Drug Database
SI

sildenafil (Liqrev)

✓ Approved

CMP Pharma, Inc. · PDE5A · Small Molecule

What is sildenafil?

sildenafil is a small molecule developed by CMP Pharma, Inc.. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesLiqrev
CompanyCMP Pharma, Inc.
Drug ClassSmall Molecule
Molecular TargetPDE5A
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, CMP Pharma, Inc.

Mechanism of Action

Molecular Targets

sildenafil acts on 1 molecular target:

PDE5Aphosphodiesterase 5A (PDE5, CGB-PDE)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

sildenafil is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Respiratory, thoracic and mediastinal disordersPulmonary hypertension✓ Approved

Related Research Articles

PubMedTurkish journal of medical sciences2026-07-25

vNOTES high uterosacral ligament suspension versus laparoscopic lateral suspension in the management of vaginal vault prolapse: initial experience in a single tertiary center.

Adan Ramazan R, Şahin Fatih F, Üskent Ulya U, Çulha Mehmet Gökhan MG et al.

The optimal technique for vaginal vault prolapse correction has yet to be identified. This study aimed to evaluate the anatomic and functional outcomes of women who underwent vaginal natural orifice transluminal endoscopic high uterosacral ligament suspension (vNOTES HUSLS) or laparoscopic lateral suspension (LLS). This retrospective study included symptomatic women with stage ≥2 vault prolapse who underwent vNOTES HUSLS or LLS between January 2019 and June 2022 at a tertiary center. The surgical efficacy, postoperative outcomes, complication rates, and recurrence frequencies of these procedures were compared. The primary outcomes of the study included anatomical success, patient-reported (subjective) success, and recurrence rates. The study included 64 women, 32 of whom underwent vNOTES HUSLS and 32 of whom underwent LLS. Demographic characteristics and preoperative Pelvic Organ Prolapse Quantification (POP-Q) values were comparable (p > 0.05). The mean Patient Global Impression of Improvement (PGI-I) score did not differ significantly between the groups (1.6 ± 0.8 vs. 1.7 ± 0.7, p = 0.344). Improvements in terms of sexual function scores (p < 0.001) were observed postoperatively in both groups. No difference was observed in postoperative sexual questionnaires scores (p > 0.05). Vault suspension by vNOTES produced better results only for point Ba (most distal portion of the remaining upper anterior side of the vaginal wall) of the POP-Q score (p = 0.03). The incidence rates and types of postoperative complications and recurrences were similar between the groups. Both vNOTES HUSLS and LLS safely support the vault and restore the normal vaginal anatomy with similar effectiveness. Functional results were also similar and satisfactory between the groups.

PMID 42499426
Read full article →
PubMedArthroscopy techniques2026-07-25

Arthroscopic Allogeneic Bone Strip Grafting for Recurrent Shoulder Dislocation With Critical Glenoid Bone Loss: A Free Graft Suspension Fixation Technique.

Wu Yingbin Y, Guo Jiang J, Liu Weitong W, Wang Changbing C et al.

In patients with recurrent anterior shoulder dislocation and glenoid bone loss between 10% and 20%, isolated Bankart repair remains associated with a certain rate of postoperative redislocation. The optimal management for this patient subset is controversial. We describe an all-arthroscopic technique using allogeneic bone strips for free graft suspension fixation in cases of critical glenoid bone loss (10%-20%). This technique is predicated on the principle that restoring both osseous and soft-tissue anatomy of the glenoid is fundamental to addressing shoulder instability.

PMID 42499863
Read full article →
PubMedExperiments in fluids2026-07-25

Synchrotron X-ray multi-projection imaging (XMPI) for high-resolution 4D characterization of multiphase flows.

Rosén Tomas T, Yao Zisheng Z, Tejbo Jonas J, Wegele Patrick P et al.

Multiphase flows where particles, bubbles, or droplets are suspended in a fluid govern critical processes in biology, medicine, materials processing, and geophysics. However, observing their microscale dynamics in opaque systems has remained a fundamental challenge. We present Synchrotron X-ray Multi-Projection Imaging (XMPI), a novel approach enabling four-dimensional (3D + time) tracking of microparticles in visibly opaque suspension flows without requiring sample rotation. By capturing simultaneous projections from multiple angles using beam-split X-rays at synchrotron facilities, we resolve instantaneous particle positions and trajectories in opaque fluids such as blood. We demonstrate the potential of XMPI through individual particle tracking velocimetry (3D PTV) in dilute conditions, as well as multi-projection image velocimetry in dense suspensions. The methodology provides otherwise inaccessible experimental validation for particle-resolved computational fluid dynamics models and allows, e.g., observation of inertial focusing effects and microstructural dynamics relevant to suspension rheology and biomedical flows. This work paves the way for high-resolution, time-resolved 4D imaging of complex multiphase flows across a range of scientific and industrial applications. Combining XMPI with recent AI-supported 4D reconstruction algorithms opens a new spatiotemporal frontier for high-speed, rotation-free microtomography. The online version contains supplementary material available at 10.1007/s00348-026-04271-6.

PMID 42499685
Read full article →
PubMedInternational journal of dental hygiene2026-07-25

The Effectiveness of Oral Exercise for Oral Function Rehabilitation in Older Adults: A Systematic Review and Meta-Analysis.

Choi Yong-Keum YK, Park Hyang-Ah HA, Cha Eun-Gyeong EG, Yun Ji-Hye JH

Older adults are prone to oral function decline due to ageing, necessitating interventions for rehabilitation. Although oral exercises are widely recommended, systematic evidence supporting their effectiveness remains insufficient. This study aimed to evaluate the effectiveness of oral exercise interventions for rehabilitating oral functions in older adults. This systematic review and meta-analysis was conducted in accordance with PRISMA guidelines. A comprehensive electronic search was performed in PubMed, Ovid Embase, Cochrane Library and CINAHL up to August 2022. Randomised controlled trials comparing oral exercise interventions with control conditions were included. The quality of the included studies was assessed using the Risk of Bias (ROB) 2.0 tool. A total of eight studies were included in the meta-analysis and pooled mean differences were estimated using a random-effects model. Among 1007 identified studies, 19 were included in the qualitative synthesis and 8 in the meta-analysis. Interventions targeted masticatory, swallowing, pronunciation and salivary functions. Tongue exercises significantly improved swallowing function (MD = 7.06; 95% CI: 4.72-9.41; p < 0.01) and masticatory exercises enhanced masticatory function (MD = 37.77; 95% CI: 15.61-59.92; p < 0.001). However, lip exercises showed no significant effect on swallowing function (MD = 1.43; 95% CI: -0.11-2.98; p = 0.07). Oral exercise interventions, particularly tongue and masticatory exercises, may improve oral function in older adults. These findings support the use of oral exercise as a practical intervention for dental hygienists and community-based oral health programmes.

PMID 42499008
Read full article →
PubMedExperimental dermatology2026-07-25

Integrated Proteogenomics and Single-Cell Transcriptomics Prioritize Putative Protective Plasma Proteins for Hidradenitis Suppurativa.

Cheng Yuzhe Y, Ma Jingyi J, Niu Jun J

Translating hidradenitis suppurativa (HS) genetic susceptibility into actionable targets remains challenging, as most genome-wide association study loci lie in non-coding regions and tissue-level transcriptomics cannot easily distinguish causal drivers from secondary inflammation. In this study, we aimed to prioritize plasma proteins whose genetically predicted levels are causally associated with HS risk and to localize them within human skin at single-cell resolution. We performed two-sample Mendelian randomization (MR) using cis-pQTL instruments for 2923 plasma proteins from the UK Biobank Pharma Proteomics Project against HS summary statistics from FinnGen R12. Following multiple-testing correction and Bayesian colocalization with a prior-sensitivity grid, the intersection of false-discovery rate (FDR)-significant MR with colocalization evidence (PP.H4 ≥ 0.5) yielded three putative protective candidates: TNFRSF6B (OR = 0.748, 95% CI 0.666-0.840; PP.H4 = 0.648), FCRL2 (OR = 0.896, 95% CI 0.819-0.979; PP.H4 = 0.550), and APOD (OR = 0.789, 95% CI 0.647-0.963; PP.H4 = 0.503). All sensitivity MR tests were concordant. Single-cell transcriptomic analysis localized FCRL2 and APOD to specific cell populations. FCRL2 was predominantly expressed in B cells and NK cells, while APOD showed multi-cellular expression across cornified keratinocytes, macrophages, and dendritic cells. Furthermore, TNFRSF6B was below the skin detection threshold, supporting its biological role as a circulating decoy receptor. Together, our integrated proteogenomic and single-cell approach prioritizes TNFRSF6B, FCRL2, and APOD as putative protective plasma proteins for HS, with TNFRSF6B emerging as the most genetically robust candidate for future translational follow-up.

PMID 42499219
Read full article →
PubMedCommunity dental health2026-07-25

Oral health impacts and socioeconomic inequalities in disability and quality of life: A population-based study.

Manriquez-Robles Diego D, Aedo Melisa M, Roa-Castillo Scarlett S

To examine whether oral health impacts function as a pathway linking socioeconomic position to functional disability and multidimensional quality of life in a nationally representative Chilean sample, we conducted a cross-sectional population-based analysis using complex survey methods and mediation modelling. Data were obtained from a national population-based household survey in Chile and included 16,590 non-institutionalized individuals aged 15 years and older, representing approximately 16.2 million individuals in the Chilean population after application of survey weights. Main outcome measures were oral health-related quality of life (OHIP-7), self-reported functional disability, and WHOQOL-BREF physical, psychological, social, and environmental domains. Pronounced socioeconomic gradients were observed in oral health impacts. Individuals in the highest education and income strata had significantly lower odds of high oral health impact (OR = 0.39 and 0.33, respectively, p < .001). High oral health impact was strongly associated with functional disability (OR = 3.85, p < .001) and with lower scores across all WHOQOL-BREF domains (physical B = -10.58, psychological B = -7.19, social B = -8.52, environmental B = -7.04, all p < .001). Inclusion of OHIP attenuated associations between socioeconomic indicators and disability. Monte Carlo simulations indicated statistically significant indirect effects of education and income on disability and quality-of-life domains through oral health impact. Oral health impacts are socially patterned and closely linked to functional disability and multidimensional quality of life. Findings are consistent with the interpretation that oral conditions may contribute to broader socioeconomic gradients in functioning and well-being, supporting the integration of oral health within primary care and health equity strategies.

PMID 42499132
Read full article →

+9996 more articles available with a free account

Sign up free to view all articles →

Ask about sildenafil