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sildenafil (Liqrev)

✓ Approved

CMP Pharma, Inc. · PDE5A · Small Molecule

What is sildenafil?

sildenafil is a small molecule developed by CMP Pharma, Inc.. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesLiqrev
CompanyCMP Pharma, Inc.
Drug ClassSmall Molecule
Molecular TargetPDE5A
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, CMP Pharma, Inc.

Mechanism of Action

Molecular Targets

sildenafil acts on 1 molecular target:

PDE5Aphosphodiesterase 5A (PDE5, CGB-PDE)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

sildenafil is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Respiratory, thoracic and mediastinal disordersPulmonary hypertension✓ Approved

Related Research Articles

PubMedJournal of the College of Physicians and Surgeons--Pakistan : JCPSP2026-09-05

Association Between Oral Health Status and Oral Frailty in Older Inpatients.

Ren Qiang Q, Chen Weican W, Zhang Bingjie B

To investigate the relationship between oral health status and oral frailty in older inpatients, provide a basis for the early detection and treatment of oral frailty, and improve their health and quality of life. An observational study. Place and Duration of the Study: Department of Stomatology, Baoding No.1 Central Hospital, Baoding, China, from January 2022 to June 2025. A total of 200 older inpatients were divided into frailty (n = 55) and non-frailty (n = 145) groups by using the Oral Frailty Index-8 (OFI-8). Data on demographics, lifestyle, medication, nutrition, inflammation, and oral health, including the General Oral Health Assessment Index (GOHAI) and results of the water-swallowing test, were collected. Statistical analyses employed univariate analysis, multivariate logistic regression, Spearman's correlation, and receiver operating characteristic curve analysis. Significant differences were found in age, oral health indicators, and dental function between the groups (p.

PMID 42698252
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PubMedThe American journal of occupational therapy : official publication of the American Occupational Therapy Association2026-09-05

Extrinsic Environmental Factors Influencing the Achievement of Independent Oral Feeding in Preterm Infants.

Cushing Avery A, Donovan Karlee K, Lewis Jasmine J, Lucyshyn Katja K et al.

ImportancePreterm infants frequently experience difficulty with the transition from full tube to independent oral feeding. The influence of extrinsic environmental factors, defined as causes external to the infant, that may affect this transition remains poorly understood.ObjectiveTo examine the association between extrinsic environmental factors and attainment of independent oral feeding in preterm infants.DesignA retrospective cohort study was conducted.SettingData were collected from a tertiary care, level II/III neonatal intensive care unit. Guided by the Oral Feeding in Preterm Infants Conceptual Model, extrinsic environmental factors were selected for analysis.ParticipantsA total of 282 preterm infants (31.2 ± 2.4 weeks gestation) were included.MethodologyFactors including maternal medical history, type of medical condition, maternal substance use, non-nutritive sucking, skin-to-skin contact, feeding therapy, and days of hospitalization prior to initiating oral feeding were extracted from electronic medical records. Simple linear regressions identified potential external variables, which were entered into a multiple linear regression model.ResultsIn the final multiple linear regression model, maternal medical history, non-nutritive sucking, and skin-to-skin contact were significant predictors of time to independent oral feeding. Maternal age, substance use, feeding therapy, and days in hospital prior to starting oral feeds were not significant.Conclusion and RelevanceMaternal health and engagement, reflected in maternal medical history, opportunities for non-nutritive sucking, and skin-to-skin contact, are key extrinsic environmental factors influencing the transition to independent oral feeding. Integrating these maternal factors into occupational therapy management may enhance the attainment of independent oral feeding in preterm infants.

PMID 42698322
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PubMedPharmaceutical development and technology2026-09-05

Sustained oral drug delivery using PEGylated liposomes incorporated into polysaccharide hydrogel formulations.

Nishida Sora S, Yamazoe Eriko E, Ito Takaaki T, Tahara Kohei K

In this study, PEGylated liposomes (PEG-Lip) were combined with polysaccharides to sustain their oral absorption-enhancing effect. PEG-Lip was prepared by the thin-film hydration method and mixed with carrageenan (CGN), xanthan gum (XG), or locust bean gum (LBG). The prepared PEG-Lip had a particle size of ∼100 nm and a zeta potential of approximately -50 mV. The polysaccharide concentrations that did not inhibit PEG-Lip behavior were 0.5% for CGN and 0.25% for XG and LBG. At 25 °C, the release of PEG-Lip from each polysaccharide was generally consistent with its diffusion within the polysaccharide. In the rheological evaluation, only XG3-LBG7, a 3:7 mixture of XG and LBG, exhibited gel-like behavior, whereas the other formulations functioned as viscosity modifiers. Oral administration in rats showed improved gastrointestinal retention compared with PEG-Lip alone. Furthermore, XG3-LBG7 provided the greatest improvement in the oral absorption of FITC-dextran (FD4). These findings suggest that optimizing both PEG-Lip release and the rheological properties of polysaccharides is important for improving oral absorption.

PMID 42698391
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PubMedInternational journal of dental hygiene2026-09-05

What Is Not Measured Cannot Be Planned: Public Dental Hygienists and Preventive Workforce Visibility in Oral Health Systems.

Enciso-Ripoll Manuel Jesús MJ, Silvestre Francisco J FJ

To examine preventive oral health workforce visibility as a prerequisite for health-system planning, governance and accountability, using Spain as an illustrative case within a broader international perspective. This Editorial synthesises current WHO workforce-monitoring frameworks, recent literature on preventive oral health workforce planning and previously reported Spanish administrative workforce data. No new dataset was generated or analysed. Workforce visibility should be distinguished from workforce sufficiency, service implementation and health outcomes. The relevant preventive workforce may include dental hygienists, dental therapists, oral health therapists and other locally recognised cadres. In Spain, 1207 publicly employed dental hygienists were previously identified, without representing the total practising workforce. A minimum monitoring set should include headcount and full-time-equivalent supply, population-adjusted density, geographical distribution, employment and contracting model, scope and activity, and integration into preventive programmes. Standardised monitoring aligned with the WHO National Health Workforce Accounts can strengthen assessment of health-system readiness while preserving the distinction between workforce measurement, service delivery and health outcomes.

PMID 42698266
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PubMedBritish dental journal2026-09-05

Oral healthcare professionals' role in reducing young people's sugar-sweetened beverage consumption: a qualitative study.

Watt Samantha S, Li Jennifer J, Brierley Catherine C, Marshman Zoe Z

Aims This qualitative study aimed to seek views from children and young people (CYP), caregivers, and oral health professionals (OHPs) on the role of OHPs in reducing sugar-sweetened beverage (SSB) consumption.Methods Thirty-eight semi-structured interviews were conducted with CYP aged 11-16 years (n = 18), caregivers (n = 9) and OHPs working in general dental practices, paediatric and orthodontic services (n = 11). Topic guides, informed by the Theoretical Domains Framework, structured the interviews. Interviews were analysed using framework analysis with concurrent data collection.Results Data from the qualitative interviews suggested agreement that OHPs have a key role in SSB reduction in CYP and identified four themes: 1) OHPs' knowledge and awareness of different types of SSBs; 2) SSB consumption in CYP - influences and consequences; 3) the role of OHPs supporting reduced SSB consumption; and 4) navigating the challenges of behaviour change in adolescents. Key influences on SSB consumption for CYP included taste, peers, and social media. OHPs reported challenges in supporting behaviour change, citing peer pressure, autonomy, and time constraints.Conclusion Given the established relationship between SSB consumption and poor oral health and inequalities, OHPs are well-placed to support its reduction in CYP.

PMID 42697940
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PubMedJournal of the College of Physicians and Surgeons--Pakistan : JCPSP2026-09-05

A Novel Metric to Guide Cancer Priorities in Pakistan.

Aslam Aashir A, Zafar Syed Nabeel SN

Pakistan faces an escalating cancer burden, with approximately 185,748 new cases and 118,631 deaths annually. According to GLOBOCAN data, breast cancer (16.5%), lip/oral cavity cancer (8.6%), and lung cancer (5.1%) are the most prevalent, with breast cancer alone accounting for 31.3% of female cases. The country's limited healthcare resources, including severe shortages of oncologists and radiotherapy facilities, exacerbate this crisis, requiring urgent intervention. The delta Mortality-to-Incidence Ratio (dMIR) metric identifies cancers with the largest outcome gaps between Pakistan and top-performing countries, highlighting where improvements could yield the greatest impact. For instance, stomach cancer (dMIR = 0.60), Kaposi sarcoma (0.58), and oral cavity cancer (0.49) represent critical priorities. By focusing resources on high-dMIR cancers through early detection, treatment access, and prevention programs, Pakistan can significantly reduce preventable mortality. To address these challenges, Pakistan must implement a comprehensive National Cancer Control Plan. Key steps include expanding screening programs for breast, cervical, and oral cancers; training healthcare workers; upgrading radiotherapy infrastructure; and launching public awareness campaigns targeting tobacco use and lifestyle risks. Strategic investments in these areas, coupled with policy reforms and public-private partnerships, could transform cancer outcomes in Pakistan. Key Words: Pakistan, Cancer burden, Delta mortality-to-incidence ratio, Cancer disparities, Low- and middle-income countries.

PMID 42698255
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