Drug Database
AB

abacavir sulfate

✓ Approved

Roche · Companion diagnostic · Companion diagnostic

What is abacavir sulfate?

abacavir sulfate is a companion diagnostic developed by Roche. It is approved for therapeutic indications via others.

Drug Profile

CompanyRoche
Drug ClassCompanion diagnostic
RouteOthers
StatusApproved
Sources: ClinicalTrials.gov, Roche

Related Research Articles

PubMedFrontiers in veterinary science2026-05-25

Recent advances in isothermal amplification techniques for detection of animal diseases.

Tooryan Fahimeh F, Enyertornye Ben B, Choudhury Farhatul J FJ, Velayudhan Binu T BT

Prompt pathogen detection is critical in protecting public health, improving animal health, welfare, food safety, and food security in both food-producing and companion animals. Although conventional and molecular diagnostic methods are highly effective, they often require expensive instrumentation, specialized laboratory infrastructure, and trained personnel, limiting their applicability in field and resource-limited settings. Isothermal amplification technologies have emerged in recent times as powerful alternatives to conventional PCR-based methods, offering rapid, sensitive and user-friendly nucleic acid detection without the need for thermocycling equipment. The present review summarizes recent advances in isothermal amplification methods and their applications in the detection of pathogens in livestock and companion animals. It also highlights innovations in assay design, improvements in analytics, and their incorporation into portable and field-deployable detection platforms. Furthermore, the review explores the challenges and future directions for the application of these technologies in routine veterinary diagnostics and integrated disease surveillance programs.

PMID 42182914
Read full article →
PubMedScientific reports2026-05-25

Comparison of three contrast agents in the diagnosis of cracked teeth using Cone Beam Computed Tomography (CBCT).

Alnaseri Mawadah K MK, Alamoudi Ruaa A RA, Sabban Hanadi H, Albassam Abdullah A AA et al.

Cracked teeth are difficult to detect on conventional cone beam computed tomography (CBCT). Contrast agents may improve visualization of fine and superficial cracks. This study compared three contrast agents for their diagnostic performance. Thirty-nine extracted premolars with induced micro-cracks were examined using three contrast agents: ioversol, barium sulfate, and meglumine ioxitalamate. Each tooth underwent CBCT before and after contrast application, followed by micro-computed tomography (micro-CT) as the reference standard. Two blinded observers recorded the number of cracks detected on CBCT and confirmed by micro-CT. Statistical analysis was performed using ANOVA with LSD post hoc comparisons. Micro-CT detected an average of 19.9 ± 9.3 cracks per tooth. On CBCT, ioversol and barium sulfate performed similarly (5.6 ± 2.3 and 5.8 ± 2.1 cracks, respectively), whereas meglumine ioxitalamate detected fewer (3.4 ± 1.7, p = 0.001). When matched against micro-CT, ioversol and barium sulfate detected ~ 4 cracks, while meglumine ioxitalamate detected fewer than 3. Barium sulfate detected the largest proportion of deep cracks (20.7%). Contrast-enhanced CBCT improves detection of fine cracks compared with unenhanced scans. Ioversol and barium sulfate demonstrated superior diagnostic value, while meglumine ioxitalamate offered limited benefit.

PMID 42178388
Read full article →
PubMedOne health (Amsterdam, Netherlands)2026-05-25

Transmission of severe fever with thrombocytopenia syndrome virus from a dog to humans and a cat in a household cluster.

Ma Dongyu D, Li Wangjun W, Liao Tao T, Song Yongqing Y et al.

The growing proximity and contact between companion animals and humans underscore the significant public health risk of zoonotic spillover, a core concern of the One Health framework. Severe fever with thrombocytopenia syndrome (SFTS), an emerging tick-borne zoonosis of increasing incidence, is capable of direct animal-to-human transmission; however, evidence detailing its transmission within households remains limited. This study documents a transmission chain involving a domestic dog, two owners, and a cohabiting cat. The owners developed symptoms approximately one week after exposure to their symptomatic dog, and the cat subsequently succumbed two weeks after the dog's death. High viral loads of SFTS virus (SFTSV) were consistently detected in samples from the patients and deceased animals. The S-fragment sequences from the patients showed 100% identity with those from the pets, confirming a common source. Phylogenetic analysis classified the virus as genotype D, and SFTSV was also detected in the shared household environment, indicating its role as a transmission hub. These findings provide clear evidence of multi-directional household transmission, demonstrating that companion animals can mediate cross-species transmission to humans and other susceptible species. Transmission likely occurred via infectious secretions, fomites, or potentially aerosols. In line with the One Health concept, our results emphasize the urgent need to implement enhanced surveillance of companion animals in SFTS-endemic regions and to establish integrated systems that disrupt transmission cycles among ticks, animals, and humans, thereby safeguarding public and animal health in tandem.

PMID 42183047
Read full article →
PubMedHarmful algae2026-05-25

Higher alkalinity increases copper toxicity in phytoplankton: The importance of pH flux when treating algal blooms.

Mollica Anna C AC, Wesche Megan T MT, Gladfelter Matthew F MF, McDonald Michael B MB et al.

For more than a century, copper sulfate pentahydrate (CuSO4·5H2O) has been used to combat harmful algal blooms in freshwater systems. Dosing recommendations for copper sulfate are often at 1% of the ambient alkalinity, thus increasing the applied dose with higher alkalinity. This methodology is based on the premise that higher ambient alkalinity makes copper sulfate less toxic to aquatic organisms due to the expected precipitation of copper-carbonate complexes. Using a 21-day, gradient-design, replicated, field experiment in a eutrophic aquaculture pond initially dominated by cyanobacteria, this study showed the opposite effect: copper sulfate became more toxic to phytoplankton as alkalinity increased. To evaluate the effect of sodium bicarbonate-based alkalinity on copper sulfate toxicity in phytoplankton, four target alkalinity concentrations (50, 125, 200, and 275 mg/L CaCO3) across three copper sulfate treatments (an untreated control (0 mg/L CuSO4·5H2O); a low, constant dose (0.324 mg/L) across all alkalinities; and increasingly higher alkalinity-based doses (0.25-1.375 mg/L)) were used. Both the low and high copper sulfate treatments effectively eliminated cyanobacteria (regardless of copper dose or alkalinity), while the low copper treatment allowed beneficial chlorophytes to quickly return to initial concentrations. Notably, the results show that as the ambient alkalinity in the enclosures increased, the effect of the constant low copper sulfate dose on phytoplankton was larger (i.e., less phytoplankton abundance; more negative algal growth rate) contradicting long-standing copper sulfate dosing methodologies. Higher pH at lower alkalinities appears to mediate these effects given that toxic Cu2+ availability decreases with higher pH. These results suggest that water resource managers should consider pH and alkalinity when making decisions about copper applications to avoid overdosing of copper sulfate that can cause other water quality problems, such as heavy metal accumulation, anoxia, non-target effects on zooplankton, and recurring treatment-resistant algal blooms.

PMID 42178164
Read full article →
PubMedPlastic and reconstructive surgery. Global open2026-05-25

Pilot Study: Vancomycin Calcium Sulfate Beads in the Prevention of Recurrent Capsular Contracture of Breast Implants.

Moulton-Barrett Rex E RE, Jewell Nicholas P NP, Rathod Aashi A

Prevention and management of capsular contracture of the breast remain the most challenging complications after breast augmentation and reconstruction. The use of resorbable calcium sulfate beads containing antibiotics within the breast pocket has been found to reduce implant extrusion from infections. No previous studies have determined whether biofilm-related recurrent capsular contracture (RCC) of the breast can be reduced using similar antibiotic beads at the time of surgery. A retrospective case series study by 1 surgeon, conducted between 2006 and 2025, was performed to determine whether placing calcium sulfate beads with either 500 mg or 1 g of vancomycin within a breast pocket, versus no beads, following capsulectomy and implant exchange could prevent RCC. Thirty-eight patients underwent 40 procedures involving 57 breasts. RCC was defined as Spear-Baker grade III or IV. The use of antibiotic beads was associated with a significant reduction in RCC (P < 0.001). Patients without beads, considering all other factors, had 15 times greater odds of developing RCC. This risk was reduced to 8 times greater odds when accounting for length of follow-up. This pilot study supports the use of calcium sulfate beads in combination with vancomycin for the prevention of RCC.

PMID 42180994
Read full article →
PubMedJournal of parasitology research2026-05-25

The Impact of pfmdr1 Gene Copy Number on the Efficacy of Dihydroartemisinin-Piperaquine in Treating Malaria in West Sumba and Kupang Districts, East Nusa Tenggara, Indonesia.

Irdayanti Irdayanti I, Aswad Hijral H, Asih Puji B S PBS, Rozi Ismail E IE et al.

The efficacy of antimalarial treatment, particularly artemisinin-based combination therapy (ACT), continues to face persistent threats due to the development of drug resistance in Plasmodium falciparum. Although artemisinin derivatives remain effective, ACT regimen failure often results from decreased efficacy of the companion drug. Therefore, robust molecular surveillance focusing on genetic markers associated with companion drug resistance is essential to maintain global efficacy. The combination of dihydroartemisinin-piperaquine (DHA-PPQ) has long been used as first-line therapy and has proven effective; however, reports of resistance to piperaquine (PPQ) in Southeast Asia are cause for concern. The study is aimed at evaluating copy number variation (CNV) of the Plasmodium falciparum multidrug resistance-1 (Pfmdr1) gene as part of a descriptive molecular surveillance approach in East Nusa Tenggara, Indonesia. A total of 41 dried blood spot (DBS) samples from patients with falciparum malaria treated with DHA-PPQ were analyzed. The DNA extraction was performed using the QIAamp DNA Mini Kit, and CNV of the Pfmdr1 gene was determined by real-time PCR. The phenotypes of all 41 patients showed a good treatment response, with 100% adequate clinical and parasitological response (ACPR) on Day 42. Analysis of the Pfmdr1 gene CNV identified 36 isolates (87.81%) with a single copy and 5 isolates (12.19%) with multiple copies. These findings indicate genetic variation related to selective pressure against PPQ. While DHA-PPQ remains clinically effective in East Nusa Tenggara for now, the presence of these genetic markers necessitates a proactive surveillance strategy to detect shifts in drug sensitivity before widespread clinical failure occurs.

PMID 42180140
Read full article →

+9996 more articles available with a free account

Sign up free to view all articles →

Ask about abacavir sulfate