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sumatriptan (Alsuma autoinjector / sumatriptan, King / Alsuma)

✓ Approved

US WorldMeds, LLC · HTR1D · Small Molecule

What is sumatriptan?

sumatriptan is a small molecule developed by US WorldMeds, LLC. It is approved for therapeutic indications via injectable (others) or subcutaneous injection.

Drug Profile

Brand NamesAlsuma autoinjector, sumatriptan, King, Alsuma
CompanyUS WorldMeds, LLC
Drug ClassSmall Molecule
Molecular TargetHTR1D
RouteInjectable (Others), Subcutaneous Injection
StatusApproved
Sources: ClinicalTrials.gov, US WorldMeds, LLC

Mechanism of Action

Molecular Targets

sumatriptan acts on 1 molecular target:

HTR1D5-hydroxytryptamine receptor 1D (HTR1DA, HT1DA)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

sumatriptan is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Nervous system disordersMigraine✓ Approved

Related Research Articles

PubMedFrontiers in medicine2026-07-25

Role of homocysteine, vitamins B12, B6, B1, and folate in Saudi patients with premature acute coronary syndrome.

Alfaraidy Khalid K, Mohamed Ayman A, Woodman Alexander A, Al-Ansari Rehab R et al.

Homocysteine (HCY) has been implicated in cardiovascular disease through adverse effects on vascular endothelium, oxidative stress, and thrombogenic pathways. Saudi Arabia has a young population and an increasing burden of cardiovascular disease, yet regional data on HCY and B-vitamin profiles in premature acute coronary syndrome (ACS) remain limited. This single-center cross-sectional exploratory study evaluated serum HCY, vitamins B12, B6, B1, and folate levels in 80 patients with premature ACS at King Fahd Military Medical Complex (KFMMC), Dhahran, Saudi Arabia. Premature ACS was defined as ACS occurring in men aged <=55 years and women aged <=65 years. Clinical, laboratory, electrocardiographic, echocardiographic, angiographic, and SYNTAX score II 2020 data were collected. Spearman correlation showed a weak but statistically significant inverse association between HCY and folate (rho = -0.254, p = 0.040; approximate R2 = 0.065), whereas correlations between HCY and vitamins B12, B1, and B6 were not statistically significant. Most patients had low SYNTAX score categories, and exploratory ordinal regression suggested associations between selected biomarkers/clinical variables and SYNTAX score category; however, these findings should be interpreted cautiously because of the small sample size, absence of a control group, and risk of model instability. The study provides preliminary descriptive data on HCY and B-vitamin status among Saudi patients with premature ACS and highlights the need for larger, controlled, multicenter studies incorporating dietary assessment and genetic determinants such as MTHFR polymorphisms.

PMID 42500536
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PubMedGalen medical journal2026-07-25

The Impact of the COVID-19 Pandemic on Medical Faculty's Academic Performance and Well-Being : Short title: COVID-19 Pandemic and Medical Faculty's Academic Performance and Well-Being.

Sharif Asim A

To investigate the effects of stress related to the pandemic on the medical faculty's well-being. This study investigated the impact of pandemic-related stress on the well-being of medical faculty at King Abdulaziz University. Using a mixed-methods approach, 82 faculty members completed online surveys, including the GAD-7 and PHQ-9 scales to measure anxiety and depression, and participated in focus group discussions. The analysis explored the relationship between these psychological stress factors and self-reported academic performance across different demographics. A high prevalence of psychological distress was found: 89.6% of faculty reported at least mild anxiety, and 84.4% reported at least mild depressive symptoms. Most participants self-rated their academic performance as good (54.5%) or excellent (36.4%), and 80.5% reported missing no crucial deadlines. Regression analyses revealed a significant positive association between depression severity and higher self-reported academic performance (β = 1.48, p = 0.025). Male gender (OR = 0.20, p = 0.022) and longer weekly working hours (OR = 0.53, p = 0.019) were associated with significantly lower odds of missing deadlines. Anxiety, depression, and other covariates were not significant predictors of overall quality of life. While the pandemic was associated with a high burden of anxiety and depression among faculty, this distress did not translate into widespread self-perceived declines in academic output. The counterintuitive link between higher depression scores and self-reported performance, alongside the protective effect of male gender and increased work hours against missed deadlines, suggests complex coping mechanisms and potential resilience or presenteeism.

PMID 42499373
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PubMedMedicine2026-07-25

Cross-cultural adaptation and validation of the Arabic version of the Edmonton Frail Scale among Saudi community-dwelling older adults: A cross-sectional study.

Alshahrani Amirah M AM, Alqahtani Sarah H SH, Alotaibi Turki M TM, Almutairi Faten F FF et al.

Frailty is a clinical condition characterized by increasing vulnerability in older adults, resulting from declines in various physiological systems. The Edmonton Frail Scale (EFS) is a multidimensional tool for assessing frailty aspects including general health, functional independence, social support, medication usage, nutrition, mood, continence, cognition, balance, and mobility. Since the EFS has not been translated and validated among Arabic-speaking populations, the aim of this study was to translate, validate, and culturally adapt the EFS into Arabic for the Saudi geriatric population while examining its reliability and validity among community-dwelling older adults. A cross-sectional study was conducted between February and May 2024 in the Riyadh region of Saudi Arabia among community-dwelling older adults. One hundred eighty-two participants (100 male and 82 female) aged 60 and above from the King Salman Social Center were included. The EFS was translated from English into Arabic following standardized guidelines. Internal consistency using Cronbach alpha was assessed among the full sample (n = 182), while test-retest reliability using the intraclass correlation coefficient was assessed with 20 participants over a 1-week interval. Concurrent validity of the Arabic EFS (A-EFS) using Spearman rank correlation coefficient was tested against other related measures in all participants, including the Arabic (Saudi) version of the Tilburg Frailty Indicator, Arabic version of the Montreal Cognitive Assessment, Arabic version of Activities of Daily Living, and grip strength using a digital dynamometer, to identify correlations. In a sample of 182 community-dwelling older adults (mean age 65.6 ± 5.2 years; 100 males and 82 females), the A-EFS demonstrated good reliability and validity. Internal consistency was acceptable (Cronbach alpha = 0.61), with item correlations ranging from 0.54 to 0.65. For test-retest reliability, the intraclass correlation coefficient was 0.89 (95% confidence interval = 0.79-0.94). Moderate correlations were observed with grip strength (r = -0.508, P < .01) and Tilburg Frailty Indicator (R = 0.503, P < .01), and a weak correlation with Activities of Daily Living and Montreal Cognitive Assessment (r = -0.330, -0.346; P < .01) respectively. The A-EFS is a reliable, valid, and culturally sensitive tool for assessing frailty among Saudi older adults in both research and clinical contexts, with the potential to support informed clinical decision-making in routine practice. Future studies should focus on establishing the validity and reliability of the A-EFS across diverse settings.

PMID 42499046
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PubMedIrish journal of medical science2026-07-24

Multidomain rehabilitation for persistent concussion symptoms after falls in older adults: A case based review.

Ziaks Lauren L, Tucker Jenna J, Cumella Dylan D, Schechter Eden E et al.

Concussions are increasingly common in older adults, with falls as the leading mechanism of injury. Older adults often experience prolonged recovery, and lingering post-concussive symptoms, perpetuating the cycle of elevated fall risk with significant public health implications. This highlights the need for age-specific concussion care incorporating multidomain assessment and individualized treatment. This retrospective case series explores the effect of a structured, stepwise evaluation and treatment framework on post-concussive symptoms in older adults. Five females over 60 years old with post-concussive symptoms completed the targeted concussion protocol as part of a larger prospective study. The protocol included modules addressing key rehabilitation domains: aerobic exercise to support autonomic regulation, brain-body integration exercises to improve motor control, and progressive visual-vestibular rehabilitation incorporating oculomotor training, postural stability challenges, and dual-tasking. Objective measures included the Post-Concussion Symptom Scale, Brain Injury Vision Symptom Survey (BIVSS), Dizziness Handicap Inventory, King Devick, a binocular vision screening tool, and an enhanced version of the Vestibulo-Oculomotor Screen (VOMS). All patients demonstrated reduced symptom burden and functional improvements. Vestibular-oculomotor and motor control gains included a 53.9% average improvement in BIVSS scores, a mean 10-s reduction in King Devick time, and a 19.05-cm improvement in binocular vision measured via Brock String. Three patients normalized ocular alignment and near point convergence, while all showed improved Super Saccades performance. Participation in a multimodal protocol shows potential in reducing post-concussive impairments and symptoms in older adults. Larger studies are needed to establish effectiveness and feasibility in this population.

PMID 42496864
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PubMedSAGE open medicine2026-07-24

Disparities in the quality of care in patients with empty sella based on etiology: A cross-sectional study from Saudi Arabia.

Alfaifi Abrar A, Alturkistani Amal A, Altaleb Fatimah F, Aboalsamh Nouf N et al.

Empty sella (ES) is characterized by the replacement of pituitary tissue with cerebrospinal fluid (CSF) in the sella turcica. Despite its frequency in clinical settings, ES is often underrecognized and incompletely evaluated. The aim of this study was to examine patterns of care and potential disparities across different ES etiologies. This retrospective cross-sectional study aimed to evaluate differences in hormonal assessment and referral patterns among patients with various etiologies of empty sella. All patients aged ≥14 years diagnosed with ES between February 2021 and December 2022 at King Fahad Medical City (KFMC), Riyadh, Saudi Arabia, were included. Relevant data were extracted from electronic medical records, and comparisons of hormonal assessment were made based on etiology and reason for endocrine referral. Among 287 patients (75.3% female, mean age 49.7 years), 84.6% had primary ES. Only 29.9% were referred to endocrinology (52.4% for ES-specific evaluation). Secondary ES patients received more comprehensive hormonal assessments than primary ES (P<0.001). Primary ES referrals for ES-specific evaluation correlated with thorough testing (P<0.001). Significant disparities exist in ES management, driven by etiology and referral intent. Standardized referral pathway and universal screening are essential to improve care.

PMID 42495593
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PubMedCardiovascular endocrinology & metabolism2026-07-24

Association of diabetes and smoking with stroke subtypes and mortality in a Saudi cohort.

Almohammed Hussain H, Alrashidi Lama L, Thalib Husna Irfan HI, Alsultan Feras F et al.

Stroke is a leading cause of morbidity and mortality in Saudi Arabia, with its incidence projected to double by 2030. Diabetes and smoking are major modifiable risk factors. This study assessed their association with stroke type and mortality in a tertiary stroke unit. We conducted a retrospective review of 336 adults admitted with acute ischemic or hemorrhagic stroke at King Fahad Hospital, Al Ahsa, between January 2023 and December 2024. Demographic characteristics, risk factors, stroke type, and mortality were analyzed using descriptive statistics and multivariable logistic regression. Among 336 patients, 83.9% were younger than 65 years, 66.4% were male, and 86.6% had ischemic stroke. Overall mortality was 4.2%. Diabetes was present in 56.3% of patients, smoking in 21.4%, and both risk factors in 11.3%. Older age (>65 years) was independently associated with hemorrhagic stroke [odds ratio (OR) = 2.29, P = 0.041] and mortality (OR = 4.77, P = 0.013). Non-Saudi nationality was associated with higher odds of hemorrhagic stroke (OR = 2.52, P = 0.014) and mortality (OR = 9.64, P = 0.001). Diabetes independently increased mortality risk (OR = 5.49, P = 0.037). Smoking was not significantly associated with mortality because no deaths occurred among smokers. Ischemic stroke predominated, and mortality was independently associated with older age, non-Saudi nationality, and diabetes. Given the low number of deaths and limited adjustment for confounders, these findings should be interpreted cautiously and validated in larger multicenter setudies.

PMID 42494976
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