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ethyl icosapentate (MND2119 / MND 2119 / icosapent, Mochida)

✓ Approved

Sumitomo Pharma Co., Ltd. · Small Molecule · Small Molecule

What is ethyl icosapentate?

ethyl icosapentate is a small molecule developed by Sumitomo Pharma Co., Ltd.. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesMND2119, MND 2119, icosapent, Mochida
CompanySumitomo Pharma Co., Ltd.
Drug ClassSmall Molecule
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, Sumitomo Pharma Co., Ltd.

Therapeutic Indications

ethyl icosapentate is developed for 2 unique indications across 1 therapeutic area.

Therapeutic AreaConditionPhase
Metabolism and nutrition disordersHyperlipidaemia✓ Approved
Metabolism and nutrition disordersHypertriglyceridaemiaPhase III

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Lessons Learned on Obtaining Reliable Conductivity Estimates From Molecular Dynamics Simulations.

Zaby Paul P, Ingenmey Johannes J, Lourenço Tuanan C TC, Zhang Yong Y et al.

The calculation of reliable ionic conductivities from molecular dynamics simulations is not a straightforward task, especially for strongly correlated systems, such as ionic liquids or highly concentrated electrolytes, where the Nernst-Einstein approach tends to fail. In this manuscript, we present the newly implemented conduct module for TRAVIS. It allows the calculation of the ionic conductivity using the Einstein-Helfand and Green-Kubo approaches, which explicitly include ionic correlations in their formalism. We provide a broad overview of accessible transport properties and compare methods and best practices for obtaining statistically reliable estimates of ionic conductivity and other physicochemical properties derived from electrolyte molecular dynamics simulations, including transport numbers and the inverse Haven ratio. To validate our implementation and demonstrate the conduct module's capabilities, we simulated the ionic liquid 1-ethyl-3-methylimidazolium dicyanamide ([EMIm][DCA]) as well as the ether-based electrolyte lithium bis(fluorosulfonyl)imide in ethylene glycol dimethyl ether (LiFSI/DME).

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Visible-light-promoted catalyst-free benzylic C-H oxidation using molecular oxygen as a green oxidant.

Li Jianing J, Wang Suwen S, Sun Huinan H, Liu Zhunchao Z et al.

Herein, we report a catalyst- and additive-free strategy for the visible-light-promoted carbonylative oxidation of benzylic C-H bonds employing molecular oxygen as the sole oxidant. This operationally simple protocol enables the conversion of a broad range of aromatic alkanes into valuable ketones, including complex drug derivatives and intermediates under mild conditions using ethyl acetate as a green solvent. Mechanistic studies reveal that the reaction proceeds via a substrate-oxygen charge-transfer (CT) complex upon photoexcitation, generating reactive oxygen species (singlet oxygen and superoxide anion) and a key benzylic radical. Interestingly, the carbonyl product can further accelerate the transformation by participating in a separate CT complex with the starting material. To address the scalability limitations, a novel solvent-free continuous-flow photoreactor was developed, which demonstrated a significant efficiency enhancement of over 150-fold compared to batch processes. This work presents a green, practical, and scalable method for benzylic oxidation, underpinned by a detailed mechanistic understanding of the photoinduced CT process.

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Polymer-Coated Nanoarchitectonics of Titanium Dioxide Nanoparticles with Enhanced Antimicrobial Activity: Mechanistic Insights into Localized Particle-Membrane Interactions.

Alsharif Nizar B NB, Caselli Lucrezia L, Thapper Anders A, Sparr Emma E et al.

While surface modifications are widely pursued to improve antimicrobial performance of photocatalytic nanoparticles (NPs), the particle-membrane interactions responsible for these effects remain underexplored. We address this gap by investigating the influence of coating TiO2 NPs with the cationic polymer poly-(2-(dimethylamino)-ethyl methacrylate) methyl chloride quaternary salt (qPDMAEMA). In contrast to bare TiO2, the coated NPs adsorb extensively to negatively charged bacteria and bacteria-like membranes, boosting membrane permeabilization upon UV illumination due to formation of reactive oxygen species (ROS). The qPDMAEMA coating was demonstrated not to interfere with ROS formation and to withstand UV illumination over time-scales sufficient for membrane binding and disruption. Such effects were highly localized near membrane-bound NPs, consistent with the short diffusion lengths of ROS (≈10 nm for hydroxyl radicals) and the formation of oxidative membrane 'hot-spots' in the corresponding vicinity of membrane regions where preferential (localized) NP binding occurs. Such preferential localization is demonstrated to occur at poles and nodes of Escherichia coli bacteria. Hypothesizing this to be driven by colocalization with anionic cardiolipin, studies with giant vesicles containing cardiolipin either uniformly distributed or present in segregated domains showed that the polymer-coated TiO2 NPs preferentially bind to cardiolipin-rich regions of the membrane. Together, these results expand on conventional studies of NP interactions with bacteria and bacteria-like membranes and demonstrate that localized interactions must be considered in studies of bacterial membrane interactions of photocatalytic NPs.

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Zwitterionic Tissue Expanders Reduce Infection and Fibrosis for Enhanced Biocompatibility.

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Current osmotic tissue expanders suffer from protein adsorption, bacterial colonization, and excessive fibrotic encapsulation that compromise device performance. In this study, we synthesized zwitterionic hydrogels using methyl methacrylate, n-vinyl pyrrolidone, and varying percentages (5-50%) of [2-(Methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl)ammonium hydroxide (SBMA) to simultaneously enhance swelling capacity while reducing biological fouling. In vitro characterization demonstrated that SBMA incorporation significantly increased swelling potential while maintaining the mechanical integrity required for effective tissue expansion. Zwitterionic hydrogels exhibited superior resistance to lysozyme, fibrinogen, and bovine serum albumin (BSA) adsorption compared to ionized controls. Bacterial attachment studies revealed reduced Staphylococcus aureus attachment on zwitterionic surfaces, particularly in lysozyme-containing environments that mimic physiological conditions. Subcutaneous implantation in Sprague Dawley rats for 14 days showed that hydrogels with 5-30% SBMA formed significantly thinner fibrous capsules compared to ionized controls, with the 30% SBMA formulation producing the most uniform and loose capsular matrix. These results demonstrate that zwitterionic hydrogels represent a significant advancement in osmotic tissue expansion technology, addressing key limitations of current devices through bulk incorporation of zwitterionic monomers, potentially improving clinical outcomes and reducing the need for revision surgeries. STATEMENT OF SIGNIFICANCE: Tissue expanders are medical devices used to stretch skin and soft tissues for reconstructive surgery, but current osmotic expanders fail due to protein buildup, bacterial infections, and excessive scar tissue formation. We developed new hydrogel materials incorporating zwitterionic compounds, i.e., molecules with balanced positive and negative charges, that resist biological fouling while maintaining effective tissue expansion properties. Our zwitterionic hydrogels demonstrated superior resistance to protein adsorption and bacterial attachment compared to conventional materials. Most importantly, when implanted in rats, these hydrogels formed significantly thinner, less dense scar tissue capsules, particularly the 30% zwitterionic formulation. This breakthrough addresses major clinical limitations of current tissue expanders and could reduce surgical complications and the need for revision procedures, ultimately improving patient outcomes in reconstructive surgery.

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PubMedNatural product research2026-07-24

Bioactivity-guided identification of a quercetin-rich ethyl acetate fraction from Ipomoea pes-tigridis L. conferring robust antioxidant defense and hepatoprotection against paracetamol-induced liver injury.

Bheemreddy Thrinitha T, Murali Radhakrishnan R, Srinivasan Nagarajan N, Manichandrika Paturi P

The present study evaluated the hepatoprotective potential of Ipomoea pes-tigridis L. whole-plants extracts in paracetamol-induced hepatotoxic rat model. Sequential Soxhlet extraction yielded petroleum ether, ethyl acetate, and methanolic extracts, which were assessed at 200 mg/kg following of acute toxicity confirmation (2000 mg/kg). Paracetamol administration (2 g/kg) significantly elevated lipid peroxidation (TBARS: liver 2.99 ± 0.04 vs. control 1.44 ± 0.02 nmol MDA/g) and reduced antioxidant defences, including superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione S-transferase (GST), and glutathione (GSH) (p < 0.01). Pre-treatment with the ethyl acetate extract markedly restored antioxidant enzymes activities (e.g. hepatic SOD 5.83 ± 0.02 vs. 3.39 ± 0.03 in paracetamol group), and normalise total protein levels (7.21 ± 0.04 vs. 4.70 ± 0.02 g/dL), comparable to silymarin. Histopathology confirmed near-complete preservation of hepatic architecture. These findings demonstrate that the quercetin-rich ethyl acetate extract of Ipomoea pes-tigridis L. confers significant antioxidant-mediated hepatoprotection against paracetamol-induced liver injury.

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Integrating spectrum-effect relationship, network pharmacology and multi-omics to decipher the mechanism of Cybister chinensis Motschulsky against chronic kidney disease.

Qu Yun-Xia YX, Zhang Zheng-Ze ZZ, Li Zhi-Huan ZH, Sun Yue Y et al.

Cybister chinensis Motschulsky is a traditional Chinese medicinal insect traditionally used to tonify the kidney, and clinically applied for the management of chronic kidney disease (CKD). The present work was dedicated to identifying bioactive ingredients in the ethyl acetate fraction of C. chinensis and elucidating their mechanisms underlying the treatment of CKD. Compounds were isolated and used to establish fingerprints. Anti-inflammatory and anti-injury activities in vitro and grey relational analysis were applied to establish spectrum-effect relationships. Network pharmacology combined with molecular docking was employed to identify the candidate bioactive components. The effects of ethyl acetate fraction of C. chinensis were explored in doxorubicin-induced CKD rat model via Western blot, RT-PCR, transcriptomics, and metabolomics. Molecular dynamics simulation was applied to assess binding affinity of bioactive components. Cell experiments verified effects of components on inflammation, oxidative stress, and fibrosis. The ethyl acetate fraction of C. chinensis was confirmed as the active fraction. Compounds 6, 10, 22, 23 and 27 were screened as the potential active components. Ethyl acetate fraction improved the condition of CKD rats, while multi-omics identified a triple-functional network against inflammation, oxidative stress, and fibrosis, with PI3K-AKT/MAPK/HIF-1 pathways verified. Cell experiments and molecular dynamics simulation identified compound 6 as the key active component, with its regulatory effects validated through PI3K-AKT/MAPK/HIF-1 pathways. Ethyl acetate fraction of C. chinensis and its active component exerted renoprotective effects by suppressing inflammation, oxidative stress, and fibrosis in CKD via regulating PI3K-Akt, MAPK, and HIF-1 pathways.

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