripe), revealing the activation of ester production during fruit ripening. Additionally, a comparison of the volatile profiles of six durian cultivars at the ripe stage detected differences in ester contents among cultivars. We identified three pulp-specific AAT genes, of which DzAAT1 was strongly upregulated during ripening and its expression was correlated with ester content variation among cultivars. The distinct features of durian volatiles, especially the predominance of ethyl esters, are likely due to ethanolic fermentation under hypoxia-like ripening conditions. We identified two ripening-associated pyruvate decarboxylase genes (DzPDC1a/b) that are highly expressed in ripe durian pulp. Furthermore, we analyzed RNA-seq data of three durian cultivars, which showed distinct volatile profiles associated with ester biosynthesis based on partial least squares-discriminant analysis. An integrated volatile and transcriptome analysis indicated that differentially expressed genes in the ester biosynthesis pathway, including carboxylesterase, branched-chain amino acid aminotransferase, and methionine γ-lyase genes, were associated with cultivar-specific volatile profiles. The identification of key genes associated with ester biosynthesis provides a molecular foundation for improving postharvest durian fruit flavor quality and breeding new cultivars with optimized fruit flavors.

PMID 42176410
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PubMedScientific reports2026-05-23

Phytochemical profiling and in-vitro antibacterial activity of Croton macrostachyus Hochst. ex Delile leaf and stem bark extracts against selected human pathogens.

Yohanis Getayawukal G, Sivalingam Krishna Moorthy KM, Meseret Abebe Gedif G, Narayanan Mukunthan Sankar MS et al.

Medicinal plants have long been utilized for their antiseptic, antiallergic, antibacterial, and antiviral properties in the treatment of human diseases. Croton macrostachyus is a prominent medicinal plant widely used in traditional African medicine for the treatment of various diseases like malaria, tuberculosis, cough, diabetes, rabies and dysentery. This study aimed to investigate the in-vitro antibacterial activity of ethanol, methanol and ethyl acetate extracts derived from the leaves and stem bark of C. macrostachyus against selected human bacterial pathogens. Crude extracts were prepared using the maceration method with the aforementioned solvents. Antibacterial activity, minimum inhibitory concentration (MIC), and minimum bactericidal concentration (MBC) were determined following clinical laboratory standards institute guidelines. Additionally, qualitative phytochemical analyses were also performed using the standard protocols. All extracts exhibited the inhibitory against Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus, with S. aureus showing the highest susceptibility. The antibacterial effect was concentration dependent, and leaf extracts demonstrated greater activity compared to stem bark extracts. Among the tested solvents, the methanolic crude extracts ahowed the strongest antibacterial activity. The MIC values of leaf extracts ranged from 0.625 to 2.25 mg/mL while MBC values ranged from 1.25 to 5 mg/mL. Phytochemical analysis of leaf extracts revealed the presence of tannins, alkaloids saponins, flavonoids, glycosides and phenolic compounds in ethanol and methanol based extraction, whereas alkaloids were absent in ethyl acetate based extraction. In contrast stem bark extracts contained glycosides across all solvents, while alkaloids, flavonoids, and phenolic compounds were absent. Tannins and saponins were detected in ethanol and ethyl acetate extracts but not in methanol extracts. Therefore, the present research concludes that the leaf extracts of C. macrostachyus exhibited highest antibacterial activity compared to stem bark extracts. The presence of bioactive phytochemicals supports the traditional use of C. macrostachyus in the treatment of various diseases.

PMID 42174014
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