Drug Database
CH

chloral hydrate (Escre suppositories)

✓ Approved

Hisamitsu · Small Molecule · Small Molecule

What is chloral hydrate?

chloral hydrate is a small molecule developed by Hisamitsu. It is approved for therapeutic indications via rectal.

Drug Profile

Brand NamesEscre suppositories
CompanyHisamitsu
Drug ClassSmall Molecule
RouteRectal
StatusApproved

Therapeutic Indications

chloral hydrate is developed for 2 unique indications across 2 therapeutic areas.

Therapeutic AreaConditionPhase
Nervous system disordersEpilepsy✓ Approved
Psychiatric disordersInsomnia✓ Approved

Related Research Articles

PubMedMarine pollution bulletin2026-09-18

Marine oil spill pollution detection in remote sensing imagery using semantic sub-prototype modeling.

Yang Qian Q, Li Ying Y, Zhang Zhaoyi Z, Wu Peng P et al.

Remote sensing monitoring of marine oil spills supports marine environmental protection, pollution surveillance, and emergency response. However, accurate detection remains difficult because oil-water boundaries are blurred and irregular, oil slicks are often small or fragmented, and oil spill look-alikes and complex backgrounds cause false alarms and missed detections. In unmanned aerial vehicle (UAV) RGB and SAR imagery, water-surface reflections, harbor structures, and dark-spot look-alikes further complicate oil spill identification. To address these challenges, we propose SSP-Net, a semantic sub-prototype network for marine oil spill pollution detection. Specifically, we design a multi-level feature aggregation module that combines shallow spatial details with deep semantic cues to represent weak boundaries and small oil spill regions. Second, we develop a class-semantic sub-prototype modeling mechanism that uses multiple fine-grained sub-prototypes to capture diverse appearances within oil slick, look-alike, water-body, and complex-background categories. In addition, we introduce a prototype-feature interaction decoder (PFID) that iteratively refines semantic sub-prototypes and image features through cross-attention, strengthening discrimination between oil slicks and interfering categories. Finally, we design a multi-class joint loss (MCJL) that reinforces segmentation supervision and semantic constraints on sub-prototypes. Experiments on the public M4D and Oil-Spill-Drone datasets demonstrate that SSP-Net outperforms several advanced methods, achieving 72.97% mIoU on M4D and 93.42% mIoU on Oil-Spill-Drone. The segmentation masks generated by this model can provide critical spatial information for marine pollution monitoring, emergency response, and environmental management.

PubMedInternational journal of hematology-oncology and stem cell research2026-09-18

Rhesus Box as the Primary Mechanism of RHD Gene Deletion in RhD-Negative Blood Donors from Eastern Iran.

Nakhaei Shamahmood Mobina M, Zangooie Alireza A, Anani Sarab Gholamreza G, Sajjadi Seyed Mehdi SM et al.

Background: The Rh blood group system is highly significant in transfusion medicine because of the strong immunogenicity of the D antigen. The RhD-negative phenotype arises through various molecular mechanisms in different populations, most commonly complete deletion of the RHD gene caused by unequal recombination between upstream and downstream Rhesus box sequences. Although this mechanism has been well documented in some populations, limited data are available from Iran, particularly its eastern regions. This study aimed to determine the molecular basis of the RhD-negative phenotype among blood donors in eastern Iran. Materials and Methods: In this cross-sectional study, a total of 16,190 blood donors referred to blood transfusion centers in South Khorasan Province, eastern Iran, over a one-year period were screened serologically for RhD status. Among them, 2,198 individuals were identified as RhD-negative, and 100 serologically confirmed RhD-negative donors were randomly selected for molecular evaluation. RhD typing was performed using standard serologic methods and verified by indirect antiglobulin testing. Molecular investigations included PCR-sequence-specific priming (PCR-SSP) targeting RHD exons 5, 7, and 10, real-time PCR for confirmation, and PCR-restriction fragment length polymorphism (PCR-RFLP) to detect the hybrid Rhesus box and determine RHD zygosity. Results: Among 16,190 blood donors screened during the study period, 2,198 (13.57%) were identified as RhD-negative. From this group, 100 samples were randomly selected for molecular analysis. Both PCR-SSP and real-time PCR confirmed the absence of RHD exons 5, 7, and 10 in all samples, indicating complete deletion of the RHD gene. PCR-RFLP analysis further confirmed that all donors were homozygous for the hybrid Rhesus box, with full concordance observed between exon-specific assays and hybrid Rhesus box genotyping. Conclusion: These findings indicate that the RhD-negative phenotype in eastern Iran is primarily due to homozygous RHD gene deletion mediated by the hybrid Rhesus box. Hybrid Rhesus box analysis may therefore serve as a reliable molecular marker for accurate RhD typing, which could improve transfusion safety and perinatal management in this population.

PubMedACS omega2026-09-18

Influence of Seawater Salts on Magnesium Oxide Hydration: Implications for Carbonation.

Evans Barbara R BR, Chung Dong Youn DY, Moseley Brittany B, Dorsey Geordan G et al.

The effects of individual component salts on MgO hydration and subsequent carbonation have not been systematically investigated despite the increase in utilization of seawater and other brines in the production of MgO-containing next-generation cements, fire retardants, and sorbents for CO2. Here, we present a study of MgO hydration in the presence of individual saltwater cations at a range of concentrations, as well as binary mixtures at seawater concentrations, and subsequent carbonation. We observed that the presence of the cations increased MgO dissolution rates and that the subsequent carbonation extent of the hydrated material remained constant or even increased. Since the presence of these salts during hydration does not show negative effects on subsequent carbonation in our experimental study, the application of seawater and other brines containing high concentrations of these salts to hydrate MgO in industrial processes is likely feasible.

PubMedActa crystallographica. Section C, Structural chemistry2026-09-18

Hydrogen bonding in cocrystals of trans-NiII(hfac)2(H2O)2.

Clemmer Grace L GL, York Caden W CW, Gray Mackenzie G MG, Fatila Elisabeth M EM et al.

Chemical vapor deposition (CVD) precursors often employ fluorinated β-diketonate ligands bonded to metal atoms; however, these are prone to the formation of hydrates under ambient conditions and form hydrogen-bond networks which hinder the CVD process. This work investigated the use of 1,2-dimethoxybenzene (DMB) as a ligand to prevent the formation of hydrogen-bonding networks. The single-crystal structures of two complexes of diaquabis(1,1,1,5,5,5-hexafluoro-4-oxopent-2-en-2-olato-κ2O,O')nickel(II), trans-NiII(hfac)2(H2O)2, were determined, one as a 4/3 hydrate, [Ni(C5HF6O2)2(H2O)2]3·4H2O, and one as a 1,2-dimethoxybenzene (DMB) pentasolvate, [Ni(C5HF6O2)2(H2O)2]·5C8H10O2. The hydrogen-bond networks of these two materials were compared to previously reported hydrogen-bond networks seen in NiII(hfac)2(H2O)2. DMB was found to disrupt the formation of an extended hydrogen-bond network without coordinating to the Ni center.

PubMedPharmaceutical development and technology2026-09-18

Solid Modification Strategies for Active Pharmaceutical Ingredients (APIs): A Systematic Review on Approaches, Improvements, and Limitations.

Devon George Patrick GP, Ismail Dzava Prawinsyah Fairus DPF, Lagut Jenio J, Sopyan Iyan I

Poor aqueous solubility remains a major barrier in drug development, affecting approximately 40% of marketed drugs, up to 75% of drugs under development, and nearly 90% of new chemical entities. To overcome this limitation, solid modification of active pharmaceutical ingredients (APIs) emerged as a strategy to enhance drug physicochemical properties, particularly for Biopharmaceutics Classification System (BCS) II and IV drugs. This review systematically analyzes recent advancements in solid modification techniques, including salt formation, cocrystallization, polymorphs, solvate and hydrate forms, amorphous and co-amorphous systems, inclusion complexes, and nanocrystallization. A systematic literature search spanning 2020-2025 was conducted using PubMed and ScienceDirect databases, focusing on studies that improve the physicochemical properties of the APIs. By categorizing APIs, matrices, and methods of each study, this review shows the most frequently used techniques and their matrices, advantages, and limitations of each modification, providing insights for optimizing drug performance and future research in pharmaceutical development. Among the various approaches reviewed, cocrystals, amorphous systems, nanocrystals, and inclusion complexes emerged as the most frequently used techniques. Amorphous systems and inclusion complexes offer the highest median solubility enhancements by maximizing kinetic supersaturation or equilibrium solubility, respectively, while nanocrystals efficiently improve equilibrium solubility via particle size reduction, and cocrystals provide reliable, moderate gains with superior long-term thermodynamic stability.

PubMedACS omega2026-09-18

Review of Formation Damage Assessment for CO2 Injection and Storage.

Sagandykova Dilyara D, Kakharov Islam I, Aitkazy Shynggys S, Khanjani Maral M et al.

Carbon capture and storage (CCS) has become an essential strategy for reducing CO2 emissions, with injection and storage projects increasingly implemented around the world. However, the long-term effectiveness of geological storage depends on maintaining injectivity and reservoir integrity, both of which face challenges from various formation damage mechanisms that are specific to CO2 injection. First, this review covers recent advances in understanding the physical, chemical, thermal, and biological processes that cause permeability loss, including salt precipitation from brine drying, fines migration, hydrate and ice formation due to Joule-Thomson cooling, acid-induced mineral dissolution, clay swelling, asphaltene precipitation, microbial activity, and phase trapping. The second part of this paper provides an in-depth review of assessment techniques used to diagnose and predict formation damage such as experimental methods, numerical simulations, analytical techniques, machine learning, and molecular modeling. Despite significant progress, many uncertainties remain regarding how these mechanisms interact over operational time scales and under real-world reservoir conditions. Future research should focus on integrating experimental and numerical approaches, expanding studies across different lithologies, and developing advanced in situ monitoring methods to improve the risk assessment and manage injectivity more effectively. Overcoming these challenges is crucial for enabling safe, efficient, and scalable deployment of CO2 storage technologies, with particular emphasis on conducting long-term studies that capture the coupled processes and reservoir responses over extended operational time scales.

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