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glycopyrronium bromide (Sialanar)

✓ Approved

Proveca · Small Molecule · Small Molecule

What is glycopyrronium bromide?

glycopyrronium bromide is a small molecule developed by Proveca. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesSialanar
CompanyProveca
Drug ClassSmall Molecule
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, Proveca

Therapeutic Indications

glycopyrronium bromide is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Gastrointestinal disordersSalivary hypersecretion✓ Approved

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Gao Siyuan S, Zhuang Wei W, Song Qi Q, Yan Dengfeng D et al.

Long-acting muscarinic antagonist (LAMA) and long-acting β2-agonist (LABA) combinations are widely prescribed for chronic obstructive pulmonary disease (COPD). This study evaluated post-marketing safety signals for four dual bronchodilators (formoterol/glycopyrronium, indacaterol/glycopyrronium, vilanterol/umeclidinium, and olodaterol/tiotropium). A retrospective pharmacovigilance study of four bronchodilators was conducted using the data from Food and Drug Administration Adverse Event Reporting System (FAERS) database between January 1, 2014 and March 31, 2025. The association between drugs and adverse events (AEs) was evaluated using reporting odds ratio (ROR), proportional reporting ratio (PRR), Bayesian confidence propagation neural network (BCPN), and multi-item gamma Poisson shrinker (MGPS). Venn analysis was performed to identify drug-specific disproportionality signals for the four bronchodilators. A total of 18,677 cases were included. Venn analysis identified 13 common safety signals and various drug-specific disproportionality safety signals, including 56 important medical events (IMEs) that met signaling thresholds for only one drug. Urinary retention emerged as a common IME among four bronchodilators. Indacaterol/glycopyrronium was associated with distinct cardiovascular risks, including arrhythmia, cardiac arrest, myocardial infarction, angina pectoris, and coronary artery disease. Olodaterol/tiotropium showed signals for ileus, retinal vein occlusion, cataract, and hip fracture, and exhibited the longest latency period among the other three bronchodilators. This pharmacovigilance study identified significant safety signals associated with four bronchodilators, highlighting both common and drug-specific disproportionality signals and thereby providing essential evidence to support drug monitoring in clinical practice.

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PubMedEnvironmental research communications2026-05-25

Exceptional use: examining methyl bromide applications in California 2016-2022.

Ornelas Van Horne Yoshira Y, Johnston Jill E JE

Methyl bromide (MeBr) has been widely used as a fumigant to control for pests, fungi and weeds as well as for disinfection of warehouses, shipping containers, and other commodities. MeBr is a known developmental, neurologic and respiratory toxin. Due to its ozone-depleting properties, MeBr was listed under the Montreal Protocol in 1992. While MeBr use was set to phase out by 2005, the Montreal Protocol and the US Clean Air Act allows critical use exemptions, such as fumigation of freight containers for quarantine and preshipment purposes. To evaluate state-wide spatial and temporal patterns, we examine publicly available pesticide data on the use of MeBr in California from 2016-2022. We found that MeBr applications continue in 36 out of 58 CA counties. For non-agricultural fumigation applications (e.g., commodity fumigation) of MeBr from 2016-2022, a total of 582,050 kilograms (1,283,201 pounds) were applied across 25 counties in CA, home to 24 million people. Los Angeles ranks as the highest use county, with a total of 269,571 or 46% of the total kilograms (594,302 pounds) applied from 2016-2022 for non-agricultural fumigation applications. Additionally, we characterized ambient MeBr concentrations in the West Long Beach community of LA County, based on a state monitor active since 2023, observing concentrations exceeding CA standards. This study underscores the importance of evaluating chemical phaseouts and improving enforcement and monitoring to ensure public health protections.

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Proton-coupled alternating access in a versatile Spns drug efflux pump from Mycobacterium smegmatis.

Gies Samantha S, Jagessar Kevin L KL, Wu Tianqi T, Miller Ian I et al.

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Next-generation CsPbBr3 perovskite nanocrystal chloride sensors: stability engineering and halide-exchange mechanisms in aqueous, biological, and environmental media.

Shuheil Mohamed Abu MA, Aldulaimi Ahmed A, Ray Subhashree S, Qassem Talal Aziz TA et al.

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Liu Ying Y, Sun WenPing W

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