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Factor VIII

✓ Approved

Quimbiotec · F8 · Cell-based Therapies

What is Factor VIII?

Factor VIII is a cell-based therapies developed by Quimbiotec. It is approved for therapeutic indications via injectable (others) or intravenous (iv).

Drug Profile

CompanyQuimbiotec
Drug ClassCell-based Therapies
Molecular TargetF8
RouteInjectable (Others), Intravenous (IV)
StatusApproved
Sources: ClinicalTrials.gov, Quimbiotec

Mechanism of Action

Molecular Targets

Factor VIII acts on 1 molecular target:

F8coagulation factor VIII (AHF, FVIII)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

Factor VIII is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Congenital, familial and genetic disordersFactor VIII deficiency✓ Approved

Related Research Articles

PubMedFrontiers in psychology2026-05-25

Altered regional homogeneity in Parkinson's disease with mild cognitive impairment: a resting-state fMRI study.

Zhu Xudong X, Zhou Jiaojiao J, Wei Qiancheng Q, Pu Hong H et al.

To explore changes in regional homogeneity (ReHo) of brain function in patients with Parkinson's disease with mild cognitive impairment (PD-MCI) using resting-state functional magnetic resonance imaging (rs-fMRI), and to analyze the correlation between ReHo values in differential brain regions and cognitive function, so as to identify potential neuroimaging biomarkers for PD-MCI. A total of 43 patients with PD were enrolled and divided into the PD-MCI group (n = 23) and the PD with normal cognitive function (PD-NC) group (n = 20). Additionally, 20 healthy controls (HC) were recruited. The ReHo method was used to evaluate differences in functional consistency of brain regions, and the Montreal Cognitive Assessment (MoCA) scale was employed to assess cognitive function. Further, a correlation analysis was performed between the ReHo values of each brain region and MoCA scores in patients with PD-MCI and PD-NC and the receiver operating characteristic (ROC) curve was used to evaluate the discriminative efficacy of these brain regions for PD-MCI. Compared with the PD-NC group, the PD-MCI group showed significantly decreased ReHo values in the right middle frontal gyrus and right superior frontal gyrus (t = -3.3113, -4.1326, both p < 0.05), and significantly increased ReHo values in the right cerebellar lobule VIII, left inferior temporal gyrus, and right fusiform gyrus (t = 4.9059, 2.9759, both p < 0.05). MoCA scores were negatively correlated with ReHo values in the right cerebellar lobule VIII, left inferior temporal gyrus, and right fusiform gyrus (r = -0.5597, -0.6239, p < 0.05), and positively correlated with ReHo values in the right middle frontal gyrus and right superior frontal gyrus (r = 0.5690, 0.5296, p < 0.05). ROC analysis showed that the ReHo values of the right cerebellar area VIII and the left inferior temporal gyrus had high efficacy in distinguishing PD-MCI from PD-NC, with an area under the curve (AUC) of 0.9326. Functional abnormalities in brain regions including the right middle frontal gyrus, right superior frontal gyrus, right cerebellar lobule VIII, left inferior temporal gyrus, and right fusiform gyrus are closely associated with the occurrence and development of PD-MCI. ReHo indicators in these regions are promising potential neuroimaging biomarkers for auxiliary diagnosis and monitoring the progression of PD-MCI.

PMID 42183505
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PubMedInternational journal of public health2026-05-25

Japanese version of the motivation to change lifestyle and health behaviors for dementia risk reduction scale: a cross-cultural validation.

Nakai Fumiya F, Horigome Toshiro T, Fujikawa Mayu M, Horie Haruaki H et al.

This study examined the reliability and validity of a Japanese version of the Motivation to Change Lifestyle and Health Behaviors for Dementia Risk Reduction (MCLHB-DRR) scale, which assesses the motivation to change lifestyle and health behavior for preventing major neurocognitive disorder based on the health belief model. The scale was translated using Brislin's translation model. A total of 500 Japanese adults aged 40-89 years were recruited online. The translated version was evaluated for content validity, internal consistency, and test-retest reliability over 2 weeks. Exploratory factor analysis revealed a seven-factor model that explained 58% of the variance. Cronbach's α was >0.7 for all seven subscales and item-total correlations were significant for all items. Confirmatory factor analysis exhibited a moderate fit, and the factor loadings were significant for all items. ICC (1,1) showed moderate test-retest reliability. The Japanese version of the MCLHB-DRR test showed high reliability and validity among Japanese older adults.

PMID 42181985
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PubMedFrontiers in plant science2026-05-25

Extreme low temperature is the key meteorological limiting factor for winter wheat yield in Shihezi.

Zhang Shuai S, Hu Haonan H, Peng Jingting J, Zhai Jianrong J et al.

In the background of global climate change, extreme weather events occur frequently, leading to various agricultural meteorological disasters worldwide. However, the key meteorological limiting factor for winter wheat (Triticum aestivum L.) production in Shihezi (Xingjiang, China) remains unclear. Clarifying this factor is a core prerequisite for ensuring regional food security. In this study, standard anomaly (s) was used to define extreme climate conditions (extreme: ≤ -2.0 s or ≥ 2.0 s; moderate: -2.0 s ~ 2.0 s). Based on long-term series (1980- 2024) winter wheat yield data and daily meteorological datasets (precipitation, sunshine hours, average temperature, average maximum temperature, average minimum temperature, average wind speed) from the Wulanwusu Agricultural Meteorological Experimental Station, we quantified the impact of each meteorological factor on yield using the yield loss ratio (YLR). The results showed that extreme low temperature (average minimum temperature ≤ -2 s) is the key limiting meteorological factor for winter wheat yield in Shihezi, causing a yield reduction of 43.58%, significantly higher than the impacts of extreme wet (-12.60%) and extreme high temperature (-13.54%). Moreover, extreme low temperature mainly exacerbates yield loss by inhibiting 1000-grain weight during the tillering stages (r=-0.302). This study identified the core meteorological limiting factors and their mechanisms for winter wheat yield in Shihezi, providing a scientific basis for optimizing stress-resistant and stablecultivation techniques and formulating climate-adaptive management strategies for regional winter wheat production.

PMID 42179501
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PubMedAssessment2026-05-25

On the Structure of Fears of Evaluation: Testing for a General Factor and Its Validity in Bifactor Models.

Zhang Yifei Y, Chen Junwen J, Lv Sixuan S, Turel Ofir O et al.

The Bivalent Fear of Evaluation model posits that individuals with social-anxiety experience both Fear of Negative Evaluation (FNE) and Fear of Positive Evaluation (FPE). Previous research has empirically supported a two-factor structure comprising FNE and FPE. More recently, theoretical reviews and empirical studies have turned to a broader construct, Fear of General Evaluation (FGE). Here, we sought to examine the existence and validity of FGE in two samples (644 Chinese undergraduates and 448 junior high school students). We captured two distinct measures of FNE and FPE, along with mental-health outcomes (social anxiety, generalized anxiety, and depression). The findings showed that both the two-factor and bifactor models fit the data well, with a slightly better fit for the bifactor model. The bifactor diagnostics also suggested that a reliable general factor likely exists. Moreover, FGE showed a clear pattern of criterion-related associations, relating most strongly to social anxiety and more moderately to generalized anxiety and depression. In conclusion, our results advance a plausible bifactor account of fears of evaluation, emphasizing the role of FGE in social anxiety and outlining implications for clinical practice.

PMID 42178146
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PubMedBMC psychology2026-05-25

Psychometric properties of the Vietnamese version of the 12-item HIV stigma scale (HSS-12) among people living with HIV in Vietnam.

Thuong Cao Nguyen Hoai CNH, Thu Nguyen Vu Anh NVA, Cam Bui Hong BH, Nhan Le Minh LM et al.

HIV-related stigma remains a major psychosocial challenge affecting mental health, healthcare engagement, and quality of life among people living with HIV. Reliable and culturally appropriate brief instruments are essential for stigma assessment in both research and clinical practice; however, validated Vietnamese measures remain limited. This study aimed to evaluate the psychometric properties of the Vietnamese version of the 12-item HIV Stigma Scale (HSS-12). A cross-sectional study was conducted among 245 people living with HIV receiving antiretroviral therapy at a primary healthcare facility in Ho Chi Minh City, Vietnam. Internal consistency was assessed using Cronbach's alpha. Test-retest reliability was evaluated in a subsample of 56 participants over a 4-week interval using the intraclass correlation coefficient (ICC). Construct validity was examined using confirmatory factor analysis (CFA), comparing a hypothesized four-factor model with a one-factor alternative model. Convergent validity was assessed through correlations with depressive symptoms (Patient Health Questionnaire-9; PHQ-9) and perceived social support (Multidimensional Scale of Perceived Social Support; MSPSS). The Vietnamese HSS-12 demonstrated good internal consistency (Cronbach's alpha = 0.85) and excellent test-retest reliability (ICC = 0.95). CFA supported a four-factor structure with improved model fit after allowing correlations between item residuals (CFI = 0.962; TLI = 0.945; RMSEA = 0.064; SRMR = 0.050), whereas the one-factor model showed poor fit. Convergent validity was supported by positive correlations between HSS-12 scores and PHQ-9 scores, and negative correlations with MSPSS scores, except for the disclosure concerns subscale. The Vietnamese version of the HSS-12 is a reliable and valid instrument for assessing perceived HIV-related stigma among people living with HIV in Vietnam. This brief measure may facilitate standardized stigma assessment in psychological research and routine care settings.

PMID 42178585
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PubMedCureus2026-05-25

Multi-species Microbial Modulation of the RANK/RANKL (Receptor Activator of Nuclear Factor κB/Receptor Activator of Nuclear Factor κB Ligand) Pathway Induces Osteoclastogenic Priming in Apical Periodontitis.

Gutiérrez-López Victoria Alejandra VA, Martínez-Martínez Rita Elizabeth RE, Alderete-Hernández José Manuel JM, López-González Emmanuel E et al.

Apical periodontitis (AP) is a prevalent inflammatory condition affecting the periapical tissues surrounding the tooth root, often initiated by microbial invasion.  Objective: The objective of this study is to evaluate the osteoclastogenic priming effects of microbial species associated with primary and secondary AP on human macrophages and to determine their capacity to modulate the RANK/RANKL-OPG (receptor activator of nuclear factor kappa-B, receptor activator of nuclear factor kappa-B ligand, osteoprotegerin) pathway​. THP-1 monocytes/macrophages were stimulated with live bacteria, with or without RANKL, and analyzed for RANK/RANKL/OPG expression by flow cytometry. Cytokine levels (interleukin-1β (IL-1β), tumoral necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10 (IL-10), interleukin-12p70 (IL-12p70)) were measured using cytometric bead arrays.  Results: Macrophages challenged with Enterococcus, Streptococcus, Actinomyces, and Candida exhibited an increase in RANK⁺, RANKL⁺, and RANK⁺RANKL⁺ cellular populations. Enterococcus and Candida promoted sustained RANK/RANKL expression across conditions, while Streptococcus and Actinomyces elicited significant double-positive cell expansion. Early microbial stimulation triggered robust TNF-α, IL-1β, and IL-6 production, peaking with Streptococcus intermedius, Enterococcus faecalis, and Actinomyces, followed by a decrease at 96 hours. In contrast, IL-8 secretion remained high among species and time points, with Actinomyces inducing the strongest response. Our data suggest that AP-associated bacteria can induce osteoclastogenic priming and promote the release of pro-inflammatory cytokines via RANK/RANKL activation, indicating a potential role in the early processes leading to periapical bone resorption.

PMID 42181479
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