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ethyl icosapentate (MND2119 / MND 2119 / icosapent, Mochida)

✓ Approved

Sumitomo Pharma Co., Ltd. · Small Molecule · Small Molecule

What is ethyl icosapentate?

ethyl icosapentate is a small molecule developed by Sumitomo Pharma Co., Ltd.. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesMND2119, MND 2119, icosapent, Mochida
CompanySumitomo Pharma Co., Ltd.
Drug ClassSmall Molecule
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, Sumitomo Pharma Co., Ltd.

Therapeutic Indications

ethyl icosapentate is developed for 2 unique indications across 1 therapeutic area.

Therapeutic AreaConditionPhase
Metabolism and nutrition disordersHyperlipidaemia✓ Approved
Metabolism and nutrition disordersHypertriglyceridaemiaPhase III

Related Research Articles

PubMedInternational journal of analytical chemistry2026-11-11

Role of Solvent Polarity in the Extraction and Electrochemical Behavior of Antioxidants From Ziziphus jujuba Leaves.

Kalsoom Umme U, Hussain Zahid Z, Khan Salman S, Ahmad Naveed N et al.

Ziziphus jujuba is a medicinal plant known for its rich content of antioxidants including flavonoids, saponins, phenolics, and triterpenoids. This study determines the effect of solvent polarity on the extraction yield and investigates phytochemical distribution of the extracts and its electrochemical behavior. Reflux extraction was used for the preparation of crude extracts, using methanol, ethanol, and water. The ethanolic extract was selected for solvent fractionation, using n-hexane, dichloromethane, chloroform, and ethyl acetate. Among the extraction solvents, ethanol produced the highest crude yield (6.0% w/w). Following solvent-solvent fractionation, the ethyl acetate fraction showed the highest recovery among all fractions (0.30% w/w). The presence of flavonoid and saponin fractions was confirmed by phytochemical screening. The highest absorbance was observed in ethyl acetate fraction through UV visible spectrophotometric analysis, A = 0.711 for flavonoids at 415 nm and 0.330 for saponin at 406 nm. Cyclic voltammetry (CV) for ethyl acetate and chloroform fractions showed oxidation peaks at 0.50 V (vs. Ag/AgCl). Fourier transformed infrared spectroscopy (FT-IR) analyzed functional groups of flavonoids and saponins. Liquid chromatography mass spectrometry (LC-MS) identified major flavonoids, that is, vicenin II, spinosin, kaemferol (glycoside), and saponins (jujubosides). The result stated that the polarity of solvents plays a vital role in extracting redox-active antioxidants from the leaves of Z. jujuba. Furthermore, it stated that ethyl acetate is the most effective fractionation solvent. This study gives analytical framework for extraction and characterization of antioxidant-rich fraction of Z. jujuba leaves along with emphasis on the role of solvent polarity in phytochemical recovery.

PMID 43011746
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PubMedAnalytical chemistry2026-11-11

Computational Chemistry-Guided Rational Hapten Design and Elucidation of the Molecular Recognition Mechanism Enable Immunochromatographic Detection of Maltol and Ethyl Maltol in Food and E-Liquid Samples.

He Feng F, Guo Lingling L, Kuang Hua H, Xu Xinxin X et al.

Given the potential health risks arising from the abuse or adulteration of maltol (MA) and ethyl maltol (EM)representative synthetic flavor enhancersparticularly in e-liquids, infant formulas, and fraudulently mislabeled foods, there is an urgent need for rapid and sensitive detection methods. Herein, guided by a computational chemistry-based rational hapten design strategy, four haptens were screened, and H4 was identified as the optimal candidate. Using animal immunization combined with hybridoma technology, a high-affinity, dual-specificity monoclonal antibody (mAb-2D6) was generated, exhibiting half-inhibitory concentrations (IC50) of 17.34 ng/mL for MA and 15.97 ng/mL for EM. Molecular docking revealed that key amino acid residuesGly103, His31, Tyr101, Ala104, and Phe99mediate the dual-specific recognition of mAb-2D6 through hydrogen bonds and π-alkyl interactions. Leveraging this mAb-2D6, two immunochromatographic assays (ICAs)a colorimetric format based on gold nanoparticles and a fluorescent format based on quantum dot microsphereswere developed for the first time for on-site rapid detection of MA and EM in soybean oil, infant formula, and e-liquids, with limits of detection ranging from 12.64 to 20.78 μg/kg. The ICA completes the entire detection workflow within 15 min and demonstrates excellent sensitivity, accuracy, practicality, and user-friendliness, enabling deployment in resource-limited field settings.

PMID 43010443
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PubMed3 Biotech2026-11-11

Enterococcus duransstrain AMA1 prohibiting free radicals, colon cancer and methicillin-resistantStaphylococcus aureus.

Arafat Hussam H HH, Shoulkamy Mahmoud A MA, Imam Mohamed M MM, Ali Amany M A AMA

This research was conducted to determine bioactivity of ethyl acetate extract of our strain Enterococcus durans AMA1 that was previously isolated from bovine yoghurt. The study includes detecting of antimicrobial efficiency against Methicillin-Resistant S. aureus ATCC 33591 (MRSA), antibiofilm, antioxidant activity, anti-colon cancer activity and cytotoxicity. We also investigated the bioactive polyphenols in E. durans extract, which are widely documented in plants, fungi and Actinomycetes, but not well-discovered in enterococci. The isolate E. durans strain AMA1 showed high antimicrobial potency towards MRSA with antibiofilm activity of 90.58% at a concentration (75% of MBC), while the least recorded effect was 58.15% at a concentration of (25% of MBC). Scavenging activities of free radicals were (30.9%) and (91.0%) at concentrations of (1.95 µg/mL) and (1,000 µg/mL) respectively, while Ascorbic ranged from (42.0%) to (98.2%) at the same concentrations. Ethyl acetate extract caused toxicity of 97.19% to normal cells at 1,000 µg/mL, but no serious effect (0.46%) was recorded at 125 µg/mL. It was also highly toxic to colon cancer with percentage of 96.64% at 1,000 µg/mL, and was still effective at 125 µg/mL with toxicity of 58.60%. Using HPLC technique, it was detected that gallic acid was the major one (511.75 µg/mL), followed by catechin (378.67 µg/mL), naringenin (372.10 µg/mL), coumaric acid (174.40 µg/mL) and methyl gallate (145.87 µg/mL). The online version contains supplementary material available at https://doi.org/10.1007/s13205-026-05109-y.

PMID 43011007
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PubMedAfrican journal of laboratory medicine2026-11-11

Antibacterial activity of mangrove-derived Streptomyces pseudogriseolus NELs-50 against methicillin-resistant Staphylococcus epidermidis.

Qin Yutian Y, Wang Wenqing W, Rajaofera Mamy Jayne Nelly MJN

Methicillin-resistant Staphylococcus epidermidis (MRSE) represents a growing healthcare threat, necessitating novel antimicrobial agent development. Mangrove-derived Streptomyces species offer promising potential as sources of bioactive compounds against drug-resistant pathogens. To isolate and characterise a mangrove-derived Streptomyces isolate with anti-MRSE activity and identify its bioactive metabolites. Mangrove soil samples were screened for anti-MRSE activity. Isolate NELs-50 was identified through morphological, biochemical, and 16S rRNA gene sequencing. Fermentation parameters were optimised, bioactive metabolites extracted with organic solvents, and characterised using gas chromatography-mass spectrometry (GC-MS). Minimum inhibitory concentration (MIC) and stability assessments were conducted. NELs-50 was identified as Streptomyces pseudogriseolus (99% sequence similarity) with potent anti-MRSE activity (28.67 mm inhibition zone). Culture conditions were optimised for maximum antimicrobial production. Ethyl acetate extract showed highest activity (28.83 mm). The extract retained 41% activity at 121 °C, tolerated pH 2-12, and resisted enzymatic degradation. Gas chromatography-mass spectrometry analysis identified nine compounds, with major components being pyrrolo[1,2-a]pyrazine derivatives (100% peak area), and 2,4-Di-tert-butylphenol (12.64%). Minimum inhibitory concentration against MRSE was 125 µg/mL. S. pseudogriseolus NELs-50 shows promising anti-MRSE activity and produces putative bioactive metabolites with broad pH tolerance but reduced activity at elevated temperatures, supporting its potential as a source of antimicrobial lead compounds. This study reports the isolation and characterisation of S. pseudogriseolus NELs-50 from Hainan mangroves. The ethyl acetate extract showed broad pH tolerance but was heat-sensitive at elevated temperatures, retaining only 41% activity after treatment at 121 °C. Gas chromatography-mass spectrometry analysis identified nine putative metabolites, suggesting that NELs-50 may serve as a promising source of antimicrobial lead compounds against multidrug-resistant pathogens.

PMID 43011134
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PubMedJournal of agricultural and food chemistry2026-11-11

Allelo-Labdane Diterpenoids from Abies fabri Targeting CYP707A2 to Inhibit Arabidopsis Seed Germination.

Cui Xiaoyun X, Lu Chunhua C, Hu Zhanxing Z, Shen Yuemao Y

Gymnosperm plants are rich in allelochemicals that can be used as ideal eco-friendly alternatives to chemical herbicides. Petroleum ether and ethyl acetate crude extracts from the leaves of Abies fabri (Mast.) Craib (Pinaceae) inhibited seed germination of Arabidopsis thaliana. Twenty-four terpenoids were isolated and identified by chromatographic separation and NMR spectral analysis. Compounds 7 and 14-17 showed germination inhibitory activity, among which 7, namely 13-epitorreferol, was selected for mechanistic investigation. Transcriptomic analysis revealed that differentially expressed genes (DEGs) were mainly enriched in stress response and plant hormone signaling, especially abscisic acid (ABA) pathways. The results of the in vitro enzyme activity assay and mutant phenotypic analysis indicated that CYP707A2 (ABA 8'-hydroxylase) was one of the targets mediating the inhibitory activity of 7 on seed germination. This work expands allelochemical resources, offering a tool for investigating ABA signaling and providing leads for the development of eco-friendly herbicides.

PMID 43012708
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PubMedAnalytical chemistry2026-11-11

Physically Constrained Inverse-Gaussian Deconvolution of Diffusion-Broadened Drift-Tube Ion Mobility Spectra.

Huang Haoran H, Li Zhicheng Z, Chen Lu L, Yu Jianna J et al.

Peak overlap limits chemical assignment in drift-tube ion mobility spectrometry (DT-IMS). Diffusion broadening is commonly modeled with symmetric Gaussian kernels, although a fixed detector records ion first-passage times. We developed an inverse-Gaussian-Nernst-Townsend-Einstein (IG-NTE) deconvolution framework in which the point-spread function (PSF) follows an inverse-Gaussian distribution and its temporal width is constrained by instrument settings through the NTE relation. The resulting drift-time-dependent measurement operator was inverted by nonnegative Richardson-Lucy iteration without peak-width calibration or specification of component number. In simulations, relative to a Gaussian kernel, IG-NTE deconvolution reduced the average full-residual root-mean-square value by 11.4%, the right-tail residual by 18.1%, and the mean absolute peak-area deviation from 5.10% to 1.19%. Applied to a 63Ni DT-IMS instrument, the method separated ethyl 2-methylpentanoate and 1,8-cineole responses 0.040 ms apart while retaining 2,6-di-tert-butylpyridine (DTBP) as a single-component control. It also recovered paired alkyl-pyrazine mobility features consistent with protonation site- and hydration-dependent collision cross sections. In the negative mode, dichloromethane-derived chloride responses assigned to 35Cl- and 37Cl- exhibited a 3.08:1 area ratio and were supported by GC-TOF-MS. These results show that detector-domain transport modeling can improve the effective reconstructed resolution of diffusion-broadened DT-IMS spectra without hardware modification, provided that controls and forward residual analysis are used to assess reconstruction artifacts.

PMID 43010528
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