Drug Database
SU

sumatriptan (Alsuma autoinjector / sumatriptan, King / Alsuma)

✓ Approved

US WorldMeds, LLC · HTR1D · Small Molecule

What is sumatriptan?

sumatriptan is a small molecule developed by US WorldMeds, LLC. It is approved for therapeutic indications via injectable (others) or subcutaneous injection.

Drug Profile

Brand NamesAlsuma autoinjector, sumatriptan, King, Alsuma
CompanyUS WorldMeds, LLC
Drug ClassSmall Molecule
Molecular TargetHTR1D
RouteInjectable (Others), Subcutaneous Injection
StatusApproved
Sources: ClinicalTrials.gov, US WorldMeds, LLC

Mechanism of Action

Molecular Targets

sumatriptan acts on 1 molecular target:

HTR1D5-hydroxytryptamine receptor 1D (HTR1DA, HT1DA)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

sumatriptan is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Nervous system disordersMigraine✓ Approved

Related Research Articles

PubMedFrontiers in medicine2026-11-11

Assessment of leadership competence among medical students in Saudi Arabia using the MeLeCoS scale: a cross-sectional study.

Alnajjar Jawad S JS, Almarzooq Mohammed A MA, Al Dandan Ali M AM, Almaqhawi Abdullah A

Leadership competence is increasingly recognized as an essential attribute for physicians, enabling effective teamwork, healthcare system management, and improvement of patient outcomes. Medical schools worldwide are increasingly integrating leadership training into their curricula; however, limited evidence exists regarding leadership competence among medical students in Saudi Arabia. This study aimed to assess self-perceived leadership competencies among medical students at King Faisal University and to explore demographic and academic factors associated with leadership competence. A cross-sectional study was conducted among medical students at the College of Medicine, King Faisal University, Alahsa, Saudi Arabia. Participants were selected using a proportionate stratified sampling technique to achieve representation across different academic years. Data were collected through a structured questionnaire consisting of demographic characteristics and the 37-item Medical Leadership Competency Scale (MeLeCoS), which assesses six domains of leadership competence: self-management, responsible behavior, teamwork, managing services, innovation in undergraduate education, and systemic perspectives. Descriptive statistics were used to summarize participant characteristics. Independent sample t-tests, one-way analysis of variance (ANOVA), Pearson's correlation, and multiple linear regression analyses were performed to identify factors associated with leadership competence. A total of 191 medical students participated in the study (overall response rate 59.5%). The mean age of participants was 21.76 ± 1.53 years and the mean GPA was 4.32 ± 0.63. Female students constituted 59.7% of the sample. The overall mean leadership competence score was 3.72 ± 0.58, indicating a moderate to high level of perceived leadership competence. Among the MeLeCoS domains, responsible behavior and teamwork demonstrated the highest competence levels, whereas innovation in undergraduate education showed the lowest score. Female students had significantly higher leadership competence scores compared with male students (p = 0.001). Academic performance (GPA) was positively correlated with leadership competence (r = 0.217, p = 0.006). In multiple regression analysis, gender (β = 0.256, p = 0.002) and GPA (β = 0.201, p = 0.010) were identified as significant predictors of leadership competence. Medical students at King Faisal University reported moderate to high levels of self-perceived leadership competence, particularly in responsible behavior and teamwork. Gender and academic performance were significant predictors of self-perceived leadership competence. These findings highlight the importance of incorporating structured leadership development programs within undergraduate medical education to enhance leadership capacity among future physicians.

PMID 43010974
Read full article →
PubMedThe Journal of manual & manipulative therapy2026-11-11

Persistent post-concussion symptoms are associated with more cranial and upper cervical mobility restrictions as measured by manual clinical evaluation.

Demers Kyla K, Fait Philippe P, Dover Geoffrey G, DeMont Richard R

There are approximately 1.7-3.8 million sport concussions annually in the United States with twenty percent presenting persistent symptoms. However, few studies examine manual therapy as a part of the clinical assessment in concussions. Our purpose was to investigate the prevalence of cranial bone and upper cervical mobility restriction in persistent post-concussion symptoms. Twenty-one adults with persistent post-concussion symptoms (PCS), 11 with a history of concussion (CHx) and 12 controls (Ctl) participated. An osteopath assessed cranial bones and C0-C1-C2 mobility using a standard protocol to determine the number of restrictions. An athletic therapist assessed participants on the Post-Concussion-Symptom-Scale, King-Devick, Tandem Gait Test, Sensory Organization Test, and Vestibulo-Oculo-Motor-Screening. Assessments were blinded to group assignment. We used a one-way ANOVA to assess group differences and a Pearson Correlation to assess relationships between variables. PCS (8.24 ± 4.25) had a higher mean number of restrictions compared with the Ctl (2.92 ± 3.8), (p = .003). There was a significant relationship between the number of restrictions and Post-Concussion-Symptom-Scale severity (r = 0.333, p = .027) and Vestibulo-Oculo-Motor-Screening vestibular score (r = 0.305, p = .044). There was no significant association between the number of restrictions and the number of symptoms (r = 0.283, p = .062), visual (r = 0.267, p = .079) and total Vestibulo-Oculo-Motor-Screening score (r = 0.293, p = .054). There was no relationship with King-Devick, Tandem Gait Test, and Sensory Organization Test. Number of restrictions was significantly higher in the PCS group compared to the Ctl group. Additional investigation is warranted to refine the location and magnitude of restrictions with the type and severity of symptoms.

PMID 43012732
Read full article →
PubMedThe South African journal of psychiatry : SAJP : the journal of the Society of Psychiatrists of South Africa2026-11-11

Utilisation of coercive measures in involuntary patients admitted to two psychiatric hospitals in KwaZulu-Natal, South Africa.

Mashaphu Sibongile S, Shozi Zinhle P ZP, Ntlantsana Vuyokazi V, Saloojee Shamima S

There is a high prevalence of involuntary psychiatric admissions in South Africa, with literature on the measures used to coerce patients into care being limited. This study aimed to quantify the coercive measures that were used during involuntary admissions to two psychiatric hospitals in KwaZulu-Natal province, and to identify factors associated with their use. King Dinuzulu Hospital Complex in Durban and Townhill Psychiatric Hospital in Pietermaritzburg. This was a sub-analysis of a cross-sectional, descriptive, quantitative study of involuntarily admitted patients aged 18 years and above. Data were collected through participant interviews at discharge and by extracting information from patients' clinical records and Mental Health Care Act forms. Of the 131 patients included, 66% were male, 85.5% were single, and 71.4% were unemployed. The prevalence of chemical, mechanical, physical restraint, and seclusion was 73.3%, 14.5%, 24.43%, and 16.8%, respectively, with 38.2% being exposed to more than one method. Significantly more male patients than female patients were physically restrained h(81% vs 19%; p = 0.04), and placed in seclusion (86.4% vs 13.6%; p = 0.05). Except for mechanical restraint, a longer length of hospital stay was significantly associated with the other three coercive measures (p ≤ 0.05). Chemical restraint was the most common method of coercion, with more than one-third of patients being exposed to two or more methods. This study highlights the high utilisation of coercive methods and informs the need for reducing their use in psychiatric hospitals in South Africa.

PMID 43011153
Read full article →
PubMedInternational journal of endocrinology2026-11-11

Prevalence of Celiac Disease in Children and Adolescents With Type 1 Diabetes in Saudi Arabia: A 20-Year Experience in a Tertiary Care Center.

AlShaikh Adnan A, Alghamdi Abdulaziz A, Alshaikh Sahl S, Almatihmy Yahya Y et al.

Variable rates of co-occurrence of celiac disease (CD) and Type 1 diabetes mellitus (T1DM) in the pediatric population have been reported across numerous studies. This retrospective study aimed to determine the prevalence of CD and other autoimmune disorders in children and adolescents (1 to 18 years) from Saudi Arabia with T1DM at King Abdulaziz Medical City-Jeddah. Additionally, we assessed the specificity and sensitivity of different CD serological diagnostic tests. A total of 595 children and adolescents with T1DM were included in the study. Positive CD serological tests were reported in 9.4% and positive biopsy in 5.4%. Duodenal biopsy confirmed CD in 62.5% of children and adolescents with positive tissue transglutaminase immunoglobulin A (IgA), 65.6% with positive endomysia antibodies, and 46.9% with positive anti-gliadin antibodies. The tissue transglutaminase IgA test at diagnosis demonstrated the highest specificity (91%), while the anti-gliadin antibody IgA test exhibited the highest sensitivity (68.2%). Children and adolescents with diabetes and CD exhibited a significantly higher prevalence of Hashimoto's thyroiditis (18.8%) compared to those without CD (8.3%). No significant differences were observed in anthropometric parameters between the two groups. However, children and adolescents with both diseases demonstrated higher hemoglobin A1c levels and more frequent occurrence of episodes of ketoacidosis and hypoglycemia. These glycemic abnormalities may be attributed to the carbohydrate content of gluten-free (GF) foods and/or poor compliance with GF diets, leading to nutrient malabsorption. A precise diagnosis of CD through serological testing, selected endoscopic evaluation, and dietary control, including accurate carbohydrate counting in GF foods along with adjustments in prandial insulin doses, can significantly enhance glycemic control in these patients.

PMID 43011252
Read full article →
PubMedThe journal of poultry science2026-11-09

Temporal Changes in Redox Status in the Liver and Intestine of Squab Pigeons.

Chang Chenyu C, Han Yuxin Y, Meng Yao Y, Yao Jinxiu J et al.

This study investigated temporal changes in the redox status of squab pigeons from hatching to slaughter, providing insights for improved pigeon production. A total of 60 White King squabs were allocated to five groups. Samples were collected on the day of hatching and then on days 7, 14, 21, and 28. Serum catalase (CAT) activity, hepatic malondialdehyde (MDA) content, jejunal CAT activity and glutathione (GSH) level, and ileal MDA content increased linearly and quadratically, and these alterations suddenly occurred in squabs aged 21 to 28 d. Hepatic total superoxide dismutase (T-SOD) activity increased linearly and quadratically between 7 and 28 d. Serum MDA level, hepatic CAT activity and GSH level decreased linearly and quadratically. Age led to a linear increase in jejunal MDA and serum GSH levels, with a peak at 28 d. Ileal T-SOD activity increased quadratically in squabs aged 14 to 21 d. Hepatic CAT and jejunal NFE2 like bZIP transcription factor 2 (Nrf2) mRNA exhibited linear and quadratic upregulation with increasing age; whereas hepatic Nrf2 expression displayed linear and quadratic downregulation. While expression of jejunal SOD1, and hepatic SOD1 and SOD2 increased linearly; that of hepatic and jejunal kelch like ECH associated protein 1 rose quadratically, peaking at 21 d. In conclusion, we report marked changes in the redox status between days 21 and 28 of squab during the rearing pattern. SOD contributes substantially to the antioxidant capacity of the liver and ileum. Hence, nutritional strategies that target SOD activity could optimize health and production of squab pigeons.

PMID 43001281
Read full article →
PubMedThe Journal of heredity2026-11-08

A chromosome-level genome of the king penguin (Aptenodytes patagonicus): a resource for linking genotype to fitness in a long-lived vertebrate.

Paris Josephine R JR, Nitta Fernandes Flávia A FA, Santos Camilla A CA, Pointon Damon-Lee B DB et al.

The king penguin (Aptenodytes patagonicus) is a long-lived seabird of the Southern Ocean that is emerging as a promising model in the wild for studying evolution. We present a high-quality, haplotype-resolved 1.35 Gb chromosome-level genome of an adult female king penguin - 'Pen/Se-guin' - assembled using PacBio HiFi long-reads and Hi-C proximity data. A total of 95% of the assembly is assigned to 34 chromosomes (32 autosomes, plus the Z and W chromosomes). The primary haplotype has a BUSCO completeness of 97.2%, and across both haplotypes the assembly has a k-mer completeness of 99.7% and a quality value of 63.8. We also assembled a circularised mitogenome (20,520 bp) containing the avian tandem duplication. Repetitive sequence annotation showed that 16.3% of the genome comprises repetitive elements, with LINEs representing the most abundant transposable element class (5.6%). Gene prediction using an extensive multi-tissue RNA-seq dataset resulted in 18,081 predicted protein-coding genes, of which 17,081 were functionally annotated, with a BUSCO completeness of 98.4% and an OMArk completeness of 97.3%. Compared with the previous draft genome, the presented genome shows a 30-fold increase in assembly contiguity and a substantially improved genome annotation, exceeding the standards of the Earth BioGenome Project and Vertebrate Genomes Project. This genome provides a foundation for ongoing and future studies using the king penguin to investigate genotype-fitness relationships, ageing, life-history evolution, and adaptation.

PMID 42998033
Read full article →

+9996 more articles available with a free account

Sign up free to view all articles →

Ask about sumatriptan