Drug Database
GR

griseofulvin (Grisol)

✓ Approved

Transdermal · Small Molecule · Small Molecule

What is griseofulvin?

griseofulvin is a small molecule developed by Transdermal. It is approved for therapeutic indications via topical.

Drug Profile

Brand NamesGrisol
CompanyTransdermal
Drug ClassSmall Molecule
RouteTopical
StatusApproved
Sources: ClinicalTrials.gov, Transdermal

Therapeutic Indications

griseofulvin is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
InvestigationsDermatologic examination✓ Approved

Related Research Articles

PubMedMedical mycology2026-11-10

Avian Dermatophytosis Caused by Lophophyton gallinae in Thailand: Emergence in a Broiler Breeder Farm and Surrounding Community, Multilocus Molecular Characterization, and Antifungal Susceptibility.

Dachakul Nirawit N, Jenjirawatn Koramit K, Punperm Purun P, Thamprisarn Rapeewan R et al.

Avian dermatophytosis, caused by the zoophilic dermatophyte Lophophyton gallinae, is a neglected superficial mycosis. This study explored an outbreak across a commercial broiler breeder farm and neighboring backyard poultry flocks in Thailand. A total of 133 samples were collected for dermatophyte culture, comprising suspected chicken samples from broiler breeder farms (n = 89) and three backyard flocks around outbreak farms (n = 29), along with environmental samples from outbreak farms (n = 15). L. gallinae was isolated and morphologically identified from 40 birds, comprising 32/89 broiler breeders (36.0%) and 8/29 backyard poultry samples (27.6%). All environmental samples were negative for dermatophyte culture. To determine their phylogenetic relationships and genetic diversity, 10 representative positive isolates were subjected to single-locus sequence analysis of the internal transcribed spacer (ITS) region and concatenated multilocus sequence analyses of the combined ITS and partial β-tubulin (TUB2) loci. Phylogenetic inference revealed that the L. gallinae clade diverges into two groups associated with avian and nonavian hosts, with all Thai isolates clustering specially within the avian-associated group. Furthermore, in vitro antifungal susceptibility testing of 40 isolates revealed low minimum inhibitory concentration (MIC) values across all tested agents, with MIC ranges of < 0.016-0.125 µg/mL for enilconazole, <0.03-0.25 µg/mL for clotrimazole, 0.03-0.25 µg/mL for itraconazole, and < 0.125-1.00 µg/mL for griseofulvin. Overall, this study represents the first report of a severe L. gallinae outbreak within a commercial poultry farm in Thailand and provides molecular characterization of the L. gallinae clade within the Arthrodermataceae family.

PMID 43008276
Read full article →
PubMedDiagnostics (Basel, Switzerland)2026-10-27

Atypical Periocular Dermatophytosis Caused by Trichophyton mentagrophytes Species Complex Misdiagnosed as Refractory Bacterial and Viral Infection.

Battistella Veronica V, Meneghesso Davide D, Zoppelletto Maira M, Meneguzzo Alberto A et al.

A previously healthy 4-year-old boy presented with progressive left eyelid swelling and erythema, without reported animal exposure. Initially diagnosed as impetiginized eczema, the lesion was treated with topical antibiotic and corticosteroid therapy. Due to early clinical worsening, this was subsequently escalated with oral amoxicillin-clavulanate (50 mg/kg/day) and azithromycin (10 mg/kg/day). However, this local and systemic regimen failed and worsened the clinical presentation over a 9-day period. Inflammatory markers and blood cultures remained normal. Due to outpatient treatment failure, an initial periorbital skin and ciliary margin swab was collected on day 9 of oral antibiotics. Two days later, worsening symptoms prompted hospital admission for intravenous broad-spectrum antibiotics (ceftriaxone and clindamycin) and fluconazole. Pending culture results, suspected vesicular lesions led to empirical oral acyclovir (20 mg/kg/dose, 4 times daily); this was discontinued after 3 days when the initial swab returned negative for HSV. Ultimately, after an 8-day incubation, the outpatient swab culture yielded Trichophyton mentagrophytes species complex. Following microbiological identification of the dermatophyte, antifungal treatment was optimized with systemic griseofulvin and topical terbinafine, leading to complete clinical resolution. This case highlights atypical periocular dermatophytosis masquerading as a refractory bacterial and viral infection. Since direct animal exposure was not reported and phenotypic identification alone cannot distinguish between zoophilic (T. mentagrophytes) and anthropophilic (T. interdigitale) subtypes, the exact source of infection remains undetermined. In conclusion, while 'tinea incognito' is well documented, this report illustrates an exceptionally atypical periocular manifestation that mimicked a refractory bacterial cellulitis and simulated a herpetic infection. The novelty of this case lies in its severe clinical mimicry-including the development of chalazion-like lesions-which confounded a multidisciplinary team and led to unnecessary systemic antiviral and broad-spectrum antibiotic therapies, strongly highlighting the clinical importance of considering dermatophytosis in atypical orbital presentations.

PMID 42938146
Read full article →
PubMedInternational journal of pharmaceutics2026-10-15

Evaluating the effect of griseofulvin on the disintegration properties of tablets.

Armstrong John A JA, Maclean Natalie N, Markl Daniel D, Johnston Blair F BF

Understanding how active pharmaceutical ingredients (APIs) influence tablet disintegration remains essential for optimising oral drug product performance. In this work, we present an integrated, data-driven framework that combines deep-learning-based image segmentation, automated regime detection and mechanistic modelling to characterise liquid absorption and swelling behaviours from sessile drop experiments. Using this workflow, we investigated the effect of incorporating griseofulvin into directly compressed tablets containing a variety of excipient combinations. Across all formulations, the presence of griseofulvin significantly reduced wettability and maximum swelling size, consistent with replacing hygroscopic excipients with a poorly soluble, hydrophobic drug. Bayesian hierarchical modelling confirmed credible decreases in swelling capacity for all formulations and formulation-dependent changes in initial swelling rate. Notably, MCC/lactose tablets exhibited faster initial swelling and shorter disintegration times despite reduced porosity, suggesting API-induced microstructural changes that enhance access of liquid to the swellable excipients. Overall, the proposed framework provides a rapid (<6 min), mechanistic and minimally subjective method for probing formulation-dependent disintegration behaviour. For griseofulvin, the method was sensitive to changes in absorption and swelling behaviour, highlighting its potential as a high-throughput formulation screening approach. Further studies involving a wider range of APIs are needed to determine whether these observations are generalisable and relevant to disintegration and dissolution performance.

PMID 42880651
Read full article →
PubMedToxicon : official journal of the International Society on Toxinology2026-10-15

Mycotoxin-induced DNA damage response and its association with carcinogenesis.

Singh Priyanka P, Bilachi Ravindranath S RS, Yegneswaran Prakash Peralam PP, Pandit Depanshi D et al.

Fungal species produce various secondary metabolites with carcinogenic and genotoxic properties, including aflatoxins, ochratoxins, fumonisins, sterigmatocystin, and griseofulvin. Acute or chronic exposure to these mycotoxins through contaminated food and feed can cause DNA damage, chromosomal instability, and epigenetic changes, ultimately leading to cancer. This review focuses on IARC-classified carcinogenic mycotoxins and their contribution to cancer development by disrupting the DNA damage response (DDR), thereby affecting apoptosis, cell cycle regulation, and genomic stability. Current knowledge of co-exposure to mycotoxins, host susceptibility, and validated biomarkers remains limited, particularly regarding the regulation of DDR genes. This necessitates more in-depth mechanistic and epidemiological research. Network analysis of host genes associated with mycotoxins in the CTD, integrated with DDR-related genes curated from CancerSEA, identified candidate DDR-associated genes implicated in pathways related to cell cycle regulation, DNA repair, oxidative stress response, and apoptosis. These findings represent database-derived associations and computational prioritization, rather than evidence of causal mechanistic roles in mycotoxin-induced carcinogenesis. Enrichment analysis using the Enrichr tool further identified the association between mycotoxin-associated DDR genes and cancer. In brief, this review enhances the understanding of the role of mycotoxins in DDR mechanisms and their potential contribution to cancer development, thereby providing a basis for improved molecular and translational approaches to address the associated health risks.

PMID 42880423
Read full article →
PubMedJournal of computer-aided molecular design2026-10-07

Identification of new ER-targeted anticancer hits active against MCF-7 breast cancer cells in the marine fungal secondary metabolite library using computative and experimental approaches.

Yurchenko Ekaterina A EA, Nesterenko Liliana E LE, Kaluzhskiy Leonid A LA, Yablokov Evgeniy O EO et al.

The identification of novel estrogen receptor (ER)-targeted anticancer compounds from marine fungal secondary metabolites was performed using a combined computational and experimental approach. A library of 461 marine fungal metabolites was analyzed using chemical space visualization, structural similarity assessment using Tanimoto indices, and target-prediction tools to identify potential ER ligands. Scaffold analysis of predicted hits suggested decalin/bicyclic terpenoid (6-6), tricyclic 6-6-6 terpenoid, bicyclic 5-6 system and several polycyclic system chemotypes as novel for ER ligands. The ER-dependence of the proposed hits cytotoxicity was tested in vitro against ER-positive human breast cancer MCF-7 cells using a 4-hydroxytamoxifen (4-OHT)-competitive viability assay. The compounds virescenoside M, cladosporin, zosteropenilline S, and griseofulvin exhibited ER-dependent cytotoxic effects on MCF-7 cells, confirming the in silico predictions. In 48 h experiments, cladosporin, zosteropenilline S, and griseofulvin at 100 µM decreased the MCF-7 cell viability by 73.6%, 33.2%, and 45.8%, respectively, but statistically significant cytotoxic effect of griseofulvin also was observed at its concentration of 1 µM. Surface plasmon resonance (SPR) experiments confirmed the direct binding of griseofulvin to ERα, with a dissociation constant (Kd) of 8.00 µM. These findings highlight marine fungi as a valuable source of novel ER-targeted anticancer agents and suggest a novel ER-dependent mechanism for the antifungal drug griseofulvin, providing a basis for its potential repositioning in ER-positive breast cancer therapy. This integrated computational-experimental strategy provides a framework for discovering new lead compounds for breast cancer treatment.

PMID 42839117
Read full article →
PubMedSkin health and disease2026-09-30

A single-centre, retrospective cohort study of paediatric tinea capitis in the United Kingdom.

Herd Elliot E, Gardner Louis L, Leech Suzy S, Weiand Daniel D et al.

Contemporary understanding of the epidemiology and clinical spectrum of paediatric tinea capitis in the UK is limited, with implications for both clinical management and public health interventions. To examine recent trends in the incidence, clinical presentation and microbiological profiles of paediatric tinea capitis, and to explore the implications for quality of care and infection prevention. A single-centre retrospective cohort study was conducted of all patients aged < 18 years with microbiologically confirmed tinea capitis during two 3-year intervals: 2016-19 and 2022-25. Clinical records were reviewed for demographic features, clinical presentation, organisms identified and transmission sources, with a focus on practice standards and preventive strategies influencing quality of care. A total of 102 patients were identified: 32 from 2016-19 and 70 from 2022-25, representing a 118.8% increase in cases. Severe inflammatory presentations (kerion) rose from 19% (n = 6/32) in 2016-19 to 36% (n = 25/70) in 2022-25. Trichophyton tonsurans remained the predominant organism in both cohorts (72% vs. 74% of cultured organisms), but Trichophyton mentagrophytes newly emerged as the second most common pathogen (9% in 2022-25), having been absent in 2016-19. Barber-associated transmission was only reported in 2022-25 (n = 22), exclusively among relatively older boys, who also had a higher rate of kerion (41%). A shift in preferred oral antifungal therapy from griseofulvin to terbinafine was observed with the changing microbiological profile. Our findings demonstrate a significant rise in paediatric tinea capitis, with a disproportionate increase in inflammatory cases and a shift in causative organisms. The emergence of barber-associated transmission and T. mentagrophytes highlights evolving risk factors and the need to adapt practice standards and preventive measures to influence quality of care. Enhanced surveillance targeted educational interventions for practitioners and public, and routine practice measures to moni-tor infection sources are warranted to improve the quality of care and patient outcomes.

PMID 42813165
Read full article →

+3240 more articles available with a free account

Sign up free to view all articles →

Ask about griseofulvin