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Ypeginterferon alpha-2b (PegBeron)

✓ Approved

Xiamen Amoytop Biotech Co.ltd · Recombinant Proteins · Recombinant Proteins

What is Ypeginterferon alpha-2b?

Ypeginterferon alpha-2b is a recombinant proteins developed by Xiamen Amoytop Biotech Co.ltd. It is approved for therapeutic indications via injectable (others) or subcutaneous injection.

Drug Profile

Brand NamesPegBeron
CompanyXiamen Amoytop Biotech Co.ltd
Drug ClassRecombinant Proteins
RouteInjectable (Others), Subcutaneous Injection
StatusApproved
Sources: ClinicalTrials.gov, Xiamen Amoytop Biotech Co.ltd

Therapeutic Indications

Ypeginterferon alpha-2b is developed for 3 unique indications across 2 therapeutic areas.

Therapeutic AreaConditionPhase
Infections and infestationsHepatitis B✓ Approved
Infections and infestationsHepatitis C✓ Approved
Neoplasms benign, malignant and unspecified (incl cysts and polyps)Essential thrombocythaemiaPhase II

Related Research Articles

PubMedZhonghua nan ke xue = National journal of andrology2026-11-11

[Experimental study on Qiangjing decoction modulating the expression of testis/epididymis-specific LncRNAs (Dmr/Mrhl/Tsx/HongrES2) and its regulatory mechanisms in oligoasthenospermic rats].

Bin Bin B, Lu Haiwang H, Wang Desheng D, Lin Siwei S et al.

Objective To investigate the therapeutic mechanism of Qiangjing decoction (QJD) in oligoasthenospermia model rats by regulating the expression of testis-specific long non-coding RNAs (LncRNAs) Dmr, Mrhl, Tsx, and epididymis-specific HongrES2. MethodsSixty sexually mature male Sprague-Dawley rats were randomly divided into the normal group, the model group, the Shengjing capsule group and the QJD group, with 15 rats in each group. Rat models of oligoasthenospermia were induced by intraperitoneal injection of cyclophosphamide (CTX). After successful modeling, the normal group received no intervention, the model group was given normal saline, and the QJD group and the Shengjing capsule group were administered the corresponding drugs for 38 consecutive days, sperm quality parameters were evaluated. Spermatogenic function was assessed by the method of testicular histomorphology. The mRNA expression levels of lncRNAs (Dmr, Mrhl, Tsx, HongrES2) and related genes (Sox8, Utf1, Wnt-2b, β-catenin, Gsk-3β, p68, Stra8) were detected by quantitative real-time PCR, while corresponding protein expression was analyzed by Western blot. Results In the normal group, the testicular tissue exhibited intact and regularly arranged seminiferous epithelium with active spermatogenesis. In the model group, the seminiferous epithelium showed partial detachment and disorganized arrangement, accompanied by a marked reduction in spermatozoa. In contrast, both the QJD group and the Shengjing capsule group displayed more layers of spermatogenic cells with relatively orderly arrangement, and abundant spermatozoa were observed. Sperm concentration and motility in the epididymis were markedly elevated following QJD treatment. Gene expression analysis revealed significant downregulation of Dmr, HongrES2, GSK-3β, and CES7 in the model group versus normal controls (P<0.05), while Tsx showed a non-significant decreasing trend. No significant differences were observed in Mrhl, Wnt-2b, β-catenin or Sox8 gene expression. QJD intervention significantly upregulated the expression of Dmr, HongrES2, GSK-3β, Tsx, CES7, and Wnt-2b. Protein expression of STRA8, SOX8, P68, UTF1, WNT-2b, β-CATENIN, GSK-3β and CES7 was significantly reduced in the model group but restored after QJD and Shengjing capsule treatment. Conclusion QJD may ameliorate oligoasthenospermia by upregulating testis-specific LncRNAs (Dmr, Mrhl, Tsx) and epididymis-specific HongrES2, thereby activating the Wnt-2b/β-catenin signaling pathway. This mechanism promotes spermatogonial proliferation and meiosis, while modulating key proteins (UTF1, CES7) crucial for spermatogenesis and maturation, ultimately improving sperm production and motility of rats with oligoasthenospermia.

PMID 43012205
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PubMedAnalytical chemistry2026-11-11

Single-Cell ICP-MS Quantification of Intracellular Chromium and Cell-Surface TNFR2 for Assessing Cr(III/VI)-Induced Lung Epithelial Injury and COPD-Relevant Responses.

Lu Xinyi X, Chen Beibei B, He Man M, Hu Bin B

An integrated platform combining droplet microfluidics, lanthanide labeling, and inductively coupled plasma mass spectrometry (ICP-MS) was proposed to quantify intracellular heavy metal and cell-surface protein at single-cell resolution. The workflow performs parallel measurements on homologous single-cell subsets to establish statistical correlations between metal accumulation and functional protein responses. Using tumor necrosis factor receptor 2 (TNFR2) as a model protein, we investigated the effects of atmospheric particulate matter-associated heavy metals on human lung epithelial cells (BEAS-2B). Several heavy metals trigger TNFR2 upregulation, with Cr(VI) exerting the most pronounced effect. The Cr(VI)-induced increase in TNFR2 expression was associated with elevated TNF-α release, higher intracellular ROS, and reduced SOD activity but did not correlate directly with intracellular Cr accumulation, likely due to distinct cellular uptake mechanisms between Cr(III) and Cr(VI). High-concentration Cr(III) exposure, however, led to intracellular Cr enrichment and provoked inflammatory responses. Integration of differential gene expression, TNF-α release, and TNFR2 expression support TNFR2 as a potential indicator of metal-induced oxidative stress, epithelial injury, and COPD-relevant inflammatory responses. This single-cell dual-parameter approach provides a new strategy for linking metal uptake to functional protein responses in environmental toxicology.

PMID 43010549
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PubMedOral health & preventive dentistry2026-11-11

Validation of the Turkish Oral Health Impact Profile-17 for Assessing Oral Health-Related Quality of Life in Endodontic Patients.

Çetinkaya Oğuz Burhan OB, Gözübüyük Betül Banu BB, Yüksekkaya İrfan İ, Gündoğar Hasan H

To evaluate the reliability and construct validity of the Turkish version of the Oral Health Impact Profile-17 (OHIP-17-TR) in patients receiving endodontic treatment. This methodological, cross-sectional validation study included 229 adult patients undergoing or having recently completed endodontic treatment. Participants completed the OHIP-17-TR questionnaire. Internal consistency was assessed using Cronbach alpha and corrected item-total correlations. Construct validity was evaluated through exploratory factor analysis (EFA). Sampling adequacy was examined using the Kaiser-Meyer-Olkin (KMO) measure and Bartlett test of sphericity. Test-retest reliability was not assessed. The OHIP-17-TR showed high internal consistency, with a Cronbach alpha of 0.894. Corrected item-total correlations ranged from 0.345 to 0.675. The KMO value was 0.882, and the Bartlett test was significant (P 0.001), indicating suitability for factor analysis. Exploratory factor analysis identified a four-factor structure explaining 51.8% of the total variance, with all items demonstrating salient factor loadings. Subscale Cronbach alpha values ranged from 0.689 to 0.862. The OHIP-17-TR demonstrated good reliability and acceptable construct validity in this sample of endodontic patients. These findings support the use of OHIP-17-TR as a brief and practical patient-reported outcome measure for assessing oral health-related quality of life in endodontic research and clinical practice.

PMID 43012462
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PubMedJournal of pediatric rehabilitation medicine2026-11-11

Professionals' perceptions of complexity and preferences for interprofessional collaborative practice in pediatric rehabilitation: Insights from social network analysis.

Klaveren Lisa-Maria van LV, de Vos Rien R, Geukers Vincent V, Ketelaar Marjolijn M et al.

PurposeIntegrated care for children with disability and complex care needs requires professionals to collaborate across various disciplines and settings. However, it remains uncertain how professionals interpret complexity and how these interpretations influence composition and collaboration in integrated care networks. This study aimed to investigate professionals' perceptions of complexity and their preferences for interprofessional collaborative practice.MethodThis cross-sectional study using a web-based survey with scripted cases included 120 professionals working in pediatric rehabilitation medicine across the Netherlands. Scripted cases were created using the ICF-framework, selecting two elements per domain and modeling each domain at three levels of difficulties (low, medium, high). Thirteen scripted cases were randomly selected using conjoint methodology. For each case, professionals' 1) perceived case complexity and 2a) preferred interprofessional composition were recorded. Social network analysis was applied to examine 2b) preferred collaborative practice per case using four integrated care network metrics: density, overall span (diameter), mean distance between members, and cohesiveness (transitivity).ResultsHigher levels of difficulties in each ICF-domain significantly increased professionals' perceptions of complexity. Preferences for interprofessional composition varied according to levels of domain difficulties and exhibited substantial inter-individual variation. Although higher perceived case complexity was generally associated with preferences for greater cohesiveness, shorter mean distances, and more compact and denser networks, domain-specific difficulties also influenced preferred interprofessional collaborative practices even when overall perceived case complexity was low.ConclusionsThe study identified that preferences for interprofessional collaborative practice varied in relation to perceived case complexity and among professionals. Recognizing these differences at network-level is vital, as it enables the effective functioning of these networks and contributes to improved integrated care for children with disability.

PMID 43012573
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PubMedMedicine2026-11-11

Association between alpha-fetoprotein elevation and recurrence in patients who achieved normalized alpha-fetoprotein after curative resection for hepatocellular carcinoma: A retrospective cohort study.

Hwang Jeong Ah JA, Lee Jisun J, Yi Kyung Sik KS, Choi Chi-Hoon CH et al.

Alpha-fetoprotein (AFP) is a cornerstone biomarker for hepatocellular carcinoma (HCC) surveillance following curative resection. Although AFP normalization generally indicates effective tumor control, subsequent AFP elevation poses a diagnostic dilemma due to its potential association with both tumor recurrence and nonneoplastic liver conditions. This study aimed to determine the factors influencing AFP elevation and to assess the role of serial AFP testing for the early detection of recurrent HCC, thereby addressing an unmet need in refining postoperative surveillance strategies. In this retrospective cohort study, 705 patients who underwent curative resection for HCC between January 2018 and March 2020 and achieved AFP normalization were analyzed. Postoperative surveillance included AFP and imaging exams, with AFP elevation defined as ≥ 20 ng/mL and normalization as AFP < 20 ng/mL post-surgery. Multivariable analysis identified factors associated with AFP elevation. Recurrence occurred in 34.6%. Independent factors associated with AFP elevation included recurrence (odds ratio [OR] = 21.9; 95% confidence interval [CI] = 7.5-64.2), preoperative AFP elevation (OR = 3.6; 95% CI = 1.7-7.6), logAFP at normalization (OR = 12.7; 95% CI = 3.5-45.7), and cirrhosis (OR = 2.2; 95% CI = 1.0-4.5). In patients without recurrence, logAFP at normalization (OR = 12.6; 95% CI = 3.7-43.4) and cirrhosis (OR = 2.2; 95% CI = 1.1-4.5) were independently associated with false positive elevation. Intrahepatic recurrence accounted for 69.2%, with lesions of ≤ 1 cm composing 88.9%. Following a preceding AFP elevation, recurrence was detected after a median of 4.8 months and within 12 months in all cases. AFP elevation during postoperative surveillance is a strong indicator of HCC recurrence. In cases where AFP elevation occurs without clear radiologic evidence of recurrence, early and frequent liver MRI (at intervals of ≤ 3 months for at least 12 months) is recommended to facilitate prompt detection of intrahepatic lesions. Moreover, clinicians should be mindful that elevated normalized AFP levels and underlying cirrhosis increase the risk of false positive elevations. These findings underscore the need for a tailored surveillance strategy to optimize the early diagnosis and management of recurrent HCC.

PMID 43012784
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PubMedMRS bulletin2026-11-11

Electron probe microanalysis as a versatile tool to probe the chemistry of radioactive wasteforms.

Creasey-Gray Stuart S, Stennett Martin M, Thorpe Clare C, Manifold Garry G et al.

Electron probe microanalysis (EPMA) is a powerful, nondestructive microscopy tool that finds ubiquitous application in the broader field of materials science. Herein, it was demonstrated that EPMA is a versatile tool for probing the chemistry of nuclear materials, particularly wasteform systems for the immobilization of intermediate and high-level radioactive waste, with constituents such as Cs, Sr, U and Pu. This communication evidences the efficacy of EPMA to further understand the five distinct wasteform systems for both nonradioactive surrogate material particularly relevant to the UK radioactive waste management and disposal program, including alpha-active systems containing 238U.

PMID 43011317
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