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sumatriptan (Alsuma autoinjector / sumatriptan, King / Alsuma)

✓ Approved

US WorldMeds, LLC · HTR1D · Small Molecule

What is sumatriptan?

sumatriptan is a small molecule developed by US WorldMeds, LLC. It is approved for therapeutic indications via injectable (others) or subcutaneous injection.

Drug Profile

Brand NamesAlsuma autoinjector, sumatriptan, King, Alsuma
CompanyUS WorldMeds, LLC
Drug ClassSmall Molecule
Molecular TargetHTR1D
RouteInjectable (Others), Subcutaneous Injection
StatusApproved
Sources: ClinicalTrials.gov, US WorldMeds, LLC

Mechanism of Action

Molecular Targets

sumatriptan acts on 1 molecular target:

HTR1D5-hydroxytryptamine receptor 1D (HTR1DA, HT1DA)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

sumatriptan is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Nervous system disordersMigraine✓ Approved

Related Research Articles

PubMedMarine genomics2026-05-25

Whole-genome sequencing uncovers the extreme adaptation mechanisms of Pseudomonas sp. Ma2-10 screened from the Antarctic sea sediment near King George Island.

Deng Rui R, He Yuanfang Y, Zhang Xiying X, Wang Guofang G et al.

Pseudomonas sp. Ma2-10 was isolated from marine sediment near King George Island, South Shetland Islands, Antarctica. In this study, we determined the complete genome sequence of this strain. The results showed that the strain has a genome size of 5,811,804 bp with a GC content of 58.5 mol%, and the coding region accounted for 89.03% of the total genome length, containing 5095 protein-coding genes. Through annotation with the CAZy database, we identified 120 carbohydrate-active enzymes, indicating that Ma2-10 has an extremely strong ability to synthesize extracellular polysaccharides (EPS). Functional annotation of the strain's genome using KEGG and GO databases revealed that the strain's genes were significantly enriched in amino acid metabolism, carbohydrate metabolism, membrane transport, and signal transduction pathways, providing a molecular basis for its adaptation to the extreme environments of low temperature, high salt, and oligotrophy. Nine secondary metabolite biosynthetic gene clusters were identified through secondary metabolite synthesis analysis. These gene clusters indicate that the strain has the potential to produce various bioactive substances such as antibiotics and siderophores, which can be used for niche competition and stress resistance, and possesses a genetic basis for antioxidant activity and hyperosmotic tolerance. The results of this study can provide a reference for further understanding and exploitation of the beneficial functions of Pseudomonas sp. Ma2-10.

PMID 42178710
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PubMedForensic science international. Genetics2026-05-24

Identifying unknown contributors to two-person DNA mixtures via whole-genome sequencing.

Lei Yuting Y, Liu Zhen Z, Han Shuang S, Lin Xinyi X et al.

Forensic investigative genetic genealogy (FIGG) has demonstrated considerable promise in identifying perpetrators and unidentified human remains. While whole-genome sequencing (WGS) offers a robust foundation for FIGG, DNA mixtures-prevalent in forensic casework-remain a challenge as standard algorithms require single-source profiles. Potential solutions fall broadly into two categories: (1) deconvoluting mixtures into genotype calls (which can be susceptible to allelic drop-out and miscalls in imbalanced scenarios), and (2) analyzing mixture profiles directly using likelihood ratio (LR) frameworks (which, though currently incompatible with genealogical database search algorithms, are powerful for kinship verification). Utilizing the DNBSEQ platform, we performed WGS on two-person mixtures across varying ratios (1:1, 1:2, 1:5, and 1:9), generating genome-wide data comprising an average of 4.34 million SNPs per sample. Our findings yield several practice-oriented insights: First, the hidden Markov model (HMM)-based Allele-Haplotype Hybrid Assignment (AH-HA) algorithm outperforms the locus-based EuroForMix (EFM) in deconvolution-especially for minor contributors-by effectively leveraging haplotype information, conditioned on one known contributor. Second, for major contributors, deconvolution error rates remain below 10%, enabling the identification of up to 6th- to 7th-degree relatives using error-aware algorithms (e.g., clusIBD) without imputation. Third, for minor contributors, despite error rates exceeding 10%, integrating imputation with the KING algorithm and empirical kinship correction facilitates the resolution of 3rd- to 4th-degree relatives. Finally, EFM is validated as a reliable confirmatory tool for direct kinship verification undeconvoluted profiles. Collectively, this work provides a comprehensive methodological comparison and proposes practical solutions to advance genetic genealogy analysis based on DNA mixture data.

PMID 42176415
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PubMedReproductive health2026-05-24

Initiation of immediate postpartum family planning and its determinants among women delivering in health facilities: a cross-sectional study.

Claudien Uhawenimana Thierry UT, Alice Muhayimana M, Edouard Ndikumana N, Eugenie Mbabazi M et al.

The immediate postpartum period represents a critical yet underutilized opportunity to prevent unintended and closely spaced pregnancies, particularly in low- and middle-income countries. In Rwanda, despite high rates of facility-based delivery, initiation of contraception before hospital discharge remains suboptimal. Evidence on how sociodemographic characteristics, childbirth-related factors, male partner presence during childbirth, and health provider practices jointly determine immediate postpartum family planning (IPPFP) uptake is limited. This study assessed IPPFP uptake, examined male partner involvement, and identified associated factors. The study was conducted in the maternity units of Muhima District Hospital and King Faisal Hospital in Kigali, Rwanda. Quantitative data were collected from 480 women aged ≥ 18 years within 96 h postpartum. Qualitative in-depth interviews were conducted with five male partners to explore perspectives on postpartum contraceptive decision-making. Immediate postpartum family planning was defined as self-reported initiation of a modern contraceptive method before discharge. Quantitative data were analyzed using descriptive statistics, chi-square tests, and regression analysis, and qualitative data were analyzed thematically to complement quantitative findings. Overall, 60.6% (291/480) of women initiated a contraceptive method before discharge, with intrauterine devices being the most commonly chosen method (33.7%). Male partners were present during childbirth for 48.3% of women; however, partner presence was not significantly associated with IPPFP uptake (χ² = 1.409, p = 0.262). Qualitative findings from a small exploratory sample suggest that contraceptive decisions were largely made during pregnancy, driven by considerations such as maternal health, parity, and household economic capacity, rather than male partners' physical presence at childbirth. IPPFP uptake in these two urban Rwandan hospitals was moderate. Initiation of contraception before discharge was associated with selected sociodemographic and obstetric characteristics, although these associations were based on unadjusted analyses. Male partner presence during childbirth was not statistically associated with IPPFP uptake, and qualitative findings suggest that contraceptive decisions are often made earlier in pregnancy. Strengthening postpartum counseling and clinical assessment may improve informed decision-making. However, findings should be interpreted in light of the study's limited scope and design.

PMID 42177551
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PubMedPediatric research2026-05-23

Vancomycin loading dose and AUC0-24 target attainment in pediatric sepsis: a single-center randomized controlled trial.

Sujjavorakul Kritsaporn K, Kerr Stephen J SJ, Wacharachaisurapol Noppadol N, Samransamruajkit Rujipat R et al.

Achieving target vancomycin exposures is crucial for treating pediatric sepsis but is complicated by altered pharmacokinetics in critically ill children. This study investigated whether a loading dose improve target attainment of the area under the concentration curve in the first 24 h (AUC0-24). This single-center, open-label, randomized controlled trial enrolled pediatric sepsis patients (3 months - 18 years) at King Chulalongkorn Memorial Hospital, Thailand. Patients were randomized 2:1 to receive a vancomycin loading dose or a standard dose. The primary outcome was achieving target AUC0-24 (400-800 mg·h/L). An AUC0-24 < 400 mg·h/L was defined as underdosing and >800 mg·h/L as overdosing. Secondary outcomes included serious adverse events and factors influencing target attainment. Of 78 participants (loading dose n = 51; standard dose n = 27), overall target AUC₀₋₂₄ attainment did not differ significantly. However, the loading dose reduced AUC0-24 underdosing and improved steady-state target attainment. No significant differences in 90-day mortality or acute kidney injury were observed. Estimated glomerular filtration rate and receiving the loading dose were associated with achieving a therapeutic AUC₀₋₂₄. Although a loading dose did not increase overall target AUC₀₋₂₄ attainment, it reduced AUC0-24 underdosing and improved steady-state target achievement without additional adverse events. This randomized controlled trial showed that vancomycin loading doses in pediatric sepsis patients significantly reduced the proportion of patients with area under the concentration curve (AUC) in the first 24 h that were underdosing compared to the standard dose. The loading dose also improved target attainment of AUC over 24 h at steady-state levels, without increasing the risk of serious adverse events. This study highlights the importance of optimizing vancomycin dosing, particularly in patients with augmented renal clearance. These findings support incorporating a loading dose strategy into vancomycin therapy for pediatric sepsis patients, especially those with augmented renal clearance.

PMID 42174204
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PubMedMedicine2026-05-23

Hidden burden: Prevalence of anemia in Taif pediatric population.

Zaini Rana G RG, Kamal Naglaa M NM, Alshumrani Ajwan M AM, Alshaibani Shihanah M SM et al.

This study aimed to assess the prevalence and characteristics of previously undiagnosed anemia among children in Taif. The objective was to estimate the prevalence of undiagnosed anemia in a broader pediatric population (aged 2-12 years) across 3 hospitals, and to evaluate severity and morphological patterns. A cross-sectional study was conducted across Taif region's main hospitals serving children; including Taif Children's Hospital, King Faisal Hospital, and Taif Armed Forces Hospitals. A total of 264 children aged 2 to 12 years, presenting to outpatient clinics or emergency departments for acute, non-hematological conditions, were included. Children with previously diagnosed anemia or chronic diseases were excluded. Blood samples were collected to measure hemoglobin (Hb) levels, and anemia was diagnosed based on age-specific Hb thresholds. Descriptive statistics, chi-square tests, and independent t tests were used for data analysis. Out of 264 children, 28 (10.6%) were found to have undiagnosed anemia. The majority (75%) were aged 2 to 5 years, and a higher prevalence was noted among males (67.9%) compared to females (32.1%), though the gender difference was not statistically significant. There was a significant association between younger age and anemia (P < .001). Mean Hb levels were significantly lower in anemic children (10.13 ± 0.90 g/dL) than in non-anemic children (13.11 ± 0.93 g/dL; P < .001). Most cases were mild (71.4%), followed by moderate anemia (28.6%). Normocytic normochromic anemia was the most common type (53.6%), followed by microcytic hypochromic (39.3%) and macrocytic anemia (7.1%). This study highlights a notable prevalence of undiagnosed anemia among children in Taif, particularly in the preschool age group. The findings underscore the need for routine screening in pediatric outpatient and emergency settings, even in the absence of overt symptoms. Early detection and intervention are essential to prevent long-term developmental complications. Public health efforts should focus on nutritional education, iron supplementation, and comprehensive diagnostic evaluations to address this hidden burden.

PMID 42175420
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PubMedCureus2026-05-22

Behind the Procedure: Understanding Complications in Anterior Cervical Surgery.

Abu Nowar Hussam H, Khraisat Wesam W, Halasah Mu'taz M, Alomari Laith L et al.

Degenerative cervical disc disease (DCDD) is a frequent cause of neck pain, radiculopathy, and disability in adults. Anterior cervical discectomy and fusion (ACDF) is widely used due to its favorable outcomes and high fusion rates but carries potential perioperative and postoperative complications that require systematic evaluation. This study aims primarily to evaluate complication rates and patterns following ACDF and, secondarily, to assess radiographic fusion outcomes in a tertiary referral center. We conducted a retrospective review of adult patients undergoing ACDF for DCDD at King Hussein Medical Center - Royal Medical Services, Amman, Jordan, from 2021 to 2024. Demographics, clinical presentation, operative details, radiological findings, and postoperative complications were analyzed. Patients with at least one-year radiographic follow-up were included in fusion analysis, and fusion was defined as CT trabecular bridging + no motion on flexion-extension. Final cohort included 284 patients (342 levels). The overall complication rate was 10.56% (n=30), with dysphagia being the most frequent complication (n=6, 2.11%), which lies within the lower range of reported values in the literature (1.7%-9.5%). Radiographic fusion was observed in 98.59% (n=280) of patients with adequate imaging follow-up. ACDF demonstrated low complication rates and high radiographic fusion in a single-center retrospective cohort. Findings should be interpreted within the limitations of the retrospective design.

PMID 42170151
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