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indometacin plaster

✓ Approved

Kowa · PTGS1 · Small Molecule

What is indometacin plaster?

indometacin plaster is a small molecule developed by Kowa. It is approved for therapeutic indications via transdermal.

Drug Profile

CompanyKowa
Drug ClassSmall Molecule
Molecular TargetPTGS1, PTGS2
RouteTransdermal
StatusApproved
Sources: ClinicalTrials.gov, Kowa

Mechanism of Action

Molecular Targets

indometacin plaster acts on 2 molecular targets:

PTGS1prostaglandin-endoperoxide synthase 1 (COX3, PCOX1)
PTGS2prostaglandin-endoperoxide synthase 2 (GRIPGHS, hCox-2)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

indometacin plaster is developed for 2 unique indications across 2 therapeutic areas.

Therapeutic AreaConditionPhase
Gastrointestinal disordersAbdominal pain✓ Approved
Skin and subcutaneous tissue disordersPruritus✓ Approved

Related Research Articles

PubMedPolymers2026-09-15

Mechanical and Microstructural Performance of Different Plaster Mortars Used to Protect Interior Concrete Exposed to Elevated Temperatures.

Türkmen İbrahim İ, Gürkan Muhammed Şamil MŞ, Ekinci Enes E, Demirboğa Ramazan R et al.

The physical, mechanical, and microstructural degradation that occurs in concrete elements exposed to high temperatures constitutes an important research topic in terms of the fire safety and service performance of structures. In this study, the behavior of plaster mortars produced with cement-based and ground granulated blast furnace slag (GGBFS)-based binders, as well as normal concrete (interior concrete) specimens coated with these mortars, under high-temperature exposure was experimentally investigated. After the prepared mortars and plastered concrete specimens were exposed to temperatures of 100, 300, 500, and 700 °C, changes in compressive strength, ultrasonic pulse velocity (UPV), water absorption, mass loss, and bulk density were evaluated. Analysis of the experimental results showed that high temperatures, particularly 300 °C and above, caused significant performance losses in all binder systems. Although calcium aluminate cement-based mortars developed high early-age strength, they exhibited more pronounced strength losses under elevated temperatures, whereas geopolymer-based binders demonstrated more stable performance at low and medium temperatures. Additionally, a strong correlation (R2 ≈ 0.89) was observed between UPV and compressive strength in the plastered interior concrete specimens. At 500 and 700 °C, the plastered concrete specimens exhibited 9.8-13.3% and 10.4-18.1% higher residual compressive strength, respectively, compared with the unplastered control specimens. At 700 °C, the PC-based plaster provided the highest improvement in residual compressive strength (18.1%), while the G-Na system exhibited the lowest water absorption, which was 19.5% lower than that of the control concrete. Plastered concrete specimens retained their mechanical and physical properties better than the control (unplastered) concrete specimens at all temperature levels, and this finding was further supported by microstructural analyses. The results indicate that plaster systems produced with different binders are effective in limiting thermal damage to the interior concrete.

PMID 42737114
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PubMedSensors (Basel, Switzerland)2026-09-15

Design and Fitting Performance of a 3D-Printed Personalized Upper-Limb Socket: A Comparative Case Report.

Díaz-Fernández J Carlos JC, Roda-Sales Alba A, Gonell-Cruz Carlos C, Llop-Harillo Immaculada I

The prosthetic socket is the essential interface between the residual limb and the prosthesis. However, traditional upper-limb sockets are highly sensitive to residual-limb volume fluctuations and rely on experience-dependent manual fabrication processes. Additive manufacturing and 3D scanning technologies offer the possibility of producing personalized sockets, potentially improving accessibility, repeatability, and cost-effectiveness. Despite this potential, there is still a lack of systematic experimental validation directly comparing the fitting performance of personalized 3D-printed sockets with that of conventionally manufactured sockets. This study presents the design, fabrication, and comparative validation of a personalized 3D-printed upper-limb socket and a traditionally manufactured socket produced for the same user. The 3D-printed socket was developed from a 3D scanning of a clinically rectified plaster mold, computer-aided design, and material extrusion by thermal reaction bonding. A comparative validation framework evaluated both sockets under equivalent conditions, including mechanical testing, thermal behavior assessment, and sensorized fitting measurements. The results provide quantitative evidence on how a personalized 3D-printed socket performs relative to a traditional socket in terms of structural behavior, thermal patterns, and interface-related fitting parameters. This work contributes objective data supporting 3D-printed personalized sockets as a technically feasible and promising alternative to conventional methods.

PMID 42739994
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PubMedApplied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine2026-09-15

Natural radioactivity and radiological hazard assessment of sand used for construction in South Korea.

Jeong S H SH, Choi J G JG, Hwang S R SR, Bae D U DU et al.

Sand is widely used in concrete, mortar and plaster, but its natural radioactivity has received little systematic attention in South Korea. This study provides a descriptive, screening-oriented assessment of 50 construction sand samples obtained over approximately one year from multiple supply sites; regional identifiers were available for 33 samples and unavailable for 17 (34%). Mean activity concentrations were 31.2, 52.3 and 944.2 Bq/kg for 226Ra, 232Th and 40K, respectively. Mean radium equivalent activity was 178.7 Bq/kg, and 45 samples had Iγ ≤ 1. The model-based mean indoor annual effective dose and excess lifetime cancer risk were 0.79 mSv/y and 2.78 × 10-3, respectively; these are screening estimates, not measurements of personal exposure or cancer risk. 40K contributed 40.7% of mean radium equivalent activity and 46.7% of mean indoor absorbed dose rate. Nineteen samples had 40K above 1 Bq/g, two had 226Ra above 0.1 Bq/g and one had 232Th above 0.1 Bq/g; these are definition-level observations under Korean law, not stand-alone use limits or non-compliance determinations. None reached the separate registration concentration levels. At the default indoor occupancy factor of 0.8, 11 calculated AEDE values exceeded 1 mSv/y, but these generic-model results do not demonstrate finished-product non-compliance. Because sampling was not probability based and regional metadata were incomplete, the results characterize only the analyzed sample set and not nationwide averages.

PMID 42743649
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PubMedShanghai kou qiang yi xue = Shanghai journal of stomatology2026-09-15

[A study on the clinical effects of resin hybrid ceramic inlays in restoring posterior tooth defects].

Xu Zhou Z, Liu Kaiwei K, Long Qiao Q, Lu Weiqing W et al.

To compare and evaluate the clinical effects of glass ceramics and resin hybrid ceramics for inlay restorations, thereby providing guidance for the selection of inlay restoration materials. Forty patients with posterior tooth defects who underwent inlay restoration at the Department of Prosthodontics, Putuo District Eye and Tooth Disease Control and Prevention Hospital from January 2023 to February 2023 were selected and randomly divided into two groups, which were further categorized based on the material used: lithium disilicate glass-ceramic (e.max ceramic) in the control group, while resin-matrix composite ceramic (Enamic) in the experimental group. Follow-up visits were conducted at 6, 12 and 24 months post-restoration. The restoration effects were evaluated through intraoral examinations according to the modified United States Public Health Service(USPHS) criteria, and plaster models were made to observe the surface conditions of the restorations under scanning electron microscope (SEM). In the Enamic group, 19 restorations achieved grade A in all indices, with a success rate of 95%; while in the e.max group, 15 restorations achieved grade A in all indices, with a success rate of 75%. There was no significant difference in the success rates between the two groups of inlays (P＞0.05). The resin hybrid ceramic demonstrates excellent clinical restoration outcomes after two years, making it a favorable choice for inlay. However, further validation is still needed to compare the long-term clinical performance between VITA Enamic and IPS e.max.

PMID 42736249
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PubMedHead & face medicine2026-09-11

Evaluation of precision and trueness of intraoral scanners for newborns with cleft lip and palate: 3D analysis of digital models.

Schell Juliana-Theresa JT, Braumann Bert B, Kruse Teresa T, Achterrath Sarah S et al.

Children born with cleft lip and palate (CLP) require intensive interdisciplinary care from birth onward. Intraoral scanners (IOS) have emerged as a promising alternative for neonatal maxillary data acquisition. This study evaluated the precision and trueness of five commonly used IOS using a standardized landmark-based methodology complemented by full-surface deviation analysis, applied to neonatal maxillary models with increasing morphological complexity. Three neonatal plaster casts were digitized: An edentulous maxilla without cleft, a unilateral and a bilateral cleft maxilla. Ten pyramidal landmarks defining five transversal distances were constructed along the alveolar ridge. These resulting digital master models (DMM) were 3D-printed (Formlabs Form 2, 25 μm) and their dimensional fidelity independently verified by digital caliper (± 0.01 mm). Each printed model was scanned ten times by the same operator using Primescan, CS3600, Trios 3, iTero Element 2 and Medit i500. Linear trueness and precision were quantified in Rhinoceros 3D. Full-surface trueness was assessed in Geomagic Control 3D using a standardized alignment protocol. Statistical analysis was performed using the Kruskal-Wallis test and Mann-Whitney U post-hoc tests (p < 0.05). Trueness varied between IOS and depended on the combination of device and cleft morphology. Mean signed linear deviations were minimal in the non-cleft model (all scanners within ± 0.03 mm) and reached - 0.147 mm for Medit in the bilateral cleft model, where Primescan and Trios remained essentially unbiased in the non-cleft and bilateral cleft models. Between-scanner differences were significant in both cleft models (p < 0.001). Intra-scanner reliability, an aspect of precision, ranged from ICC 0.832 to 1.000. Full-surface trueness differed significantly between scanners in all three models (p < 0.01). Mean RMS deviations remained below 0.07 mm for four of the five devices in every model, whereas iTero reached 0.224 mm in the bilateral cleft model. Compared with the non-cleft model, in-tolerance percentages decreased in both cleft models, most markedly in posterior and undercut regions. Under in-vitro conditions, all IOS digitized neonatal maxillary anatomy with high technical accuracy. Trueness and precision depended on the combination of device and cleft morphology rather than on morphological complexity alone, but all IOS captured the relevant morphological features. Clinical feasibility in neonates was not assessed and remains to be established in in-vivo studies. Not applicable.

PMID 42723089
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PubMedFrontiers in pediatrics2026-09-10

Elastic intramedullary nailing for recurrent radial fracture associated with persistent ulnar bowing deformity in a pediatric patient: a case report.

Yang Wenrong W, Pu Guangmin G, Zhao Zhigang Z, Yang Shuchun S et al.

Pediatric forearm bowing fracture is an occult incomplete injury with a high misdiagnosis rate. Persistent ulnar bowing deformity is a potential risk factor for recurrent radial fracture due to altered forearm biomechanical stress distribution, and unified management protocols for this combined injury remain lacking. This case report describes the diagnosis and treatment of an 8-year-old girl who sustained a second ipsilateral radial fracture four years after an initial forearm trauma accompanied by ulnar bowing deformity at 4 years old, aiming to provide practical clinical evidence and generate preliminary treatment hypotheses for this clinical scenario. The patient, an 8-year-old girl, first presented at 4 years old with a middle-distal third radial fracture concurrent with ulnar diaphyseal bowing deformity. Initial management consisted of closed manual reduction and splint immobilization, and no corrective intervention was performed for the ulnar bowing deformity. Four years following the initial injury, she fell and sustained a displaced recurrent radial fracture at the middle-proximal third of the same forearm. Closed manipulative reduction and plaster casting failed to sustain adequate fracture alignment, prompting surgical intervention with open reduction and elastic intramedullary nailing to repair the radial fracture; the pre-existing ulnar bowing deformity was left unaddressed intraoperatively. At the two-month postoperative follow-up, elbow and forearm function were fully preserved, with only mild residual forearm angular deformity and no functional deficits noted. No surgical complications occurred, and the family tolerated the mild residual deformity. This single case observation generates a preliminary clinical hypothesis rather than universal clinical guidance: Elastic intramedullary nailing serves as a safe and reliable minimally invasive surgical option for children with recurrent displaced radial fractures when conservative treatment yields unsatisfactory reduction maintenance. Additional corrective osteotomy is not indicated for pediatric patients presenting with mild ulnar bowing deformity, normal inner-epiphyseal ulna-radius length ratio. Targeted treatment focused solely on the radial fracture can achieve satisfactory radiological recovery and short-term functional outcomes in this patient population.

PMID 42719112
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