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INJEX system

✓ Approved

Equidyne · therapeutic agent

What is INJEX system?

INJEX system is a therapeutic agent developed by Equidyne. It is approved for therapeutic indications via injectable (others) or intramuscular (im) injection or subcutaneous injection.

Drug Profile

CompanyEquidyne
RouteInjectable (Others), Intramuscular (IM) Injection, Subcutaneous Injection
StatusApproved
Sources: ClinicalTrials.gov, Equidyne

Therapeutic Indications

INJEX system is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Surgical and medical proceduresOral appliance application✓ Approved

Related Research Articles

PubMedArrhythmia & electrophysiology review2026-11-11

Patient-specific Visualisation of the Cardiac Conduction System to Guide Structural Interventions and Physiological Pacing.

Tretter Justin T JT, Ponnusamy Shunmuga Sundaram SS, Asyraf Tarikh T, Spaziani Stefano S et al.

The cardiac conduction system is frequently injured during structural heart disease procedures and it remains difficult to target accurately during conduction system pacing. These current approaches both lead to increased mortality and morbidity. The authors review the anatomical basis, estimated conduction system calibration and subsequent clinical application of a novel CT angiography-based conduction system visualisation platform that enables patient-specific 3D estimation and mapping of the atrioventricular conduction axis for real-time procedural guidance. This breakthrough technology enables clinicians to avoid iatrogenic damage by implanting devices with respect to patient-specific conduction anatomy and to achieve true physiological pacing by targeting precise locations along the conduction system. The authors have applied this visualisation system in more than 2,000 patients undergoing structural heart disease and conduction system pacing procedures, and the results of this early experience are reviewed here. Conduction system-guided intervention provides a framework for a potential shift in cardiac care, with planned prospective trials to further validate these promising outcomes.

PMID 43011812
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PubMedInternational journal of mental health nursing2026-11-11

Just a Tick Box: A Qualitative Study of Peer Workers' Experiences Driving System Change in Mental Health Services.

Watson Natalie N, River Jo J

Peer workers in public mental health settings engage in direct support to service users and system change advocacy. Yet, peer workers' experiences of driving system change are often under-researched. To address this gap, this qualitative study examined the experiences of eight peer workers engaged in system change via committees and working groups in an Australian mental health service. Findings are captured in the four themes: I'm just there as a tick box, which describes experiences of tokenistic engagement; They held the power, which points to the privileging of clinical perspectives; You've got to be assertive and proactive, which shows the considerable labour exercised by peer workers to navigate system inequity; and It's just kind of burnt me out, which describes the psychosocial impacts of navigating entrenched power dynamics. Findings indicate an urgent need for structural and cultural reforms to ensure peer workers have genuine influence in shaping mental health system change.

PMID 43010585
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PubMedHealth services research2026-11-11

Coordination of Specialty Care Within and Across Health Systems: Patient Experience in the Veterans Health Administration.

Vimalananda Varsha G VG, Li Mingfei M, Wormwood Jolie B JB, Leibowitz Alison J AJ et al.

To compare patients' experience of specialty care coordination within a single health system to that across organizational boundaries, and whether coordination varies by illness burden and across coordination domains. National cross-sectional survey of patients referred from Veterans Health Administration (VA) primary care to VA specialty care ("within-system") or VA-paid community specialty care ("cross-system"). The primary outcome was patient-reported overall coordination. Illness burden was assessed using the Veterans RAND 12-item Health Survey. Secondary outcomes included 10 different domains of coordination. Data were collected between September 2022 and March 2025 using the Coordination of Specialty Care-Patient Survey and linked to VA administrative data. Eligible participants were Veterans with a recent first visit to cardiology, endocrinology, or pulmonary medicine and no prior visit to the same specialty within 18 months. The analytic sample included 1388 respondents (40% response rate). We used mixed-effects logistic regression models with primary care facility as a random effect. In adjusted analyses, within-system patients were 5.3 percentage points more likely than cross-system patients to report well-coordinated care [average marginal effect (AME) 0.053, 95% CI: 0.052, 0.053]. Higher illness burden was associated with worse coordination (AME -0.145, 95% CI: -0.147, -0.144), and this did not differ by care setting. Among 10 coordination domains, only Specialist Knowledge of Patient History differed consistently, favoring within-system care. Patients receiving within-system specialty care reported better overall coordination than those receiving cross-system care despite similar scores across most domains. Coordination was worse among those with higher illness burden, identifying a higher-risk group in both settings. The divergence between overall coordination and individual domains highlights a challenge in cross-system comparisons: differences in patient experience may arise from processes not represented in available data.

PMID 43010624
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PubMedFrontiers in nutrition2026-11-11

Development and evaluation of an integrated clinical nutrition management system for inpatients.

Shan Haili H, Zhou Quan Q, Hu Wei W, He Yi Y et al.

Malnutrition is highly prevalent in hospitalized patients. Standardized nutritional interventions have been associated with improved clinical outcomes and reduced healthcare expenditures. Fragmented workflows, challenges in interdisciplinary coordination, and the absence of structured digital decision support often compromise the quality of nutritional care for hospitalized patients. Consequently, a dedicated information system that integrates nutrition data and decision support into routine workflows is critically needed. To construct and evaluate a nutrition management module fully integrated into the Hospital Information System (HIS) to unify information flows and optimize the efficiency of clinical nutrition management. Conduct surveys to identify issues within the clinical nutrition management system and analyze clinical needs. Assemble a multidisciplinary expert team to define system functionality and use cases. Translate the functional requirements into code and implement them as a modular application designed for subsequent expansion. Test and debug the system before embedding it into the HIS for deployment. After deployment, evaluate clinical utility through treatment data analysis, and assess software performance and user satisfaction via surveys. An integrated Clinical Nutrition Management System (CNMS) grounded in an integrative framework was successfully developed. The application adopts a modular design and covers the core steps of the nutritional-care pathway, from nutritional assessment through the prescription of parenteral and enteral nutrition to intake monitoring. Compared to the old system, the new module obtained higher user satisfaction scores (8.48 ± 1.21 vs. 6.70 ± 1.78). Users particularly praised the application's visualization logic, medication list, real-time alerts, preset PN packages, and knowledge modules. The application demonstrated acceptable usability and user satisfaction. Its logic-driven, workflow-integrated design pattern, combined with potential for scalability, holds promise for scaled interdisciplinary implementation. This system may support more structured nutrition management and workflow efficiency; however, its impact on clinical outcomes such as complications, length of stay, and mortality was not evaluated in this study and should be examined in future research.

PMID 43011248
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PubMedBMC oral health2026-11-11

Comparative evaluation of matrix systems on proximal contact strip force and surface geometry in class II direct composite restorations: an in vitro study.

Noorudeen Aqeel A AA, Shetty S Vidhyadhara SV, Jose Jeslee Ann JA, Sharma Shyam Ranjan SR et al.

Proximal contact strip force and surface geometry remain challenging in Class II composite restorations, with matrix system selection being a key factor. This study aimed to compare the proximal contact strip force and surface geometry of the myQuickmat Classico sectional matrix system and the myQuickmat all-round circumferential matrix system in Class II MOD composite resin restorations. Twenty typodont molar teeth (Nissin Dental Products Inc., Kyoto, Japan) with standardised MOD cavities were selected and equally allocated into two groups. Group 1 consisted of the myQuickmat Classico sectional matrix system (Polydentia SA, Mezzovico-Vira, Switzerland), and Group 2 consisted of the myQuickmat all-round circumferential matrix system (Polydentia SA, Mezzovico-Vira, Switzerland). Composite restorations were done using Tetric N-Ceram composite resin (Ivoclar Vivadent, Liechtenstein). Proximal contact strip force and surface geometry were evaluated using a universal testing machine and confocal profilometer (NANOVEA ST 400, USA). Normality was confirmed by the Shapiro-Wilk test, and differences between groups were analyzed by Student's t-test and the Mann-Whitney U test (Jamovi 2.6.44); P < 0.05. The sectional matrix produced greater proximal contact strip force at mesial (1.903 ± 0.333 N vs. 1.473 ± 0.413 N; P = 0.020) and distal (2.807 ± 0.557 N vs. 1.721 ± 0.405 N; P < 0.001) surfaces. Both systems showed surface concavity; the circumferential system had significantly greater concavity area, depth, and smaller radius of curvature compared with the sectional matrix system (P < 0.001). The sectional matrix outperformed the circumferential system; however, concavity was observed on the proximal surface with both systems, reflecting limitations in the design of the matrix band.

PMID 43009929
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PubMedComputational and structural biotechnology journal2026-11-11

Computational Frameworks, System-Level Platforms, and Emerging Trends in DNA Data Storage.

Luo Jun J, Meng Ziqi Z, Tai Xinyao X, Ge Chunxia C

DNA storage has emerged as a promising approach for long-term digital information preservation owing to its ultrahigh storage density, long-term stability, and potential for passive long-term preservation without continuous electrical power under appropriate storage conditions. Recent advances in DNA synthesis, sequencing, and molecular manipulation technologies have accelerated the development of the field, broadening the scope of research from sequence-based encoding to biochemical channel modeling, system implementation, structured DNA storage, and information management. However, existing studies are often focused on individual components of DNA storage systems, and the relationships among these components remain insufficiently characterized from a computational and system-level perspective. This structured narrative review examines selected representative studies based on their technical importance and relevance to a computational and system-level analytical framework for DNA storage. We first outline the development of sequence-based and non-sequence-based DNA storage technologies, highlighting the expansion of information representation beyond nucleotide sequences to encompass multidimensional molecular structures and states. We then examine representative computational tools and system-level platforms, including coding toolchains, biochemical channel modeling, automated storage platforms, and user-oriented information management systems. We present an analytical framework comprising 5 interconnected functional layers: information representation, encoding and decoding, biochemical channel, system implementation, and access and management. Using this framework, we analyze the relationships among existing technologies, current technical challenges, and emerging research directions. DNA storage is evolving from a high-density storage technology toward an integrated molecular information system that supports information representation, storage, retrieval, and management. Further progress will require coordinated advances in multidimensional information representation, content-based querying, cross-layer system optimization, and interdisciplinary research to support the development of practical DNA-based information systems.

PMID 43011157
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