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glycopyrronium bromide (Sialanar)

✓ Approved

Proveca · Small Molecule · Small Molecule

What is glycopyrronium bromide?

glycopyrronium bromide is a small molecule developed by Proveca. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesSialanar
CompanyProveca
Drug ClassSmall Molecule
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, Proveca

Therapeutic Indications

glycopyrronium bromide is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Gastrointestinal disordersSalivary hypersecretion✓ Approved

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PubMedRSC advances2026-11-11

One-dimensional Bi-Br pyrazinamide-based hybrid halide perovskite: crystal architecture, intermolecular interactions, and structure-optical properties relationship.

Alibi Amin A, Elleuch Nour N, Khdhiri Emna E, Shova Sergiu S et al.

A one-dimensional bismuth bromide organic-inorganic hybrid halide perovskite based on protonated pyrazinamide cations, (C5H6N3O)2·[BiBr5], is reported and comprehensively investigated. Single-crystal X-ray diffraction reveals a perovskite-related architecture built from corner-sharing [BiBr6] octahedra forming one-dimensional chains, stabilized by a dense network of N-H⋯Br and N-H⋯O hydrogen bonds together with significant π-π stacking interactions. Hirshfeld surface analysis quantitatively confirms the dominance of halogen-mediated hydrogen bonding in governing the supramolecular organization. Diffuse reflectance spectroscopy establishes the material as a direct-band-gap semiconductor with an optical gap of ∼2.8 eV, supported by a sharp absorption edge, low Urbach energy, and consistent threshold wavelength analysis. Photoluminescence measurements reveal a single intense phosphorescent emission centered at 540 nm, with CIE coordinates located in the yellowish-green region. Density functional theory calculations, including DOS, PDOS, ELF, LOL, and NCI-RDG analyses, provide microscopic insight into the electronic structure and intermolecular interactions, highlighting charge-transfer contributions from the inorganic sublattice to the organic moiety near the band edges. The combined results establish clear structure-property correlations in this lead-free Bi-based hybrid system and underline its relevance within the broader family of perovskite-inspired semiconductors.

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PubMedAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026-11-10

Multiband Optical Physical Unclonable Functions Based on Mixed-Phase Multilevel Emissive Perovskites.

Park Seungbeom S, Kim Jiyoun J, Boo Jiyoung J, Kim Giho G et al.

Physical unclonable functions (PUFs) are hardware-based security primitives that exploit intrinsic physical randomness in materials or devices to prevent counterfeiting and enhance authentication across diverse applications. Among various sources of randomness, the optical signatures of luminescent materials represent a particularly robust and easily distinguishable feature. However, many optical PUF systems rely on environmentally hazardous materials or energy-intensive fabrication processes while remaining vulnerable to counterfeiting due to deterministic and spectrally fixed emission characteristics. Here, we demonstrate sustainable multiband optical PUFs by forming heterostructures between lead-free phase-mixed perovskites and cellulose fibers via a water-assisted drop-casting process. Cesium manganese bromide perovskites provide an environmentally benign composition while exhibiting excitation-dependent multilevel photophysical responses arising from mixed-phase interactions. By leveraging these excitation-dependent multilevel emission characteristics, we construct strong PUFs that significantly expand the challenge and response pairs from a single device through controlled optical feature extraction of the perovskites and the spatial randomness of cellulose fibers. Moreover, the multiband optical PUF platform is demonstrated for image encryption/decryption as well as currency authentication. These results establish an environmentally responsible optical PUF platform that combines sustainable materials and fabrication processes with distinctive photophysical characteristics for next-generation hardware security technologies.

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PubMedInternational journal of biological macromolecules2026-11-10

A novel pH/salt dual-responsive aqueous two-phase system for efficient separation of polysaccharides from Eucommia ulmoides leaves.

Liu Yan Y, Long Yang Y, Liu Leilei L, Tan Zhijian Z

A novel pH/salt dual-responsive aqueous two-phase system based on deep eutectic solvents (DESs) was developed for the efficient purification of polysaccharides from Eucommia ulmoides leaves. DES-19 (tetradecyltrimethylammonium bromide-hexanoic acid) exhibited superior dual pH/salt-responsive performance. Response surface optimization yielded a polysaccharide extraction yield of 25.41%. A lower-phase extraction efficiency of 82.57%was achieved under the conditions of 1:4 volume ratio of extract to NaCl solution, 5% NaCl, 25 °C, and 30 min. Deproteinization and dialysis of the upper and lower phases afforded EUP-T and EUP-B polysaccharides, respectively, which shared similar FT-IR spectra and monosaccharide types but differed markedly in molecular weight (Mw). EUP-T was dominated by a high-Mw component (96,655 Da, 92.08%), with a minor component at 5554 Da, whereas EUP-B contained low-Mw components (3594 and 1591 Da). EUP-T was rich in galactose, arabinose, and mannose, whereas EUP-B was dominated by glucose with minor arabinose and galactose. Furthermore, EUP-B exhibited significantly stronger DPPH•/ABTS+• scavenging activity than EUP-T. This study provides a streamlined and feasible alternative for the efficient extraction and refined fractionation of natural polysaccharides.

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PubMedMolecular biology reports2026-11-10

DNA extraction from planarians for PCR and qPCR.

Korbová Eliška E, Plšková Karolína K, Vašek Jakub J

DNA extraction from freshwater planarians (Continenticola) is difficult because mucus and pigments co-purify with DNA and inhibit polymerase chain reaction (PCR) and quantitative PCR (qPCR). For most species, no standardised extraction protocols are available. We tested approximately 30 lysis buffer formulations combining guanidine thiocyanate (GTC), cetyltrimethylammonium bromide (CTAB), sodium dodecyl sulfate (SDS) and polyvinylpyrrolidone (PVP K10 and K30, including concentration gradients) on six European freshwater species: Polycelis felina, Polycelis sp., Dendrocoelum lacteum, Dugesia gonocephala, Girardia sp. and Schmidtea sp. Protocols were evaluated by DNA pellet colour, UV spectrophotometry using the A260/280 and A260/230 ratios, DNA integrity on agarose gel and PCR amplification without BSA supplementation. Previously published protocols produced coloured pellets or low DNA yields in most species. A CTAB/PVP K30 buffer, with the PVP K30 concentration adjusted for each species (2-8 %), yielded high-purity DNA suitable for PCR in P. felina, D. lacteum, Schmidtea sp., Polycelis sp. and Girardia sp. The heavily pigmented D. gonocephala required an additional protocol combining CTAB, SDS and PVP K30. A broadly applicable CTAB/PVP K30 protocol in which only the PVP K30 concentration is adjusted, together with a separate protocol for D. gonocephala, enables extraction of DNA suitable for PCR and qPCR from pigmented planarians without BSA.

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PubMedApplications in plant sciences2026-11-10

Room temperature lysis incubation improves DNA yield in the Norgen Plant/Fungi DNA Isolation Kit across multiple plant species.

Ohali Shachar S, Abu-Nassar Jackline J, Shalit-Kaneh Akiva A, Draru Emily E et al.

Commercial plant DNA extraction kits typically include a 65°C lysis incubation step, inherited from cetyltrimethylammonium bromide (CTAB)-based methods. Recent work suggests that cooler lysis temperatures can improve DNA purity in CTAB extractions; whether this also improves yield in CTAB-based column kits has not been tested. We compared room temperature (RT, ~25°C) and 65°C lysis incubation using the Norgen Plant/Fungi DNA Isolation Kit (CTAB-based lysis buffer) across six plant species in a paired split-tissue design (n = 59 pairs). RT incubation significantly increased Qubit fluorometric DNA yield by 47% overall, with a significant treatment × species interaction. RT-extracted Cucurbita pepo DNA was compatible with genotyping-by-sequencing. In a focused generalization test, the modification did not improve yield with the Qiagen DNeasy Plant Mini Kit, whose lysis buffer uses the anionic detergent sodium dodecyl sulphate, indicating that the effect is specific to kit lysis chemistry. For the Norgen kit, omitting the heating step is a zero-cost modification that significantly improves DNA yield and the ratio of absorbance at 260 nm and 230 nm (A260/A230 purity ratio) for most eudicot species tested, with no loss of downstream compatibility. This benefit appears specific to CTAB-based lysis and should be validated for each kit and species before adoption.

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PubMedRSC advances2026-11-10

Bioactive half-sandwich Ru(ii) arene imidazolyl-benzylidene phenolate complexes: synthesis, in silico studies and cytotoxicity against HeLa and MCF-7 cells.

Salimath Shivabasayya V SV, S Arunkumar V AV, Gundakanal Srushti S SS, Ghosh Arjita A et al.

A series of half-sandwich type Ru(ii) arene complexes [(η6-p-cymene)RuCl(L)] (RuL1-RuL4) have been synthesized and characterized using various spectroscopic techniques such as FT-IR, NMR and ESI-MS. Their interactions with bovine serum albumin (BSA) and calf thymus DNA were studied employing various spectroscopic methods, which revealed significant biomolecular affinity, with RuL2 exhibiting the highest binding constants (2.48 × 105 M-1 for DNA and 0.919 × 106 M-1 for BSA). The molecular docking studies supported the experimental results by elucidating favourable binding modes with both target biomolecules. Furthermore, TD-DFT calculations were carried out to analyze the electronic transitions and molecular properties of the complexes. The antiproliferative activity of these complexes was tested on different human cell lines, including human breast (MCF-7), cervical (HeLa), and non-cancerous human embryonic kidney (HEK-293) cells. Among these, RuL1 = 28.74 ± 0.43 µM and RuL2 = 21.88 ± 1.21 µM showed the highest cytotoxicity with the highest efficacy towards MCF-7 cells over the HeLa cells. Furthermore, RuL1 and RuL2 displayed a very low toxicity on HEK-293 cells, signalling their selectivity. Mechanistic studies revealed that these lead complexes stimulated the generation of intracellular reactive oxygen species (ROS), as confirmed by DCFH-DA staining, and induced apoptosis, as evidenced by acridine orange/ethidium bromide staining. The experimental and theoretical findings show that the half-sandwich Ru(ii) arene imidazolyl-benzylidene phenolate complexes can be utilized to create selective anticancer drugs based on ruthenium.

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