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indometacin plaster

✓ Approved

Kowa · PTGS1 · Small Molecule

What is indometacin plaster?

indometacin plaster is a small molecule developed by Kowa. It is approved for therapeutic indications via transdermal.

Drug Profile

CompanyKowa
Drug ClassSmall Molecule
Molecular TargetPTGS1, PTGS2
RouteTransdermal
StatusApproved
Sources: ClinicalTrials.gov, Kowa

Mechanism of Action

Molecular Targets

indometacin plaster acts on 2 molecular targets:

PTGS1prostaglandin-endoperoxide synthase 1 (COX3, PCOX1)
PTGS2prostaglandin-endoperoxide synthase 2 (GRIPGHS, hCox-2)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

indometacin plaster is developed for 2 unique indications across 2 therapeutic areas.

Therapeutic AreaConditionPhase
Gastrointestinal disordersAbdominal pain✓ Approved
Skin and subcutaneous tissue disordersPruritus✓ Approved

Related Research Articles

PubMedWest African journal of medicine2026-05-24

Long-term Outcomes of Low-Energy Open Tibial Shaft Fractures: A 10-Year Follow-up Study of Infection Rates.

Adedire A A, Oluwadiya K S KS, Ajibade A A, Faniyi A J AJ et al.

Low-energy open tibial shaft fractures present a clinical challenge, particularly in resource-limited settings. While high-energy injuries have been widely studied, the long-term outcomes of low-energy mechanisms remain underreported. This study assessed the clinical outcomes and long-term complications of cast immobilization following surgical debridement in patients with low-energy open tibial shaft fractures. A prospective study was conducted over ten years at UNIOSUN Teaching Hospital, Osogbo, Nigeria. Sixty-six patients with Gustilo-Anderson type I or II open tibial shaft fractures caused by low-energy mechanisms were enrolled. Data were collected on demographics, injury characteristics, treatment timelines, and outcomes. Follow-up assessments were performed at 1, 5, and 10 years post-treatment to evaluate bone union, joint stiffness, and chronic osteomyelitis. The majority of patients were male (77.3%) and young adults (57.6%). Most injuries were due to road traffic accidents (78.8%). All patients were managed by surgical debridement followed by plaster cast immobilization. Primary wound closure was delayed in 59.1% of cases. Bone union complications were observed in 16.7% of patients at 1 year, decreasing to 10.6% at 5 years, and 6.1% at 10 years. Joint stiffness was reported in 3.0% at 1 year but resolved by year 5. Chronic osteomyelitis occurred in 7.6% at 1 year and declined to 4.5% at 10 years. Overall, the majority of patients achieved satisfactory wound healing and functional outcomes. Cast immobilization following timely debridement remains a viable treatment for low-energy open tibial shaft fractures in low-resource settings, with a low rate of long-term complications. Early intervention and adequate follow-up are critical to optimizing outcomes.

PMID 42177835
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PubMedEuropean journal of orthodontics2026-05-22

Evaluation of imaging protocols for detecting tooth ankylosis using different CBCT devices: an in vitro study.

Özel Şelale Ş, Köse Taha Emre TE, Şatır Samed S

To compare the diagnostic accuracy of CBCT images acquired with different imaging protocols for detecting tooth ankylosis. Thirty extracted permanent teeth (20 single-rooted, 10 three-rooted) were prepared; ankylosis was simulated in 20 by selectively removing Teflon from roots previously coated to mimic the periodontal ligament. Samples were embedded in stone plaster and imaged using 4 protocols on 2 CBCT units. CBCT images were primarily evaluated by a blinded radiologist (present/absent). Micro-CT was performed on 20% of specimens to verify the model. Agreement and accuracy metrics (Fleiss/Cohen κ, sensitivity, specificity, PPV, NPV) were calculated. Protocol 2 (0.25 mm voxel) showed the most favorable performance (κ = 0.113; sensitivity 71.4%; PPV 52.6%; NPV 60%). Protocol 3 (0.35 mm voxel) performed worst (κ = -0.104; sensitivity 53.8%; PPV 43.8%; NPV 45.5%). Except for Protocol 3, sensitivity was high (≥71.4%) while specificity remained low (35.7%-42.9%). The study has its own limits. Different imaging protocols using in clinical practice to detect ankylosis can be investigated as well to provide different approaches assessing ankylosis. CBCT demonstrated high sensitivity but low specificity for ankylosis detection, indicating a propensity for false positives. Smaller voxel sizes (0.25-0.30 mm) improved detection, whereas 0.35 mm was least reliable.

PMID 42172532
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PubMedJournal of pediatric orthopedics2026-05-19

Comfort and Ease of Care in Pediatric Hip Spica Casts: A Comparison of Fiberglass Versus Plaster of Paris.

Estefania McKinley-Pacheco MP, Ramirez-Schneider Laura Cecilia LC, Zaldivar Brandon B, Sergio Nossa-Almanza NA et al.

Pediatric patients with femur fractures or those undergoing pelvic surgery for dysplasia or dislocation require immobilization with a spica cast to maintain reduction, protect the correction, and ensure adequate rehabilitation. Materials used for immobilization include plaster of Paris (POP) and fiberglass casts. The study objective is to compare fiberglass spica cast immobilization with plaster of Paris in terms of comfort and ease of care. A prospective cohort study comparing the comfort and ease of care of pediatric patients immobilized with a spica cast POP and fiberglass was conducted, encompassing patients treated between 2022 and 2025. Outcomes were assessed using an observer-rated outcome (ObsRO) questionnaire adapted from the one described by Inglis and colleagues, and the correlation between the ObsRO score and the constructs of comfort and ease of care was assessed using Pearson correlation coefficient. In addition, complication rates and cast modifications by spica material were reported. The median ObsRO questionnaire score was higher for fiberglass than for POP (P<0.001). The Pearson correlation matrix between this questionnaire and the constructs for validity yielded 0.59 and 0.63 for comfort and ease of care, respectively. There was no statistically significant difference in adverse events related to each material. The fiberglass pelvic spica cast is more comfortable and easier to care for than plaster of Paris in immobilized pediatric patients. There were no differences in complication rates between the 2 materials. Level II.

PMID 42153642
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PubMedBone & joint open2026-05-19

Negotiating research in the Emergency Department: a qualitative study of staff experience of the Distal Radius Acute Fracture Trial CAst versus SPlint (DRAFT3-CASP) RCT for distal radius fractures.

Phelps Emma E EE, Tutton Elizabeth E, Gould Jenny J, Baird Liz L et al.

We sought to explore staff experience of conducting an orthopaedic trauma randomized controlled trial (RCT) in the Emergency Department (ED). The Distal Radius Acute Fracture Trial: CAst versus SPlint (DRAFT3-CASP) RCT explores the effectiveness of two treatment pathways for patients with a fracture of the distal radius that does not require manipulation. These are, a plaster cast which is removed four to six weeks later in a fracture clinic, and discharge from emergency care with a wrist splint that patients remove themselves. A total of 20 multidisciplinary staff recruiting to the DRAFT3-CASP RCT from 14 NHS trusts across England took part in a telephone/online qualitative interview. Interviews were informed by Heideggerian Phenomenology and data were analyzed using thematic analysis. The findings highlight the struggle to undertake research in emergency settings through the overarching theme 'negotiating research'. Staff identified three enablers of research: 1) fitting within clinical practice; 2) finding meaning; and 3) being supported. The fast pace of work and high service demand in emergency care prevented clinical staff from fully engaging with the study. Research delivery staff were vital and supported screening, recruitment, and data collection. Finding meaning in the research question by linking it to patient benefit helped staff to maintain enthusiasm despite the challenges encountered. Negotiating research in the ED is challenging. Protected time is essential for clinical staff to undertake research training and recruitment. Research delivery teams with research expertise are vital for successful recruitment. Increased investment in research delivery staff can ensure patients are given the opportunity to take part in research studies and can promote enthusiasm for research.

PMID 42153233
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PubMedWiadomosci lekarskie (Warsaw, Poland : 1960)2026-05-15

An assessment of the results of self-monitoring after conservative treatment of hand and wrist fractures.

Żyluk Andrzej A, Piotuch Bernard B, Kotowski Maciej Jozef MJ

Aim: The objective of this study was to evaluate the effectiveness and safety of this method after simple fractures of the hand and wrist. Materials and Methods: 202 patients, 117 males (58%) and 85 females (42%) at mean 57 years of age, with stable, non- or minimally displaced hand and wrist bone fractures were enrolled in the study. Patients were treated conservatively by immobilization in a plaster or thermoplastic splint, or functionally, without any immobilization. After one visit to the clinic and receiving instructions on how to deal with a broken finger or hand, the patients were dismissed with recommendation to remove the plaster splint after 4-5 weeks and start using the hand. After 2 months all patients were interviewed by phone, asking about the course of treatment and satisfaction with this method of care. Results: 179 patients (89%) were fully satisfied with the self-monitoring program, and 23 (11%) were partially satisfied. The most common problems in these patients were pain at the fracture site and limited mobility of the affected finger or wrist. No complications requiring hospitalization and surgery were found. Conclusions: The change in the post-fracture care system from a traditional to a self-monitoring has shown great effectiveness and safety for patients. This improved the work of the hand clinic, improved patients' access, increased satisfaction and reduced costs.

PMID 42139607
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PubMedCureus2026-05-15

Rapid Low-Cost Production of a Patient-Specific Thumb Orthosis Using Smartphone Light Detection and Ranging (LiDAR) Scanning and Three-Dimensional (3D) Printing.

Papadakis Konstantinos K, Mileva-Popova Rene D RD, Yanev Krasimir K KK, Peychinov Dimitar D et al.

Three-dimensional (3D) printing technologies are increasingly used to produce patient-specific orthoses. Traditional manufacturing methods, such as plaster casting, are fast to apply but produce heavy, non-removable, and poorly ventilated immobilization devices. Many digital workflows for producing custom orthoses require expensive scanners and commercial software, limiting their widespread clinical use. This technical report presents a rapid, low-cost workflow for producing a patient-specific orthosis using a smartphone's light detection and ranging (LiDAR) scanner, free software, and fused deposition modeling (FDM) 3D printing. The workflow included 3D scanning of the injured limb using an iPhone 15 Pro LiDAR scanner (Apple Inc., Cupertino, CA, USA), mesh processing and region selection in Meshmixer (Autodesk, Inc., San Rafael, CA, USA), orthosis shell generation in Shapr3D (Shapr3D Zrt., Budapest, Hungary) with a shell thickness of 2-2.4 mm, integration of fixation elements for Velcro straps, print preparation, and additive manufacturing using an FDM 3D printer (Bambu Lab X1C; Bambu Lab, Shenzhen, China) with polylactic acid (PLA) filament. The orthosis was designed for thumb immobilization and fixed using three Velcro straps positioned around the wrist, thumb, and metacarpal region. The total production time from scanning to orthosis placement was approximately three hours. The scanning and digital modeling process took less than one hour, while the 3D printing process was the main time-consuming step. The final orthosis weighed 43 g, was ventilated, removable, and appeared to provide adequate immobilization of the thumb and wrist. The presented workflow enables rapid, low-cost, and accessible production of patient-specific orthoses using consumer-grade hardware and free software. The method enables same-day orthosis production and may be particularly useful in emergency departments, outpatient clinics, and educational settings where rapid, personalized immobilization is required.

PMID 42137666
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