Bibliometric analysis of key biomarkers in sepsis-induced coagulopathy (2006-2025).
Zhao Yidan Y, Yao Huaxing H, Lai Dong D, Xiao Pingping P et al.
Sepsis-induced coagulopathy is life-threatening in critically ill patients. Thrombin-antithrombin complex and thrombomodulin are key biomarkers, but no 20-year bibliometric analysis exists. We searched PubMed and Web of Science Core Collection (2006-2025) and analyzed 577 articles using CiteSpace and VOSviewer. Publications peaked in 2016 to 2018 and then declined. Japan, the United States, and China were the most productive; the United States had the highest citations. Hotspots focused on sepsis-induced coagulopathy, endothelial injury, and intensive care unit anticoagulation. Thrombin-antithrombin complex/thrombomodulin research is globally established, led by the United States. Future work should enhance international collaboration and develop multi-biomarker models.