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INJEX system

✓ Approved

Equidyne · therapeutic agent

What is INJEX system?

INJEX system is a therapeutic agent developed by Equidyne. It is approved for therapeutic indications via injectable (others) or intramuscular (im) injection or subcutaneous injection.

Drug Profile

CompanyEquidyne
RouteInjectable (Others), Intramuscular (IM) Injection, Subcutaneous Injection
StatusApproved
Sources: ClinicalTrials.gov, Equidyne

Therapeutic Indications

INJEX system is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Surgical and medical proceduresOral appliance application✓ Approved

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Multispecialty Dental EMRs from Chairside Audio: An Exploratory Study.

Wei L L, Wang Y Y, Lu J J, Wang H H et al.

The objective of this study was to develop and internally evaluate a modular large language model (LLM) system for generating standardized electronic medical records (EMRs) from dental chairside consultations under conditions of acoustic interference and specialty-specific heterogeneity. We built a controllable pipeline integrating multistage audio enhancement and local automatic speech recognition with a cascaded LLM generator. A baseline end-to-end system (system 1) was compared with an evidence-enhanced system (system 2) that added module A (multisource evidence capture and fact table construction) and module B (multiversion collaboration and consensus voting; N = 3, consensus ≥2/3). We evaluated 100 deidentified outpatient recordings from periodontics, orthodontics, and prosthodontics. Output quality was assessed by double-blind clinician scoring and an automated scoring system across completeness, language quality, medical accuracy, and structural standardization (0 to 100 per dimension). System 1 achieved clinically acceptable performance across models, with Kimi-K2 showing the highest stability. System 2 improved robustness with standard deviation reductions of 33.8% (periodontics), 55.9% (orthodontics), and 42.6% (prosthodontics), with the largest gains in complex prosthodontic cases. Analysis of dataset characteristics and acoustic patterns confirmed the clinical authenticity of the corpus and established its suitability for performance evaluation. Artificial intelligence-generated scores correlated with human expert ratings (r = 0.823; R2 = 0.678) with a stable positive bias (mean difference 12.54 points). Our evidence-grounded and consensus-constrained LLM system demonstrated methodological feasibility for generating EMRs from authentic chairside audio, with improvements in medical accuracy and consistency and reduced variability in complex clinical workflows.

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PubMedJournal of participatory medicine2026-07-25

Participatory System Mapping of a Hospice Care System With Hospice Stakeholders: Hybrid Design Workshop Study.

Tibbles Andrew A, Nickpour Farnaz F

Palliative and end-of-life care (PEoLC) systems are expanding across services, settings, and stakeholders, increasing their complexity and the need for systemic understanding to support patient outcomes and service delivery. Hospice care is central to the future of PEoLC, as hospices provide holistic services and engage diverse stakeholders. Participatory system mapping offers a way to collectively understand and visualize complex dynamics with those who live and work within these systems. This study aims to capture hospice system dynamics and preliminary leverage points via participatory causal loop diagram (CLD) mapping while evaluating method suitability through 3 research questions: (RQ1) What key variables and causal interrelationships do stakeholders identify in a hospice through participatory system mapping workshops? (RQ2) What preliminary leverage points emerge from the system map? and (RQ3) How effective are participatory system mapping workshops for capturing hospice dynamics? We developed and iteratively refined an innovative hybrid, asynchronous, multimodal design workshop series in a hospice in North West England. Stakeholders were introduced to core concepts in technology, design, systems thinking, and CLDs before engaging in participatory system mapping focused on the hospice experience quality. CLDs generated in workshops and through asynchronous participation were consolidated into a composite hospice system map. Twenty-seven participants, including patients, health care professionals, volunteers, managers, maintenance staff, and chaplaincy, contributed to the mapping process. The resulting map was analyzed using quantitative network analysis (in-degree, out-degree, betweenness, and closeness centrality) alongside qualitative interpretation of key system dynamics. The participatory hospice system map contained 84 variables connected by 175 causal links. Network analysis highlighted patient experience (highest in-degree, 20), advanced care planning (highest out-degree, 8), fundraising (highest betweenness centrality, 0.19), and relationships with community organizations and external stakeholders (highest closeness centrality, 0.23) as central elements in the map. Qualitative analysis illuminated important dynamics, including the impact of hospital admissions and hospice stereotypes, as well as uncertainties around how advanced care planning is shaped and enacted in practice. Participatory system mapping with hospice stakeholders was feasible in a time-pressured setting and generated a nuanced, stakeholder-led representation of hospice system dynamics. The hybrid, multimodal workshop model enhanced access and flexibility, supporting diverse engagement. Network analysis of the CLD suggested preliminary structural and conceptual leverage points and revealed gaps in shared understanding, indicating candidate areas for service development, policy attention, and further research. Future work should examine the replicability of this approach across PEoLC settings and integrate context-specific processes to validate and act on candidate leverage points.

PMID 42497842
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PubMedInternational journal of food science2026-07-25

Fatty Acid Profile in Liver Tissue From Cattle Raised in Different Systems in the Eastern Amazon, Brazil.

da Cruz Andréa Viana AV, da Silva Jamile Andréa Rodrigues JAR, E Silva André Guimarães Maciel AGM, Alves Susana Paula Almeida SPA et al.

Bovine liver is a food that is known to be nutritious and easily accessible to consumers. The nutritional quality of this food can be influenced by several factors, such as the rearing system. The objective of this study was to characterize the fatty acid profile in the liver tissue of cattle raised in the Brazilian Eastern Amazon, taking into account the effect of the rearing system and seasonality. Liver tissue samples from cattle raised in native pastures, in flooded areas, in cultivated pastures, in highlands and in a confinement, system was evaluated. The liver tissue from the extensive systems showed (p < 0.05) a higher proportion of saturated fatty acids (C16:0 and 17:0) and a higher proportion of monounsaturated fatty acids compared with the confinement liver tissue. The sum of polyunsaturated fatty acids was higher for the hepatic tissue of the feedlot system compared with the pasture system; however, the tissue of animals from the pasture system showed much higher percentages of long-chain PUFA's such as EPA, DHA, DPA, and their precursor, alpha-linolenic acid. The information gathered is important for optimizing the production of beef and its offal with desirable nutritional properties for promoting human health.

PMID 42499997
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PubMedWorld journal of otorhinolaryngology - head and neck surgery2026-07-25

Novel Surgical Strategy System for Juvenile Nasopharyngeal Angiofibroma: A Focus on Feeding Artery Management.

Zheng Nian-Zhen NZ, Wen Yi-Hui YH, He Zi-Cheng ZC, Wang Yong-Quan YQ et al.

For intraoperative bleeding control in patients with juvenile nasopharyngeal angiofibroma (JNA), we developed a novel surgical strategy system. This system is focused on feeding artery management, based on the spatial relationship between the tumor entity and feeding artery as determined by three-dimensional reconstruction. This historical controlled study was conducted at a tertiary medical institution from October 2013 to September 2022. The retrospective group comprised of previous JNA patients received traditional nasoendoscopic sursery. Three-dimensional CT reconstruction based on their preoperative contrast-enhanced CT and CTA was used for segmentation of spatial relationship between dominant feeding artery (DFA) and tumor entity. The prospective group comprised JNA patients undergoing endoscopic/endoscopic-assisted surgery reinforced DFA management by intraoperative ligation. Efficacy evaluation between two groups focused on intraoperative bleeding, complete resection rate and Postoperative hospitalized duration. Twelve patients were included in the retrospective group. The three-dimensional reconstruction models were successfully performed, and the DFA was located in all patients. According to the segmentation of the DFA, we established a novel surgical strategy system focused on feeding artery management. All 11 patients in the prospective group underwent successful management of the DFA by intraoperative ligation with less intraoperative bleeding. In this study, we introduced a novel surgical strategy system for JNA. The system focuses on feeding artery management, ensuring bleeding control based on the location of DFA on three-dimensional image reconstruction. As a result of clear and straightforward image classification, intraoperative bleeding was decreased. This system may become a meaningful reference for JNA preoperative planning.

PMID 42500071
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PubMedMedical physics2026-07-25

A Comparative dose and image quality assessment of a portable, multi-modality extremity imaging system for austere environments.

Yang Xiangyu X, Stafford Edward J EJ, DeBrosse Hadley A HA, Wei Yi Y et al.

Rapid technological innovation in diagnostic imaging requires timely, evidence-based safety and quality assessment to ensure optimal patient care. This study evaluates a novel multi-modality extremity imaging system (OXOS MC2) designed for deployment in remote and austere environments. To systematically evaluate the radiation safety and image quality characteristics of the MC2 system in its three imaging modalities (radiography, fluoroscopy, and Dynamic Digital Radiography [DDR]), and to compare them with two conventional, single-modality reference systems: a portable radiographic unit and a mobile C-arm fluoroscopic unit. Radiation dose and image quality were assessed for four extremity regions (hand, shoulder, ankle, knee). Patient dose metrics (Entrance Air Kerma [EAK] and Entrance Air Kerma Rate [EAKR]) were estimated using clinical techniques and measured primary radiation output. Operator dose (effective dose equivalent, HE) was estimated using a "virtual badge" method based on measured scatter map, leakage rate, and clinical setups provided by practicing orthopedic surgeons. Spatial resolution was quantified by the Modulation Transfer Function (MTF) using the slant-edge method. Contrast performance was analyzed using a Gammex contrast-detail phantom. The image receptor input dose (IRID) and input dose rate (IDRIR) were also measured. Dose comparisons were summarized descriptively due to the small sample size. Image quality comparisons were performed using generalized linear models with Bonferroni correction for multiple comparisons (statistical significance set at p < 0.0019 for each individual test). The MC2 system demonstrated substantially lower patient EAK compared to the radiographic reference system (14%-59% of the reference). Although EAKR varied relative to the reference fluoroscopic system (15%-245% of the reference) due to differences in setup, the MC2's maximum AKR (3.53 mGy/min) remained well below the regulatory limit (44 mGy/min), indicating a negligible risk of radiation-induced skin injury for the patient. The IRID and IDRIR exhibited trends similar to the EAK and EAKR. Operator doses for the MC2 were consistently lower than those of both reference systems, with the HE at 9%-45% of the radiographic reference and 2%-80% of the fluoroscopic reference. Patient and operator doses of DDR were comparable to those of fluoroscopy. The MC2 system showed consistent image quality across all three imaging modalities. Its spatial resolution (1.8-1.9 lp/mm) was comparable to the fluoroscopic reference system (1.8-1.9 lp/mm, p = 0.92) but significantly lower than the radiographic reference system (2.1-2.2 lp/mm, p < 0.001). Despite delivering a lower dose to the detector, the MC2 demonstrated no significant difference in low-contrast performance (all p ≥0.11). Handheld operation showed no significant impact on image quality. The OXOS MC2 is a safe and versatile imaging system capable of meeting various extremity imaging needs in remote and austere environments. With substantially reduced radiation dose and improved portability, it provides a robust alternative to conventional portable radiographic systems. While the MC2 system exhibits compromises in spatial resolution and beam hardness, its unique multi-modality capabilities enable the field deployment of previously inaccessible fluoroscopic and DDR imaging, thereby greatly enhancing patient access to advanced imaging techniques in resource-limited settings.

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PubMedBMC emergency medicine2026-07-25

Reframing disaster simulation as a translational systems intervention: a design-based comparative analysis of MRMI and the Emergo Train System (ETS).

Amir Khorram-Manesh KM, Eric Carlström C

Disaster simulation is central to emergency preparedness; however, many simulation designs insufficiently represent disasters as prolonged, system-disruptive, and ethically complex events. Exercises frequently emphasize mass-casualty throughput, rely on simplified assumptions, and evaluate success primarily in terms of task completion rather than system performance and organizational learning. This study examines how disaster simulation design shapes preparedness outcomes and explores how simulation may be reframed as a translational systems intervention. A qualitative design-based research approach was used to conduct an inductive comparative framework analysis of two established disaster simulation paradigms: Medical Response to Major Incident (MRMI) and the Emergo Train System (ETS). Documentary sources included curricula, instructional materials, scenario templates, published evaluations, disaster evidence literature, and World Health Organization Emergency Medical Team standards. Simulation design features were extracted and compared using constant comparative analysis, and the findings were subsequently interpreted through socio-technical systems and resilience engineering perspectives. Four recurrent design-level tensions were identified using harmonized terminology: (1) divergent disaster conceptualization (governable surge versus unstable system disruption); (2) fidelity emphasis imbalance (cognitive versus behavioral realism); (3) incident-centric temporal framing; and (4) inconsistent translation into organizational learning. Published evaluation reports suggest that MRMI may support governance alignment and coordinated surge reasoning, whereas ETS may provide greater operational realism and more opportunities to expose teamwork under stress. Neither paradigm alone appears to fully address all design requirements relevant to sustained disaster-level system resilience. MRMI and ETS appear complementary but individually incomplete. A staged hybrid architecture integrating governance modeling, operational stress testing, longitudinal degradation modeling, and structured reflective translation is proposed as a design-oriented framework. This framework may help position disaster simulation as a translational systems intervention that connects exercise performance to potentially measurable organizational preparedness and system resilience, while still requiring empirical validation in practical settings.

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