Drug Database
AB

abacavir sulfate

✓ Approved

Roche · Companion diagnostic · Companion diagnostic

What is abacavir sulfate?

abacavir sulfate is a companion diagnostic developed by Roche. It is approved for therapeutic indications via others.

Drug Profile

CompanyRoche
Drug ClassCompanion diagnostic
RouteOthers
StatusApproved
Sources: ClinicalTrials.gov, Roche

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PubMedHealth science reports2026-11-11

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PubMedWater environment research : a research publication of the Water Environment Federation2026-11-11

Impacts of Longwall Mining-Induced Goafs on Sulfate Generation and Biogeochemical Transformation in a Multiaquifer System: Insights From C, S, O, and H Isotopes.

Yang Zhengqiu Z, Fang Jie J, Zhao Yongqiang Y, Zhang Yaobin Y et al.

Longwall mining disrupts overlying strata and creates goafs, altering groundwater conditions and the chemical composition of affected aquifer systems. In arid and semiarid regions, understanding how deep coal extraction influences sulfate biogeochemistry is essential for assessing mining-related groundwater degradation and protecting scarce groundwater resources. This study combined major-ion chemistry, water isotopes (δD and δ18Owater), sulfate isotopes (δ34S and δ18OSO4), δ13CDIC, and Bayesian isotope mixing analysis to investigate sulfate sources and transformation in the multiaquifer system and goaf of the Jinjie Coal Mine, China. The results reveal a marked contrast between sulfate generation in the goaf and its subsequent transformation in the Jurassic aquifers. Pyrite oxidation and associated carbonate dissolution dominate sulfate and dissolved inorganic carbon (DIC) production in goaf water, whereas Bayesian source apportionment identifies pyrite oxidation as the principal sulfate source in most goaf-water samples. The spatial variation in source contributions is consistent with differences in the thickness and continuity of the Baode aquitard. Mining-induced fracturing, locally extending to the surface, facilitates the exposure of pyrite-bearing strata to oxygenated water and air, promoting sulfate generation in the goaf. The resulting sulfate subsequently enters the Jurassic aquifers, where relatively confined and reducing conditions favor bacterial sulfate reduction. Sulfate depletion, enrichment of residual sulfate in heavy sulfur and oxygen isotopes, and relatively depleted δ13CDIC values provide complementary evidence for this transformation. These findings provide a process-based framework for understanding sulfate evolution in mining-affected groundwater systems.

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PubMedSmall methods2026-11-11

Modulated Laser-Assisted Nanopore Fabrication With Ammonium Sulfate for Single-Molecule Sensing.

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Nanopore sensing provides a label-free platform for single-molecule analysis. To achieve reliable solid-state nanopore sensing, however, it is essential to optimize appropriate nanopore fabrication methods, as variations in pore diameter, geometry, surface state, and fabrication residues can affect molecular discrimination capability. Here, we report a temporally modulated CW laser-assisted dielectric breakdown method for facilitating in-situ fabrication of nanopores in silicon nitride membranes, coupled with ammonium sulfate electrolytes to improve sensing performance. Systematic characterization revealed that temporally modulated CW laser minimizes contamination/debris formation during pore fabrication and yields improved nanopore sensing. Streaming-potential measurements and interfacial ion-transport simulations suggest that ammonium-containing electrolytes modify the SiN nanopore interface by promoting NH4 + adsorption on the inner pore surface as well as SO4 2- ions, thereby enhancing DNA-pore interactions. This effect slowed a subset of DNA translocation events, enabling longer dwell-time observations and differentiation between poly(dA) and poly(dC) blockade populations. Furthermore, aptamer-assisted detection enabled detection of Scp1-bound aptamer complexes under conditions where the protein alone tended to clog the pore. The Scp1-aptamer complex showed prolonged dwell times compared with those of free aptamers, even under 0.14 M KCl. Together, these results demonstrate that integrating our approach provides an improved approach for high-performance single-molecule nanopore detection.

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PubMedMedicine2026-11-11

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PubMedAmerican journal of health promotion : AJHP2026-11-11

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