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collagenase (Plaquase / Nucleolysin / lipolysin)

✓ Approved

Johnson & Johnson Services, Inc. · therapeutic agent

What is collagenase?

collagenase is a therapeutic agent developed by Johnson & Johnson Services, Inc.. It is approved for therapeutic indications via injectable (others) or topical.

Drug Profile

Brand NamesPlaquase, Nucleolysin, lipolysin
CompanyJohnson & Johnson Services, Inc.
RouteInjectable (Others), Topical
StatusApproved
Sources: ClinicalTrials.gov, Johnson & Johnson Services, Inc.

Therapeutic Indications

collagenase is developed for 10 unique indications across 7 therapeutic areas.

Therapeutic AreaConditionPhase
Skin and subcutaneous tissue disordersDecubitus ulcer✓ Approved
Injury, poisoning and procedural complicationsThermal burn✓ Approved
Skin and subcutaneous tissue disordersDiabetic foot✓ Approved
Musculoskeletal and connective tissue disordersDupuytren's contracture✓ Approved
Eye disordersGlaucoma✓ Approved

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Related Research Articles

PubMedPlastic and reconstructive surgery. Global open2026-09-17

Collagenase Versus Operative Management for Dupuytren Contracture: A Propensity-matched Cohort of 16,888 Patients.

Tanas Yousef Y, Chen Stephen S, Zak Peter P, Bhatti Hamza H et al.

Dupuytren contracture (DC) is a fibroproliferative disorder of the palmar fascia, commonly managed through enzymatic collagenase injections or surgical interventions such as fasciotomy or fasciectomy. This study aims to compare clinical outcomes and complication rates between patients undergoing collagenase injection and those receiving surgical treatment for DC. Using the TriNetX US Collaborative Network, a retrospective cohort study was conducted including 8444 patients who underwent collagenase injection and 8444 propensity score-matched patients who received surgical management for DC. Key outcomes assessed included postoperative infection, hematoma, nerve injury, reintervention rates, functional outcomes (occupational therapy utilization), and emergency room visits. Risk differences, risk ratios, and odds ratios (OR) were calculated using risk analysis. Follow-up was 180 days. Collagenase treatment was associated with significantly lower risks of postoperative infection (0.7% versus 1.4%, OR 0.49, P < 0.001) compared to surgery. Nonetheless, collagenase was associated with a significantly higher reintervention rate (31.7% versus 16.2%, OR 2.40, P < 0.001). No significant differences were observed in iatrogenic nerve injuries (0.2% in both groups), hematoma (0.3% in both groups), functional outcomes (35.9% versus 36.7%, P = 0.284), or emergency room utilization (24.6% versus 24.5%, P = 0.915). Collagenase injection for DC is associated with fewer short-term complications but nearly doubles the risk of reintervention compared to surgical management.

PMID 42751438
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PubMedInflammopharmacology2026-09-17

Liposomal curcumin nanocarrier ameliorates synaptic dysfunction after intracerebral hemorrhage.

Saberi Kianoush K, Ghadiminia Nikki N, Mamataliyev Abdumalik A, Turaev Telmon T et al.

Neuroinflammation and synaptic dysfunction in the medial prefrontal cortex (mPFC) contribute to cognitive impairment after intracerebral hemorrhage (ICH). Curcumin, a natural polyphenol from Curcuma longa, has anti-inflammatory properties but limited bioavailability. Liposomal curcumin (Lipo-Cur, 103.2 nm, 74% encapsulation) was prepared by thin-film hydration. Adult male rats were assigned to Sham, ICH (collagenase + empty liposomes), and ICH-Cur (collagenase + Lipo-Cur, 30 mg/kg, i.p. at 2, 24, 48 h post-surgery). On day 7, we assessed NLRP3/caspase-1 inflammasome activation, BDNF/TrkB/CREB/Erk signaling, PSD-95 expression, neuronal survival (Nissl staining), and working memory (Y-maze). Lipo-Cur significantly suppressed NLRP3/caspase-1, restored p-CREB/CREB and p-TrkB/TrkB, normalized p-Erk/Erk, and upregulated PSD-95 (all p < 0.01). It also reduced neuronal loss, restored BDNF (p < 0.05), attenuated NLRP3 (p < 0.01), and improved Y-maze alternation (p < 0.001) without affecting locomotion. These findings suggest that liposomal curcumin exerts neuroprotective effects in the mPFC after ICH, likely through mechanisms involving suppression of NLRP3/caspase-1 and enhancement of BDNF/TrkB/CREB signaling. This supports its potential as a natural product-based therapeutic for stroke-induced cognitive impairment, though further mechanistic studies are warranted.

PMID 42753069
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PubMedBrain research bulletin2026-09-16

The mechanism of NEDD4 attenuating intracerebral hemorrhage injury through restoring glymphatic function by ubiquitin-mediated degradation of LPAR1.

Tan Cong C, Zheng Xiaobin X, Peng Li L, Chen Weiming W et al.

Intracerebral hemorrhage (ICH) induces severe neurological injury, and the glymphatic system plays a critical role in post-ICH brain recovery. This study investigated the role of neural precursor cell expressed developmentally down-regulated protein 4 (NEDD4), an E3 ubiquitin ligase, in modulating glymphatic function and neuroprotection after ICH. An ICH model was established in mice via intrastriatal collagenase injection. Neurological function was assessed using modified Neurological Severity Score (mNSS). Histopathological damage was evaluated by hematoxylin and eosin (H＆E) staining and Nissl staining. Evaluate Aquaporin-4 (AQP4) polarization and glymphatic system function through the co-localization of AQP4 and CD31, as well as cerebrospinal fluid (CSF) tracing with RITC-Dextran. Molecular mechanisms were explored in vitro using hemin-treated astrocytes. The physical interaction between NEDD4 and lysophosphatidic acid receptor 1 (LPAR1) was validated via co-immunoprecipitation. Ubiquitination assays and pathway analysis verified the ubiquitination of LPAR1 by NEDD4 and the subsequent suppression of the LPAR1/RhoA/MMP9 axis. NEDD4 was significantly downregulated in peri-lesional astrocytes after ICH. NEDD4 overexpression improved neurological function, reduced hematoma volume and cerebral edema. Meanwhile, NEDD4 overexpression alleviated ICH-induced glymphatic dysfunction by promoting AQP4 polarization. Mechanistically, NEDD4 bound to LPAR1 and promoted its ubiquitin-mediated degradation, suppressing the RhoA/matrix MMP9 axis. Co-overexpression of LPAR1 abolished NEDD4-induced AQP4 polarization and glymphatic protection. NEDD4 attenuates ICH injury by ubiquitinating LPAR1 and inhibiting RhoA/MMP9 signaling, thereby restoring AQP4 polarization and glymphatic function. Targeting the NEDD4/LPAR1 axis may offer a novel therapeutic strategy for ICH.

PMID 42748983
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PubMedClinical and experimental dental research2026-09-15

Accessing Polyphenols Effect on Bond Strength and Dentin Enzymatic Degradation.

Alves Ana Catarina Rios Castro ACRC, da Silva Adonias Antonio AA, da Silva Roberta Bruno RB, de Lima França Rayan R et al.

Polyphenols have been investigated in dental materials and restorative techniques due to their interactions with metal cations, antioxidant activity, and collagen crosslinking ability, which make them a promise for reinforcing the dental substrate and improving material adhesion. However, more studies are necessary before to support their use in clinical procedures. This study evaluated the effects of quercetin and resveratrol on bond strength and the protection of dentin collagen fibrils against enzymatic degradation. Demineralized human dentin specimens were immersed for 1 min in solutions of quercetin or resveratrol (100, 250, and 500 µg/mL), 2% chlorhexidine (CHX), or 0.9% saline (control). The specimens were then incubated in collagenase for 24 h at 37°C, and changes in dry mass were measured. For microtensile bond strength testing, quercetin, resveratrol, CHX, or distilled water (DW) were applied to phosphoric acid-conditioned dentin, followed by application of Single Bond 2 (3 M/ESPE) adhesive and Z350XT resin (3 M/ESPE). Adhesive strength was measured after 24 h and after 1 year in distilled water. Data were analyzed using the Kruskal-Wallis and Dunn tests or ANOVA followed by Tukey's test (p < 0.05). Quercetin-treated specimens showed a significant weight increase compared with CHX (p < 0.05). Both quercetin- and resveratrol-treated groups exhibited resistance to collagenase similar to CHX (p > 0.05). After 1 year, only the DW group showed a significant decrease in bond strength (p = 0.001). Dentin treatment with quercetin or resveratrol effectively preserved adhesive strength and protected collagen against enzymatic degradation, suggesting their potential as agents to improve the longevity of adhesive restorations.

PMID 42743388
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PubMedACS biomaterials science & engineering2026-09-15

Genipin-Cross-Linked Decellularized Amnion Membrane with Antioxidant and Anti-Inflammatory Properties.

Zhang Tong T, Shao Mingfei M, Wu Jingwen J, Guo Yanchuan Y

The regulation of post-implantation inflammatory responses is essential for biomaterials to achieve their intended functions, with macrophages playing a pivotal role in this process. The persistence of M1 macrophages impairs the timely resolution of acute inflammation, thereby delaying tissue healing and compromising biomaterial performance. The decellularized amnion membrane (DAM) exhibits notable anti-inflammatory properties. However, its limited mechanical strength and poor degradation resistance restrict its clinical applications. This study employed genipin cross-linking to improve the mechanical strength and enzymatic degradation resistance of DAM, resulting in a genipin-cross-linked DAM scaffold (GED) with enhanced anti-inflammatory properties. GED demonstrated markedly enhanced mechanical strength, thermal stability, and degradation resistance, retaining its structural integrity even after 28 days of collagenase-mediated degradation in vitro. Moreover, GED exhibited the ability to scavenge excess reactive oxygen species (ROS) and suppress LPS-induced pro-inflammatory cytokine expression in macrophages, thereby effectively mitigating inflammation. This research provides new insights into the development of extracellular matrix-based materials and highlights GED as a promising multifunctional anti-inflammatory scaffold for tissue engineering applications.

PMID 42742158
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PubMedDental traumatology : official publication of International Association for Dental Traumatology2026-09-15

In Vitro Evaluation of the Efficacy of Liquid Platelet-Rich Fibrin (PRF) for Maintaining and Restoring Periodontal Ligament Cell Viability in Avulsed Teeth After 3 and 4 h of Extra-Alveolar Dry Time.

Kowaltschuk Tatiana Carvalho TC, Juglair Mariana Martins MM, Grigolo Daniel D, Barchiki Fabiane F et al.

This in vitro study evaluated whether liquid platelet-rich fibrin could maintain or recover periodontal ligament cell viability in extracted human teeth after three and four hours of dry extra-alveolar time. Sixty-six erupted third molars with complete root formation were allocated to four groups: three-hour dry control, three-hour dry storage followed by forty-five minutes in liquid platelet-rich fibrin, four-hour dry control, and four-hour dry storage followed by forty-five minutes in liquid platelet-rich fibrin. periodontal ligament cells were isolated by enzymatic digestion with type II collagenase and dispase. cell concentration and viability were determined by trypan blue exclusion in a neubauer chamber. HBSS- and milk-treated groups were not included. Liquid platelet-rich fibrin was associated with higher periodontal ligament cell viability after both dry-storage periods. cell concentration differed significantly in the four-hour comparison, whereas the three-hour concentration comparison was not statistically significant. Within the limitations of this in vitro study liquid platelet-rich fibrin was associated with greater recovery of viable periodontal ligament cells after prolonged dry storage. these findings do not establish superiority or equivalence to HBSS or milk and should be interpreted cautiously.

PMID 42736707
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