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Ypeginterferon alpha-2b (PegBeron)

✓ Approved

Xiamen Amoytop Biotech Co.ltd · Recombinant Proteins · Recombinant Proteins

What is Ypeginterferon alpha-2b?

Ypeginterferon alpha-2b is a recombinant proteins developed by Xiamen Amoytop Biotech Co.ltd. It is approved for therapeutic indications via injectable (others) or subcutaneous injection.

Drug Profile

Brand NamesPegBeron
CompanyXiamen Amoytop Biotech Co.ltd
Drug ClassRecombinant Proteins
RouteInjectable (Others), Subcutaneous Injection
StatusApproved
Sources: ClinicalTrials.gov, Xiamen Amoytop Biotech Co.ltd

Therapeutic Indications

Ypeginterferon alpha-2b is developed for 3 unique indications across 2 therapeutic areas.

Therapeutic AreaConditionPhase
Infections and infestationsHepatitis B✓ Approved
Infections and infestationsHepatitis C✓ Approved
Neoplasms benign, malignant and unspecified (incl cysts and polyps)Essential thrombocythaemiaPhase II

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Respiratory syncytial virus (RSV) is the leading cause of acute lower respiratory tract infections in infants and young children, with insufficient early diagnostic biomarkers and unclear molecular mechanisms. Oxidative stress (OS) is central to RSV-associated immune disorders and tissue damage. GEO datasets (GSE105450, GSE77087) were used to screen differentially expressed genes (DEGs); OS-related DEGs were identified via WGCNA. Four machine learning algorithms screened core diagnostic genes, with in vitro validation (A549/BEAS-2B cells) by qRT-PCR, shRNA-ID3 silencing, immunofluorescence and ELISA. ID3, MATK and ZMAT3 were potential diagnostic biomarkers (training AUC = 0.859, validation AUC = 0.725), upregulated in RSV-infected samples, correlated with immune cell infiltration, and involved in AKT/ERBB pathways. RSV upregulated ID3; ID3 knockdown promoted RSV replication and exacerbated OS. ID3, MATK and ZMAT3 are potential RSV diagnostic biomarkers; ID3 exerts host protection by regulating OS and inhibiting RSV replication, providing new targets for early diagnosis and intervention.

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Infliximab (IFX) is a chimeric monoclonal antibody against tumor necrosis factor-alpha (TNF-α) that is widely used for induction and maintenance therapy in pediatric inflammatory bowel disease (IBD), yet its effects on the developing intestinal microbiome and treatment response remain unclear. To systematically synthesize evidence on IFX-associated microbiome changes in pediatric IBD and evaluate microbiome features linked to treatment response. A systematic review was conducted following the PRISMA 2020 guidelines. PubMed, Scopus, Embase, and CENTRAL were searched from database inception until March 2026, and our results were synthesized narratively. Of the 945 records identified, 13 studies met the inclusion criteria, comprising 242 pediatric patients. Findings for alpha diversity were variable across studies. In contrast, beta-diversity patterns, taxonomic profiles, and functional analyses more consistently showed positive IFX-associated microbial changes. Responders to treatment more frequently showed enrichment of beneficial taxa, including Faecalibacterium, Subdoligranulum, and Bifidobacterium, while non-responders exhibited a tendency towards dysbiotic microbial signatures, evidenced by increased levels of Gammaproteobacteria and Candida. Functional and metabolomic studies suggested beneficial shifts in bile-acid metabolism, short-chain fatty acid-related pathways, and inflammatory signaling post IFX treatment. Clinical and biochemical improvements with IFX were consistently reported; however, these improvements were not always accompanied by uniform recovery of overall microbial diversity. In pediatric IBD, IFX is more consistently associated with shifts in microbial composition and function than with broad increases in overall microbial diversity. Further large, standardized studies are warranted to refine the role of microbiome features in biologic treatment stratification. https://www.crd.york.ac.uk/PROSPERO/view/CRD420251133625, identifier CRD420251133625.

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