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indometacin plaster

✓ Approved

Kowa · PTGS1 · Small Molecule

What is indometacin plaster?

indometacin plaster is a small molecule developed by Kowa. It is approved for therapeutic indications via transdermal.

Drug Profile

CompanyKowa
Drug ClassSmall Molecule
Molecular TargetPTGS1, PTGS2
RouteTransdermal
StatusApproved
Sources: ClinicalTrials.gov, Kowa

Mechanism of Action

Molecular Targets

indometacin plaster acts on 2 molecular targets:

PTGS1prostaglandin-endoperoxide synthase 1 (COX3, PCOX1)
PTGS2prostaglandin-endoperoxide synthase 2 (GRIPGHS, hCox-2)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

indometacin plaster is developed for 2 unique indications across 2 therapeutic areas.

Therapeutic AreaConditionPhase
Gastrointestinal disordersAbdominal pain✓ Approved
Skin and subcutaneous tissue disordersPruritus✓ Approved

Related Research Articles

PubMedInternational dental journal2026-07-21

Effects of Structural Designs on the Accuracy, Dimensional Stability, and Material Consumption of Digital Light Processing-Printed Models.

Liu Huan H, Wang Jiaying J, Zhao Yanfang Y, Zhang Yan Y et al.

To evaluate the effects of 4 structural designs on the accuracy, long-term dimensional stability and material efficiency of digital light processing (DLP)-printed resin dental models. A reference digital cast was obtained by scanning a standard maxillary plaster model with a tabletop 3D scanner to create 4 types of structural designs, including complete palatal solid (CPS), complete palatal hollow (CPH), horseshoe-shaped solid (HSS) and horseshoe-shaped hollow (HSH) designs. Digital casts with 4 structural designs were printed with a 3D printer with DLP technology. Material consumption and printing time were recorded. Afterwards, the printed casts were scanned by using a scanner to obtain standard research digital casts. All of the reference models and research digital casts were imported into Geomagic software for comparison and analysis of trueness and precision. The dimensional stability of the resin-printed models with 4 distinct structures within 28 days was evaluated and analysed. Differences between the reference and research digital casts were quantitatively indicated by the root mean square (RMS) value. On day 1, the HSS group exhibited the greatest trueness, whereas the CPS group exhibited the lowest precision. The solid models (CPS and HSS) remained stable over the 28 days. However, the hollow models (CPH and HSH) significantly deviated after 7 days. The HSS design reduced the printing time by 19%, and the material consumption by 30% compared to CPS. The structural design significantly influences the accuracy and dimensional stability of 3D-printed models. The HSS design offers the optimal balance between stability and material efficiency, thus making it clinically advantageous. The accuracy of the models in all of the groups remained within the clinically acceptable range. The structural design significantly influences model performance. The HSS design offers clinically advantageous for maxillary dental models.

PMID 42480138
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PubMedBone & joint open2026-07-20

Incidence of nonunion after open tibia fractures in Malawi : associated factors and Radiographic Union Score for Tibial fractures reliability.

Schade Alexander Thomas AT, Dimock Richard R, Mendes da Costa Thomas T, Nohakhelha Nyamulani N et al.

Open tibia fractures are a common and severe injury in low-income countries (LICs), and worsened by fracture-related infection (FRI). The Radiographic Union Score for Tibial fractures (RUST) is widely used to assess fracture healing, but its reliability and factors associated with nonunion in LICs remain unclear. We conducted a multicentre prospective cohort study in six hospitals across Malawi, enrolling 287 adults with open tibia fractures between February 2021 and March 2022. Participants underwent standardized clinical and radiological follow-up at three, six, and 12 months post-injury. Fracture union at follow-up was assessed independently by two reviewers using the RUST score. Patient function was measured using the Short Musculoskeletal Function Assessment (SMFA) score. Multilevel regression models examined associations between RUST scores, functional outcomes, baseline factors, and treatment methods. Participants had a median age of 34 years (IQR 25 to 44), and 84% (248/287) were male. Overall, 45/177 (25.4%) of participants with open tibia fractures had a nonunion at one year, with 34.2% (13/38) with FRI having nonunion compared with 15.4% (20/130) no FRI (p = 0.001). After adjusting for other variables, compared with external fixation, intramedullary nailing (odds ratio (OR) 1.35, 95% credible interval (CrI) 0.98 to 1.93) and plaster of Paris (POP) fixation (OR 2.05, 95% CrI 1.29 to 3.64) were associated with higher RUST scores. Each one-point increase in RUST score was associated with -4.1 (95% CrI -6.2 to -2.1) SMFA score, reflecting better function. Interobserver reliability of RUST was moderate (ICC 0.51, 95% CI 0.28 to 0.61), despite 74% of radiographs being of suboptimal quality at one year. Nonunion is common after open tibia fracture in Malawi, particularly with external fixation and FRI. The RUST score is reliable and correlates with patient function in LIC settings, even with variable radiograph quality. Poor function should prompt a careful assessment for nonunion and consideration of intervention where appropriate.

PMID 42472625
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PubMedData in brief2026-07-19

Heritage cracks dataset: Superficial damage.

Garcia-Chiquito Maybelin C MC, Alonso-Guzmán Elia M EM, Guzmán-Torres José A JA, Martínez-Molina Wilfrido W

The Heritage Cracks dataset contains a total of 1,716 high-resolution images documenting superficial cracking in ignimbrite masonry and lime-based plaster surfaces from heritage buildings in the historic center of Morelia, Mexico, a UNESCO World Heritage Site. A total of 686 images were acquired under real field conditions using smartphone cameras along representative streets and architectural elements with visible deterioration, while 1,030 images were generated through data augmentation. The dataset was designed to support artificial intelligence applications for cultural heritage inspection, particularly object detection and computer vision-based damage assessment. All images were organized, preprocessed, automatically oriented, resized to 640 × 640 pixels, and manually annotated with bounding boxes by specialists in construction pathology. Crack selection considered visible damage associated with weathering, material degradation, structural adjustment, environmental exposure, erosion, overload effects, and biological activity. The dataset is divided into training, validation, and testing subsets; includes image, annotation files, configuration metadata, and documentation to facilitate reproducibility. Its structure allows direct use in deep learning workflows, including YOLO-based models and other object-detection architectures. By providing field-acquired images from real heritage construction systems, this dataset contributes to the development, evaluation, and benchmarking of non-invasive tools for crack detection, preventive conservation, and structural health monitoring. It is useful for researchers, engineers, conservation specialists, and developers working on AI-assisted inspection of vulnerable historic infrastructure in Latin American urban heritage contexts.

PMID 42472180
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PubMedMedical science monitor : international medical journal of experimental and clinical research2026-07-19

Influence of Scan Body Geometry, Implant Angulation, and Interimplant Distance on the Accuracy of Maxillary Full-Arch Digital Implant Scans: An In Vitro Study.

Ekin Ebru Sümer ES, Uyar Sozdar Başkan SB, Güler Merve M, Ayna Emrah E

BACKGROUND This study compared the accuracy of different scan body geometries under different implant angulation and interimplant distance conditions. Evidence regarding full-arch digital implant scanning under these conditions remains limited. MATERIAL AND METHODS In this in vitro study, 5 implants were placed in maxillary edentulous plaster models representing 3 implant systems (Bioinfinity, Meisinger, and Mode). The reference implant was positioned perpendicular to the ridge crest at the midline. Implant angulations (5° and 10°) and interimplant distances (5 mm and 10 mm) were standardized. Scan bodies were attached to the master model, and each model was scanned 10 times using an intraoral scanner (TRIOS 5). Three-dimensional deviations were calculated. Data were analyzed using 1-way ANOVA and Tukey HSD tests (alpha=0.05). RESULTS No significant differences were observed among the groups at 5° angulation (P>0.05), whereas significant differences were detected at 10° angulation for implants 1 and 5 (P<0.01). Bioinfinity showed higher deviation values at implant 1, while Meisinger demonstrated higher deviations at implant 5. At a 10-mm interimplant distance (implants 1 and 2), significant differences were found among the groups (P<0.001), with Bioinfinity exhibiting lower deviation values. At a 5-mm distance, no significant difference was observed at implant 4 (P>0.05), whereas a significant difference was found at implant 5 (P<0.001), with the highest deviation in the Meisinger group. CONCLUSIONS Increased implant angulation and interimplant distance are associated with reduced accuracy and higher deviation values in digital full-arch scans. The influence of scan body geometry varies depending on implant position.

PMID 42471755
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PubMedFrontiers in microbiology2026-07-17

Expanding genomic resources for heritage science: characterization of selected microbial isolates from salt-weathered historic sites.

Fürnwein Lukas L, Lehner Elias E, Tichy Johannes J, Waldherr Monika M et al.

On historic masonry and plaster, moisture-driven salt crystallization cycles impose mechanical stress and create niches for halophilic and halotolerant microbial communities. Halotolerant/halophilic microorganisms isolated from these man-made heritage environments are usually not as well characterized as those isolated from natural environments and represent a genetic and biotechnological potential that has not been thoroughly studied to date. This study provides insights into the genomes of five selected halophilic and halotolerant microorganisms isolated from two salt-weathered heritage sites in Austria: the subterranean St. Virgil Chapel beneath St. Stephen's Cathedral (13th century) and the Charterhouse Mauerbach (14th century). Isolates displaying coloration under 10-20% NaCl were sequenced using Oxford Nanopore long-read technology, yielding complete genomes and plasmids. Functional annotation focused on metabolic, osmoregulatory and pigment biosynthesis pathways to elucidate adaptive strategies underpinning their persistence under extreme salinity. Comparative genomic analyses revealed variations between the isolated strains with their respective references, as well as species-specific traits that have not been described in detail before and confirmed the presence of robust carotenoid pathways including bacterioruberin synthesis in Halococcus, mixed C40/C50 carotenoids in Nesterenkonia, and C30/C40 carotenoids in Halobacillus. Furthermore, two isolates, Marinobacter sp. 119-V2 and Modicisalibacter sp. 110-V3, likely represent novel taxa, indicating that salt-weathered heritage sites represent a specific environmental niche that selects for specific microbial colonizers. By integrating cultivation, phenotypic characterization, and genomic analysis, this work advances beyond descriptive community surveys toward mechanistic understanding of microbial functions relevant to conservation science. Genome-informed insights into pigment biosynthesis and osmotic stress response help predict microbial behavior under environmental or treatment-induced salinity fluctuations, supporting the development of targeted, scientifically grounded preservation approaches for salt-affected cultural heritage.

PMID 42466124
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PubMedEnvironmental research2026-07-16

Feasibility of using a novel optically filtered monochromatic portable X-ray fluorescence (MXRF) to quantify lead in wild bird bones.

Adesina Kolawole E KE, DiNatale James A JA, Costa Stephanie S SS, Faber Bethany B et al.

Lead (Pb) threatens wildlife and humans through neurological, cardiovascular, and renal damage. Conventional tissue Pb assessment relies on costly wet-lab methods such as inductively coupled plasma mass spectrometry (ICP-MS). Monochromatic X-ray fluorescence (MXRF) enables rapid, non-destructive, field-deployable Pb detection with lower detection limits than prior portable XRF systems. We evaluated the feasibility, calibration, attenuation correction, and ICP-MS agreement of a doubly curved crystal (DCC)-enhanced MXRF (X-ray Optical Systems, East Greenbush, NY) for bone Pb quantification in American black vultures (Coragyps atratus). Thirty-eight bird bones were analyzed ex vivo (n=19 femurs; n=19 tarsometatarsi[TMT]) using an HD Mobile XRF (1-mm spot;Mo anode;silicon drift detector;200s). Calibration used Pb-doped plaster phantoms (0-100ppm) with polymethyl methacrylate soft-tissue equivalents (0-5 mm). Spectra (10.0-13.6keV) were fit with a Gaussian Pb-peak on a smooth background and Compton sideband normalization. Matched samples were quantified by ICP-MS. Agreement was assessed by ordinary least squares (OLS) regression, Pearson r, Passing-Bablok, intraclass correlation coefficient (ICC; two-way, absolute), reduced major axis (RMA) regression, and Bland-Altman analysis. Detection limits were obtained using blank-and-slope calibration and 30 repeated measurements on two bones. Signal attenuated exponentially, limiting reliable quantification beyond ∼3mm soft tissue. Calibration was linear (counts vs. ppm: R2=0.996; phantom nominal vs. MXRF:R2=0.994). MXRF agreed closely with ICP-MS (femur r=0.959, ICC=0.933;TMT r=0.962,ICC=0.953). Bland-Altman mean biases were small (femur: -1.73μg/g; TMT: -0.42μg/g) without proportional bias. Passing-Bablok slopes approached unity (≈0.86-0.96) with small intercepts. Practical DLs were 1.79μg/g(femur) and 0.80μg/g(TMT) and are the relevant benchmarks for biological measurement; the calibration-derived instrumental DL of 0.03μg/g at 200 s is an idealized zero-matrix value. This DCC-based MXRF delivered rapid, non-destructive bone Pb estimates concordant with ICP-MS and low DLs. Attenuation correction and fixed geometry support ex vivo Pb surveillance, carcass triage, and program evaluation in birds, with extension to other species, including humans.

PMID 42457114
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