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isosorbide dinitrate + hydralazine (hydralazine + ISDN / BiDil / ISDN + hydralazine)

✓ Approved

Arbor Pharmaceuticals, LLC · CACNA1C · Small Molecule

What is isosorbide dinitrate + hydralazine?

isosorbide dinitrate + hydralazine is a small molecule developed by Arbor Pharmaceuticals, LLC. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand Nameshydralazine + ISDN, BiDil, ISDN + hydralazine
CompanyArbor Pharmaceuticals, LLC
Drug ClassSmall Molecule
Molecular TargetCACNA1C
RouteOral (PO)
StatusApproved

Mechanism of Action

Molecular Targets

isosorbide dinitrate + hydralazine acts on 1 molecular target:

CACNA1Ccalcium voltage-gated channel subunit alpha1 C (CACNL1A1, CACNA1C-IT2)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

isosorbide dinitrate + hydralazine is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Cardiac disordersCardiac failure✓ Approved

Related Research Articles

PubMedThe journal of physical chemistry. B2026-05-24

Orientation of the Electronic Qy Transition Dipole Moment in Chlorophyll a.

Zahn Clark C, Nag Probal P, Stensitzki Till T, Müller-Werkmeister Henrike H et al.

The orientation of the Qy transition dipole moment (tdm) in Chlorophyll a (Chl a) is a fundamental parameter for optimizing energy transfer in light harvesting systems. Here, we apply polarization resolved transient VIS-pump/IR-probe and 2D-IR spectroscopy in combination with density functional theory (DFT) calculations to determining the orientation of the Qy tdm for hexacoordinated Chl a. Analysis of the 2D-IR spectra provide a comprehensive study of the C═O vibrations, allowing us to refine the modeling of the vibrational tdm (vtdm) vectors. Polarization resolved transient IR spectra provide relative angles between the Qy tdm and different probed vtdms, which determine cones of possible orientations of the Qy tdm. Calculating the intersection of three cones from linearly independent vtdm vectors, we determine the orientation of the Qy tdm. We find that the Qy tdm for hexacoordinated Chl a is oriented along the y-axis of the macrocycle, exhibiting only a small angular deviation within -1° to 4°.

PubMedJournal of ISAKOS : joint disorders & orthopaedic sports medicine2026-05-24

Shelf Acetabuloplasty Restores Native Rotational Motion in a Cadaveric Acetabular Dysplasia Model.

Nishimura Haruki H, Yamaura Kohei K, Brown Justin J, Garcia Alex A et al.

Developmental dysplasia of the hip is associated with inferior clinical outcomes when treating concomitant intra-articular pathologies. Shelf Acetabuloplasty has been proposed as a less invasive alternative to periacetabular osteotomy for developmental dysplasia of the hip; however, there is a lack of biomechanical studies regarding its efficacy. We hypothesized that a cadaveric dysplasia model would cause increased range of motion and lateral femoral head translation compared to native, and that shelf acetabuloplasty would restore native biomechanics. Ten cadaveric hips were dissected down to the capsule and mounted to a 6-degrees of freedom robotic arm. Each specimen was tested sequentially in 4 states: 1) Native, 2) Capsular repair, 3) Acetabular dysplasia model created by acetabular rim resection to achieve a lateral center-edge angle (LCEA) of 15-20° under fluoroscopic guidance, and 4) Shelf acetabuloplasty restoring LCEA of 35-40° utilizing a bone graft harvested from the iliac crest. Robotic testing included: 1) 5- Newton Meter (Nm) abduction, 2) 5-Nm internal rotation (IR) at 75° flexion, 3) 5-Nm flexion, and 4) 88-N Lateral Drawer. Range of motion under standardized torque was used as a surrogate measure of rotational stability. The effect of specimen state was determined using analysis of variance, and post hoc pairwise comparisons were made using Tukey's method. Capsular repair did not statistically significantly differ from native state. Compared to native, the acetabular dysplasia model showed increased abduction (+2.3°, p=0.004) and IR at 75° flexion (+0.9°, p=0.017) without statistically significant changes in flexion or lateral translation. Shelf acetabuloplasty restored native abduction and IR at 75° flexion but reduced hip flexion (-1.7°, p=0.003). This study demonstrated that acetabular rim resection increased rotational motion under applied torque, while shelf acetabuloplasty restored rotational motion to native levels. However, shelf acetabuloplasty resulted in a statistically significant reduction in hip flexion (-1.7°, p=0.003), suggesting potential over-constraint depending on graft positioning. Not Applicable, Controlled Laboratory Study.

PubMedPediatric transplantation2026-05-24

Dosing, Safety, and Tolerability of Extended-Release Tacrolimus in Pediatric and Young Adult Solid Organ Transplant Recipients.

Dang Terry T, Hewlett Jennifer J, McAteer John J, Downes Kevin J KJ

Complicated immunosuppression regimens can contribute to non-adherence in pediatric solid organ transplant (SOT) recipients. Once-daily tacrolimus formulations, such as LCP-tacrolimus (LCPT), may help simplify dosing, but pediatric data on dosing, safety, and early tolerability are limited. We conducted a single center retrospective cohort study of SOT recipients prescribed LCPT from December 2016 to July 2024 at our institution. LCPT:IR-Tac daily dosing ratios were calculated. The frequency of laboratory-associated adverse events (AE) and of new patient-reported adverse events in the first 90 days were collected and compared across pediatric- and adult-aged SOT recipients. Ninety-one SOT recipients were prescribed LCPT at a median age of 16.8 years (range 8.4-24.1) and 75 months after transplant (range 0.25-217). Among 53 patients who were therapeutic on both IR-Tac and LCPT, the median daily dosing ratio of LCPT:IR-Tac was 0.75 (range 0.33-1.5) for pediatric patients and 0.75 (IQR: 0.46-1.33) for adults. Eleven (5 patient-reported and 6 laboratory) AEs were identified, none of which resulted in cessation of LCPT therapy. There were no significant differences in the frequency of AEs between children and adults. LCPT was well tolerated and typically required about a 25% dose reduction compared with IR-tacrolimus, though conversion ratios varied widely. These findings offer practical guidance for LCPT dosing in pediatric transplant care and highlight the need for individualized titration and monitoring.

PubMedFood chemistry2026-05-24

Structure-property evolution of insoluble dietary fiber from wheat bran under solid-state fermentation and its effect on functional and processing properties.

Liang Wei W, Lin Qian Q, Xiong Ke K, Li Wenhao W

This study investigated the role of co-fermentation in converting wheat bran biomass by characterizing insoluble dietary fiber (IDF) extracted at different stages (12, 24, 48 h) of fermentation with various strains (Control, NF, YF, LF, MF). Microscopic observations (SEM, CLSM) showed that fermentation caused IDF structural breakdown, particle size reduction, and honeycomb-like porous morphology. FT-IR and XRD verified structural degradation and increased molecular disorder. These changes enhanced thermal stability, water retention, and oxygen vacancy intensity, with particle size reduced. The porous structure improved physicochemical and functional properties, promoted phenolic release, and strengthened antioxidant activity. The mixed fermentation (MF) group exhibited the most significant degradation and superior structural and functional properties compared with single strains. These findings provide a feasible approach for high-value utilization of wheat bran biomass.

PubMedPhytochemistry2026-05-24

Hypurpurins A-P, furanolabdane diterpenoids from the aerial parts of Hypoestes purpurea and their bioactivities.

Ding Lin-Fen LF, Cheng Bin B, Zhang Mei-Yi MY, Yin Shi-Huan SH et al.

Sixteen previously undescribed furanolabdane diterpenoids, designated hypurpurins A-P (1-16), along with two known analogs, hypopurins B and C (17 and 18), were isolated from the aerial parts of Hypoestes purpurea. The chemical structures of 1-16 were elucidated through comprehensive spectroscopic analyses, including HR-ESI-MS, NMR, UV, and IR spectroscopy. The absolute configurations of these new compounds were further determined by electronic circular dichroism and single-crystal X-ray diffraction analysis. Structurally, compounds 1 and 2 are unprecedented furanolabdane diterpenoids bearing an 8,20:12,20-diepoxy unit; compounds 3 and 4 are unique furanolabdane diterpenoids featuring 12,20-epoxy and 19,20-lactone moieties; compounds 5 and 6 represent the first examples of furanolabdane diterpenoids possessing an 8,12-epoxy and 19,20-lactone ring. All isolated compounds were evaluated for their nitric oxide (NO) inhibitory effects and cytotoxicity against HPAC and ASPC-1 cancer cell lines. Among them, compounds 7 and 17 exhibited moderate inhibitory effects on lipopolysaccharide-induced NO release in RAW 264.7 cells, with IC50 values of 44.14 and 36.48 μM, respectively.

PubMedTalanta2026-05-24

Enrichment and highly sensitive detection for the chemical agent markers via the rare earth metal ion-modified magnetic nanomaterials.

Li Kexuan K, Zhao Yuxin Y, Wu Jina J, Li Xiaosen X et al.

The rapid detection and trace analysis of the chemical warfare agents (CWAs) are of great practical importance due to the threat influence to global security. Herein, the magnetic nanomaterial as Fe3O4@SiO2-IDA-Eu3+ has been successfully synthesized and utilized for the enrichment of ethyl methylphosphonate (EMPA), the primary marker for the nerve agent VX. Comprehensive characterization by XPS, FT-IR and EDS confirmed the successful synthesis of Fe3O4@SiO2-IDA-Eu3+. The synthesized materials were applied for the sensitive detection of EMPA combined with liquid chromatography-tandem mass spectrometry (LC-MS/MS). The material exhibited rapid adsorption equilibrium (8.0 min) following the pseudo-second-order kinetic model (R2=0.9802) and the high capacity (8.24 mg/g) for the Langmuir isotherm. When coupled with liquid chromatography-tandem mass spectrometry (LC-MS/MS), the method achieved the detection limit of 1.0 ng/mL for EMPA in plasma, with recoveries ranging from 96% to 114%. Compared with commercial materials, the synthesized material exhibited higher adsorption capacity. The method was successfully validated by the actual plasma samples in the Organization for the Prohibition of Chemical Weapons Biomedical Proficiency Test, demonstrating the practical applicability for chemical weapons verification.

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